@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : BKRB2_HUMAN: (2016-01-09 )
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60....---..-..70........80........90........100.......110.......-120.......130.......140.......150.......160.-.....---.170.......180.......190...-------------------....200..--.....210...----.---..----.-220..-----.-----....230---........240.--------------------......250------------------------....-----------------------------.---...--------------------------------------------------------------------------------------------------------------------------------------------------------------260.--.---.---------------------.---...270..------.....280.......290......------.-300.-..--......310..-.....320.......330-------........340......-----.350.......360.......370.......380...--....390--------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFSP
W
K
I
S
M
F
L
S
VREDSVPTTASFSA
D
M
L
N
V
T
LQGPTLNGTFAQSKCPQ
V
E
W
L
G
W
L
NTIQ
P
P
F
L
W
---
V
L
-
F
V
L
A
T
L
E
N
I
F
V
L
S
V
F
C
LHKSS
C
T
V
A
E
I
Y
LG
N
L
A
A
A
D
L
I
L
ACGL
P
F
W
A
I
T
ISN-NF
D
W
L
F
G
E
T
L
C
R
V
V
N
A
I
I
S
M
N
L
Y
S
S
I
C
F
L
M
L
V
S
I
D
R
Y
L
A
L
V
K
T
M
-
S
MGRM---RG
V
R
W
A
K
L
Y
S
L
V
I
W
G
C
T
L
L
LSS
P
M
L
V
F
-------------------
R
T
M
K
E
YSDE--GH
N
V
T
A
C
VIS
Y
----
P
---
S
L
----
I
-
W
E
V
F
T
-----
N
-----
M
L
L
N
V
V
----
G
F
L
L
P
L
S
V
I
T
F
C
--------------------
T
M
Q
I
M
Q
V
L
-------------------------RN
N
E
-----------------------------
M
---
Q
K
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
I
Q
--
T
---
E
---------------------
R
---
R
A
T
V
L
V
L
V
------
V
L
L
L
F
I
I
C
WLP
F
Q
I
S
T
F
L
D
T
L
H
RL------
G
-
I
--
L
-
S
S--CQD
E
R
I
I
D
V
I
T
-
Q
I
A
S
F
M
A
Y
S
N
S
C
L
N
P
L
V
--------
Y
V
I
V
G
K
R
F
R
K
KS
W
E
V
Y
Q
-----
G
V
C
QKGGCRSEPIQMENSMGT
L
R
T
S
I
S
V
E
R
Q
I
H
K
L
Q
D
--WAGSRQ---------------------------------------------------------------------------------------------------
22
HHSearch
90.79
27%
-134
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-497]
---------------------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
---
I
I
-
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-------------------
A
N
V
S
E
A
------
D
D
R
Y
I
C
D
R
F
Y
----
P
---
N
D
----
L
W
V
V
V
F
Q
-----
F
-----
Q
-
H
I
M
V
----
G
L
I
L
P
G
I
V
I
L
S
C
--------------------
Y
C
I
I
I
S
K
L
-------------------------
S
H
S
G
-----------------------------
S
---
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
K
G
H
--
Q
---
K
---------------------
R
---
K
A
L
K
T
T
V
I
------
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
------
E
-
I
--
I
K
Q
G
--
C
E
F
E
N
T
V
H
K
W
I
-
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
--------
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
-----
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
84.91
23%
-108
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
--------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
---
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-------------------
W
S
--
R
Y
I
P
E
--
G
M
Q
-
C
S
C
G
I
D
Y
YTPH
E
---
E
T
----
N
-
N
E
S
F
V
-----
I
-----
Y
M
F
V
V
H
-----
F
I
I
P
L
I
V
I
F
F
C
--------------------
Y
G
Q
L
V
F
T
V
-------------------------
K
E
A
A
-----------------------------
A
---
S
A
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
-
K
--
A
---
E
---------------------
K
---
E
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------------------
G
S
D
F
G
P
I
F
M
-
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------
48
Fugue
83.77
23%
-112
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
---------------------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
---
I
I
-
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
P
F
W
A
V
D
A
V
A
-
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
-
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-------------------
A
N
V
S
E
------
A
D
D
R
Y
I
C
D
R
F
Y
----
P
---
N
D
----
L
-
W
V
V
V
F
-----
Q
-----
F
Q
H
I
M
V
----
G
L
I
L
P
G
I
V
I
L
S
C
--------------------
Y
C
I
I
I
S
K
L
-------------------------
S
H
S
G
-----------------------------
S
---
N
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
L
R
--
I
---
D
---------------------
E
---
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
IGRNTN
G
-
V
--
I
-
T
K
--
D
E
A
E
K
L
F
N
Q
D
V
-
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GT
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
33
HHSearch
80.95
27%
-138
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------
Y
A
L
S
Y
C
---
A
L
-
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-------------------
F
N
T
T
G
--------
D
P
T
V
C
S
I
S
N
----
P
-------------
D
F
V
-----
I
-----
Y
-
S
S
V
V
----
S
F
Y
L
P
F
G
V
T
V
L
V
--------------------
