@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP150_HUMAN: (2016-01-10 )
MEDLFSPSILPPAPNISVPILLGWGLNLTLGQGAPASGPPSRRVRLVFLGVILVVAVAGNTTVLCRLCGGGGPWAGPKRRKMDFLLVQLALADLYACGGTALSQLAWELLGEPRAATGDLACRFLQLLQASGRGASAHLVVLIALERRRAVRLPHGRPLPARALAALGWLLALLLALPPAFVVRGDSPSPLPPPPPPTSLQPGAPPAARAWPGERRCHGIFAPLPRWHLQVYAFYEAVAGFVAPVTVLGVACGHLLSVWWRHRPQAPAAAAPWSASPGRAPAPSALPRAKVQSLKMSLLLALLFVGCELPYFAARLAAAWSSGPAGDWEGEGLSAALRVVAMANSALNPFVYLFFQAGDCRLRRQLRKRLGSLCCAPQGGAEDEEGPRGHQALYRQRWPHPHYHHARREPLDEGGLRPPPPRPRPLPCSCESAF
Atome Classification :
(20 SA)
---.........10........-20........-30........40........50.......-.60........70..-----..-...-.80........90....-.....100.......110---.-........120.......130..-----------------.....140.......150..-..-----..--------.160......-.170.....-..180......-------.190.......200.......210-...---..-..220....-..-...230.--......240.....-----..250.......260.......270------..----------------------------.----------------------------.---------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------.-------------------------------------------------------------------------------.--------------.--------------280------------.-------------....-..-..290.......300..----------.....310....-....320..------.-.------...330..----.....340---....-....350.......360......-.370........380........390.---......400.......-410..-.-....420.-......430..---------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---MEDLFSPSILPPAPNI
S
V
P
-
I
L
L
GWG
L
N
L
T-LGQGAPASGPPS
R
R
V
R
L
V
F
L
G
V
I
L
V
V
AVA-GN
T
T
V
L
C
R
L
CGGGGP-----WA-GPK-RR
K
M
D
F
L
L
V
Q
L
A
-
L
A
D
L
-YAC
G
G
T
A
L
S
Q
L
A
W
E
L
L-----G-EPRAA
T
G
D
L
A
C
R
F
L
Q
L
L
Q
ASGRG-----------------A
S
A
H
L
V
V
L
I
A
LERR
R
A
VRLP-HG-----RP--------L
P
A
R
A
L
A
A
L
G
-
W
L
L
A
L
L
L
AL-P
P
A
F
V
V
RGDSP-------SPLPPPPPPTSLQPGAPPAARAWP-GER---RC-HGI--FAPL-P
R
-
W
H
L
Q
V
Y
A
--
F
Y
E
A
V
A
G
F
V
A
P
V
T
V
-----
L
G
V
A
C
G
H
L
L
S
V
W
W
RHRPQAPAAAA-------PW----------------------------S----------------------------A---------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------P-------------------------------------------------------------------------------G--------------R--------------A--------------P-------------APSA-L
P
-
R
A
K
V
Q
S
L
K
M
S
L
L
L
A
L
L
F
----------VGCE
L
P
Y
-
F
A
A
R
-
L
A
A
AWSSGP------A-G------DWEGE
G
L
S
----
A
A
L
R
V
V
-
A
---
M
A
N
S-ALN
P
F
V
Y
L
F
FQAG
D
C
R
L
R
R
Q
L
R
K
-
R
L
-
G
S
LCCAPQGG-AEDEEGPR
G
H
Q
A
L
---
Y
R
QRWPHPHY
H
H
A
RRE-PLDEG-G-LRPPPPRP-RPLPCSCESAF---------------------------------------------------------------
29
HHSearch
89.02
17%
-106
* C4 *
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
-
G
N
I
L
V
M
V
S
I
K
V
----------
N
-
R
H
L
-
Q
T
V
N
N
Y
F
L
F
S
L
A
-
C
A
D
L
-
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
--------
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
-----------------
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
-
L
T
-----
Y
P
VKRT
T
---
K
M
A
G
M
M
I
A
A
A
-
W
V
L
S
F
I
L
W
A
-
P
A
I
L
F
W
Q
F
I
V
G
-------
V
R
--------------------
T
V
-
E
D
G
---
E
C
-
Y
I
Q
--
F
F
S
-------
N
A
A
V
T
--
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
-----
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
-------
D
E
----------------------------
G
----------------------------
L
RL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT-----------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
--------------
T
--------------
P
N
R
A
K
R
V
I
T
T
F
R
TGT
W
-------------
D
A
Y
P
-
P
P
-
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
----------
I
I
T
W
A
P
Y
-
N
V
M
V
-
L
I
N
T
F
C
A
P
C
-----------------
I
P
N
T
V
W
----
T
I
G
Y
W
L
-
C
---
Y
I
N
S
-
T
I
N
P
A
C
Y
A
L
C
N
---
A
T
F
K
K
T
F
K
H
-
L
L
-
M
--------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
