@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP149_HUMAN: (2016-01-10 )
MSLFLSNLSTNDSSLWKENHNSTDLLNPPGTLNIYLFCLTCLMTFAALVGSIYSLISLLKMQNRTVVSMLVASWSVDDLMSVLSVTIFMFLQWPNEVPGYFQFLCTTSALMYLCQGLSSNLKATLLVSYNFYTMHRGVGSQTASRRSGQVLGVVLTVWAASLLLSALPLCGWGAFVRTPWGCLVDCSSSYVLFLSIVYALAFGLLVGLSVPLTHRLLCSEEPPRLHSNYQEISRGASIPGTPPTAGRVVSLSPEDAPGPSLRRSGGCSPSSDTVFGPGAPAAAGAEACRRENRGTLYGTRSFTVSVAQKRFALILALTKVVLWLPMMMHMVVQNVVGFQSLPLETFSFLLTLLATTVTPVFVLSKRWTHLPCGCIINCRQNAYAVASDGKKIKRKGFEFNLSFQKSYGIYKIAHEDYYDDDENSIFYHNLMNSECETTKDPQRDNRNIFNAIKVEISTTPSLDSSTQRGINKCTNTDITEAKQDSNNKKDAFSDKTGGDINYEETTFSEGPERRLSHEESQKPDLSDWEWCRSKSERTPRQRSGYALAIPLCAFQGTVSLHAPTGKTLSLSTYEVSAEGQKITPASKKIEVYRSKSVGHEPNSEDSSSTFVDTSVKIHLEVLEICDNEEALDTVSIISNISQSSTQVRSPSLRYSRKENRFVSCDLGETASYSLFLPTSNPDGDINISIPDTVEAHRQNSKRQHQERDGYQEEIQLLNKAYRKREEESKGS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60.-.-......70........80..---..-....90--.........100.......110.........120...-....130......--.140..---.....---150.......160.......170-------......-.----.--.--180------....-.-----.----.----190.-........200.......210.......220..-.....230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330......--.-----------340.......350.......360-........370.......380.......390.....---..400.......410...---....420.......430..-.....440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
L
F
LSNLSTND
S
S
L
W
KENHNSTDLLNPPG
T
L
N
I
Y
L
F
C
L
T
C
L
M
T
F
A
A
L
V
G
S
I
Y
S
L
I
S
L
L
K
MQ-N-
R
T
V
V
S
M
L
V
A
SW
S
V
D
D
L
M
S
V
L
---
S
V
-
T
I
F
M
F
---LQWPNEV
P
G
Y
F
Q
F
L
C
T
T
S
A
L
--
M
Y
L
C
Q
G
L
SSNL
K
A
T
L
-
L
V
S
Y
N
F
Y
T
M
HRGV--GSQTAS---RRSG
Q
---
V
L
G
V
V
L
T
V
W
A
A
S
L
L
L
S
ALPLC---------GW
G
A
F
V-R----T--P--
W
G
C
------
L
V
DC-S-----S----
S
----
Y
--
V
-
L
F
L
S
I
V
Y
A
L
A
F
G
L
L
V
GLSV
P
L
T
H
R
LLCSEEP
P
R
-
L
H
S
N
Y
Q
E
I
SRGASIPGTPPTAG
R
V
V
SLSPEDAPGPSLRRSGGCSPSSDTVFGPGAPA
A
A
G
A
E
A
C
R
RENRG
T
L
Y
GTR
S
F
T
V
S
V
A
Q
K
R
F
A
L
I
L
A
L
T
K
V
V
L
W
L
P
M
M
M
H
M
V
V
Q
N
V
VGF--Q-----------SL
P
L
E
T
F
S
F
L
L
T
L
L
A
T
TVT
P
V
F
--
V
LSKRWTHLPC
G
C
I
I
NCRQ
N
A
Y
A
VASD
G
K
K
I
KRKG
F
---
E
F
N
L
S
F
QKSY
G
I
Y
K
I
AHE---DYYDDDEN
S
I
F
Y
H
NLMNSE-CETTKDPQRDNRNI
F
N
A
I
K
V
E
I
STTPSLD
S
S
T
Q
R
G
I
N
KCTNTDITEAKQDSNNKKDAFSDKTGGDINYEETTFSEG
P
E
R
RLSHEESQKPDL
S
D
W
E
W
C
R
SKSERTPRQRS
G
Y
A
L
A
I
P
LCAFQ
G
T
V
S
L
HAPTG
K
T
L
S
L
S
T
Y
E
VSAEGQKITPAS
K
K
I
E
V
Y
RSKSVGHEPNSEDSSS
T
F
V
D
T
S
V
K
I
H
L
E
V
L
E
ICDN
E
E
A
L
D
T
V
S
I
I
S
N
I
SQSSTQVRSPSLRYSRKEN
R
F
V
S
CDLGETA
S
Y
S
L
F
L
PTSNPDG
D
I
N
I
SIP
D
T
V
E
A
H
R
QN
S
K
R
Q
H
Q
ERD
G
Y
Q
E
E
I
Q
L
L
N
K
A
Y
R
K
R
E
EESKGS
33
HHSearch
86.23
13%
-104
- C2 -
2Z73
5
OPSD_TODPA
A:
[29-324]
---------------------------
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
-
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
---
V
N
G
F
P
L
M
T
---
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
--
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-
I
S
I
D
R
Y
N
V
I
G
R
P
M
--
A
A
-
S
K
K
---
M
S
H
R
R
---
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
---------
G
W
G
A
Y
T
-
L
----
E
GV
L
--
C
N
C
------
S
F
D
Y
-
I
-----
S
----
R
----
D
S
T
T
-
R
S
N
I
L
-----
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
---------
K
---
R
L
N
---------------
A
K
E
-----
L
R
K
---
A
--
Q
--------
A
G
A
N
A
E
M
R
L
------
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
EW
V
-----------
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
---
E
I
P
A
G
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
83.70
14%
-124
- C2 -
1U19
13
OPSD_BOVIN
A:
[41-316]
---------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
-
T
L
Y
T
S
------
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
-
F
R
F
----
G
E
N
H
---
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
I
-
P
----
E
--
G
MQ
C
S
C
------
G
I
D
Y
-
Y
-----
T
PHEE
T
----
N
--
N
-
E
S
F
V
I
-----
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
-----------
F
T
V
K
E
A
A
A
Q
Q
-------------------------
Q
------
E
S
A
---
T
------------
T
Q
K
A
E
K
E
V
------
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
SD
F
-----------
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
