@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_ESR2_HUMAN: (2016-03-19 )
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Atome Classification :
(66 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280........290.......300.......310.......320.......330.......340.......350.----......360.......370.......380.....-..390.......400.......410...-....-420.......430.......440.......450.......460.......470.......480...---....490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDIKNSPSSLNSPSSYNCSQS
I
L
PLEHG
S
I
Y
I
P
S
S
YV
D
S
HHEYPA
M
T
F
YS
P
A
V
MNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGH
L
S
P
L
V
V
H
R
Q
L
S
H
L
YAEPQKSPWCEARSLEHTLPV
N
R
E
T
L
K
R
KVSGNRCASPVTGPGSKRD
A
H
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
ICPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
M
V
KCG
S
R
R
E
R
C
G
Y
R
L
V
R
R
QRSADE
Q
L
HCAGKAKRSGGH
A
P
R
V
R
E
L
L
L
D
AL
S
P
E
Q
L
V
L
T
L
LEAEPP
H
V
L
-
I
SRPSAPF
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
KIPG
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
RSIDHPG
K
----
L
I
FAPD
L
V
LDRDE
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
LNSSM
Y
P
L
V
T
-ATQD-AD
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
KSGI
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
HASNK
G
M
E
H
L
L
NMKCKNVV---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
G
C
K
SSITGSECSPAEDSKSKEGSQNPQSQ
69
HHSearch
94.53
100%
-158
- C5 -
3OLL
1
ESR2_HUMAN
A:
[3-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
---
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
58
PsiBlast_CBE
94.41
99%
-158
- C5 -
3OLL
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
---
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
34
PsiBlast_CBE
93.71
100%
-156
- C5 -
4J24
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
57
PsiBlast_CBE
93.45
99%
-160
- C5 -
3OLL
1
B:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
T
----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
36
PsiBlast_CBE
92.78
100%
-158
- C5 -
3OMQ
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
32
PsiBlast_CBE
92.76
100%
-159
- C5 -
4J24
1
ESR2_HUMAN
C:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
19
PsiBlast_PDB
92.38
100%
-158
- C5 -
3OLS
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
28
PsiBlast_CBE
92.28
100%
-159
- C5 -
1U3R
1
B:
[3-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
20
PsiBlast_PDB
92.19
100%
-156
- C5 -
3OMO
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
42
PsiBlast_CBE
92.06
100%
-160
- C5 -
2YJD
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
38
PsiBlast_CBE
92.00
100%
-157
- C5 -
3OMP
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
33
PsiBlast_CBE
91.94
100%
-157
- C5 -
4J24
1
ESR2_HUMAN
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
31
PsiBlast_CBE
91.77
100%
-161
- C5 -
4J24
1
D:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
---------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
11
PsiBlast_PDB
91.76
100%
-156
- C5 -
1U3R
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--------
Q
D
-
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
3
PsiBlast_PDB
91.74
100%
-158
- C5 -
1QKM
1
A:
[6-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
41
PsiBlast_CBE
91.69
100%
-158
- C5 -
2YJD
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
47
PsiBlast_CBE
91.54
100%
-156
- C5 -
1U3S
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
37
PsiBlast_CBE
91.50
100%
-161
- C5 -
3OMP
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
---------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
18
PsiBlast_PDB
91.46
100%
-152
- C5 -
1U3S
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
40
PsiBlast_CBE
91.40
100%
-159
- C5 -
3OLS
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
---------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
35
PsiBlast_CBE
91.37
100%
-160
- C5 -
3OMQ
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
---------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
39
PsiBlast_CBE
91.33
100%
-161
- C5 -
3OMO
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-
A
---------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
15
PsiBlast_PDB
91.04
100%
-157
- C5 -
1X7B
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
30
PsiBlast_CBE
90.98
100%
-155
- C5 -
4J26
1
ESR2_HUMAN
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
10
PsiBlast_PDB
90.86
100%
-156
- C5 -
1U9E
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
12
PsiBlast_PDB
90.59
100%
-160
- C5 -
2GIU
1
A:
[1-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
-
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
----
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
49
PsiBlast_CBE
90.57
100%
-159
- C5 -
1U3Q
1
ESR2_HUMAN
C:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
-----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
29
PsiBlast_CBE
90.56
100%
-155
- C5 -
4J26
1
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
17
PsiBlast_PDB
90.56
100%
-157
- C5 -
1U3Q
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
-----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
45
PsiBlast_CBE
90.54
100%
-155
- C5 -
1X78
1
B:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
2
PsiBlast_PDB
90.50
100%
-159
- C5 -
1YYE
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
52
PsiBlast_CBE
90.46
100%
-157
- C5 -
2NV7
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
65
HHSearch
90.42
100%
-158
- C5 -
1YYE
1
ESR2_HUMAN
A:
[2-238]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
44
PsiBlast_CBE
90.39
100%
-155
- C5 -
1X7B
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
54
PsiBlast_CBE
90.38
99%
-154
- C5 -
1ZAF
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
67
HHSearch
90.29
100%
-158
- C5 -
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
-----
