@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP143_HUMAN: (2016-01-10 )
MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSPATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSAMWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPSVSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGAVIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNPAQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVGGQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL
Atome Classification :
(20 SA)
------------------------------------------------------------------------.........10........20........30........40........50........60........70........80....-....90.......--.100.......110........120.......130.......140.......------150----.---------..----------......160...----....170....--.---.---.--180-........--190---.---------..----.-----.----....200.......210.......-220......------.230........240.......250..---.....260.......270.......280-........290......----.300.----......310..-.....320--.--........330.......340....------------...350.......360.......370-----........380.......390.----......400..------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------MASPRLG
T
F
CCPTR
D
A
A
T
Q
L
V
L
SFQPR
A
F
H
A
L
C
LGSG
G
L
R
L
A
L
G
L
L
Q
LLPGRRPAGPGSPATSPP
A
S
V
R
I
L
R
A
A
A
A
C
D
L
L
G
C
L
G
M
-
V
I
R
S
T
V
WLG
F
P
N
F
--
V
D
S
VSDMNHTE
I
-
W
P
A
A
F
C
V
G
S
A
M
W
I
Q
L
L
Y
S
A
C
F
W
W
L
F
C
Y
A
V
D
A
Y
L
V
IRRSA------
G
------
L
---------
S
T
----------
I
L
L
Y
H
I
M
A
W
G
L
A
----
T
L
L
C
VEG
A
A
M
L
--Y---Y---P--
S
V
--
S
R
C
E
RG
L
D
--
H
-----
A
---------
I
P
----
H
-----
Y
----
V
T
M
Y
L
P
L
L
L
V
L
VAN
P
I
L
F
Q
K
T
V
T
A
-
V
A
S
L
L
KGRQ------GIY-TENERRM
G
A
V
I
K
I
R
F
F
K
I
M
L
V
L
I
---
I
C
W
L
S
N
I
I
N
E
S
L
L
F
Y
L
E
M
Q
TDINGGSL--
K
P
V
RTAA
K
T
T
W
F
I
M
GIL----NP
A
Q
G
----
F
L
L
S
L
A
F
YGWT-GCSLGF----Q--SPRK
E
I
Q
W
ESLTTSAAEGAHPSPLM------------PHENPASG
K
V
S
QVGGQ
T
S
D
E
A
L
S
M
L
------SEGSDA
S
T
I
E
I
HTASESCNKNE----GDPALPTHGDL------
26
Fugue
81.04
14%
-89
- C3 -
2CY7
-
ATG4B_HUMAN
A:
[5-377]
--------------------------------------------------------------------------
