@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF08515_ACVL1_HUMAN: (2014-10-15 )
MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEGRHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLALILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKISNSPEKPKVIQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTLGSP
R
K
G
L
L
M
L
L
M
A
L
VTQGDPVKPSRG
P
L
V
T
C
TCESPHCKGPTCRG
A
W
C
T
V
V
L
V
REEGRH
P
Q
E
HR
G
C
G
N
L
H
R
E
L
CRGR
P
T
E
F
V
N
H
Y
CCDSHLCNHN
V
S
L
V
L
E
ATQPPSEQPGTDG
Q
L
A
L
I
L
G
P
V
L
A
L
L
A
L
V
A
L
G
V
L
G
L
W
H
V
R
R
R
Q
E
K
Q
R
G
L
H
S
E
LGES
S
L
I
L
K
ASEQG
D
S
M
L
G
D
L
L
DSDCTTGSGSG
L
P
F
L
V
Q
R
T
V
A
R
Q
V
A
L
V
E
C
VGKGR
Y
G
E
V
W
R
G
LWHG
E
S
V
A
V
K
I
FSSR
D
E
Q
S
W
F
R
E
T
E
I
Y
N
T
V
L
L
RHDN
I
L
G
F
I
A
S
D
MTSRNSS
T
Q
L
W
L
I
T
H
YHEHG
S
L
Y
D
F
L
Q
R
QTL
E
P
H
L
A
L
R
L
A
V
S
AACG
L
A
H
L
H
V
E
I
F
GTQGKPAIAHRDFKSR
N
V
L
VKSN
L
Q
C
C
I
A
D
L
G
L
A
V
MHSQGSD
Y
L
DIGNNPRVGTKRYM
A
P
E
V
L
D
E
Q
I
R
T
D
C
F
E
SYKW
T
D
I
W
A
F
G
L
V
L
W
E
I
A
R
R
T
I
V
N
G
I
V
E
DYRPP
F
Y
DVVPNDP
S
F
E
D
M
K
K
V
V
C
VDQQTPTIPNRLAA
D
P
V
L
S
G
L
A
Q
M
M
R
E
CWYPNP
S
A
R
L
T
A
L
R
I
K
K
T
L
Q
K
I
SNSPEKPKVIQ
3
PsiBlast_PDB
91.34
79%
-116
- C2 -
4C02
11
ACVR1_HUMAN
A:
[9-329]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
A
D
L
L
D
----
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
--
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
---
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
2
PsiBlast_PDB
91.13
79%
-111
- C2 -
3H9R
4
ACVR1_HUMAN
A:
[7-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
D
S
T
L
A
D
L
L
D
H
S
C
T
S
G
S
G
S
G
L
P
F
L
V
Q
R
T
V
A
R
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
---
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
-------------
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
4
PsiBlast_PDB
85.49
78%
-108
- C2 -
3MTF
12
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
8
PsiBlast_PDB
84.44
78%
-111
- C2 -
4DYM
5
ACVR1_HUMAN
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
5
PsiBlast_PDB
84.09
78%
-107
- C2 -
3OOM
16
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
46
PsiBlast_CBE
83.49
78%
-109
- C2 -
3Q4U
6
ACVR1_HUMAN
C:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
47
PsiBlast_CBE
83.40
78%
-111
- C2 -
3Q4U
3
ACVR1_HUMAN
B:
[2-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
7
PsiBlast_PDB
83.36
78%
-108
- C2 -
4BGG
2
ACVR1_HUMAN
A:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
43
PsiBlast_CBE
83.07
78%
-108
- C2 -
4BGG
1
ACVR1_HUMAN
C:
[6-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
----
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
---
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
--------
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
------------
6
PsiBlast_PDB
82.78
78%
-108
- C2 -
3Q4U
7
ACVR1_HUMAN
A:
[4-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
44
PsiBlast_CBE
82.74
78%
-108
- C2 -
4BGG
1
ACVR1_HUMAN
B:
[5-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
S
R
H
S
S
T
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
42
PsiBlast_CBE
82.70
78%
-108
* C2 *
4BGG
1
ACVR1_HUMAN
D:
[6-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
