@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF07714_TIE1_MOUSE: (2014-10-13 )
MVWWGSSLLLPTLFLASHVGASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSDPPLLLEKDDRIVRTFPPGQPLYLARNGSHQVTLRGFSKPSDLVGVFSCVGGAGARRTRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQTDVIWKNNGSYFNTLDWQEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPGCLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYGCSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDRIPQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRKPDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVPLTAPRLLAKQSRQLVVSPLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSENVTLMNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLESWHVEGPDRLRVSWSLPSVPLSGDGFLLRLWDGARGQERRENISFPQARTALLTGLTPGTHYQLDVRLYHCTLLGPASPPAHVHLPPSGPPAPRHLHAQALSDSEIQLMWQHPEAPSGPISKYIVEIQVAGGSGDPQWMDVDRPEETSIIVRGLNASTRYLFRVRASVQGLGDWSNTVEEATLGNGLQSEGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLALVCIRRSCLHRRRTFTYQSGSGEETILQFSSGTLTLTRRPKPQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLEARKAYVNMSLFENFTYAGIDATAEEA
Atome Classification :
(13 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830--..----......840.......850-.---....--..860----.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990......---.---1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100...--...1110......1120......1130.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVWWG
S
S
L
L
L
P
T
L
F
L
A
S
HVGA
S
V
D
L
T
L
L
A
N
L
R
ITDP
Q
R
F
F
L
T
C
VSGEAGAGRSSDP
P
L
L
LEKDD
R
I
V
R
TFPPGQ
P
L
Y
L
ARNGS
H
Q
V
T
L
RGFS
K
P
S
D
L
V
G
V
F
S
CVGGAGA
R
R
T
R
V
L
Y
V
HNSPGAHLFPDK
V
T
H
TVNKGD
T
A
V
L
S
A
H
VHKEKQT
D
V
I
WKNNG
S
Y
FNTLDWQEADD
G
R
F
Q
L
Q
L
QNVQPPSSG
I
Y
S
A
T
Y
LEASP
L
G
S
A
F
F
R
L
I
V
R
GCGAGRWGP
G
C
V
K
DC
P
G
C
LHGGVCHDHDG
E
C
VCPPGF
T
G
T
R
C
E
Q
A
C
REGRFG
Q
S
C
Q
E
QCPGTAGC
R
G
L
T
F
CLPDPYGCSCGSGWRG
S
Q
C
Q
E
ACAPGHFGAD
C
R
L
Q
C
Q
CQNGGT
C
D
RFSGCVCPSGWHGVHCEKSDR
I
P
Q
I
L
S
M
A
T
E
V
E
F
NIGTMP
R
I
N
CAAAGNPFPVRG
S
M
K
LRKPD
G
T
M
L
L
S
T
K
V
I
VEPDRTTA
E
F
EV
P
S
L
TLGDSG
F
W
E
C
R
V
STSGGQD
S
R
R
F
K
V
N
V
KVPPVPL
T
A
P
R
L
L
A
K
QS
R
Q
L
V
V
S
P
L
V
SFSGDGPI
S
S
V
R
L
H
Y
RPQDS
T
I
A
W
S
A
I
V
VDPSE
N
V
T
L
M
N
LKPKTG
Y
N
V
R
V
Q
L
SRPGEGGEGGWGPSALMTTDC
P
E
P
L
L
Q
P
W
L
E
SWHVEGP
D
R
L
R
V
S
WSLPSVPLSGD
G
F
L
L
R
L
WDGAR
G
Q
E
R
RENISF
P
Q
A
R
T
A
L
L
TGLTPG
T
H
Y
Q
L
D
V
R
L
Y
H
C
T
LLGPASPP
A
H
V
HLPPSGPPAPR
H
L
H
A
QALSDS
E
I
Q
L
M
W
QHPEAPSGPI
S
K
Y
I
V
E
I
Q
V
AGGSGDPQWMDVDRPEE
T
S
I
I
V
RGLNAS
T
R
Y
L
F
R
V
R
A
S
VQGLGDWSN
T
V
E
E
A
TLGNGLQSEGPVR
E
S
R
A
A
E
EG
L
D
Q
Q
L
V
L
A
V
V
G
S
V
S
A
T
C
L
T
I
L
A
A
L
L
A
L
V
C
I
R
R
S
C
L
H
RRR
T
F
T
YQSGSGE
E
T
I
L
Q
FSS
G
T
L
T
L
TRRPKPQPEPLSYPVLE---WE----DI
T
F
E
D
LIGEG
N
F
G
Q
V
I
R
A
-
M
---
I
K
KD--GL
K
M
N
----
A
A
I
K
M
L
K
E
Y
ASENDH
R
D
F
A
G
E
L
E
V
L
C
KLGHHP
N
I
I
N
L
L
G
ACENR
G
Y
L
Y
I
A
I
EYAPY
G
N
L
L
D
F
L
R
KSRVLETD
P
A
F
A
R
EHGTAS
T
L
S
S
R
Q
L
L
R
F
A
S
D
A
A
N
G
M
Q
Y
L
S
E
K
Q
F
I
H
R
D
L
A
ARNVLV
G
E
N
L
A
S
K
I
A
D
FGLSR---G---
E
E
V
Y
V
K
K
TMGRL
P
V
R
W
M
A
I
ESL
N
Y
S
V
Y
T
TK
S
D
V
W
S
F
G
V
L
L
W
E
I
V
SLGGTPYCG
M
T
C
A
E
L
Y
E
KLPQGYRMEQPRNC
D
D
E
V
Y
E
L
M
R
Q
C
W
RDRPYERP
P
F
A
Q
I
A
L
Q
L
G
R
M
--
L
E
A
R
K
A
Y
V
N
M
S
L
F
EN
F
T
YAGIDATAEEA
4
PsiBlast_PDB
76.23
81%
-102
- C1 -
3L8P
1
A:
[7-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
Y
P
V
L
D
---
W
N
----
D
I
K
F
Q
D
V
I
G
E
G
N
F
G
Q
V
L
K
A
-
R
---
I
K
K
D
--
G
L
R
M
D
----
A
A
I
K
R
M
-----------
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
---
Q
E
V
Y
V
K
K
-----
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
E
--
1
PsiBlast_PDB
66.74
80%
-98
- C1 -
2WQB
1
A:
[16-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
P
V
L
D
---
W
N
----
D
I
K
F
Q
D
V
I
G
E
G
--
G
Q
V
L
K
A
-
R
---
I
K
K
D
--
G
L
R
M
D
----