T
L
T
Y
D
T
L
R
F
A
E
F
E
-------
D
F
P
E
T
S
E
P
V
W
I
L
G
----------------------------
R
K
Y
S
I
F
T
E
K
D
E
I
L
S
D
V
A
S
R
L
W
F
-
T
Y
R
K
----
N
F
P
A
I
GG
T
G
P
T
S
D
T
G
-----
W
G
C
M
L
R
C
G
Q
M
I
F
A
Q
A
L
V
C
R
H
L
G
R
D
W
R
W
T
Q
R
K
----
R
Q
P
D
------
S
------
Y
---------
F
S
----------
V
L
N
A
F
I
----------------
D
R
K
D
S
--
Y
---
Y
---
S
--
I
H
--
Q
I
A
Q
M
G
V
G
--
E
-----
G
----------
K
----
S
-----
I
----
G
Q
W
Y
G
P
N
T
V
A
Q
V
L
K
K
L
A
V
F
D
T
W
S
S
L
A
V
H
I
A
M
D
N
T
------
V
V
M
-
E
E
I
R
R
L
C
R
T
S
V
P
C
S
P
W
R
P
L
V
L
L
I
---
P
L
R
L
G
L
-------------
T
D
I
N
E
A
Y
V
--
E
T
L
K
H
C
F
M
M
P
-
Q
S
L
G
V
I
G
G
K
P
N
S
A
H
Y
----
F
I
---
G
Y
V
G
E
E
-
L
I
Y
L
D
P
----
H
--
T
T
Q
P
A
V
E
G
C
F
I
P
D
E
S
F
H
C
Q
H
P
P
C
R
M
------------
S
I
A
E
L
D
P
S
I
A
V
G
F
F
C
K
T
E
D
D
F
N
D
W
C
------
Q
Q
V
K
K
L
S
L
L
P
M
F
E
L
V
E
Q
Q
P
D
V
L
----
N
L
S
L
D
S
S
D
V
E
R
L-----
27
Fugue
79.97
15%
-87
- C2 -
2OCC
-
COX1_BOVIN
A:
[1-514]
MFINRWLFSTN
H
K
D
I
G
T
L
Y
L
L
F
G
A
W
A
G
M
V
G
T
A
L
S
L
L
I
R
A
E
L
GQPGTLLGD
D
Q
I
Y
N
V
V
V
T
A
H
A
F
V
M
I
FFMVMP
I
M
I
G
G
F
G
N
W
L
V
P
L
M
I
G
A
P
D
M
A
F
P
R
M
N
N
M
S
F
W
L
L
P
P
S
F
L
L
L
L
A
S
S
M
V
E
-----
A
G
A
G
T
G
W
T
V
-
Y
P
P
L
A
G
N
L
A
H
A
G
A
S
V
D
L
T
I
F
S
L
H
-
L
A
G
V
S
S
I
L
G
A
I
N
F
--
I
T
T
I
I
N
M
K
P
P
A
M
---
S
Q
Y
Q
T
P
L
F
V
W
S
V
M
I
T
A
V
L
L
L
L
S
L
P
V
L
A
A
G
I
T
M
L
L
T
D
R
------
N
------
L
---------
N
T
TFFDPAGGGD
P
I
L
Y
Q
H
L
F
W
F
F
G
H
P
E
V
Y
I
L
I
L
P
G
F
G
M
I
--
S
---
H
---
I
--
V
T
--
Y
Y
S
G
K
K
E
P
--
F
---------------------
G
-----
Y
----
M
G
M
V
W
A
M
M
S
I
G
F
L
G
F
I
V
W
A
H
H
M
F
T
-
V
-
G
M
D
V
D
T
R
------
A
Y
F
-
T
S
A
T
M
I
I
A
I
P
T
G
V
K
V
F
S
W
L
A
T
L
H
GGN
I
K
W
S
P
A
M
M
W
A
L
G
F
I
F
L
F
T
V
G
G
L
T
G
I
V
L
AN
S
S
L
D
I
V
L
H
D
T
Y
Y
V
V
A
H
F
----
H
Y
V
L
S
MG
A
V
F
A
I
M
G
G
F
V
H
W
F
-
P
L
F
S
G
Y
----
T
LN
D
T
W
A
K
I
H
F
A
I
M
F
V
G
V
N
M
T
F
F
P
Q
H
F
L
G
L
S
G
M
P
R
RYSDY
P
D
A
Y
T
M
W
N
T
I
S
S
M
G
S
F
I
S
L
T
A
V
M
L
M
V
F
I
I
W
E
A
F
A
S
K
R
E
V
L
---
T
V
D
L
T
T
T
N
L
E
WLNG
C
P
P
P
Y
H
T
F
E
E
P
T
Y
V
N
LK
22
Fugue
76.16
17%
-132
- C1 -
4ZR1
13
?
