@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ADA1A_HUMAN: (2016-01-08 )
MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEVLGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYLPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGMASAKTKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLCRKQSSKHALGYTLHPPSQAVEGQHKDMVRIPVGSRETFYRISKTDGVCEWKFFSSMPRGSARITVSKDQSSCTTARVRSKSFLQVCCCVGPSTPSLDKNHQVPTIKVHTISLSENGEEV
Atome Classification :
(26 SA)
.........10........20........30........40........50........60........70........80.......-.90........100.......110.......120.......130.....---..140.......150.......160-.--......---170----.-------.------.-------...-...-180--........190.......200.......210.......220..--------....-------.----------------------230------------------------.-------.---.------------------------------.----------.------------..------..----------------240-------------------.-------------------------------------.-----------------------------------------.-----------------------------------------------.------------------------------.--------------.--------------.----------------------------.------------.-----250-----------------.-------.--------.---------......260..--.-....270.......280.......---290.......300........310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
F
LSGNASDSSNCTQPPAPV
N
I
S
K
A
I
L
L
G
V
I
L
G
G
L
I
L
F
G
V
L
G
N
I
L
V
I
L
S
V
A
C
H
R
H
L
H
S
V
T
H
Y
Y
I
V
N
L
A
V
A
D
L
L
L
T
STVL
P
F
S
A
I
F
E
V
-
L
G
Y
W
A
F
G
R
V
F
C
N
I
W
A
A
V
D
V
L
C
C
T
A
S
I
M
G
L
C
I
I
S
I
D
R
YIGVSYPLRY
P
T
I
---
V
T
QRR
G
L
M
A
L
L
C
V
W
A
L
S
L
V
I
S
IGPL-F--GWRQPA---P------E-------D------E-------
T
I
C
-
Q
IN-EE---PG
Y
V
L
F
S
A
L
G
S
F
Y
L
P
L
A
I
I
L
V
M
Y
C
R
V
Y
V
V
A
KRESRGLKSGLKT--------DKSD-------S----------------------
E
--------------------------
Q
-------
V
---
T
------------------------------
L
----------
R
------------
I
H
------RK----------------N---------------------A-------------------------------------P-----------------------------------------A-----------------------------------------------G------------------------------G--------------S--------------G----------------------------M------------A-----S-------------------A-------K--------T---------
K
T
H
F
S
V
R
L
L
K
F--S-
R
E
K
K
A
A
K
T
L
G
I
V
V
G
C
F
V
L
C
W
L
P
F
F
---
L
V
M
P
I
G
S
FFPDF-KPS
E
T
V
F
K
I
V
F
W
L
G
Y
L
N
S
C
I
N
P
IIYPC
S
S
Q
E
F
K
K
A
F
Q
N
V
L
R
I
Q
C
L
CRKQSSKHA
L
G
Y
TLHP
P
S
Q
AVEGQHK
D
M
V
RIPVGSR
E
T
F
Y
R
ISKTDG
V
C
E
W
K
F
F
SSMPRG
S
A
R
I
T
V
SKDQSSC
T
T
A
R
VR
S
K
S
F
L
Q
V
C
CCVGPSTPSLDKNHQV
P
T
I
K
V
H
T
I
SLSENGEEV
64
HHSearch
92.51
35%
-140
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-
F
--
G
F
N
T
T
-----------
G
-------
D
------
P
-------
T
V
C
-
S
I
S
-
N
----
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
--------
I
D
E
G
-------
L
RL
K
I
------------------
Y
--------------------------
K
-------
D
---
T
EG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
G
R
----------
N
TNGVIT------
K
D
------
E
A
----------------
E
---------------------
K
-------------------------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
-----------------------------------------------
T
------------------------------
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
----------------------------
Q
------------
T
-----
P
-------------------
N
-------
R
--------
A
K
R
V
I
T
T
F
--
R
T
G
T
W
D
A
Y
G
V
P
--
L
-
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
---
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
---------------------------------------------------------------------------------------------------------------------------
60
HHSearch
91.75
32%
-137
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
-
H
W
Y
R
A
T
---
H
------
Q
-------
E
A
I
N
C
Y
A
E
-------
E
T
C
C
D
F
F
-
T
N
---
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
--------
E
G
L
R
-------
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSP
S
--------------------------
L
-------
N
---
A
------------------------------
A
K
S
E
L
D
K
A
I
GR
N
------------
T
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
--------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
-------------------------------
N
-----------------------------------------
M
-----------------------------------------------
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
--------------
K
--------------
S
----------------------------
R
------------
W
-----
Y
N
Q
T
P
---------------
N
R
A
K
R
V
I
T
T
--------
F
