@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00105_GCR_HUMAN: (2016-03-19 )
MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRRLLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLKLLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGNVKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGNSNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTVYCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVGSENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
Atome Classification :
(39 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740-.......750.......760.......770.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDSKESLTPGREE
N
P
S
S
V
L
A
Q
ERG
D
V
M
D
F
Y
K
T
LRGG
A
T
V
K
V
SASSP
S
L
A
V
ASQSDSKQ
R
R
L
L
V
DFPKGSVSNAQQP
D
L
S
K
A
V
S
LS
M
G
L
Y
MGETE
T
K
VMGNDLGFPQQG
Q
I
S
LSSGE
T
D
L
K
L
L
E
E
S
I
A
NLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDV
S
S
E
Q
Q
H
LKGQTGTNGG
N
V
K
L
Y
TTDQ
S
T
F
D
I
L
Q
D
LEFSSGSPGKETNESPWRSD
L
L
IDENCLLSPLAGEDD
S
F
L
L
EGNSNEDCK
P
L
ILPDTKPKIKDNG
D
L
V
LSSPSNVTLPQVKT
E
K
E
D
F
I
E
LCTPGV
I
K
QEKL
G
T
V
Y
C
Q
ASFPGANIIGNK
M
S
A
I
S
V
H
G
V
STSG
G
Q
M
Y
H
Y
DMNTASLSQQQDQKP
I
F
NVIPPIPVGSENWNRCQGSGDDNL
T
S
L
GTLNFPG
R
T
V
FSNGYSSPSMRPDVSSPPSSSSTATTGPPP
K
L
C
L
V
CSDEASG
C
H
Y
G
V
L
TCG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
Y
R
K
C
L
Q
AGMNL
E
A
R
K
T
K
K
K
I
K
G
I
Q
Q
A
TTGVSQETSENPGN
K
T
I
V
PATLPQL
T
P
T
L
V
S
L
L
E
VIEP
E
V
L
Y
AGYDSSVPDS
T
W
R
I
M
T
T
L
N
MLG
G
R
Q
V
I
A
A
V
K
W
A
K
AIPGFRNLHLD
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
A
F
A
L
G
W
R
S
Y
R
QSSA
N
L
L
C
FAPD
L
I
INEQRMTL
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
SE
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
SSVPKDGL
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
KREGNS
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
TMSIE
F
P
E
M
L
A
E
I
I
T
N
QIPKYSNGN
I
K
K
L
L
FHQK
13
PsiBlast_PDB
98.17
97%
-137
- C4 -
4P6W
1
A:
[1-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
A
A
I
V
A
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
31
PsiBlast_CBE
97.93
97%
-138
- C4 -
4P6X
1
GCR_HUMAN
G:
[1-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
7
PsiBlast_PDB
97.49
99%
-138
- C4 -
3K22
2
GCR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
-
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
21
PsiBlast_CBE
96.93
98%
-143
- C4 -
1P93
1
D:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
28
PsiBlast_CBE
96.92
99%
-143
- C4 -
3E7C
3
B:
[5-256]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
--
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
-----
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
15
PsiBlast_PDB
96.91
93%
-137
- C4 -
3MNP
3
A:
[4-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
4
PsiBlast_PDB
96.84
99%
-139
- C4 -
1M2Z
4
GCR_HUMAN
A:
[3-257]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
24
PsiBlast_CBE
96.80
99%
-137
- C4 -
1M2Z
1
D:
[5-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
32
PsiBlast_CBE
96.38
97%
-134
- C4 -
4P6X
1
GCR_HUMAN
E:
[1-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
74
HHSearch
96.22
94%
-137
- C4 -
3MNP
3
A:
[10-260]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
F
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
A
K
R
G
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
33
PsiBlast_CBE
96.19
97%
-137
- C4 -
4P6X
1
GCR_HUMAN
C:
[1-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
22
PsiBlast_CBE
96.16
98%
-144
- C4 -
1P93
1
GCR_HUMAN
C:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
8
PsiBlast_PDB
96.06
99%
-142
- C4 -
3E7C
2
GCR_HUMAN
A:
[6-256]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
29
PsiBlast_CBE
96.04
97%
-137
- C4 -
4P6X
1
K:
[1-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
26
PsiBlast_CBE
95.86
99%
-137
- C4 -
3K23
1
GCR_HUMAN
B:
[9-258]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
---
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
30
PsiBlast_CBE
95.83
97%
-141
- C4 -
4P6X
1
GCR_HUMAN
I:
[1-255]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
A
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
Y
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
10
PsiBlast_PDB
95.27
98%
-139
- C4 -
3BQD
1
A:
[3-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
3
PsiBlast_PDB
95.22
98%
-134
- C4 -
4CSJ
2
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
M
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
5
PsiBlast_PDB
95.02
99%
-140
- C4 -
3CLD
1
GCR_HUMAN
A:
[8-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
12
PsiBlast_PDB
