@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ECR_LUCCU: (2016-03-18 )
MMKRRWSNNGGFAALKMLEESSSEVTSSSNGLVLSSDINMSPSSLDSPVYGDQEMWLCNDSASYNNSHQHSVITSLQGCTSSLPAQTTIIPLSALPNSNNASLNNQNQNYQNGNSMNTNLSVNTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHTNGHMGIGGGGGGLSVNINGPNIVSNAQQLNSLQASQNGQVIHANIGIHSIISNGLNHHHHHHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTSDASDVKKIKKGPAPRLQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYCCKFGHACEMDMYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRREKKAQKEKDKIQTSVCATEIKKEILDLMTCEPPSHPTCPLLPEDILAKCQARNIPPLSYNQLAVIYKLIWYQDGYEQPSEEDLKRIMSSPDENESQHDASFRHITEITILTVQLIVEFAKGLPAFTKIPQEDQITLLKACSSEVMMLRMARRYDHNSDSIFFANNRSYTRDSYKMAGMADNIEDLLHFCRQMYSMKVDNVEYALLTAIVIFSDRPGLEEAELVEAIQSYYIDTLRIYILNRHCGDPMSLVFFAKLLSILTELRTLGNQNAEMCFSLKLKNRKLPKFLEEIWDVHAIPPSVQSHIQATQAEKAAQEAQATTSAISAAATSSSSINTSMATSSSSSLSPSAASTPNGGAVDYVGTDMSMSLVQSDNA
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290...-....300.......310.......320.......330..--.....340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470-..----.-.....----.480--.......490.......500.......510.......520.......530.......540.......550.......560........570.......580.......590..-.....600.......610.......620.......630.......640.......650.......660-........670.......680.......690.......700.......710.......720.......730.......740.......750.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MM
K
R
RWSNNG
G
F
A
A
L
K
M
L
E
ESSSEVTSSSN
G
L
V
L
SSDINMSPSSLDSPVYGDQ
E
M
W
L
CNDSASYNNS
H
Q
H
S
V
I
T
S
L
Q
G
C
T
SSLPA
Q
T
T
I
I
P
L
SALPNSNNASLNNQNQNYQNGNSMN
T
N
L
S
V
NTNNSVGGGGGGGGVPGMTSLNGLGGGGGSQVNNHNHSHNHLHHNSNSNHSNSSSHHTNGH
M
G
IGGGGG
G
L
S
V
NINGPNIV
S
N
A
Q
Q
L
N
S
L
QASQNG
Q
V
I
H
ANI
G
I
H
S
I
I
S
NGLNHHHHHHMNNSSMMHHTPRSESANSISSGRDDLSPSSSLNGFSTS
D
A
S
D
V
K
K
I
KKGPA
P
R
-
L
Q
E
E
L
C
L
VCGDRASG
Y
H
YN
A
L
T
C
E
G
C
K
G
F
F
R
RSVTKN
A
V
--
Y
C
CKFGHAC
E
M
D
M
Y
M
R
R
K
C
Q
E
C
R
L
K
K
C
L
AVGMRPECVVP
E
N
Q
C
A
M
K
R
R
E
K
K
A
Q
K
E
K
D
K
I
Q
T
S
V
C
A
T
E
I
K
K
E
I
L
D
L
MTCEPPSHPTCPLL
P
E
D
I
L
A
K
C
QARNIPPL
S
Y
N
Q
L
A
V
I
Y
K
L
I
W
YQDGYEQP
S
E
E
D
L
K
R
I
MS---SP----D-ENESQ----HDAS--F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
KGL
P
A
F
TKIPQED
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
YDHNSD
S
I
F
F
ANNRSYTR
D
S
YKMAGM-AD
N
I
E
D
L
L
H
F
C
R
Q
M
Y
SMKVD
N
V
E
Y
A
L
L
T
A
I
V
I
FS-DRPGL
E
E
A
E
L
V
E
A
I
Q
S
Y
Y
I
D
T
L
R
I
Y
I
L
NRHCGD
P
M
S
L
V
F
F
A
K
L
L
S
I
L
T
E
L
R
T
LGNQNA
E
M
C
F
S
L
KLK--NR
K
L
P
K
F
L
E
E
I
W
D
VHAIP
P
S
V
Q
S
H
I
Q
A
T
Q
A
E
K
A
A
Q
E
A
Q
A
T
T
S
A
I