A:
[23-296]
--------------------------------------------------------------FDSTTFVKEL
P
A
E
E
K
L
S
I
A
T
D
Y
S
N
D
Y
K
K
H
K
F
L
D
L
N
R
P
L
L
M
Q
I
L
R
S
D
F
K
K
D
F
Y
V
D
Q
I
H
-----
R
P
R
H
Y
G
K
G
S
A
P
L
F
G
N
F
L
--------
E
P
L
T
K
T
A
W
-
W
V
V
P
V
A
W
L
P
V
V
V
Y
--
H
M
G
V
A
L
K
N
M
N
Q
L
F
A
C
F
L
F
C
V
G
V
F
V
W
T
L
I
E
Y
G
L
H
R
F
L
F
H
---
F
D
D
W
L
-----
P
------
E
------
S
---------
N
I
----------
A
F
A
T
H
F
L
L
----------------------------------------------
H
-----
G
---------
C
H
----
H
-----
Y
----
L
P
M
D
K
Y
R
L
---
V
M
P
P
T
L
F
V
I
L
C
A
P
-
F
Y
K
L
V
F
A
L
L
------------------------
P
L
Y
W
A
Y
A
G
F
---
A
G
G
L
F
G
Y
V
C
Y
D
E
C
H
F
F
L
H
H
S
K
-----
L
--
P
P
F
M
R
K
L
K
K
Y
H
L
E
H
H
Y
K
----
N
Y
Q
L
G
----
F
G
V
T
S
W
F
W
D
E
V
F
G
T
Y
L
G
P
----
D
--
A
P
L
S
K
M
K
Y
E
S
G
L
E
V
L
------------------------------------------------------------------------------------------------
14
HHSearch
75.48
13%
-151
- C5 -
2KS9
1
NK1R_HUMAN
A:
[38-271]
----------------------------------------------------------------------------------------------------
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
---------
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
-------------
E
W
Y
-
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
------
Q
PRLS--
A
---------
T
A
----------
T
K
V
V
I
C
V
I
W
V
L
A
----
L
L
L
A
F
P
Q
G
Y
Y
S
--
T
TET
M
---
P
--
S
R
--
V
V
C
M
I
E
W
P
--
E
HPN--
K
IY
E
------
K
V
----
Y
H
I
C
V
T
V
----
L
I
Y
F
L
P
L
L
V
I
G
Y
A
----
Y
T
V
V
G
I
T
-
L
W
A
S
E
I
P
G
D
------
S
S
D
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
---
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
Y
L
K
K
F
I
Q
Q
--
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
----
I
I
Y
C
C
----
L
N
D
R
F
R
L
G
F
K
H
-
A
F
R
C
C
P
----
F
--
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
------------
V
S
R
L
E
T
T
I
S
T
V
V
G
A
------------------------------------------------------------
15
HHSearch
70.40
21%
-157
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[44-266]
---------------------------------------------------------------------------------------------------
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
---------
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
-
P
I
W
A
A
S
K
---
V
N
------------
G
W
I
-
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
------
R
------
T
LTQ
K
R
----
H
L
----------
V
K
F
V
C
L
G
C
W
G
L
S
----
M
N
L
S
L
P
F
F
L
F
R
QA
Y
---
H
---
P
NN
S
S
--
P
V
C
Y
E
V
L
G
--
N
-----
D
TA-------
K
W
RMVL
R
-----
I
LPHT
F
G
F
I
V
P
L
F
V
M
L
----
F
C
Y
G
F
T
L
R
T
-
L
F
K
A
H
------------------
M
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
---
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
Q
V
I
Q
E
S
C
E
R
--
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
----
H
S
C
L
N
----
P
I
I
Y
A
F
I
G
Q
N
F
-
R
H
G
F
L
K
----
I
--
L
A
M
H
G
----------------------------------------------------------------------------------------------------------
11
HHSearch
69.02
16%
-154
- C5 -
1U19
10
OPSD_BOVIN
A:
[47-274]
-----------------------------------------------------------------------------------------------------
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
---------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
------------
Y
F
V
-
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
F
G
-
E
---------
N
H
----------
A
I
M
G
V
A
F
T
W
V
M
A
----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
---
P
--
E
G
MQ
C
S
C
G
I
D
Y
Y
TP
H
EETN
N
E
---------
S
F
----
V
-----
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
----
F
C
Y
G
Q
L
V
F
T
-
V
K
E
A
A
A
Q
Q
Q
------
E
---
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
---
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
--
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
----
I
M
M
N
K
----
Q
F
R
N
C
M
V
T
T
L
C
-
C
G
K
N
P
L