Y
A
R
I
Y
V
V
L
-------------------------
K
Q
R
R
-----------------------------
R
---
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
V
P
L
--
R
---
E
---------------------
K
---
K
A
T
Q
M
V
A
I
------
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
--------------------
C
H
V
S
P
E
L
Y
-
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
--------
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
-----
C
-----------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.80
24%
-152
- C3 -
4MBS
8
CCR5_HUMAN (first)
A:
[36-366]
------------------------------------------------------------
P
P
L
Y
S
---
L
V
-
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
V
P
F
W
A
H
Y
A
A
A
-
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
-
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
V
A
V
F
A
S
L
P
N
I
I
F
T
------------------
R
S
Q
K
----
E
--
G
L
H
Y
T
-
C
S
S
H
F
----
P
YSQ
Y
Q
----
F
-
W
K
N
F
Q
-----
T
-----
L
K
I
V
I
L
----
G
L
V
L
P
L
L
V
M
V
I
C
--------------------
Y
S
G
I
L
K
T
L
L
R
M
K
K
Y
T
C
TVCG
Y
I
-----------
Y
N
P
E
DGDPDNGVNPGTDFKDIPDDWVCPLCGVG
K
---
D
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
E
--
E
---
E
---------------------
K
K
R
H
R
D
V
R
L
I
F
T
------
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
V
L
L
L
N
T
F
Q
E
F
------
F
-
G
--
L
-
N
N
--
C
S
S
S
N
R
L
D
Q
A
M
-
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
--------
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.20
26%
-135
- C3 -
3C9L
13
OPSD_BOVIN
A:
[35-315]
------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
---
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------------------
G
W
S
R
Y
I
P
E
--
G
M
Q
C
S
-
C
G
I
D
Y
----
Y
---
T
P
----
H
-
E
E
--
T
-----
N
N
E
S
F
V
I
Y
M
F
V
V
----
H
F
I
I
P
L
I
V
I
F
F
C
--------------------
Y
G
Q
L
V
F
T
V
-------------------------
K
E
A
A
-----------------------------
A
---
Q
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
--
T
Q
K
A
E
---------------------
K
---
E
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--------------------
Q
G
S
D
F
G
P
I
F
M
-
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.80
26%
-139
- C3 -
1F88
7
OPSD_BOVIN
A:
[35-315]
------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
---
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------------------
G
W
S
R
Y
I
P
E
--
G
M
Q
C
S
-
C
G
I
D
Y
----
Y
---
T
P
----
H
-
E
E
--
T
-----
N
N
E
S
F
V
I
Y
M
F
V
V
----
H
F
I
I
P
L
I
V
I
F
F
C
--------------------
Y
G
Q
L
V
F
T
V
-------------------------
K
E
A
A
-----------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
--
T
QK
A
E
---------------------
K
---
E
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--------------------
Q
G
S
D
F
G
P
I
F
M
-
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.16
24%
-143
- C3 -
4XNW
2
RUBR_CLOPA
A:
[54-382]
-------------------------------------------------------------
P
A
V
Y
---
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
L
---
K
K
-
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
-------------------------
Y
S
G
T
--
G
V
R
K
N
K
T
I
T
C
Y
----
D
---
T
T
----
S
-
D
E
Y
L
R
S
Y
F
I
Y
S
-----
M
C
T
T
V
A
----
M
F
C
V
P
L
V
L
I
L
G
C
--------------------
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDN
G
V
N
P
-----------------------------
G
---
T
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
I
P
--
D
---
D
WVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
---
K
S
I
Y
L
V
I
I
------
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
------
D
-
F
--
Q
-
T
P
AM
C
A
F
N
D
R
V
Y
A
T
Y
-
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
77.98
21%
-128
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
-----------------------------------------------------------
I
V
L
V
A
G
---
S
L
-
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-------------------
W
Q
F
I
V
G
V
R
---
T
V
E
D
G
E
C
Y
I
Q
F
----
F
---
S
-------
N
A
A
V
T
-----
F
-----
G
-
T
A
I
A
----
A
F
Y
L
P
V
I
I
M
T
V
L
--------------------
Y
W
H
I
S
R
A
S
-------------------------
K
S
R
I
-----------------------------
N
---
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
P
P
S
--
R
---
E
---------------------
K
---
K
V
T
R
T
I
L
A
------
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
---------------------
C
I
P
N
T
V
W
-
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
--------
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.82
24%
-148
- C3 -
4XNV
15
P2RY1_HUMAN
A:
[54-382]
-------------------------------------------------------------
P
A
V
Y
---
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-K
S
L
G
R
L
---
K
K
-
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
-------------------------
Y
S
G
T
--
G
V
R
K
N
K
T
I
T
C
Y
----
D
---
T
T
----
