@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_ROS1_HUMAN: (2014-10-13 )
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
Atome Classification :
(14 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850......1860......1870......1880......1890......1900......1910......1920......1930......1940......1950......1960......1970......1980......1990......2000......2010......2020......2030......2040......2050......2060......2070......2080......2090......2100......2110......2120......2130......2140......2150......2160......2170......2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
N
I
Y
C
L
I
P
K
L
V
N
F
A
T
L
G
C
L
W
I
S
V
V
Q
C
T
V
L
N
S
C
L
K
S
C
V
T
N
L
GQQLDLGTPHNL
S
E
P
C
I
Q
G
C
HFWNSVDQK
N
C
A
L
K
C
R
E
S
CEVGCSSAEG
A
Y
E
E
E
V
L
ENADLPTA
P
F
A
S
SIGSH
N
M
T
L
R
W
KSANFS
G
V
K
Y
I
I
Q
W
K
Y
A
Q
L
LGSWT
Y
T
K
TVSRPS
Y
V
VKPL
H
P
F
T
E
Y
I
F
R
V
V
W
I
F
T
A
Q
L
Q
L
YSPPSPSYRTHPHGVP
E
T
A
P
L
I
R
NIESSSP
D
T
V
E
V
SWDPPQFPGG
P
I
L
G
Y
N
L
R
L
I
SKNQKLDAGTQR
T
S
F
Q
F
YSTLPN
T
I
Y
R
F
S
I
A
A
V
N
EVGEGPEAESSITTS
S
S
A
V
Q
QEE
Q
W
L
F
LSRKT
S
L
R
K
R
S
L
K
H
L
V
D
E
A
H
C
L
R
L
D
A
I
Y
HNITG
I
S
V
D
V
H
Q
Q
I
V
Y
FSE
G
T
L
I
W
A
KKAANMSDVS
D
L
R
I
F
Y
RGSGL
I
S
S
I
S
I
D
W
L
Y
Q
R
M
Y
F
I
M
D
E
L
V
C
V
CDLENCSN
I
E
EITPPSISA
P
Q
K
I
V
ADSYN
G
Y
V
F
Y
L
LRDGIYRADLPVPS
G
R
C
A
E
A
V
R
I
V
E
SCTLKDFAIKPQA
K
R
I
I
Y
FN
D
T
A
Q
V
F
M
S
T
F
LDGSAS
H
L
ILPRI
P
F
A
D
V
K
S
FACENN
D
F
L
VTD
G
K
V
I
F
QQDAL
S
F
N
E
F
I
VGC
D
L
S
H
I
E
E
FGFG
N
L
V
I
FGSSSQLHPLPGR
P
Q
E
L
S
V
LFGS
H
Q
A
L
V
Q
WKPP
A
L
A
IG
A
N
V
I
L
I
S
D
I
I
E
L
F
ELG
P
S
A
WQ
N
W
T
Y
E
V
K
VSTQDPP
E
V
T
H
I
F
L
NISG
T
M
L
N
V
P
E
L
Q
S
A
M
K
Y
K
V
S
V
R
ASSPKRPGPWSEPSVG
T
T
LVPASEP
P
F
I
M
A
V
KEDGLWSKPLNSFG
P
G
E
F
L
S
S
D
IGNVSDMDWYNN
S
L
Y
Y
SDTKG
D
V
F
V
W
L
LNGTDISENYHLPSIAG
A
G
A
L
A
F
E
W
L
G
H
F
L
Y
WAG
K
T
Y
V
I
Q
R
QSVLTG
H
T
D
I
V
T
H
V
K
L
L
V
N
D
M
V
V
DSVG
G
Y
L
Y
W
T
T
L
Y
S
V
E
S
T
RLNGE
S
S
L
V
L
Q
TQPWFSG
K
K
V
I
A
L
T
L
DLSD
G
L
L
Y
W
L
VQDS
Q
C
I
H
L
Y
T
A
V
L
RGQSTGD
T
T
I
T
E
FAAWS
T
S
E
ISQN
A
L
M
Y
YS
G
R
L
F
W
I
N
G
F
R
I
I
T
T
Q
EIGQKTS
V
S
VLEPARF
N
Q
F
T
I
I
QTSLKPLPGNFSFTPKVIPDSVQES
S
F
R
IEGNA
S
S
F
Q
I
L
WNGPPA
V
D
W
G
V
V
F
Y
S
V
E
FSAH
S
K
F
L
ASEQHS
L
P
V
F
T
VEGLE
P
Y
A
L
F
N
L
SVT
P
Y
TYWGKGPKT
S
L
S
LRAPETVPSAPEN
P
R
I
F
I
LPSGKCCNKN
E
V
V
V
E
F
R
WNKPKHENG
V
L
T
K
F
E
I
F
Y
NISNQSITNKTCE
D
W
I
A
V
NVTP
S
V
M
S
F
Q
LEGMSP
R
C
F
I
A
F
Q
V
R
A
FTSKGPG
P
Y
A
D
V
V
K
S
TTSEINP
F
P
H
L
I
T
L
LG
N
K
I
V
F
L
DMDQ
N
Q
V
V
W
T
F
S
A
E
R
V
I
S
A
V
C
YTADNEM
G
Y
Y
AEG
D
S
L
F
L
L
H
LHNR
S
S
S
E
L
FQDS
L
V
F
D
I
T
V
I
T
I
D
W
I
S
R
H
L
Y
F
A
L
KESQNG
M
Q
V
F
DVD
L
E
H
KVKYP
R
E
V
K
I
HNRN
S
T
I
I
S
F
S
V
Y
P
L
L
S
R
L
Y
W
T
E
VSNF
G
Y
Q
M
F
Y
Y
S
I
I
S
H
T
L
H
R
I
LQPTATNQQNKRNQCSCN
V
T
E
F
E
LS
G
A
M
A
IDTSNLEKP
L
I
Y
F
AKA
Q
E
I
W
A
MDLEG
C
Q
C
W
R
V
I
T
V
P
A
M
LAG
K
T
L
V
S
L
T
VDG
D
L
I
Y
W
I
I
TAKDS
T
Q
I
Y
Q
AKKGN
G
A
I
V
S
Q
V
K
A
L
R
S
R
H
I
L
A
Y
S
S
V
MQPFP
D
K
A
F
L
S
L
A
SDTVE
P
T
I
L
NATN
T
S
L
T
I
R
L
PLAKT
N
L
T
W
Y
GITSPT
P
T
Y
L
V
Y
Y
A
E
VNDRKNSSD
L
K
Y
R
I
L
EFQD
S
I
A
L
I
E
DLQ
P
F
S
T
Y
M
I
Q
I
A
V
K
N
YYSD
P
L
E
HLP
P
G
K
E
I
WGKTKNG
V
P
E
A
V
Q
L
I
N
T
T
VRSD
T
S
L
I
I
S
W
R