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
-
A
T
Q
D
-
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
14
PsiBlast_PDB
90.29
100%
-157
- C5 -
1X78
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
53
PsiBlast_CBE
90.28
99%
-157
- C5 -
1ZAF
1
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
9
PsiBlast_PDB
90.15
100%
-152
- C5 -
1NDE
1
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
--
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
-----
A
T
Q
D
-
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
------
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
16
PsiBlast_PDB
90.09
100%
-158
- C5 -
1X7J
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
48
PsiBlast_CBE
90.06
100%
-161
- C5 -
1U3Q
1
D:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
-----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
43
PsiBlast_CBE
89.92
100%
-156
- C5 -
1X7J
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
51
PsiBlast_CBE
89.86
100%
-154
- C5 -
2NV7
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
56
PsiBlast_CBE
89.85
99%
-162
- C5 -
2YLY
1
ESR2_HUMAN
A:
[2-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
22
PsiBlast_CBE
89.74
100%
-160
- C5 -
1YY4
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
13
PsiBlast_PDB
89.69
100%
-156
- C5 -
1X76
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
4
PsiBlast_PDB
89.69
97%
-158
- C5 -
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
-----
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
-
A
T
Q
D
-
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
46
PsiBlast_CBE
89.60
100%
-155
- C5 -
1X76
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
21
PsiBlast_CBE
89.10
100%
-153
- C5 -
1YYE
1
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
----------------------------------
59
PsiBlast_CBE
89.07
91%
-158
- C5 -
2J7Y
7
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
-
V
S
-----
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
--------
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
60
PsiBlast_CBE
89.01
91%
-157
- C5 -
2J7X
5
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
-
V
S
---
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
--------
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
24
PsiBlast_CBE
88.93
100%
-159
- C5 -
2Z4B
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
5
PsiBlast_PDB
88.93
100%
-158
- C5 -
2I0G
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
7
PsiBlast_PDB
88.92
100%
-157
- C5 -
2Z4B
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
1
PsiBlast_PDB
88.83
100%
-154
- C5 -
1YY4
1
ESR2_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
50
PsiBlast_CBE
88.78
100%
-159
- C5 -
1U3Q
1
ESR2_HUMAN
B:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
27
PsiBlast_CBE
88.48
100%
-157
- C5 -
2I0G
1
B:
[12-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
55
PsiBlast_CBE
88.38
99%
-154
- C5 -
2YLY
1
B:
[1-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
--------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
8
PsiBlast_PDB
88.21
100%
-159
- C5 -
2QTU
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
---------
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
25
PsiBlast_CBE
88.16
100%
-161
- C5 -
2QTU
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
-
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
---------
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
61
PsiBlast_CBE
87.45
91%
-153
- C5 -
1QKN
1
A:
[8-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
-
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
S
-
A
N
Q
E
-
A
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
-----------
D
L
L
L
E
M
L
N
A
---------------------------------
23
PsiBlast_CBE
87.18
97%
-162
- C5 -
1L2J
1
ESR2_HUMAN
B:
[21-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
L
L
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
--------------
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--
L
V
T
-
A
T
Q
D
-
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
-----
V
---
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
62
PsiBlast_CBE
83.08
91%
-157
- C5 -
1HJ1
2
A:
[9-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
-
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
----
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
-
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----------------
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
-----------------------------------------------------
71
HHSearch
82.98
59%
-152
- C5 -
1XPC
1
A:
[6-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
S
T
L
K
S
-
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
Y
D
L
L
L
E
M
L
D
A
H
R
L
H
A
----------------------------
66
HHSearch
80.49
57%
-147
- C5 -
2OCF
1
A:
[11-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
I
L
Y
S
E
Y
D
P
T
R
P
F
S
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
H
P
G
K
----
L
L
F
A
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
-
R
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
------------
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
K
N
V
V
---
P
L
S
D
L
L
L
E
M
L
D
A
H
R
-------------------------------
88
Fugue
74.05
46%
-127
- C5 -
3ERT
1
A:
[13-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
L
S
L
T
A
D
Q
M
V
S
A
L
L
D
A
E
P
P
---------------------
I
---
L
Y
S
E
Y
D
P
-------
T
R
P
F
S
-------------
E
A
S
M
M
G
L
L
T
N
L
A
D
R
E
L
V
H
M
I
N
W
A
K
R
V
P
G
F
V
D
L
T
L
H
D
Q
V
H
L
L
E
C
A
W
L
E
I
L
M
I
G
L
V
W
R
S
M
E
--
H
P
GKLL
F
A
--
P
N
L
L
L
D
R
N
Q
G
K
C
V
E
G
M
V
E
I
F
D
M
L
L
A
T
S
S
R
F
R-
M
M
N
L
Q
G
E
E
F
V
C
L
K
S
I
I
L
L
N
S
G
V
Y
T
F
L
S
-
S
T
L
K
S
L
E
E
K
D
H
I
H
R
V
L
D
K
I
T
D
T
L
I
H
L
M
A
K
A
G
L
T
L
Q
Q
Q
H
Q
R
L
A
Q
L
L
L
I
L
S
H
I
R
H
M
S
N
K
G
M
E
H
L
Y
S
M
K
C
----KNV
V
---
P
L
Y
D
L
L
L
E
M
L
D
--------
A
H
R
L
H
A
----------------