@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GP156_HUMAN: (2016-01-10 )
MEPEINCSELCDSFPGQELDRRPLHDLCKTTITSSHHSSKTISSLSPVLLGIVWTFLSCGLLLILFFLAFTIHCRKNRIVKMSSPNLNIVTLLGSCLTYSSAYLFGIQDVLVGSSMETLIQTRLSMLCIGTSLVFGPILGKSWRLYKVFTQRVPDKRVIIKDLQLLGLVAALLMADVILLMTWVLTDPIQCLQILSVSMTVTGKDVSCTSTSTHFCASRYSDVWIALIWGCKGLLLLYGAYLAGLTGHVSSPPVNQSLTIMVGVNLLVLAAGLLFVVTRYLHSWPNLVFGLTSGGIFVCTTTINCFIFIPQLKQWKAFEEENQTIRRMAKYFSTPNKSFHTQYGEEENCHPRGEKSSMERLLTEKNAVIESLQEQVNNAKEKIVRLMSAECTYDLPEGAAPPASSPNKDVQAVASVHTLAAAQGPSGHLSDFQNDPGMAARDSQCTSGPSSYAQSLEGPGKDSSFSPGKEEKISDSKDFSDHLDSGCSQKPWTEQSLGPERGDQVPMNPSQSLLPERGGSDPQRQRHLENSEEPPERRSRVSSVIREKLQEVLQDLGLGPEASLSTAPSCHQQTWKNSAAFSPQKMPLSKELGFSPYMVRRRRAAQRARSHFPGSAPSSVGHRANRTVPGAHSRLHVQNGDSPSLAPQTTDSRVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGSKAAFLRQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVPSGCASLSSQHSYFDTESSSSDEFFCRCHRPYCEICFQSSSDSSDSGTSDTDPEPTGGLASWEKLWARSKPIVNFKDDLKPTLV
Atome Classification :
(20 SA)
.........10........20........30........40........50.......-.-60........70........80...----.....90........100.......110.......120..------.....130.......140..---.....150..--.....160.......170.......180.......190.......200.......210---.........220.......230.......240---.......250-.......260.......270---------........280.......290......------.300.......310.......-320.......330.......340.......350-........360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560........570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPEI
N
C
S
E
L
C
D
SFPGQELDR
R
P
L
H
D
L
C
K
T
T
ITSSHHSSK
T
I
S
S
L
S
P
V
L
L
G
I
V
W
T
F
L
S
-
C
-
G
L
L
L
I
L
F
F
L
A
F
T
I
H
CRKN
R
I
V
K
MSS----PN
L
N
I
V
T
L
L
G
S
C
L
T
Y
S
S
A
Y
L
F
G
I
Q
D
V
LVG
S
S
M
E
T
L
I
Q
T
R
L
------
S
M
L
C
IGT
S
L
V
F
G
PILGKS
W
R
---
L
Y
K
V
F
T
Q
RVP--D
K
R
V
I
I
K
D
L
Q
L
L
G
L
V
A
A
L
L
M
A
D
V
I
L
L
M
T
W
V
LT
D
P
I
Q
C
L
Q
I
L
S
V
S
M
T
V
TGKD
V
S
CTS-----TS
T
H
F
C
A
S
RYSD
V
W
I
A
L
I
WGC
K
G
L
L
L
L
Y
G
A
Y
L
---AGLTGHVSSP-PVNQ
S
L
T
I
M
V
G
V
N
L
L
V
L
A
A
----------
G
L
L
F
V
V
T
R
Y
L
H
SWP
N
L
V
F
G
LTSG
G
I
F
V
------
C
T
TT
I
N
C
F
I
F
IPQ
L
K
Q
W
K
A
F
E
-EE
N
Q
T
I
R
R
M
A
K
Y
FSTPNKS
F
H
TQYGEEENCHP--RG
E
K
S
S
M
E
R
L
L
T
E
K
N
A
V
I
E
S
L