E
SHKPNG
P
K
E
S
V
R
Y
Q
L
A
I
S
H
L
ALIPETPLRQSEFPNG
R
L
T
L
L
V
T
RLSGG
N
I
Y
V
L
K
V
L
ACHSEEMWCTESH
P
V
T
V
E
MFNTPEK
P
Y
SLVPEN
T
S
L
Q
F
NWKAPL
N
V
N
L
I
R
F
W
V
E
L
Q
KWKYN
E
F
Y
H
V
KTSCSQG
P
A
Y
V
C
NITNLQPYTSY
N
V
R
V
V
V
V
Y
KTGENSTSL
P
E
S
FKTKAGVPNKPGI
P
K
L
LEGSKNS
I
Q
W
EKAEDNG
C
R
I
T
Y
Y
I
L
E
I
RKSTSNNLQNQN
L
R
W
K
M
T
FNGSCS
S
V
C
T
WKSKNL
K
G
I
F
Q
F
R
V
V
A
ANNLGFGEYSGISE
N
I
I
L
VGDDFWIP
E
T
S
F
I
L
T
I
I
V
G
I
F
L
V
V
T
I
P
L
T
F
V
W
H
R
R
LKNQKSAKE
G
V
T
V
L
INE
D
K
E
L
A
E
L
R
G
L
A
AGV
G
L
A
N
A
C
Y
A
IHTLP
T
Q
E
E
I
E
NLPAFPRE
K
L
T
L
R
L
L
LGSGAFGEVYEG
T
A
V
D
I
L
GVGSG
E
I
K
V
A
V
K
T
L
KKGST
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
KFN
H
P
N
I
L
K
Q
L
G
V
C
LLNEPQ
Y
I
I
L
E
L
MEGG
D
L
L
T
Y
L
R
K
A
R
M
A
T
F
Y
G
P
L
L
T
L
V
D
L
V
D
L
C
V
D
IS
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
ARN
C
L
V
S
VKDYTS
P
R
I
V
K
IGDF
G
L
A
R
D
I
Y
KN
D
Y
Y
R
KRGEGL
L
P
V
R
WM
A
P
E
S
L
M
D
G
I
FTTQ
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
LGHQPYPAHSNL
D
V
L
N
Y
V
QTGGRLEPPRN
C
P
D
D
L
W
N
L
M
T
Q
C
WAQEPDQRP
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
KSRDEANNSGVINESFEGEDG
D
V
I
C
LNSDD
I
M
P
V
A
L
M
ETKNREG
L
N
Y
M
V
L
A
TECGQGEEKSEGPLGSQ
E
S
E
SCGLRKEEKEPHA
D
K
D
F
C
Q
EK
Q
V
A
YCPSGKPEG
L
N
Y
A
C
L
T
HSGYGDGSD
8
PsiBlast_PDB
59.30
48%
-50
- C1 -
3LCS
3
A:
[30-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
M
P
N
D
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
58.43
48%
-47
- C1 -
3LCT
3
A:
[29-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
M
P
N
D
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.76
48%
-49
- C1 -
3L9P
4
A:
[52-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
54.44
48%
-56
- C1 -
2YFX
1
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
--
A
F
G
E
V
Y
E
G
Q
-
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
53.78
48%
-54
- C1 -
4CCU
1
?
A:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
--------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
53.26
48%
-54
* C1 *
4CD0
1
?
A:
[26-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
51.82
49%
-55
- C1 -
4FOC
1
A:
[48-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
50.75
49%
-53
- C1 -
4FOD
2
A:
[28-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
50.64
49%
-53
- C1 -
4FOB
1
A:
[48-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
---
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
48.31
48%
-56
- C1 -
3AOX
5
A:
[28-317]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
47.32
48%
-54
- C1 -
2XB7
1
A:
[3-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
45.92
49%
-50
- C1 -
4FNZ
1
A:
[22-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
G
-----
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.72
48%
-60
- C1 -
2XBA
1
A:
[3-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
-------
V
Y
E
G
Q
-
V
S
-------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
40.20
49%
-50
- C1 -
4DCE
1
ALK_HUMAN
A:
[28-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
-----
P
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
S
Q
P
S
S
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------