87.99
18%
-106
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
---------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
----------
F
-
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
-
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-----
K
---
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
-----------------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
-
F
K
-----
Y
Q
SLLT
K
---
N
K
A
R
V
I
I
L
M
V
-
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
-------
H
Q
------------
E
A
I
N
C
----
Y
-
A
E
E
---
T
C
-
C
D
F
--
F
--------
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-----
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
-------
D
E
----------------------------
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
-------------------------------------------------
A
K
S
R
W
Y
--------------------------------------------------------------------------
N
-------------------------------------------------------------------------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
--------------
T
--------------
W
-------------
D
A
Y
K
-
F
C
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
----------
T
L
C
W
L
P
F
-
F
I
V
N
-
I
V
H
V
I
Q
D
N
L
-----------------
I
R
K
E
V
Y
----
I
L
L
N
W
I
-
G
---
Y
V
N
S
-
G
F
N
P
L
I
Y
C
-
R
S
---
P
D
F
R
I
A
F
Q
E
-
L
L
-
C
L
-------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
85.35
19%
-117
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
-
L
N
L
L
V
L
Y
A
V
R
S
----------
E
-
R
K
L
-
H
T
V
G
N
L
Y
I
V
S
L
S
-
V
A
D
L
-
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
M
-----
S
---
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
-----------------
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
-
L
R
-----
Y
L
KYRT
K
---
T
R
A
S
A
T
I
L
G
A
-
W
F
L
S
F
L
W
V
I
-
P
I
L
G
W
N
H
----------------------------------
R
-
R
E
D
---
K
C
-
E
T
D
--
F
Y
D
-------
V
T
W
F
K
--
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
-----
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
-------
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
----------------------------
A
A
K
S
E
L
D
K
A
I
GRNTNGVI----------------------------------------------------------------------------------------------------------------------------
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
------------------
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
------------------------------------------------------------
Q
--------------
T
P
-------------
N
--------------
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
L
-
H
M
-
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
----------
I
L
C
W
I
P
Y
-
F
I
F
F
-
M
V
I
A
F
C
K
N
C
-----------------
C
N
E
H
L
H
----
M
F
T
I
W
L
-
G
---
Y
I
N
S
-
T
L
N
P
L
I
Y
P
L
C
N
---
E
N
F
K
K
T
F
K
R
-
I
L
-
H
I
-------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
85.04
19%
-110
- C4 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
-
G
N
G
L
V
C
M
A
V
L
K
----------
E
-
R
A
L
-
Q
T
T
T
N
Y
L
V
V
S
L
A
-
V
A
D
L
-
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
-------
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
-----------------
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
-
V
H
-----
Y
Q
H
G
T
G
Q
SS
C
R
R
V
A
L
M
I
T
A
V
-
W
V
L
A
F
A
V
S
C
-
P
L
L
F
G
F
N
T
T
--------------------------------
G
-
D
P
T
---
V
C
-
S
I
S
--
N
----------
P
D
F
V
--
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
-----
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
-------
R
I
----------------------------
D
----------------------------
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT---------------------------------------------------------------------------------------------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-------------------------------------------------------------------------------