S
AAATSSSSI
N
T
S
MATSSSSSLSPSAASTPNGGA
V
D
YVGTDM
S
M
S
LVQSDNA
46
Fugue
88.19
40%
-106
- C1 -
4NQA
1
NR1H2_HUMAN
I:
[5-389]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
P
A
P
K
M
L
G
H
E
L
C
R
V
C
G
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
C
K
G
F
F
R
R
S
V
V
R
G
G
A
RR
Y
A
C
R
G
G
G
T
C
Q
M
D
A
F
M
R
R
K
C
Q
Q
C
R
L
R
K
C
K
E
A
G
M
R
E
Q
C
V
L
S
E
E
Q
I
R
K
K
K
I
R
K
Q
Q
Q
Q
E
S
Q
S
Q
S
Q
S
P
V
G
P
Q
G
S
S
S
S
A
S
----
G
P
G
A
S
P
G
G
S
E
A
G
S
Q
G
S
G
E
G
E
G
V
Q
---
L
T
A
A
Q
E
L
M
I
Q
Q
L
V
A
A
Q
L
Q
C
N
K
R
S
F
S
D
Q
P
K
V
T
P
---
W
P
LGAD
P
-
Q
S
R
D
A
----
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
I
S
V
Q
E
I
V
D
F
A
K
Q
V
P
G
F
L
Q
L
G
R
E
D
Q
I
A
L
L
K
A
S
T
I
E
I
M
L
L
E
T
A
R
R
Y
N
H
E
T
E
C
I
T
F
L
K
D
F
T
Y
S
K
D
D
F
H
R
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
R
R
L
G
L
D
D
A
E
Y
A
L
L
I
A
I
N
I
F
S
A
D
R
P
N
V
Q
E
P
G
R
V
E
A
L
Q
Q
P
Y
V
E
A
L
L
S
Y
T
R
I
K
R
---
P
Q
D
Q
L
R
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
6
PsiBlast_PDB
86.36
69%
-139
- C1 -
4UMM
1
?
G:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
---
T
W
----------------
D
S
D
MP
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
4
PsiBlast_PDB
86.26
69%
-139
- C1 -
1R1K
1
D:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
---
T
W
----------------
D
S
D
MP
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
5
PsiBlast_PDB
85.89
69%
-139
- C1 -
2R40
1
D:
[21-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
W
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
V
T
Q
---
T
-------------------
D
MP
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
7
PsiBlast_PDB
83.95
67%
-128
- C1 -
4OZT
1
?
E:
[1-238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
P
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
Q
P
S
D
E
D
L
K
R
I
S
N
---
T
P
----
S
-
E
G
E
D
Q
----
S
D
L
N
--
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
L
R
M
A
R
R
Y
D
V
G
S
D
S
I
L
F
A
N
N
Q
P
Y
T
R
D
S
Y
S
L
A
G
M
-
G
E
T
V
D
D
L
L
R
F
C
R
Q
M
Y
G
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
K
V
Y
V
D
N
R
R
--
K
P
A
S
G
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
L
N
S
E
M
C
F
S
L
K
L
K
--
N
K
K
L
P
P
F
L
A
E
I
W
D
V
----------------------------------------------------------------------------------
3
PsiBlast_PDB
82.63
69%
-136
- C1 -
3IXP
1
?
D:
[20-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
G
Y
E
Q
-----------------------------------MP
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
8
PsiBlast_PDB
82.58
67%
-126
- C1 -
2NXX
1
?