Q
E
Q
V
N
N
A
K
E
K
I
V
R
L
M
SAE
C
T
YDLPEGAAPPASSP
N
K
D
V
Q
A
V
A
S
V
H
T
L
AAAQGPSGH
L
S
DFQNDPGMAARDSQCTSG
P
S
S
Y
A
Q
S
LEGPGKDSSFSPGKEEKISDSK
D
F
S
D
H
L
DSGCSQKPWTEQSLGPERGDQVPMNP
S
Q
S
LLPERGGS
D
P
Q
R
Q
RHLENSEE
P
P
E
R
R
S
R
V
S
S
V
I
R
E
K
L
Q
E
V
L
Q
DLGLGP-EASLSTAP
S
C
H
Q
Q
T
WKNSAAFSPQKMPL
S
K
ELGFS
P
Y
M
V
R
R
R
R
A
A
Q
R
A
R
SHFPGSAPSSVGHRANRTVPGAH
S
R
L
H
V
QNGDSPSLAPQTT
D
S
RVRRPSSRKPSLPSDPQDRPGTLEGSKQSQTEPEGARGS
K
A
A
F
L
RQPSGSGRAPSPAAPCLSKASPDLPEQWQLWPPVP
S
G
C
A
SLSSQHSYFDTESSSSD
E
F
F
C
R
CHR
P
Y
C
E
I
CFQSSSDSSDSGTSDTDPEPTGG
L
A
S
W
E
K
L
W
ARSKPIVNFKDDLKPTLV
31
Fugue
79.05
15%
-86
- C1 -
4US3
13
?
A:
[10-450]
---------
G
R
E
Q
W
A
S
R
L
G
F
I
L
A
A
M
G
S
A
V
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
I
-
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
A
V
G
S
F
E
K
L
APG
K
P
W
K
V
A
G
L
M
G
V
A
A
G
F
L
I
L
S
F
Y
G
V
I
A
G
W
I
L
F
Y
L
F
N
Y
I
T
G
Q
L
WSAPAE
G
F
G
G
F
F
E
G
F
I
A
N
P
T
L
P
L
F
W
Q
A
L
F
M
I
A
T
I
W
I
V
A
I
GV
K
K
G
I
E
R
S
N
K
I
L
M
P
L
L
G
V
L
L
I
A
L
A
I
Y
S
L
T
--
L
G
G
A
K
E
G
L
A
F
L
F
------
S
P
D
W
S
A
L
K
-----
D
P
G
V
Y
L
A
A
-
I
S
Q
A
F
F
T
L
S
L
G
M
-
G
A
L
I
T
Y
G
S
Y
V
SKD
S
R
L
P
G
A
A
V
S
V
A
G
L
D
T
A
F
A
I
I
A
G
I
M
I
F
P
A
V
F
A
L
GLSPSGGP
G
L
V
F
V
V
L
P
D
I
F
D
--
S
I
R
L
G
P
I
V
G
I
A
F
F
I
L
L
G
A
A
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
D
W
S
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
------
V
--
L
G
E
V
T
I
I
P
G
L
N
I
F
D
S
V
D
F
I
A
S
S
V
F
L
P
L
G
G
M
I
I
A
L
F
I
G
W
G
----
W
K
T
S
D
A
L
A
E
S
D
L
T
D
S
V
W
G
K
L
W
I
L
S
L
R
F
-
I
A
P
I
A
I
L
I
V
F
L
S
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.38
19%
-139
- C3 -
4OR2
8
C562_ECOLX (first)
A:
[123-308]
---------------------------------------------------
I
I
A
I
A
F
S
-
C
L
G
I
L
V
T
L
F
V
T
L
I
F
V
L
Y
R
D
T
P
V
V
K
S
S
S
----
R
E
L
C
Y
I
I
L
A
G
I
F
L
G
Y
V
C
P
F
------
T
L
I
A
K
P
T
T
T
S
C
Y
L
Q
R
------
L
L
V
G
L
S
S
A
M
C
Y
S
A
L
V
T
K
T
N
R
---
I
A
R
I
L
A
------------
R
K
P
R
F
M
S
A
W
A
Q
V
I
I
A
S
I
L
I
S
V
Q
L
T
L
---
V
V
T
L
I
I
M
E
P
P
M
P
I
----
L
S
Y
P
S
-----
I
K
E
V
Y
L
I
C
N
T
S
N
L
G
V
V
A
P
L
G
Y
N
G
L
L
I
M
S
C
T
Y
Y
---
A
F
K
T
R
N
V
P
A
N
-
F
N
E
A
K
Y
I
A
F
T
M
Y
T