Q
--------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
--------------
W
-------------
D
A
Y
G
-
V
P
-
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
----------
I
V
C
W
L
P
F
-
F
L
T
H
-
V
L
N
T
H
C
Q
T
C
----------------
H
V
S
P
E
L
Y
----
S
A
T
T
W
L
-
G
---
Y
V
N
S
-
A
L
N
P
V
I
Y
T
T
F
N
---
I
E
F
R
K
A
F
L
K
-
I
L
-
S
C
-------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
81.38
18%
-105
- C4 -
3EML
13
ENLYS_BPT4
A:
[20-470]
---------------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
-
G
N
V
L
V
C
W
A
V
W
L
----------
N
-
S
N
L
-
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
D
I
-
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
----------
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
-----------------
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
-
L
R
-----
Y
N
G
L
V
T
G
---
T
R
A
K
G
I
I
A
I
C
-
W
V
L
S
F
A
I
G
L
-
T
P
M
L
G
W
N
N
C
G
Q
----------------------
S
Q
G
C
G
---
E
-
G
Q
V
---
A
C
-
L
F
E
--
D
V
V
------
P
M
N
Y
M
V
--
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
-------
D
E
----------------------------
G
----------------------------
L
RL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
--------------------------------
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T------------------------------------------------------------
P
N
R
A
K
R
V
I
T
T
F
R
T-------------------------------------------------------------------
G
--------------
T
--------------
W
--------------
D
-------------
A
Y
R
S
-
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
----------
A
L
C
W
L
P
L
-
H
I
I
N
-
C
F
T
F
F
C
P
D
C
---------------
S
H
A
P
L
W
L
M
----
Y
L
A
I
V
L
-
S
---
H
T
N
S
-
V
V
N
P
F
I
Y
A
Y
R
I
---
R
E
F
R
Q
T
F
R
K
-
I
I
-
R
S
H
V
L
R
Q
--------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
80.16
17%
-100
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[42-498]
----------------------------------------
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
-
G
N
G
L
V
I
L
V
M
G
Y
----------
Q
-
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
L
S
-
V
A
D
L
-
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
---------
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
-----------------
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
-
T
N
-----
S
Q
R
P
R
K
L
---
L
A
E
K
V
V
Y
V
G
V
-
W
I
P
A
L
L
L
T
I
-
P
D
F
I
F
A
N
V
S
E
A
------------------------------
D
-
D
R
Y
---
I
C
-
D
R
F
--
Y
P
N
D
-
L
---
W
V
V
V
F
Q
--
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
-----
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
-------
I
D
----------------------------
E
----------------------------
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------
G
--------------
T
--------------
W
--------------
D
-------------
A
Y
G
S
-
K
G
-
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
----------
F
A
C
W
L
P
Y
-
Y
I
G
I
-
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
-
F
------
E
N
T
V
H
K
W
I
----
S
I
T
E
A
L
-
A
---
F
F
H
C
-
C
L
N
P
I
L
Y
A
F
L
G
---
A
K
F
K
T
S
A
Q
H
-
A
L
-
T
S
G
R
P
L
E
V
L
F
-
Q
---------------------------------------------------------------------------------------------------------------------------
50
Fugue
78.94
19%
-77
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
-
V
R
-----
S
P
F
-
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
----------
H
-
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
-
F
M
V
F
G
G
--
F
T
T
T
L
Y
T
S
-----
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
-----------------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
F
-
G
E
--------
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
-
P
P
L
V
-------------------------------