E:
[10-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
E
E
D
V
K
R
I
I
N
-----------
D
G
E
D
Q
----
C
D
V
R
--
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
A
K
R
L
P
G
F
D
K
L
L
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
V
Q
T
D
S
I
L
F
V
N
N
Q
P
Y
S
R
D
S
Y
N
L
A
G
M
-
G
E
T
I
E
D
L
L
H
F
C
R
T
M
Y
S
M
R
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
A
L
I
E
G
W
K
V
E
K
I
Q
E
I
Y
L
E
A
L
R
A
Y
V
D
N
R
R
K
P
K
P
G
T
I
--
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
Q
N
S
E
M
C
F
S
L
K
L
K
--
N
K
K
L
P
P
F
L
A
E
I
W
D
V
----------------------------------------------------------------------------------
23
HHSearch
81.97
64%
-123
- C1 -
1Z5X
1
?
E:
[73-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
P
E
D
I
K
R
I
V
N
---
A
A
----
P
-
E
E
E
N
V
----
A
E
E
R
--
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
E
N
R
R
K
--
P
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
--
N
R
K
V
P
S
F
L
E
E
I
W
D
V
V
---------------------------------------------------------------------------------
2
PsiBlast_PDB
81.78
69%
-133
- C1 -
1R20
1
D:
[20-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
P
L
T
A
N
Q
K
S
L
I
A
R
L
V
Y
Y
Q
E
G
Y
E
Q
P
S
E
E
D
L
K
R
--------------------------
D
MP
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
S
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
S
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
S
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
1
PsiBlast_PDB
80.52
58%
-121
- C1 -
1Z5X
1
?
E:
[73-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
T
P
E
Q
E
E
L
I
H
R
L
V
Y
F
Q
N
E
Y
E
H
P
S
P
E
D
I
K
R
I
V
N
---
A
A
----
P
-
E
E
E
N
V
----
A
E
E
R
--
F
R
H
I
T
E
I
T
I
L
T
V
Q
L
I
V
E
F
S
K
R
L
P
G
F
D
K
L
I
R
E
D
Q
I
A
L
L
K
A
C
S
S
E
V
M
M
F
R
M
A
R
R
Y
D
A
E
T
D
S
I
L
F
A
T
N
Q
P
Y
T
R
E
S
Y
T
V
A
G
M
-
G
D
T
V
E
D
L
L
R
F
C
R
H
M
C
A
M
K
V
D
N
A
E
Y
A
L
L
T
A
I
V
I
F
S
-
E
R
P
S
L
S
E
G
W
K
V
E
K
I
Q
E
I
Y
I
E
A
L
K
A
Y
V
E
N
R
R
--
K
P
Y
A
T
T
I
F
A
K
L
L
S
V
L
T
E
L
R
T
L
G
N
M
N
S
E
T
C
F
S
L
K
L
K
--
N
R
K
V
P
S
F
L
E
E
I
W
D
V
----------------------------------------------------------------------------------
24
HHSearch
78.97
73%
-138
- C1 -
2R40
1
D:
[67-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
P
--
F
R
Q
I
T
E
M
T
I
L
T
V
Q
L
I
V
E
F
A
K
G
L
P
G
F
A
K
I
S
Q
S
D
Q
I
T
L
L
K
A
C
S
S
E
V
M
M
L
R
V
A
R
R
Y
D
A
A
T
D
S
V
L
F
A
N
N
Q
A
Y
T
R
D
N
Y
R
K
A
G
M
-
A
Y
V
I
E
D
L
L
H
F
C
R
C
M
Y
S
M
M
M
D
N
V
H
Y
A
L
L
T
A
I
V
I
F
S
-
D
R
P
G
L
E
Q
P
L
L
V
E
E
I
Q
R
Y
Y
L
N
T
L
R
V
Y
I
L
N
Q
N
S
A
S
P
R
C
A
V
I
F
G
K
I
L
G
I
L
T
E
I
R
T
L
G
M
Q
N
S
N
M
C
I
S
L
K
L
K
--
N
R
K
L
P
P
F
L
E
E
I
W
D
V
A
---------------------------------------------------------------------------------
13
PsiBlast_PDB
73.81
39%
-125
- C1 -
3FC6
1
NR1H3_MOUSE
B:
[24-264]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
---
W
P
----
I
-
A
P
D
P
Q
SREA
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
14
PsiBlast_PDB
73.60
39%
-124
- C1 -
3FAL
1
NR1H3_MOUSE
B:
[23-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
---
W
P
---------
P
Q
SREA
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
19
PsiBlast_PDB
73.05
39%
-127
- C1 -
3IPU
1
NR1H3_HUMAN
A:
[40-281]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
WP---------
P
H
S
R
E
A---
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
15
PsiBlast_PDB
72.56
39%
-123
- C1 -
2ACL
-
NR1H3_MOUSE
B:
[3-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
WPI
A
P
----
D
P
Q
S
R
E
A
----
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
N
H
P
H
D
P
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
20
PsiBlast_PDB
70.63
39%
-139
- C1 -
5AVI
1
?