---
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
78.50
17%
-127
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[39-314]
--------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
-
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
-
P
I
-
W
A
A
S
K
V
--
N
G
W
I
-----
F
G
T
F
L
C
K
V
V
S
L
--
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
-
I
S
V
D
R
Y
L
A
I
V
H
A
T
--
R
T
-
L
T
Q
----
K
R
H
L
---
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
---------
F
R
Q
A
Y
H
-
P
----
N
NS
S
--
P
V
C
------
Y
E
V
L
-
G
-----
N
----
D
TAK-
W
--
R
-
M
V
L
R
I
-----
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-----------
L
R
T
L
F
K
A
------------------------------------------
H
-------------
M
G
Q
K
H
R
A
------
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
T
--
Q
VIQE
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
73.85
13%
-116
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-314]
---------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
-
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
---
F
N
-
T
V
V
N
F
---
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
--
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
-
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
-
R
L
-----
S
A
T
A
---
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
---------
Y
S
T
T
E
T
M
P
----
S
--
R
--
V
V
C
------
M
I
E
W
-
P
-----
E
----
H
PNKI
Y
--
E
-
K
V
Y
H
I
-----
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
-----------
T
L
W
A
S
E
I
P
G
-
D
------------------------
S
S
----
D
R
Y
---
H
-----------
E
Q
V
S
A
K
R
K
V
------
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
--
L
YLKKF------
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
---
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
---
V
V
G
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
72.84
9%
-56
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
-
N
-
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
---
G
A
-
A
H
I
L
M
---
K
M
W
T
F
G
-----
N
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
Q
S
-
L
---
L
T
K
N
K
---
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
HWYRATH
Q
E
A
I
N
C
Y
-
A
----
E
--
E
--
T
C
C
------
D
F
F
T
-
N
-----
Q
----
A
----
Y
--
A
-
I
A
-
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
-
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
--
L
-----------
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
--
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDN
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
70.09
24%
-122
- C2 -
3C9L
6
OPSD_BOVIN
A:
[40-191]
-------------------------------
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
----
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
-
T
L
Y
T
S
---
L
H
------
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
---
V
--
C
K
P
M
S
N
---
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
I
---------
P
--
E
G
M
------
Q
C
S
C
-
G
-----
I
----
D
----
Y
--
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.42
24%
-117
- C2 -
3CAP
1
OPSD_BOVIN
A:
[40-191]
-------------------------------
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
----
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
-
T
L
Y
T
S
---
L
H
------
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
---
V
--
C
K
P
M
S
N
---
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
I
---------
P
--
E
G
M
------
Q
C
S
C
-
G
-----
I
----
D
----
Y
--
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
66.02
17%
-125
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-233]
----------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L-
P
F
-
W
A
V
D
A
V
--
A
N
W
Y
-----
F
G
N
F
L
C
K
A
V
H
V
--
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
-
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
S
-
Q
R
P
---
R
K
L
L
A
---
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
---------
F
A
N
V
S
E
A
D
----
D
--
R
--
Y
I
C
------
D
R
F
Y
-
P
-----
N
----
D
----
L
--
W
V
V
V
F
Q
F
-----
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
-
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