G
W
S
R
Y
I
P
E
G
M
Q
---
C
S
-
C
G
I
DY
Y
T
P
H
-
E
E
-
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----
I
F
F
C
Y
G
Q
L
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------
V
--------------
K
--------------
E
--------------
A
-------------
A
A
S
A
-
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
----------
L
I
C
W
L
P
Y
-
A
G
V
A
-
F
Y
I
F
T
H
Q
G
S
------
D
----------
F
G
P
I
F
M
----
T
I
P
A
F
F
-
A
---
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
-------
K
Q
F
R
N
-
C
M
-
V
T
T
L
C
C
G
K
N
P
-
S
T
T
V
S
------------------------------
K
T
E
-
T
-
S
Q
V
A
P
A
-----------------------------------------------------------------------------
36
HHSearch
78.45
20%
-102
- C4 -
2KS9
1
NK1R_HUMAN
A:
[30-323]
--------------------------------------------
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
-
G
N
V
V
V
M
W
I
I
L
A
----------
H
-
K
R
M
-
R
T
V
T
N
Y
F
L
V
N
L
A
-
F
A
E
A
-
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
--------
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
-----------------
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
-
L
Q
-----
P
R
LS
A
-----
T
A
T
K
V
V
I
C
V
I
-
W
V
L
A
L
L
L
A
F
-
P
Q
G
Y
Y
S
T
T
E
T
M
------------------------------
P
-
S
R
V
---
V
C
-
M
I
E
--
W
P
E
H
-
P
N
K
I
Y
E
K
V
Y
H
--
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
-----
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
-
Q
V
-
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
----------
A
I
C
W
L
P
F
-
H
I
F
F
-
L
L
P
Y
I
N
P
D
L
------
Y
-
L
------
K
K
F
I
Q
Q
V
Y
----
L
A
I
M
W
L
-
A
---
M
S
S
T
-
M
Y
N
P
I
I
Y
C
C
L
N
---
D
R
F
R
L
G
F
K
H
-
A
F
-
R
C
C
P
F
I
S
A
G
D
-
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
---
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
-
T
V
V
G
A
--------------------------------------------------------------------------------------
49
Fugue
77.39
19%
-68
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
-
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
-
Y
V
T
V
Q
H
K
K
L
------------------
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
-
F
M
V
F
G
G
--
F
T
T
T
L
Y
T
S
-----
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
-----------------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
N
F
R
F
-
G
E
--------
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
-
P
P
L
V
---
G
W
S
R
-------------
Y
I
P
E
G
M
Q
--------------
C
---
S
C
G
I
D
Y
--
Y
T
P
H
-
E
E
-
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----
I
F
F
C
Y
G
Q
L
V
--------------
F
-------
T
V
----------------------------
K
----------------------------
E
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------
A
--------------
Q
--------------
Q
--------------
Q
-------------
E
S
A
T
-
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
----------
L
I
C
W
L
P
Y
-
A
G
V
A
-
F
Y
I
F
T
H
Q
G
S
------
D
----------
F
G
P
I
F
M
----
T
I
P
A
F
F
-
A
---
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
-------
M
N
K
Q
F
R
N
-
C
M
-
V
T
T
L
C
C
G
K
N
P
-
L
G
D
D
E
A
S
T
T
V
S
K
T
---
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------
52
Fugue
76.90
16%
-94
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------------------
S
-
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
-
L
V
F
I
I
G
F
L
-
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
-----
W
-------
S
G
I
S
V
Y
M
F
N
L
A
-
L
A
D
F
-
L
Y
V
--
L
T
L
P
A
L
I
F
Y
Y
F
-----
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
-----------------
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
-
K
K
--------
K
N
A
I
C
I
S
V
L
V
-
W
L
I
-
V
V
V
A
I
-
S
P
I
L
F
Y
S
G
T
G
V
-------
R
K
---------------------
N
-
K
T
I
---
T
C
-
Y
D
T
--
T
S
D
E
-
Y
L
-
R
S
Y
F
I
Y
S
--
M
C
T
T
V
A
M
F
C
V
P
L
V
L
-----