A:
[40-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-----------
R
V
T
P
WP---------
P
H
S
R
E
A---
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
---------------------------------------------------------------------------------
18
PsiBlast_PDB
70.33
39%
-135
- C1 -
3IPS
1
NR1H3_HUMAN
A:
[41-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
------------
V
T
P
WP-----------
S
R
E
A---
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
H
---------------------------------------------------------------------------------
17
PsiBlast_PDB
70.14
39%
-137
- C1 -
3IPQ
1
NR1H3_HUMAN
A:
[41-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
-------------
T
P
WP-------------
E
A---
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
D
R
L
---
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------
47
Fugue
68.00
27%
-108
- C1 -
1BSX
1
THB_HUMAN
A:
[10-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
E
P
T
D
E
E
W
E
L
I
K
T
V
T
E
A
H
V
A
T
N
A
Q
G
S
H
W
K
Q
K
R
K
F
L
P
E
---
D
I
----
G
-
Q
A
P
K
V
----
D
L
E
A
--
F
S
H
F
T
K
I
I
T
P
A
I
T
R
V
V
D
F
A
K
K
L
P
M
F
C
E
L
P
C
E
D
Q
I
I
L
L
K
G
C
C
M
E
I
M
S
L
R
A
A
V
R
Y
D
P
E
S
E
T
L
T
L
N
G
E
M
A
V
T
R
G
Q
L
K
N
G
G
L
-
G
V
V
S
D
A
I
F
D
L
G
M
S
L
S
S
F
N
L
D
D
T
E
V
A
L
L
Q
A
V
L
L
M
S
S
D
R
P
G
L
A
C
V
E
R
I
E
K
Y
Q
D
S
F
L
L
A
F
E
H
Y
I
N
Y
R
K
H
H
V
T
H
---
F
W
P
K
L
L
M
K
V
T
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
M
K
V
E
CP
T
E
L
F
P
P
L
F
L
E
V
F
E
D
----------------------------------------------------------------------------------
16
PsiBlast_PDB
67.07
38%
-125
- C1 -
1UHL
1
NR1H3_HUMAN
B:
[1-240]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
E
Q
L
G
M
I
E
K
L
V
A
A
Q
Q
Q
C
N
R
R
S
F
-----------------------
E
A---
R
Q
Q
R
--
F
A
H
F
T
E
L
A
I
V
S
V
Q
E
I
V
D
F
A
K
Q
L
P
G
F
L
Q
L
S
R
E
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
T
---
D
F
S
Y
N
R
E
D
F
A
K
A
G
L
Q
V
E
F
I
N
P
I
F
E
F
S
R
A
M
N
E
L
Q
L
N
D
A
E
F
A
L
L
I
A
I
S
I
F
S
A
D
R
P
N
V
Q
D
Q
L
Q
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
V
S
I
H
H
---
P
H
D
R
L
M
F
P
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
L
Q
--
D
K
K
L
P
P
L
L
S
E
I
W
D
V
----------------------------------------------------------------------------------