S
-
D
E
Y
L
R
S
Y
F
I
Y
S
-----
M
C
T
T
V
A
----
M
F
C
V
P
L
V
L
I
L
G
C
--------------------
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDN
G
V
N
P
-----------------------------
G
---
T
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
I
--------VCPLCGVGKDQ
F
E
E
V
EE
P
L
R
-
R
---
K
S
I
Y
L
V
I
I
------
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
------
D
-
F
--
Q
-
T
P
AM
C
A
F
N
D
R
V
Y
A
T
Y
-
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.68
26%
-141
- C3 -
3CAP
6
OPSD_BOVIN
A:
[35-315]
------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
---
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------------------
G
W
S
R
Y
I
P
E
--
G
M
Q
C
S
-
C
G
I
D
Y
----
Y
---
T
P
----
H
-
E
E
--
T
-----
N
N
E
S
F
V
I
Y
M
F
V
V
----
H
F
I
I
P
L
I
V
I
F
F
C
--------------------
Y
G
Q
L
V
F
T
V
-------------------------
K
E
A
A
-----------------------------
A
---
Q
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
--
T
Q
K
A
E
---------------------
K
---
E
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
--------------------
Q
G
S
D
F
G
P
I
F
M
-
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
-----
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
77.33
23%
-82
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
-------
P
W
Q
F
S
M
L
A
A
Y
M
F
---
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
F
---
G
-
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------------------
G
W
S
R
Y
I
P
E
--
G
M
Q
C
-
S
C
G
I
D
Y
YTPH
E
---
E
T
----
N
-
N
E
S
F
V
-----
I
-----
Y
M
F
V
V
H
-----
F
I
I
P
L
I
V
I
F
F
C
--------------------
Y
G
Q
L
V
F
T
V
-------------------------
K
E
A
A
-----------------------------
A
---
Q
Q
Q
ESA-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
--
A
---
E
---------------------
K
---
E
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--------------------
G
S
D
F
G
P
I
F
M
-
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------
C
C
G
K
N
P
L
G
D
D
----
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.70
29%
-145
- C3 -
4XT3
2
US28_HCMVA
A:
[37-309]
-------------------------------------------------------
L
N
Q
S
K
P
V
T
L
F
L
Y
G
V
V
-
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
L
P
L
W
M
Q
Y
L
L
D
-
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
-----
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
P
H
F
M
V
-------------------
V
T
K
K
D
----------
N
Q
C
M
T
D
Y
----
D
---
Y
L
-------
E
V
S
Y
-----
P
-----
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
--------------------
Y
Y
R
I
S
R
I
V
-------------------------
A
V
S
Q
-----------------------------
S
---
R
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---------------------
G
---
R
I
V
R
V
L
I
A
------
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
L
L
------
K
W
I
--
S
-
S
S
--
C
E
F
E
R
S
L
K
R
A
L
-
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
--------
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
-----
E
-----------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.41
27%
-144
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[141-401]
----------------------------------------------------------------------------
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
P
F
Q
G
T
D
I
L
L
-
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-------------------
G
S
A
Q
V
E
D
E
E
------
I
E
C
L
V
E
I
----
P
---
T
P
QD--
Y
-
W
G
P
V
F
-----
A
-----
I
C
I
F
L
F
----
S
F
I
V
P
V
L
V
I
S
V
C
--------------------
Y
S
L
M
I
R
R
L
-------------------------
R
G
V
R
-----------------------------
L
LS-
G
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
--
N
---
L
---------------------
R
---
R
I
T
R
L
V
L
V
------
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
---
A
Q
G
L
------
G
-
V
--
Q
-
P
S
--
S
E
T
A
V
---
A
I
L
-
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
--------
Y
A
F
L
D
E
N
F
K
A
C
F
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
76.32
25%
-137
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------------------------------------------
S
F
K
C
A
L
T
K
-
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
---
L
V
-
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
L
---
K
K
K
N
-
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
KNKTITCYDTTSD
E
Y
L
R
S
Y
F
I
Y
--
S
M
C
T
T
V
A
M
F
C
V
----
P
---
L
V
----
L
-
I
L
G
C
Y
-----
G
-----
L
I
V
R
A
L
----
I
Y
K
M
K
K
Y
T
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNPGTD
F
K
D
I
V
C
P
L
-------------------------
C
G
V
G
-----------------------------
K
---
D
Q
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
V
E
E
P
L
---
R
---------------------
R
---
K
S
I
Y
L
V
I
I
------
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
------
D
-
F
QT
P
-
A
M
--
C
A
F