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
V
C
-------
G
Y
----------------------------
I
----------------------------
Y
---------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------
P
-------------------------------------------------------------------------------
E
--------------
D
G-------------
D
--------------
P
-------------
D
N
G
V
-
N
P
-
G
T
D
F
K
D
I
V
C
P
L
----------------
C
G
V
G
K
D
Q
-
F
E
E
V
---------------------------
E
E
P
L
R
R
----
K
S
I
Y
L
V
-
I
---
I
V
L
T
-
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
-
Q
T
-
P
A
M
C
A
F
N
D
R
V
-
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
---
N
S
C
V
N
P
I
L
Y
F
L
A
G
---------------
D
T
F
R
R
-
R
-------------------------------------------------------------------------
33
HHSearch
76.57
17%
-107
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[56-495]
---------------------------------------
S
A
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
-
E
N
I
F
V
L
L
T
I
W
K
----------
T
-
K
K
F
-
H
R
P
M
Y
Y
F
I
G
N
L
A
-
L
S
D
L
-
L
A
G
V
A
Y
T
A
N
L
L
L
S
G
A
---------
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
-----------------
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------N
N
------
F
R
L
F
L
L
I
S
A
C
-
W
V
I
S
L
I
L
G
G
-
L
P
I
M
G
W
N
C
I
--------------------------------
S
-
A
L
S
---
S
C
-
S
T
V
--
L
P
L
Y
------
H
K
H
Y
---
I
L
F
C
T
T
V
F
T
L
L
L
L
S
-----
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
D
-------
E
G
----------------------------
L
----------------------------
R
L
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
--
R
-------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------
G
--------------
T
--------------
W
--------------
D
-------------
A
Y
A
S
-
R
S
-
S
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
----------
I
A
C
W
A
P
L
-
F
I
L
L
-
L
L
D
V
G
C
K
V
K
------
T
---------
C
D
I
L
F
R
A
----
E
Y
F
L
V
L
-
A
---
V
L
N
S
-
G
T
N
P
I
I
Y
T
L
T
N
---
K
E
M
R
R
A
F
I
R
-
I
M
-
G
R
P
L
-----------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
75.25
15%
-94
- C4 -
2Z73
5
OPSD_TODPA
A:
[28-338]
----------------------------------------
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
-
G
N
G
I
V
I
Y
L
F
T
K
----------
T
-
K
S
L
-
Q
T
P
A
N
M
F
I
I
N
L
A
-
F
S
D
F
-
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-----
L
--
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
-----------------
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
-
M
A
-----
A
S
K
K
M
S
H
---
R
R
A
F
I
M
I
I
F
V
-
W
L
W
S
V
L
W
A
I
-
G
P
I
F
G
W
G
A
Y
T
L
-------
E
----------------------
G
-
V
L
C
---
N
C
-
S
F
D
--
Y
I
S
R
-
D
S
--
T
T
R
S
N
I
--
L
C
M
F
I
L
G
F
F
G
P
I
L
I
-----
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
-------
R
L
----------------------------
N
----------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------
E
--------------
L
--------------
R
-------------
K
A
Q
A
-
G
A
-
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
----------
L
L
S
W
S
P
Y
-
A
V
V
A
-
L
L
A
Q
F
G
P
L
E
----------------
W
V
T
P
Y
A
A
----
Q
L
P
V
M
F
-
A
---
K
A
S
A
-
I
H
N
P
M
I
Y
S
V
S
H
---
P
K
F
R
E
A
I
S
Q
-
T
F
-
P
W
V
L
T
C
C
Q
F
D
-
D
K
E
T
E
D
D
K
D
A
E
T
E
---
I
P
A
G
E
-------------------------------------------------------------------------------------------------------
38
HHSearch
73.45
19%
-88
- C4 -
1U19
14
OPSD_BOVIN
A:
[33-323]
---------------------------------------
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
----------
H
-
K
K
L
-
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
-
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
--------
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
-----------------
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
-
M
S
-----
N
F
R
F
G
E
----
