@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_NTRK2_HUMAN: (2014-10-13 )
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
Atome Classification :
(15 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560...--------------....570...-.-.-..-580.......590.......600.......610.......620.......630.......640..----.....650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750........760....-----...770.........780.......790.......800.......810.......820
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSS
W
I
R
WHG
P
A
M
A
R
L
W
G
F
C
W
L
V
V
G
F
W
R
A
A
FACPTSCKCSA
S
R
I
WCSDPSP
G
I
V
A
FPRLEPNSV
D
P
E
N
I
T
E
I
FIANQ
K
R
L
E
II
N
E
D
D
V
E
A
Y
VGLR
N
L
T
I
V
D
S
G
L
K
F
V
A
H
K
A
F
LKNSNL
Q
H
I
NF
T
R
N
K
L
T
S
L
S
R
K
H
F
R
HL
D
L
S
E
L
I
L
VGNPFTCSC
D
I
M
W
I
K
T
L
Q
E
AKSSPDTQ
D
L
Y
C
LNESSKNIPLANLQIPNCGLPSANLAAPN
L
T
V
EEG
K
S
I
T
L
S
C
S
VAGDPV
P
N
M
Y
W
D
V
G
N
L
V
S
K
H
MNETSHTQG
S
L
R
I
T
NISSDDSG
K
Q
I
S
C
V
A
E
N
LVGEDQD
S
V
N
L
T
V
H
FA
P
T
I
T
F
LESPTSDH
H
W
C
I
P
F
T
VKGNPK
P
A
L
Q
W
F
YN
G
A
I
LNES
K
Y
I
C
T
K
I
H
VTNHTEYH
G
C
LQLDNPTHMNNG
D
Y
T
L
I
AKNEYGK
D
E
K
Q
I
S
A
HFMGWPGIDDGANPNYPDV
I
Y
EDYGTAANDIGDTTNRSNEIPSTDVTDKT
G
R
E
H
L
S
V
Y
A
V
V
V
I
A
S
V
V
G
F
C
L
L
V
M
L
F
L
L
K
L
A
RHSKFGMKG
P
A
S
VISNDDDSASP
L
H
HISNGSNTPSSSEGGP
D
A
V
I
I
G
M
T
KIPVIENP
Q
Y
FGITNSQLK
P
D
T
F
V
Q
H
I
K
RH
N
I
V
L
K
RELGEG
A
F
G
K
V
F
L
A
E
C
Y
N
LCPEQ
D
--------------
K
I
L
V
A
V
KTLK-D-A-SD-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
CVEGD
P
L
I
M
V
F
E
Y
M
KHG
D
L
N
K
F
L
R
AHGP
D
A
V
L
M
AEGNP----PTE
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
LATRNCLVGE
N
L
L
V
K
IGDFGMSRDVYST
D
Y
Y
R
VGG
H
T
M
L
P
I
R
WMPPE
S
I
M
Y
R
KFTTES
D
V
W
S
L
G
V
V
L
W
E
I
F
T
YGK-QP
W
Y
QLSN
N
E
V
I
E
C
I
-----TQGR--VLQRPRT
C
P
Q
E
V
Y
E
L
M
L
G
C
WQREP
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
AKAS
P
V
Y
L
D
ILG
2
PsiBlast_PDB
95.10
100%
-129
- C1 -
4AT4
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
1
PsiBlast_PDB
94.87
100%
-126
- C1 -
4AT3
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
C
------------------
K
I
L
V
A
V
K
T
L
----
A
-
S
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
--
N
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
3
PsiBlast_PDB
91.10
100%
-124
- C1 -
4AT5
2
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
L
-------------------
K
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
D
-
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
E
G
N
P
----
P
T
E
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
5
PsiBlast_PDB
65.84
73%
-128
- C1 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-----------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
-------------
P
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
4
PsiBlast_PDB
65.54
82%
-127
- C1 -
3V5Q
1
NTRK3_HUMAN
A:
[9-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
L
S
P
T
K
D
--------------
K
M
L
V
A
V
K
A
L
----
P
-
T
L
-
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------
E
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
P
-------
21
PsiBlast_CBE
64.84
73%
-124
- C1 -
4AOJ
1
C:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-
Q
D
--------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
--------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
M
----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
22
PsiBlast_CBE
62.15
73%
-125
- C1 -
4AOJ
1
NTRK1_HUMAN
B:
[33-324]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
L
P
-----------------
K
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
E
-
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
--------------
G
P
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
V
Y
-----
15
PsiBlast_PDB
39.25
44%
-111
- C1 -
3ETA
1
INSR_HUMAN
A:
[12-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
-
N
N
P
G
R
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
-------------
16
PsiBlast_PDB
36.62
44%
-109
- C1 -
4IBM
1
?
A:
[13-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
I
K
G
E
A
--------------
E
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
L
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
-
N
N
P
G
R
P
----
P
P
T
L
--
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
D
-------------
10
PsiBlast_PDB
33.96
47%
-117
- C1 -
4BKJ
10
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
LVSLDFPLNVRKG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
------------
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
---------------
9
PsiBlast_PDB
32.31
47%
-111
- C1 -
3ZOS
4
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
Q
D
LVSLDFP
L
N
V
R
KG
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
K
-
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
--------AAQ
G
P
T
-
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
---------------
20
PsiBlast_PDB
29.98
44%
-115
- C1 -
3NW5
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
----
E
N
N
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
-------------------------
17
PsiBlast_PDB
26.07
44%
-114
- C1 -
3I81
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-----
E
N
N
P
V
L
A
-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
-------------------------
19
PsiBlast_PDB
24.88
44%
-113
- C1 -
2OJ9
1
A:
[10-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
M
-
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-------------
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
-------------------------
12
PsiBlast_PDB
11.16
43%
-116
- C1 -
3LVP
2
IGF1R_HUMAN
A:
[39-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
V
K
D
E
P
--------------
E
T
R
V
A
I
K
T
V
N
-
E
-
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
----
E
--
P
VLA-
P
P
S
L
--
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
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