----
G
--
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------
10
HHSearch
62.70
13%
-154
- C5 -
3PBL
1
DRD3_HUMAN (first)
A:
[44-224]
----------------------------------------------------------------------------------------------------
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
---------
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
------------
V
W
N
-
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
------
H
------
Y
Q
H
G
T
G
Q
SS
C
R
R
----------
V
A
L
M
I
T
A
V
W
V
L
A
----
F
A
V
S
C
P
L
L
F
G
F
--
N
T--
T
---
G
--
D
P
--
T
V
C
S
I
S
N
P
--
D
F
V
---
I
---------
Y
S
----
S
-----
V
----
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
-
R
R
K
N
I
F
E
M
L
------
R
I
D
-
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
---
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
--
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
----
I
L
R
N
A
----
K
L
K
P
V
Y
D
S
L
D
A
-
V
R
R
A
A
L
----
I
--
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
------------
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
------
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
----
M
V
A
I
V
L
G
A
F
I
V
------
3
HHSearch
62.21
16%
-152
- C5 -
3ODU
6
CXCR4_HUMAN (first)
A:
[54-239]
----------------------------------------------------------------------------------------------------
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
---------
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
-
P
F
W
A
V
D
A
V
-
A
-
N
-------------
W
Y
-
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
------
N
S
Q
R
P
R
K
L
---------
L
A
----------
E
K
V
V
Y
V
G
V
W
I
P
A
----
L
L
L
T
I
P
D
F
I
F
A
--
N
---
V
S
E
A
D
--
D
R
--
Y
I
C
D
R
F
Y
P
--
N
-----
D
L
W
V
V
V
F
Q
F
-
Q
H
----
I
-----
M
----
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
-
G
S
N
I
F
E
M
L
R
------
I
D
E
-
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
--
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----
L
R
N
A
K
----
L
K
P
V
Y
D
S
L
D
A
V
-
R
R
A
A
L
I
----
N
--
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
------------
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
------
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
----
T
T
V
I
L
I
L
A
F
F
A
------
4
HHSearch
60.90
10%
-130
- C5 -
2Z73
5
OPSD_TODPA
A:
[39-324]
---------------------------------------------------------------------------------------------------
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
---------
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-------------
K
W
I
-
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
AA
S
K
K
M
S
------
H
---------
R
R
----------
A
F
I
M
I
I
F
V
W
L
W
S
----
V
L
W
A
I
G
P
I
F
G
W
--
G
A
Y
-
T
L
E
-
G
--
V
L
--
C
N
C
S
F
D
Y
I
--
S
-----
R
D
S
T
T
R
S
N
I
L
C
M
----
F
-----
I
----
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
-
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
---
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
--------------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
----
A
K
A
S
A
----
I
H
N
P
M
I
Y
S
V
S
H
-
P
K
F
R
E
A
----
I
--
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
------------
T
E
I
P
A
G
E
-------------------------------------------------------------------
9
HHSearch
56.22
16%
-157
- C5 -
2RH1
5
ADRB2_HUMAN (first)
A:
[46-176]
----------------------------------------------------------------------------------------------------
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
---------
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
------------
M
W
T
-
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
------
K
YQSLLT
K
---------
N
K
----------
A
R
V
I
I
L
M
V
W
I
V
S
----
G
L
T
S
F
L
P
I
Q
M
H
--
W
---
Y
---
R
--
A
T
--
H
Q
E
A
I
N
C
Y
--
A
-----
E
---------
E
T
----
C
-----
C
----
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-
V
F
V
Y
S
R
V
F
Q