---------
R
T
G
T
W
D
A
Y
K
F
C
--
L
-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
---
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------------------------------------------------------------------------------
61
HHSearch
88.04
31%
-139
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
--------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
----
G
W
N
H
------------
R
-------
R
------
E
-------
D
K
C
-
E
T
D
-
F
Y
DV-
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
--------
E
G
L
R
L
K
I
Y
K
D
T
E
----------------------
G
Y
Y
T
I
G
IGHLLTKSPS
L
----------
N
-------
A
A
K
S
E
L
D
K
A
I
G------------------------
R
NTNGVI----
T
------------
K
D
------
E
A
----------------
E
---------------------
K
-------------------------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
-----------------------------------------------
T
------------------------------
G
--------------
V
--------------
A
----------------------------
G
F
T
----------
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
-------
P
--------
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
--
N
-
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
---
I
F
F
M
V
I
A
F
C
K
N
C
--
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
---------------------------------------------------------------------------------------------------------------------------
62
HHSearch
86.83
25%
-139
- C5 -
3EML
13
ENLYS_BPT4
A:
[20-472]
------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N
N
C
G
---
Q
---------------------
S
QGCGEGQ
V
A
C
-
L
F
E
-
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
--------
E
G
L
R
-------
L
----------------------
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
-------
S
---
E
L
D
K
A
--------------------------
I
----------
G
------------
R
N
------
T
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
---------
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-----------------------------------------
K
-----------------------------------------------
R
------------------------------
W
--------------
D
--------------
E
----------------------------
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
-----
P
-------------------
N
-------
R
A
K
R
V
I
T
T
F
R
---------
T
G
T
W
D
A
Y
R
S
T
L
--
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
---
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.72
33%
-145
- C5 -
4IAR
2
C562_ECOLX
A:
[21-398]
--------------------------
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
M
P
I
S
T
M
Y
T
V
-
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
A
K
---
R
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
S
I
S
I
S
L
P
P
F
-
F
---
W
R
Q
A
----------------------------------
S
E
C
-
V
V
N
T
D
H
---
I
L
Y
T
V
Y
S
T
V
G
A
F
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
N
D
N
L
K
V
I
E
K
A
D
N------
A
----------------------
A
--------------------------
Q
-------
V
---
K
------------------------------
D
----------
A
------------
L
T
------
K
M
----------------
R
---------------------
A
-------------------------------------
A
-----------------------------------------
A
L
D
A
Q
K
A
TPPKL
E
D
K
S
PDSPEMKD
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
GK
V
K
------------------------------
E
--------------
A
--------------
Q
----------------------------
A
------------
A
-----
A
-------------------
E
-------
Q
--------
L
---------
K
T
T
R
N
A
Y
I
Q
K
Y
L
A
A
-
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
P
I
-----
W
F
-
H
L
A
--
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
R
F
K
--------------------------------------------------------------------------------------------------------------------------
57
HHSearch
85.50
29%
-129
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-
L
--
F
W
Q
F
I
V
GVR
T
------
V
-------
E
------
D
-------
G
E
C
-
Y
I
Q
-
F
F
SN-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
--------
E
G
L
R
-------
L
K
I
Y
K
D
TE---------------
G
Y
Y
T
I
GIGHLLTK--------------
S
PS
L
N
A
A
K
S
---
E
------------------------------
L
----------
D
K
A
I
GRNTNGVIT
K
D
------
E
A
----------------
E
---------------------
K
-------------------------------------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
-----------------------------------------------
T
------------------------------
G
--------------
V
--------------
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------
T
-----
P
-------------------
N
R
A
K
R
V
I
T
T
--------
F
---------
R
T
G
T
W
D
A
Y
P
P
P
--
S
-