N
D
R
V
Y
A
T
Y
-
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
--------
Y
F
L
A
G
D
T
F
R
R
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
74.92
19%
-132
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[44-477]
------------------------------------------------------------
G
I
V
M
S
---
L
I
-
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H------------------
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
----
T
-----------
N
Q
A
Y
A
-----
I
-----
A
-
S
S
I
V
----
S
F
Y
V
P
L
V
I
M
V
F
V
--------------------
Y
S
R
V
F
Q
E
A
-------------------------
K
R
Q
L
-----------------------------
N
---
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
K
F
C
L
--
K
---
E
---------------------
H
---
K
A
L
K
T
L
G
I
------
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
---------------------
L
I
R
K
E
V
Y
-
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
--------
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-----
L
-----------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
74.85
24%
-138
- C3 -
2KS9
1
NK1R_HUMAN
A:
[36-326]
------------------------------------------------------------
A
A
A
Y
T
---
V
I
-
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-------------------
S
T
T
E
T
M
------
P
S
R
V
V
C
M
I
E
W
----
P
---
E
H
PNKI
Y
-
E
K
V
Y
H
-----
I
-----
C
-
V
T
V
L
----
I
Y
F
L
P
L
L
V
I
G
Y
A
--------------------
Y
T
V
V
G
I
T
L
-------------------------
W
A
S
E
-----------------------------
I
---
P
G
D
SSDRYH--------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
V
S
--
A
---
K
---------------------
R
---
K
V
V
K
M
M
I
V
------
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
------
L
-
Y
----------
L
K
K
F
I
Q
Q
V
Y
-
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
-----
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
--
S
T
V
V
G
A
---------------------------------------------------------------------------------------------------
28
HHSearch
74.61
21%
-140
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[14-443]
--------------------------------------------------------------
V
L
S
---
T
I
-
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
-
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-------------------
N
H
----------
R
R
E
D
K
C
E
T
D
F
----
Y
---
D
-------
V
T
W
F
K
-----
V
-----
M
-
T
A
I
I
----
N
F
Y
L
P
T
L
L
M
L
W
F
--------------------
Y
A
K
I
Y
K
A
V
-------------------------
R
Q
H
C
-----------------------------
N
---
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
L
H
M
N
--
R
---
E
---------------------
R
---
K
A
A
K
Q
L
G
F
------
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
---------------------
C
C
N
E
H
L
H
-
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
--------
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.26
27%
-141
- C3 -
5C1M
7
?
A:
[29-294]
------------------------------------------------------------------------
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
F
Q
S
V
N
Y
L
M
-
G
-
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-------------------
A
T
T
K
Y
--
R
Q
--
G
S
I
D
C
T
L
T
F
S
H
----
P
---
T
W
----
Y
-
W
E
N
L
L
-----
K
-----
I
C
V
F
I
F
----
A
F
I
M
P
V
L
I
I
T
V
C
--------------------
Y
G
L
M
I
L
R
L
-------------------------
K
S
V
R
-----------------------------
M
LSG
S
K
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
-
R
--
N
---
L
---------------------
R
---
R
I
T
R
M
V
L
V
------
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
-------------------
P
E
T
T
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
C
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
C
F
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
74.07
26%
-135
- C3 -
4RWD
6
C562_ECOLX (first)
A:
[138-406]
----------------------------------------------------------------------------
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
L
P
F
Q
S
A
K
Y
L
M
-
E
-
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
-
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-------------------
A
V
T
R
P
R
--
D
--
G
A
V
V
C
M
L
Q
F
P
S
----
P
---
S
W
----
Y
-
W
D
T
V
T
-----
K
-----
I
C
V
F
L
F
----
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
------------------
L
M
L
L
R
L
R
S
-------------------------
V
R
L
L
-----------------------------
S
---
G
S
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
--
S
---
L
---------------------
R
---
R
I
T
R
M
V
L
V
------
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
------
D
-----------
R
R
D
P
L
V
V
A
A
L
-
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
--------
Y
A
F
L
D
E
N
F
K
R
----
C
F
R
-----
Q
L
C
---------------------------------------------------------------------------------------------------------------------------------------------