@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_NTRK3_HUMAN: (2014-10-13 )
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
Atome Classification :
(10 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.....----------..560....-...570...-.-.-..580.......590.......600.......610.......620.......630.......640.......650..----.....660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760......-.770.......780.-----....--..790.......800.......810.......820.......830.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDVSLCPAKC
S
F
W
R
I
F
L
L
G
S
V
W
L
D
Y
V
G
S
V
L
ACPANCVCSKTEINCRRPDDG
N
L
F
P
L
LEGQDSGNSNG
N
A
S
I
N
I
T
DISRN
I
T
S
I
H
IENWRSLHTL
N
A
V
D
M
E
L
Y
T
G
L
Q
K
L
T
IKNSGLRSIQPRAFAKNP
H
L
R
Y
I
NLSSN
R
L
T
T
L
S
W
Q
L
F
Q
T
L
S
L
R
E
L
Q
L
EQNFFNCSC
D
I
R
W
M
Q
L
W
Q
EQGEAKLNSQ
N
L
Y
C
INADGSQ
L
P
L
F
R
MNISQCDLP
E
I
S
V
S
H
V
N
L
T
V
REGD
N
A
V
I
T
CNGSGSPLP
D
V
D
W
I
V
T
G
L
Q
SINTHQTNL
N
W
T
N
V
H
A
I
N
L
T
L
V
N
V
TSEDN
G
F
T
L
T
C
IAENVVGMSNA
S
V
A
L
T
V
YYPPRVVSLEE
P
E
L
R
L
E
H
C
I
E
F
V
VRGNPP
P
T
L
H
W
LHNGQPLRES
K
I
I
H
V
E
Y
YQEGEISE
G
C
L
L
FNKPTHYNNG
N
Y
T
L
I
AKNPLGTANQTINGHFLKEPFPESTD
N
F
I
L
F
DEVSPTP
P
I
T
V
THKPEEDTFG
V
S
I
A
V
G
L
A
A
F
A
C
V
L
L
V
V
L
F
V
M
I
N
KYGRRSKFGMKG
P
V
A
V
I
SGEEDSASP
L
H
H
I
NHGITTPSSLDAGP
D
T
V
V
I
G
M
T
RIPVIEN
P
Q
Y
F
R
QGHNCHKP
D
T
Y
V
Q
H
I
K
RR
D
I
V
L
K
RELGEGA
F
G
K
V
F
L
A
E
C----------YNLSPTKD
K
-
M
L
V
A
V
KALK-D-P-
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
GVCGDGD
P
L
I
M
V
F
E
Y
M
KHG
D
L
N
K
F
L
R
AHGP
D
A
M
I
L
VDGQPRQAKGEL
G
L
S
----
Q
M
L
H
I
A
S
Q
I
AS
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
LATRNCLVG
A
N
L
L
V
K
IGDFGMSRDVYST
D
Y
Y
R
L
FNPSGN
D
F
C
I
W
C
EVGG
H
T
M
L
P
I
R
WMPPE
S
I
M
Y
R
KFTTES
D
V
W
S
F
G
V
I
L
W
E
I
F
T
YGK-Q
P
W
F
QLSN
T
E
V
I
E
C
I
-----TQGR--VLERPRV
C
P
K
E
V
Y
D
V
M
L
G
C
W
QR
E
P
Q
QRL
N
I
K
E
I
Y
K
I
L
H
A
LGKAT
P
I
Y
L
D
ILG
1
PsiBlast_PDB
94.84
95%
-134
- C2 -
3V5Q
1
NTRK3_HUMAN
A:
[8-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
Q
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
----------
Y
N
L
S
P
T
K
D
K
-
M
L
V
A
V
K
A
L
----
P
-
T
L
A
A
R
K
D
F
Q
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
E
L
G
L
S
----
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
G
K
-
Q
P
W
F
Q
L
S
N
T
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
A
T
P
-------
4
PsiBlast_PDB
92.73
78%
-120
- C2 -
4AT5
2
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
-----
K
-
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
E
G
N
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
2
PsiBlast_PDB
92.58
78%
-125
- C2 -
4AT3
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
C
----
K
-
I
L
V
A
V
K
T
L
----
A
-
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
--
N
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
3
PsiBlast_PDB
91.89
78%
-125
- C2 -
4AT4
1
A:
[4-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
F
V
Q
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
Y
N
L
C
----
K
-
I
L
V
A
V
K
T
L
K
-
D
-
A
-
S
D
N
A
R
K
D
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
L
M
A
---
P
---
P
T
E
L
T
Q
S
----
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
--------------
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
-----
T
Q
G
R
--
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
A
S
P
V
Y
L
D
I
L
G
5
PsiBlast_PDB
85.86
70%
-129
- C2 -
4AOJ
1
NTRK1_HUMAN
A:
[33-322]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
C
V
H
H
I
K
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
----------
H
N
L
L
P
---
K
-
M
L
V
A
V
K
A
L
K
-
E
-
A
-
S
E
S
A
R
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
D
------------
P
G
P
L
G
L
G
----
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
L
V
V
K
I
G
D
F
G
------------------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
-
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
-----
T
Q
G
R
--
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
P
P
-------
12
PsiBlast_PDB
69.69
43%
-114
- C2 -
3ZOS
4
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
N
V
R
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
------------
A
A
Q
G
P
T
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
--------------
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
---------------
13
PsiBlast_PDB
69.57
43%
-119
- C2 -
4BKJ
10
DDR1_HUMAN
A:
[9-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
SPQDLVSLD
F
P
L
N
V
R
K
G
H
P
L
L
V
A
V
K
I
L
R
P
D
-
A
-
T
K
N
A
R
N
D
F
L
K
E
V
K
I
M
S
R
L
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
----------------
P
T
IS
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
------------------
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
F
F
R
D
Q
G
R
QV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
---------------
18
PsiBlast_PDB
68.29
40%
-109
* C2 *
3ETA
1
INSR_HUMAN
A:
[12-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
I
K
G
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
----
E
N
N
P
--
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
-
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
---------------
19
PsiBlast_PDB
66.16
39%
-100
- C2 -
4IBM
1
?
A:
[5-286]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
Y
V
P
D
E
W
--
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
----------
R
D
I
I
K
G
E
A
E
-
T
R
V
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
------
E
N
N
P
G
R
P
P
P
T
L
Q
----
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
--------------
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-----
M
D
G
G
--
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
---------------
15
PsiBlast_PDB
59.59
39%
-108
- C2 -
3LVP
2
IGF1R_HUMAN
A:
[39-312]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
--
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
----------
K
G
V
V
K
D
E
P
E
-
T
R
V
A
I
K
T
V
N
-
E
-
A
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
----
M
E
--
P
V
L
A
P
P
--
S
L
S
----
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
---------------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
-
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
-----
M
E
G
G
--
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-------------------