D
I
T
L
L
E
C
V
G
K
G
R
Y
G
E
V
W
R
G
S
W
Q
G
E
N
V
A
V
K
I
F
S
S
R
D
E
K
S
W
F
R
E
T
E
L
Y
N
T
V
M
L
R
H
E
N
I
L
G
F
I
A
S
D
M
T
------
Q
L
W
L
I
T
H
Y
H
E
M
G
S
L
Y
D
Y
L
Q
L
T
T
L
D
T
V
S
C
L
R
I
V
L
S
I
A
S
G
L
A
H
L
H
I
E
I
F
G
---
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
Q
C
C
I
A
D
L
G
L
A
V
M
H
S
Q
S
T
N
Q
L
D
V
G
N
N
P
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
E
T
I
Q
V
D
C
F
D
S
Y
K
R
V
D
I
W
A
F
G
L
V
L
W
E
V
A
R
R
M
V
S
N
G
I
V
E
D
Y
K
P
P
F
Y
D
V
V
P
N
D
P
S
F
E
D
M
R
K
V
V
C
V
D
Q
Q
R
P
N
I
P
N
R
W
F
S
D
P
T
L
T
S
L
A
K
L
M
K
E
C
W
Y
Q
N
P
S
A
R
L
T
A
L
R
I
K
K
T
L
T
K
I
-----------
16
PsiBlast_PDB
81.46
63%
-111
- C2 -
2WOU
2
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
13
PsiBlast_PDB
80.38
63%
-109
- C2 -
3TZM
1
TGFR1_HUMAN
A:
[6-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
--
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
14
PsiBlast_PDB
79.77
63%
-110
- C2 -
1RW8
1
TGFR1_HUMAN
A:
[1-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
15
PsiBlast_PDB
79.59
63%
-108
- C2 -
2WOT
2
TGFR1_HUMAN
A:
[3-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
18
PsiBlast_PDB
79.49
63%
-111
- C2 -
3HMM
1
TGFR1_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
-----
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
19
PsiBlast_PDB
77.80
58%
-101
- C2 -
3MDY
1
BMR1B_HUMAN
A:
[11-334]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
D
L
I
E
Q
S
Q
S
S
G
S
G
S
G
L
P
L
L
V
Q
R
T
I
A
K
Q
I
Q
M
V
K
Q
I
G
K
G
R
Y
G
E
V
W
M
G
K
W
R
G
E
K
V
A
V
K
V
F
F
T
T
E
E
A
S
W
F
R
E
T
E
I
Y
Q
T
V
L
M
R
H
E
N
I
L
G
F
I
A
A
D
I
K
G
T
G
S
W
T
Q
L
Y
L
I
T
D
Y
H
E
N
G
S
L
Y
D
Y
L
K
S
T
T
L
D
A
K
S
M
L
K
L
A
Y
S
S
V
S
G
L
C
H
L
H
T
E
I
F
S
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
K
F
I
---------
P
N
T
R
V
G
T
K
R
Y
M
P
P
E
V
L
D
E
S
L
N
R
N
H
F
Q
S
Y
I
M
A
D
M
Y
S
F
G
L
I
L
W
E
V
A
R
R
C
V
S
G
G
I
V
E
E
Y
Q
L
P
Y
H
D
L
V
P
S
D
P
S
Y
E
D
M
R
E
I
V
C
I
K
K
L
R
P
S
F
P
N
R
W
S
S
D
E
C
L
R
Q
M
G
K
L
M
T
E
C
W
A
H
N
P
A
S
R
L
T
A
L
R
V
K
K
T
L
A
K
M
S
E
S
Q
D
------
17
PsiBlast_PDB
77.62
63%
-108
- C2 -
3GXL
1
TGFR1_HUMAN
A:
[1-296]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
---
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
-----
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
---
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
--
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------
9
PsiBlast_PDB
77.27
63%
-104
- C2 -
1PY5
1
TGFR1_HUMAN
A:
[26-322]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
A
R
T
I
V
L
Q
E
S
I
G
K
G
R
F
G
E
V
W
R
G
K
W
R
G
E
E
V
A
V
K
I
F
S
S
R
E
E
R
S
W
F
R
E
A
E
I
Y
Q
T
V
M
L
R
H
E
N
I
L
G
F
I
A
A
D
N
K
D
N
G
T
W
T
Q
L
W
L
V
S
D
Y
H
E
H
G
S
L
F
D
Y
L
N
R
Y
T
V
T
V
E
G
M
I
K
L
A
L
S
T
A
S
G
L
A
H
L
H
M
E
I
V
G
T
Q
G
K
P
A
I
A
H
R
D
L
K
S
K
N
I
L
V
K
K
N
G
T
C
C
I
A
D
L
G
L
A
V
R
H
D
S
A
T
D
T
I
D
I
A
P
N
H
R
V
G
T
K
R
Y
M
A
P
E
V
L
D
D
S
I
N
M
K
H
F
E
S
F
K
R
A
D
I
Y
A
M
G
L
V
F
W
E
I
A
R
R
C
S
I
G
G
I
H
E
D
Y
Q
L
P
Y
Y
D
L
V
P
S
D
P
S
V
E
E
M
R
K
V
V
C
E
Q
K
L
R
P
N
I
P
N
R
W
Q
S
C
E
A
L
R
V
M
A
K
I
M
R
E
C
W
Y
A
N
G
A
A
R
L
T
A
L
R
I
K
K
T
L
S
Q
L
S
----------