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
-
P
P
L
V
G
W
S
R
Y
I
P
-------
E
----------------------
G
-
M
Q
C
---
S
C
-
G
I
D
--
Y
Y
T
P
H
E
E
-
T
N
N
E
S
F
V
--
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
-
T
Q
-
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
----------
L
I
C
W
L
P
Y
-
A
G
V
A
-
F
Y
I
F
T
H
Q
G
S
----------------
D
F
G
P
I
F
M
----
T
I
P
A
F
F
-
A
---
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
---
K
Q
F
R
N
C
M
V
T
-
T
L
-
C
C
G
K
N
P
L
G
D
D
-
E
A
S
T
T
V
S
K
T
E
T
S
Q
---
V
A
P
A
--------------------------------------------------------------------------------------------------------
56
Fugue
73.35
15%
-76
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-----------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
-
G
N
G
L
V
I
L
V
M
-----
G
-----
Y
Q
-
K
K
L
-
R
S
M
T
D
K
Y
R
L
H
L
S
-
V
A
D
L
-
L
F
V
--
I
T
L
P
F
W
A
V
D
A
V
--------
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
-----------------
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
-
T
N
S
Q
R
P
R
K
L
--------
L
A
E
K
V
V
Y
V
G
V
-
W
I
P
A
L
L
L
T
I
-
P
D
F
I
F
A
N
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
-
G
I
V
I
L
S
C
Y
-
C
I
I
--
I
S
K
L
-
S
H
-
S
G
S
N
I
F
E
--
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
G
H
L
L
T
----
K
S
P
S
L
N
A
A
K
S
-------
E
L
----------------------------
D
----------------------------
K
---------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------
G
--------------
R
NTNGVIT-------
K
--------------
D
-------------
E
A
E
K
-
L
F
-
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
----------
K
P
V
Y
D
S
L
-
D
A
V
R
-
R
A
A
L
I
N
M
V
F
------
Q
M
G
------
E
T
G
V
A
G
F
T
----
N
S
L
R
M
L
-
Q
Q
KR
W
D
E
A
-
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
-
G
T
W
D
A
Y
G
S
K
G
-
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
-
F
I
L
L
E
-
I
-
I
K
Q
G
C
E
F
E
-
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ-----------------------
40
HHSearch
71.47
20%
-103
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
---------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
-
G
N
S
L
V
M
L
V
I
L
Y
----------
S
-
R
V
G
-
R
S
V
T
D
V
Y
L
L
N
L
A
-
L
A
D
L
-
L
F
A
L
T
-
L
P
I
W
A
A
S
-
K
V
--------
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
-----------------
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
-
T
R
-----
T
L
TQ
K
R
----
H
L
V
K
F
V
C
L
G
C
-
W
G
L
S
M
N
L
S
L
-
P
F
F
L
F
R
Q
A
Y
H
P
-------
N
----------------------
N
-
S
S
P
---
V
C
-
Y
E
V
--
L
G
N
D
-
T
A
-
K
W
R
M
V
L
R
--
I
L
P
H
T
F
G
F
I
V
P
L
F
V
-----
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
H
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
----------
L
L
C
W
L
P
Y
-
N
L
V
L
-
L
A
D
T
L
M
R
T
Q
------
V
-
I
QE
S
C
E
R
R
N
N
I
G
R
A
L
----
D
A
T
E
I
L
-
G
---
F
L
H
S
-
C
L
N
P
I
I
Y
A
F
I
G
---
Q
N
F
R
H
G
F
L
K
-
I
L
-
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------
57
Fugue
69.04
18%
-84
- C1 -
4RQO
1
?
A:
[20-476]
NIS
V
F
D
L
F
S
I
G
I
G
P
S
S
S
H
T
V
G
P
M
L
A
A
N
A
F
L
Q
L
L
-
E
Q
K
N
L
F
---
D
K
T
Q
R
V
K
V
E
L
Y
G
S
L
A
L
T
G
K
G
H
G
T
D
K
A
I
L
N
G
L
E
N
K
A
P
ETVDP
A
S
M
I
P
R
M
H
E
I
L
D
S
N
L
L
N
L
A
G
K
K
E
I
-
P
F
H
E
A
T
D
F
L
F
L
Q
K
E
L
L
PKHSN
G
M
R
F
S
A
F
D
G
N
A
N
L
L
I
E
Q
V
Y
Y
S
I
G
G
G
F
I
T
T
EEDFDKNPPPYPF
A
T
A
T
E
L
L
K
L
C
K
K
H
H
L
T
I
A
E
L
M
L
V
-----
N
E
--------
K
T
W
R
S
T
A
E
I
H
-
K
G
I
L
D
I
A
K
V
M
D
D
C
I
N
N
G
C
K
H
D
-------
G
V
L
P
G
G
L
---
N
L
K
R
R
A
P
D
L
Y
R
K
L
-------------
I
--
F
E
Q
S
-
D
I
M
N
H
L
N
L
Y
A
M
A
V
N
E
E
N
A
A
G
G
R
I
V
T
A
-----
P
T
N
G
A
A
G
I
I
P
A
V
L
K
Y
C
Q
Q
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
M
S
N
-
E
D
I
Y
T
Y
F
L
T
A
A
A
I
G
I
L
Y
K
KGASISGAE
V
G
C
Q
G
E
V
G
V
A
S
S
M
A
A
A
G
L
T
A
V
L
------
G
-