--
T
-----------
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
--
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
---
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
---
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
-
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
66.01
26%
-108
- C2 -
2X72
3
GNAT1_BOVIN (first)
A:
[43-192]
-------------------------------
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
----
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
-
T
L
Y
T
S
---
L
H
------
G
Y
F
V
F
G
P
T
G
C
N
L
------
Q
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
---
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
I
---------
P
--
E
G
M
------
Q
C
S
C
-
G
-----
I
----
D
----
Y
--
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
C
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
62.66
16%
-116
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-230]
--------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
AV
V
P
F
-
G
A
A
H
I
L
M
-
K
M
W
T
-----
F
G
N
F
W
C
E
F
W
T
S
--
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
-
Q
S
L
---
L
T
K
N
K
---
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--------
H
W
Y
R
A
T
-
H
----
Q
E
-
A
--
I
N
C
Y
A
EETC
C
D
F
F
T
N
-----
Q
----
A
----
Y
--
A
-
I
---------
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
-
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
--
G
-----------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
--
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
K
F
C
L
K
E
H
---
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
---
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
60.89
17%
-122
- C2 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-221]
-----------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
-
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
LV
M
P
W
-
V
V
Y
L
E
V
T
G
G
V
W
N
-----
F
S
R
I
C
C
D
V
F
V
T
--
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
-
I
S
I
D
R
Y
T
A
V
V
M
P
V
--
H
Y
-
Q
H
G
T
G
Q
S
S
C
R
R
---
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
---------
G
F
N
T
T
G
------
D
--
P
--
T
V
C
------
S
I
S
N
-
P
----------
D
----
F
--
V
-
I
Y
---------
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
-
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
--
E
-----------
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
--
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
V
P
L
R
---
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
---
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
V
-
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.69
24%
-96
- C2 -
1LN6
1
OPSD_BOVIN
A:
[40-189]
-------------------------------
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
----
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GGF
T
T
-
T
L
Y
T
S
---
L
H
------
G
Y
F
V
F
G
P
T
G
C
N
L
EG
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
-
V
L
A
I
E
R
Y
V
V
---
V
--
C
K
P
M
S
N
---
F
R
F
G
E
NHA
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
V
---------
G
W
S
R
Y
I
---------
P
--
E
G
M
------
Q
C
S
C
-
G
-----
I
----
D
----
Y
--
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
--
S
-----------
K
T
E
T
S
Q
V
V
A
A
P
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
58.48
17%
-113
- C2 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-195]
----------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
-
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
-
N
I
L
Y
L
L
M
-
S
K
W
S
-----
L
G
R
P
L
C
L
F
W
L
S
--
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
-
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
--
R
Y
-
L
K
Y
---
R
T
K
T
R
---
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
----------
G
W
N
H
----R---
R
--
E
--
D
K
C
------
E
T
D
F
-
Y
-----
D
----
V
----
T
--
W
---
F
K
V
-----
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
-
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
--
G
-----------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
--
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
L
H
M
N
R
E
R
---
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