A
A
I
K
R
M
K
-------------
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
R
G
Y
L
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
N
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
S
R
---
G
---
Q
E
V
Y
V
K
K
T
-
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
D
C
S
A
---
3
PsiBlast_PDB
54.92
81%
-101
- C1 -
2OSC
1
A:
[30-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
L
K
A
-
R
---
I
--------
M
D
----
A
A
I
K
R
M
K
----
K
D
D
H
R
D
F
A
G
E
L
E
V
L
C
K
L
G
H
H
P
N
I
I
N
L
L
G
A
C
E
H
----
Y
L
A
I
E
Y
A
P
H
G
N
L
L
D
F
L
R
K
S
R
V
L
E
T
D
P
A
F
A
I
A
N
S
T
A
S
T
L
S
S
Q
Q
L
L
H
F
A
A
D
V
A
R
G
M
D
Y
L
S
Q
K
Q
F
I
H
R
D
L
A
A
R
N
I
L
V
G
E
N
Y
V
A
K
I
A
D
F
G
L
-----------------
M
G
R
L
P
V
R
W
M
A
I
E
S
L
N
Y
S
V
Y
T
T
N
S
D
V
W
S
Y
G
V
L
L
W
E
I
V
S
L
G
G
T
P
Y
C
G
M
T
C
A
E
L
Y
E
K
L
P
Q
G
Y
R
L
E
K
P
L
N
C
D
D
E
V
Y
D
L
M
R
Q
C
W
R
E
K
P
Y
E
R
P
S
F
A
Q
I
L
V
S
L
N
R
M
--
L
E
E
R
K
T
Y
V
N
T
T
L
Y
E
K
F
T
Y
A
G
I
-------
18
PsiBlast_PDB
31.90
48%
-94
- C1 -
4K33
1
A:
[44-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
-
E
A
I
G
I
D
K
D
RA
A
K
P
V
T
----
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
L
D
Y
S
F
D
T
S
----
E
Q
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
DVH
N
---
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
--
L
---------------------------
8
PsiBlast_PDB
30.73
44%
-86
* C1 *
2IVS
5
RET_HUMAN
A:
[14-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
DPK
W
E
FPRK
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
-
T
A
F
H
L
K
G
R
--
A
G
Y
T
T
----
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
--
K
V
G
P
G
Y
L
------
R
A
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
---
D
VYE
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
--
M
V
K
R
------------------------
17
PsiBlast_PDB
29.91
48%
-89
- C1 -
3C4F
1
FGFR1_HUMAN
A:
[21-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
--
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
IHH
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
11
PsiBlast_PDB
29.44
48%
-97
- C1 -
4F65
5
FGFR1_HUMAN
A:
[28-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
--
K
--
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-----------
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
12
PsiBlast_PDB
29.31
48%
-91
- C1 -
4NK9
5
FGFR1_HUMAN
A:
[28-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
---
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
----------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
16
PsiBlast_PDB
28.06
48%
-91
- C1 -
3RHX
2
B:
[25-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
---------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
10
PsiBlast_PDB
26.98
48%
-89
- C1 -
1FGI
1
FGFR1_HUMAN
A:
[29-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
------
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
IHH
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
13
PsiBlast_PDB
26.04
48%
-83
- C1 -
3JS2
1
FGFR1_HUMAN
A:
[36-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
--
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
-------
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
IHH
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------
9
PsiBlast_PDB
23.29
47%
-87
- C1 -
3GQL
1
FGFR1_HUMAN
A:
[36-323]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
--
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
-------------
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
L
D
L
S
M
----------------
15
PsiBlast_PDB
21.99
48%
-81
- C1 -
3TT0
1
FGFR1_HUMAN
A:
[77-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
---
I
G
L
D
--
K
D
K
P
N
R
V
T
K
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
Y
N
P
S
H
N
P
E
E
Q
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
--
V
---------------------------