------
E
A
K
-
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
---
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
--
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
----
L
F
N
Q
D
----
V
D
A
A
V
R
G
I
L
R
N
-
A
K
L
K
P
V
----
Y
--
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
------------
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
------
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
----
Y
K
F
C
L
K
E
H
K
A
L
------
7
HHSearch
54.00
15%
-156
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[68-248]
---------------------------------------------------------------------------------------------------
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
---------
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
T
-
T
-------------
Y
K
-
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------
N
------
N
---------
F
R
----------
L
F
L
L
I
S
A
C
W
V
I
S
----
L
I
L
G
G
L
P
I
M
G
W
N-
C
---
I
---
S
--
A
L
--
S
S
C
S
T
V
L
P
--
L
YH
K
H
Y
I
---------
L
F
----
C
-----
T
----
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
-
N
I
F
E
M
L
R
I
D
------
E
G
L
-
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
---
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
--
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
----
N
A
K
L
K
----
P
V
Y
D
S
L
D
A
V
R
R
-
A
A
L
I
N
M
----
V
--
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
------------
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
------
R
T
G
T
W
D
A
Y
A
S
R
S
S
E
N
V
A
L
L
K
T
V
----
I
I
V
L
S
V
F
I
A
C
W
------
8
HHSearch
52.58
12%
-147
- C5 -
3RZE
2
ENLYS_BPT4 (first)
A:
[14-144]
----------------------------------------------------------------------------------------------------
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
---------
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
-------------
W
S
-
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
------
R
YLKYRT
K
---------
T
R
----------
A
S
A
T
I
L
G
A
W
F
L
S
----
F
L
W
V
I
P
I
L
G
W
N
--
H
---
R
---
R
--
E
D
--
K
C
E
T
D
F
Y
D
--
V
-----
T
---------
W
F
----
K
-----
V
----
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
-
V
R
Q
H
C
N
I
F
E
------
M
L
R
-
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
---
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
----
R
G
I
L
R
----
N
A
K
L
K
P
V
Y
D
S
L
-
D
A
V
R
R
A
----
A
--
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
------------
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
------
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
R
K
A
----
A
K
Q
L
G
F
I
M
A
A
F
------
12
HHSearch
52.51
13%
-156
- C5 -
3EML
8
ENLYS_BPT4
A:
[25-155]
--------------------------------------------------------------------------------------------------
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
-
N
--------
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
-------------
F
C
-
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
---------
T
R
----------
A
K
G
I
I
A
I
C
W
V
L
S
----
F
A
I
G
L
T
P
M
L
G
W
--
N
---
N
---
C
--
G
Q
--
S
Q
G
C
G
E
G
Q
--
V
-----
A
---------
C
L
----
F
-----
E
----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-
L
G
V
Y
L
R
I
F
L
------
A
A
R
-
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
---
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
--
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
----
L
F
N
Q
D
----
V
D
A
A
V
R
G
I
L
R
N
-
A
K
L
K
P
V
----
Y
--
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
------------
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
------
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
----
Y
R
S
T
L
Q
K
E
V
H
A
------
5
HHSearch
51.36
13%
-154
- C5 -
3UON
2
ACM2_HUMAN (first)
A:
[29-160]
----------------------------------------------------------------------------------------------------
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