T
C
I
I
W
L
----------
A
F
V
P
I
Y
F
G
S
N
Y
K
I
I
T
T
C
F
A
V
S
L
S
V
T
V
A
------
L
G
C
M
F
T
P
K
M
Y
I
I
I
A
K
P
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Fugue
56.50
14%
86
- C3 -
2K48
-
V_SV5
A:
[1-107]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
H
H
H
H
H
H
G
K
P
I
P
N
P
L
L
G
L
D
S
T
E
N
L
Y
F
Q
--
G
I
D
P
F
T
M
S
T
L
Q
E
L
Q
E
N
I
T
A
H
E
Q
Q
L
V
T
A
R
Q
K
L
K
D
A
E
K
A
V
E
V
D
P
D
D
V
N
K
S
T
L
Q
N
R
R
A
A
V
S
T
L
E
T
K
L
G
E
L
K
R
Q
L
A
D
L
V
A
A
Q
K
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
49.06
15%
173
- C3 -
3QH9
3
A:
[14-79]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
E
E
K
Q
R
K
-
A
E
E
L
L
Q
E
L
R
H
L
K
I
K
V
E
E
L
E
N
E
R
N
Q
Y
E
W
K
L
K
A
T
--
K
A
E
V
A
Q
L
Q
E
Q
V
A
L
K
D
A
E
I
E
R
L
H
S
Q
L
S
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
47.45
11%
179
- C3 -
1IFP
-
?
?:
[1-44]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
Q
S
V
I
T
D
V
T
G
Q
L
T
A
V
Q
A
D
I
T
T
I
G
G
A
I
I
V
L
A
A
V
V
L
G
I
R
W
I
K
A
Q
F
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Fugue
47.43
18%
244
- C3 -
4B7Y
-
MSL1_HUMAN
A:
[6-43]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
--
S
S
Q
A
A
C
L
K
Q
I
L
L
L
Q
L
D
L
I
E
Q
Q
Q
Q
Q
L
Q
A
K
E
K
E
I
E
E
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
46.98
10%
46
- C3 -
4CQI
2
?
A:
[21-127]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
P
N
E
K
T
L
R
-
I
K
V
S
A
L
K
R
T
I
K
D
L
E
F
A
K
R
E
V
E
R
E
L
Q
R
L
D
T
L
C
Q
S
D
P
D
R
V
P
Q
Q
T
K
V
V
D
E
A
Q
M
M
V
P
H
S
V
N
R
I
M
A
S
V
K
D
L
S
D
Y
L
E
K
E
G
S
T
V
S
N
E
E
L
L
D
L
A
R
A
T
M
A
D
G
Q
A
A
V
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
HHSearch
46.87
18%
260
- C3 -
1DEB
-
APC_HUMAN
A:
[10-49]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
Q
V
E
A
L
--
K
M
E
N
S
N
L
R
Q
E
L
E
D
N
S
N
H
L
T
K
L
E
T
E
A
S
N
M
K
E
V
L
K
Q
L
Q
G
S
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
HHSearch
46.16
17%
240
* C3 *
3NMD
1
KGP1_HUMAN
A:
[19-59]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
R
D
L
--
Q
Y
A
L
Q
E
K
I
E
E
L
R
Q
R
D
A
L
I
D
E
L
E
L
E
L
D
Q
K
D
E
L
I
Q
M
L
Q
N
E
L
D
K
Y
R
S
V
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
HHSearch
45.01
23%
246
- C3 -
3HE5
-
?