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
---
V
M
V
L
I
N
T
F
C
A
P
--
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
----------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
84.27
36%
-167
- C5 -
3SN6
1
R:
[185-490]
----------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
Y
R
------------
Q
EAINCYA
E
------
E
-------
T
C
C
-
D
F
F
-
T
N
---
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
------
K
I
--------
D
K
S
E
-------
G
-------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
---
I
V
-
N
I
V
H
V
I
Q
D
N
-
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
---
C
-------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.35
35%
-166
- C5 -
2YCW
6
ADRB1_MELGA
B:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
MH
W
W
R
D
E
D
---
P
QALKCY
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.30
36%
-161
- C5 -
2Y00
12
ADRB1_MELGA
B:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
--------
S
----------------------
K
--------------------------
R
-------
K
---
T
------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.27
36%
-171
- C5 -
4AMJ
12
ADRB1_MELGA
A:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
83.24
36%
-162
- C5 -
3ZPR
12
ADRB1_MELGA
B:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
--------
S
----------------------
K
--------------------------
R
-------
K
---
T
------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.19
35%
-159
- C5 -
2YCZ
2
ADRB1_MELGA
A:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
83.16
35%
-167
- C5 -
2VT4
9
ADRB1_MELGA
B:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.13
35%
-161
- C5 -
2YCW
7
ADRB1_MELGA
A:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
83.08
36%
-160
- C5 -
3ZPQ
13
ADRB1_MELGA
B:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
--------
S
----------------------
K
--------------------------
R
-------
K
---
T
------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
83.03
36%
-170
- C5 -
3ZPR
11
ADRB1_MELGA
A:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.00
35%
-169
- C5 -
2VT4
8
ADRB1_MELGA
A:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.00
36%
-168
- C5 -
3ZPQ
11
ADRB1_MELGA
A:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------------------------------------------------------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.92
36%
-162
- C5 -
4AMJ
11
ADRB1_MELGA
B:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
--------
S
----------------------
K
--------------------------
R
-------
K
---
T
------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.69
35%
-159
- C5 -
2YCZ
2
ADRB1_MELGA
B:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
MH
W
W
R
D
E
D
---
P
QALKCY
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
82.57
35%
-169
- C5 -
2VT4
8
ADRB1_MELGA
D:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
MH
W
W
R
D
E
D
---
P
QALKCY
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
82.44
36%
-165
- C5 -
4AMI
6
ADRB1_MELGA
B:
[14-299]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
------
Q
A
L
K
C
Y
Q
-
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
-----------------------------------------------------------------------------------------------------------------
S
----------
R
------------
V
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
81.87
35%
-159
- C5 -
2YCY
6
ADRB1_MELGA
A:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
81.70
35%
-157
- C5 -
2YCX
4
ADRB1_MELGA
B:
[14-297]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
MH
W
W
R
D
E
D
---
P
QALKCY
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
81.68
35%
-156
- C5 -
2YCX
3
ADRB1_MELGA
A:
[14-294]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------
K
I
--------
D
R
A
S
-------
K
----------------------
R
--------------------------
K
-------
R
---
V
------------------------------
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
--
M
-
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
--------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
80.15
35%
-168
- C5 -
2VT4
7
ADRB1_MELGA
C:
[14-286]
----------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
R
D
E
D
---
P
Q
A
L
K
C
Y
Q
-------
D
------
P
-------
G
C
C
-
D
F
V
-
T
N
---
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
---
L
V
N
I
V
N
V
F
N
R
D
L
-
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
----------------------------------------------------------------------------------------------------------------------------------------