94.71
94%
-137
- C4 -
3MNE
3
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
-----
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
25
PsiBlast_CBE
94.56
99%
-136
- C4 -
3K23
1
C:
[7-257]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
-
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
-
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
---
N
I
K
K
L
L
F
H
--
27
PsiBlast_CBE
94.39
99%
-139
- C4 -
3CLD
1
B:
[10-258]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
---
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
-----
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
14
PsiBlast_PDB
94.28
94%
-139
- C4 -
3MNO
3
A:
[4-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
P
A
A
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
---
S
V
P
D
S
A
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
V
F
A
L
G
W
R
S
Y
R
Q
A
S
G
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
C
M
Y
D
Q
C
K
H
M
L
F
I
S
T
E
L
Q
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
E
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
V
V
E
N
L
L
S
Y
C
F
Q
T
F
L
D
-
K
S
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
2
PsiBlast_PDB
93.40
98%
-139
- C4 -
1P93
1
GCR_HUMAN
A:
[30-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
23
PsiBlast_CBE
93.24
98%
-139
- C4 -
1P93
1
GCR_HUMAN
B:
[32-279]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
---
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
6
PsiBlast_PDB
92.89
99%
-129
- C4 -
3K23
1
GCR_HUMAN
A:
[7-258]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
-
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
-----
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
-
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
9
PsiBlast_PDB
91.81
98%
-145
- C4 -
4LSJ
2
A:
[7-258]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
G
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
--------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
K
36
PsiBlast_CBE
90.05
98%
-131
- C4 -
3H52
2
GCR_HUMAN
B:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
38
PsiBlast_CBE
89.92
78%
-128
- C4 -
4E2J
3
?
B:
[4-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
19
PsiBlast_PDB
89.54
78%
-131
- C4 -
4E2J
2
?
A:
[4-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
18
PsiBlast_PDB
89.37
78%
-131
- C4 -
3GN8
1
?
A:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
37
PsiBlast_CBE
89.36
78%
-130
- C4 -
3GN8
1
?
B:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
N
-
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
17
PsiBlast_PDB
88.61
98%
-129
- C4 -
3H52
1
GCR_HUMAN
A:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
----
G
N
I
K
K
L
L
F
H
Q
-
20
PsiBlast_PDB
88.51
72%
-129
- C4 -
3RY9
2
?
A:
[2-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
39
PsiBlast_CBE
87.51
72%
-131
- C4 -
3RY9
3
?
B:
[1-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
34
PsiBlast_CBE
87.03
98%
-142
- C4 -
3H52
1
D:
[7-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
----------
E
M
L
A
E
I
I
T
N
Q
I
----
N
G
N
I
K
K
L
L
F
H
Q
-
16
PsiBlast_PDB
85.43
96%
-126
- C4 -
4MDD
1
GCR_HUMAN
A:
[11-257]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
A
L
E
T
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
Y
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
A
L
F
D
A
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
S
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
Q
I
P
K
Y
S
N
G
N
I
K
K
L
L
F
H
Q
-
1
PsiBlast_PDB
85.30
98%
-130
- C4 -
1NHZ
4
A:
[33-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
D
S
S
V
P
D
S
T
W
R
I
M
T
T
L
N
M
L
G
G
R
Q
V
I
A
A
V
K
W
A
K
A
I
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
A
L
G
W
R
S
Y
R
Q
S
S
A
N
L
L
C
F
A
P
D
L
I
I
N
E
Q
R
M
T
L
P
D
M
Y
D
Q
C
K
H
M
L
Y
V
S
S
E
L
H
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
T
L
L
L
L
S
S
V
P
K
D
G
L
K
S
Q
E
L
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
V
V
E
N
L
L
N
Y
C
F
Q
T
F
L
D
-
K
T
M
S
I
E
F
P
E
M
L
A
E
I
I
T
N
--------
N
I
K
K
L
L
F
H
Q
-
35
PsiBlast_CBE
83.46
98%
-134
- C4 -
3H52
1
GCR_HUMAN
C:
[5-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
P
T
L
V
S
L
L
E
V
I
E
P
E
V
L
Y
A
G
Y
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A
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N
Y
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F
Q
T
F
--------------
A
E
I
I
T
N
Q
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K
Y
S
N
G
N
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K
K
L
L
F
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Q
-