---
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
N
E
H
-
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
57.34
12%
-126
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[60-243]
-----------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
-
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
---
A
Y
-
T
A
N
L
L
---
L
S
-
G
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
--
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
-
I
A
I
E
R
Y
I
T
M
L
K
--------------
N
N
F
R
---
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
---------
G
W
N
C
I
S
------
A
--
L
--
S
S
C
------
S
T
V
L
-
P
-----
L
----
Y
----
H
--
K
--
H
Y
I
L
-----
F
-
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
-
L
V
R
T
R
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
--
V
-----------
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
--
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
A
S
R
S
S
E
N
V
---
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
---
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
C
D
I
-
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
55.36
13%
-120
- C2 -
3UON
2
ACM2_HUMAN (first)
A:
[24-209]
---------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
-
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
-
Y
T
L
Y
T
V
I
-
G
Y
W
P
-----
L
G
P
V
V
C
D
L
W
L
A
--
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-
I
S
F
D
R
Y
F
C
V
T
K
P
L
--
T
Y
-
P
V
K
---
R
T
T
K
M
---
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
---------
F
W
Q
F
I
V
-
G
VRTV
E
--
D
--
G
E
C
------
Y
I
Q
F
-
F
-----
S
----
N
----
A
--
A
---
V
T
F
-----
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
-
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
--
G
-----------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
--
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
P
P
P
S
R
E
K
---
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
---
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
P
N
T
-
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
54.67
14%
-113
- C2 -
3EML
8
ENLYS_BPT4
A:
[21-216]
--------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
-
A
I
T
I
S
---
T
G
F
C
-----
A
A
C
H
G
C
L
F
I
A
C
--
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-
I
A
I
D
R
Y
I
A
I
R
I
P
L
--
R
Y
-
N
G
L
---
V
T
G
T
R
---
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
---------
G
W
N
N
C
G
-
Q
-------
S
--
Q
G
C
------
G
E
G
Q
-
V
ACLFE
D
----
V
----
V
--
P
-
M
N
Y
M
V
Y
----
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
-
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
--
G
-----------
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
--
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
---
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
-
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
41.66
29%
64
- C3 -
4B5F
-
?
A:
[60-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
E
K
R
G
Y
S
G
V
A
V
Y
S
K
R
K
P
D
N
V
Q
I
G
M
G
I
E
E
F
D
R
-
E
G
R
F
V
R
C
D
F
G
R
L
S
V
I
S
L
Y
L
P
S
G
S
S
A
E
E
R
Q
Q
V
K
Y
R
F
L
D
A
F
Y
P
M
L
E
A
M
K
N
E
G
R
D
I
V
V
C
G
D
W
N
I
A
H
Q
N
I
D
L
K
N
W
K
G
N
10
PsiBlast_PDB
41.33
29%
61
* C3 *
4B5M
-
?
A:
[60-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
E
K
R
G
Y
S
G
V
A
V
Y
S
K
R
K
P
D
N
V
Q
I
G
M
G
I
E
E
F
D
R
-
E
G
R
F
V
R
C
D
F
G
R
L
S
V
I
S
L
Y
L
P
S
G
S
S
A
E
E
R
Q
Q
V
K
Y
R
F
L
D
A
F
Y
P
M
L
E
A
M
K
N
E
G
R
D
I
V
V
C
G
D
W
N
I
A
H
Q
N
I
D
L
K
N
W
K
G
N
11
PsiBlast_PDB
41.07
29%
74
- C3 -
4B5H
-
?
A:
[60-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
E
K
R
G
Y
S
G
V
A
V
Y
S
K
R
K
P
D
N
V
Q
I
G
M
G
I
E
E
F
D
R
-
E
G
R
F
V
R
C
D
F
G
R
L
S
V
I
S
L
Y
L
P
S
G
S
S
A
E
E
R
Q
Q
V
K
Y
R
F
L
D
A
F
Y
P
M
L
E
A
M
K
N
E
G
R
D
I
V
V
C
G
N
W
N
I
A
H
Q
N
I
D
L
K
N
W
K
G
N
7
PsiBlast_PDB
41.00
29%
70
- C3 -
4B5G
-
?
A:
[60-113]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
A
E
K
R
G
Y
S
G
V
A
V
Y
S
K
R
K
P
D
N
V
Q
I
G
M
G
I
E
E
F
D
R
-
E
G
R
F
V
R
C
D
F
G
R
L
S
V
I
S
L
Y
L
P
S
G
S
S
A
E
E
R
Q
Q
V
K
Y
R
F
L
D
A
F
Y
P
M
L
E
A
M
K
N
E
G
R
D
I
V
V
C
G
D
W
N
I
A
H
Q
N
I
D
L
K
N
W
K
G
N