---------
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
------------
Y
W
P
-
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
------
T
YPVKRT
T
---------
K
M
----------
A
G
M
M
I
A
A
A
W
V
L
S
----
F
I
L
W
A
P
A
I
L
F
W
--
Q
---
F
---
I
--
V
G
--
V
R
T
V
E
D
G
E
--
C
-----
Y
---------
I
Q
----
F
-----
F
----
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
-
Y
W
H
I
S
R
A
S
K
------
S
R
I
-
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
---
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
----
Q
D
V
D
A
----
A
V
R
G
I
L
R
N
A
K
L
-
K
P
V
Y
D
S
----
L
--
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
------------
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
P
P
----
P
S
R
E
K
K
V
T
R
T
I
------
24
Fugue
48.03
11%
-27
- C4 -
2LGZ
-
A:
[1-273]
------------------------------------------------------------------------
M
G
S
S
-------
H
H
H
H
H
H
S
S
G
L
V
P
R
G
S
H
S
T
W
V
T
R
T
A
Y
S
S
P
S
V
------
V
L
P
S
Q
T
P
D
G
K
L
--------------------------------------------
A
L
I
D
D
F
R
E
A
Y
Y
-
W
L
R
M
N
S
D
E
D
S
-------
K
V
A
A
W
W
D
Y
G
Y
Q
I
G
G
M
A
--
D
R
T
T
------
L
------
V
---------
D
N
-----------------
N
T
W
N
N
----
T
H
I
A
I
V
G
K
A
N
A
--
S
---
P
---
E
--
E
K
--
S
Y
-------------------------------------------------------
E
I
L
K
E
H
D
V
D
Y
-
V
L
V
I
F
G
G
L
I
------
G
F
G
-
G
D
D
I
N
K
F
L
--------------------
W
N
I
R
I
S
E
G
I
W
P
E
E
I
K
E
R
D
F
Y
T
A
E
G
E
--
Y
R
V
D
A
R
A
--------
S
E
----
T
M
R
N
S
----
L
L
Y
K
M
S
Y
K
D
F
P
-
Q
------------
L
F
N
G
G
Q
A
T
D
R
V
R
Q
Q
M
I
T
P
L
D
V
P
P
L
D
------------
Y
F
D
E
V
F
T
S
E
N
W
N
V
R
I
Y
Q
L
K
K
D
D
A
Q
G
------
R
T
L
R
D
V
G
E
L
T
R
S
S
T
K
T
R
R
S
I
K
R
----
P
E
L
G
L
R
V
----------
2
PsiBlast_PDB
20.67
36%
137
- C6 -
1BM3
-
?
H:
[10-47]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
----
N
P
G
R
S
----
L
K
L
S
C
A
A
S
G
F
T
-
F
S
S
Y
G
M
SWVR
Q
--
T
P
E
K
R
L
E
W
V
A
A
I
S
G
G
G
T
Y
I
H
Y
P
D
S
V
------------
K
G
R
F
T
I
S
R
D
N
A
K
N
N
L
Y
L
Q
M
S
S
L
R
S
E
------
D
T
A
L
Y
Y
C
T
R
H
A
M
D
H
W
G
Q
G
T
S
V
T
----
V
S
A
A
K
T
T
P
P
S
V
------
1
PsiBlast_PDB
19.19
36%
147
* C6 *
1OPG
-
IGHG1_MOUSE
H:
[10-47]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
V
----
N
P
G
R
S
----
L
K
L
S
C
A
A
S
G
F
T
-
F
S
S
Y
G
M
SWVR
Q
--
T
P
E
K
R
L
E
W
V
A
A
I
S
G
G
G
T
Y
I
H
Y
P
D
S
V
------------
K
G
R
F
T
I
S
R
D
N
A
K
N
N
L
Y
L
Q
M
S
S
L
R
S
E
------
D
T
A
L
Y
Y
C
T
R
H
P
F
Y
R
Y
D
G
G
N
Y
Y
A
----
M
D
H
W
G
Q
G
T
S
V
T
------
16
HHSearch
18.71
19%
52
- C5 -
2KI9
-
A:
[2-27]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
L
A
K
T
L
G
L
V
L
A
V
L
L
---
I
C
W
F
P
V
L
A
L
M
A
H
S
L
A
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
15.69
5%
-64
- C5 -
2Z73
3
OPSD_TODPA
A:
[37-58]
----------------------------------------------------------------------------------------------------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
-
I
S
C
F
L
K
K
W
I
F
G
F
A
--
A
C
K
V
Y
G
F
I
G
G
I
F
-
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
------
F
------
V
---------
W
L
----------
W
S
V
L
W
A
I
G
P
I
F
G
----
W
G
A
Y
T
L
E
G
V
L
C
--
N
---
C
---
S
--
F
D
--
Y
I
S
R
D
S
T
T
--
R
-----
S
---------
N
I
----
L
-----
C
----
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-
S
N
H
E
K
E
M
A
A
------
M
A
K
-
R
L
N
A
K
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
---
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
--
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
----
S
A
I
H
N
----
P
M
I
Y
S
V
S
H
P
K
F
-
R
E
A
I
S
Q
----
T
--
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
------------
P
A
G
E
----------------------------------------------------------------------
20
HHSearch
14.39
19%
63
* C5 *
3ODU
2
CXCR4_HUMAN (first)
A:
[406-437]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
---
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------