G
------
T
--
I
E
Q
V
E
----
N
A
A
E
I
A
M
E
---
H
H
L
G
M
T
C
D
P
V
L
G
L
V
-------
Q
I
P
C
I
E
R
-
N
A
M
G
A
V
K
A
V
N
A
T
R
M
A
L
I
G
D
G
Q
H
--------------
Q
I
S
L
D
K
V
I
K
T
M
K
-
Q
T
G
M
D
M
Q
S
I
Y
K
E
T
S
M
G
G
L
A
V
N
L
P
E
C
----------------------------------------------------------------
55
Fugue
68.64
14%
-74
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
F
-----------
E
R
L
-
Q
T
V
T
N
Y
F
I
T
S
L
A
-
C
A
D
L
-
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
-----
K
---
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
-----------------
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
-
F
K
-----
Y
Q
SLLT
K
---
N
K
A
R
V
I
I
L
M
V
-
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
A
T
-------
H
---------------
Q
E
A
I
N
C
Y
A
-
E
E
T
---
C
C
-
D
F
F
--
T
N
---------
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-----
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
----------------------------
K
----------------------------
D
---------------------------------------------------------------------------------------------------------------------------------------------
T
-------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------
G
--------------
Y
--------------
Y
--------------
T
-------------
I
G
I
G
-
H
L
-
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
----------
I
G
R
N
T
N
G
-
V
I
T
K
-
D
E
A
E
K
L
F
N
Q
------
D
-
V
------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-
S
---
L
D
A
V
-
R
R
A
A
L
I
N
M
V
F
Q
M
G
----
E
T
G
V
A
G
-
F
T
-
N
S
L
R
M
L
Q
Q
K
R
-
W
D
E
A
A
V
N
L
A
K
S
R
W
---
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-
T
G
T
W
--
D
-
A
Y
K
F
C
L
K
E
-
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
12
PsiBlast_PDB
52.34
23%
-123
- C4 -
3ZPQ
6
ADRB1_MELGA
A:
[177-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
--
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-----
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
-
L
M
-
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
----------
T
L
C
W
L
P
F
-
F
L
V
N
-
I
V
N
V
F
N
R
D
L
------
V
-
P
------
D
W
----
L
F
----
V
A
F
N
W
L
-
G
---
Y
A
N
S
-
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
52.29
26%
-117
- C4 -
4XT1
7
US28_HCMVA
A:
[40-174]
---------------------------------------------
S
K
P
V
T
L
F
L
Y
G
V
V
F
L
F
G
S
I
-
G
N
F
L
V
I
F
T
I
-----
T
-----
W
R
-
R
R
I
-
Q
C
S
G
D
V
Y
F
I
N
L
A
-
A
A
D
L
L
F
V
C
T
L
P
L
W
M
Q
---
Y
L
L
-----
D
------
S
--
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
-----------------
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
Y
M
-
R
Y
-----
R
P
--------
V
K
Q
A
C
L
F
S
I
F
W
W
I
F
A
V
I
I
A
I
-
P
H
F
M
V
V
T
K
K
D
N
-------
Q
C
M
T
D
Y
D
Y
L
E
V
S
Y
P
I
I
L
N
V
E
L
M
L
G
-
A
F
V
---
I
P
-
L
S
V
--
I
S
Y
C
-
Y
Y
-
R
I
S
R
I
V
A
--
V
S
Q
S
R
H
K
G
R
I
V
R
V
L
-----
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
L
K
-------
L
L
----------------------------
K
----------------------------
W
---------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------
S
--------------
S
--------------
C
--------------
E
-------------
F
E
R
S
-
L
K
-
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
----------
P
L
L
Y
V
F
V
-
G
T
K
F
-
R
Q
E
L
H
C
L
L
A
------
E
-
F
------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
51.48
23%
-121
- C4 -
2Y01
7
ADRB1_MELGA
A:
[177-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
A
--
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-----
M
-------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
-
L
M
-
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
----------
T
L
C
W
L
P
F
-
F
L
V
N
-
I
V
N
V
F
N
R
D
L
------
V
-
P
------
D
W
----
L
F
----
V
A
F
N
W
L
-
G
---
Y
A
N
S
-
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------