A:
[7-45]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
E
V
A
S
L
--
E
N
E
N
E
T
L
K
K
K
N
L
H
K
K
D
L
I
A
Y
L
E
K
E
I
A
N
L
R
K
K
I
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
44.88
14%
266
- C3 -
2ZXX
-
GEMI_MOUSE
A:
[106-140]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
Y
E
A
--
L
K
E
N
E
K
L
H
K
E
I
E
Q
K
D
S
E
I
A
R
L
R
K
E
N
K
D
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
44.68
21%
296
- C3 -
3A2A
1
HVCN1_HUMAN
A:
[18-50]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
M
N
V
Q
L
--
A
A
K
I
Q
H
L
E
F
S
C
S
E
K
E
Q
E
I
E
R
L
N
K
L
L
R
Q
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
HHSearch
44.12
20%
291
- C3 -
3M91
-
ARC_MYCTU
A:
[60-94]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
I
D
S
L
--
A
A
R
N
S
K
L
M
E
T
L
K
E
A
R
Q
Q
L
L
A
L
R
E
E
V
D
R
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
HHSearch
43.95
21%
310
- C3 -
3VN0
-
HVCN1_MOUSE
A:
[229-261]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
I
Q
L
--
A
T
K
I
Q
H
L
E
F
S
S
S
E
K
E
Q
E
I
E
R
L
N
K
L
L
K
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
43.48
29%
-37
- C2 -
4HBC
-
?
H:
[42-106]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
L
Q
W
I
G
I
I
S
N
F
---
G
V
I
Y
Y
A
T
W
A
K
G
R
-------
F
T
I
S
K
T
S
T
T
V
D
L
K
I
T
S
PTTED
T
A
T
Y
F
C
V
R
K
Y
G
S
E
W
G
G
D
L
W
G
P
G
T
L
V
T
V
S
S
G
Q
P
---
K
A
P
S
V
F
P
L
A
P
-
C
C
G
D
T
P
T
V
T
L
G
C
L
V
K
G
Y
L
P
----------
E
P
V
T
V
T
W
N
S
G
T
L
T
N
G
V
R
T
F
P
S
V
R
Q
S
S
G
------
L
Y
S
L
S
S
V
V
S
V
T
S
P
V
T
C
N
V
A
H
P
-
A
T
N
T
K
V
D
K
T
V
A
P
S
T
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
43.06
21%
293
- C3 -
2YY0
-
MYCBP_HUMAN
A:
[60-92]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
I
E
L
L
R
L
E
L
A
E
M
K
E
K
Y
E
A
I
V
E
E
N
K
K
L
K
A
K
L
A
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
42.09
15%
235
- C3 -
2Q6Q
3
SPC42_YEAST
A:
[3-39]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
N
K
E
L
N
F
K
L
R
E
K
Q
N
E
I
F
E
L
K
K
I
A
E
T
L
R
S
K
L
E
K
Y
V
D
I
T
K
K
L
E
D
Q
N
L
N
L
Q
I
K
I
S
D
L
E
K
K
L
S
D
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Fugue
41.48
17%
350
- C3 -
1BB1
1
?
A:
[4-34]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
I
A
A
I
E
Y
E
Q
A
A
I
K
E
E
I
A
A
I
K
D
K
I
A
A
I
K
E
Y
I
A
A
I
N
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
41.44
14%
282
- C3 -
1UII
-
GEMI_HUMAN
A:
[109-143]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
Y
E
A
--
L
K
E
N
E
K
L
H
K
E
I
E
Q
K
D
N
E
I
A
R
L
K
K
E
N
K
E
L
A
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
39.40
13%
318
- C3 -
1T6F
-
GEMI_HUMAN
A:
[3-33]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
A
--
L
K
E
N
E
K
L
H
K
E
I
E
Q
K
D
N
E
I
A
R
L
K
K
E
N
K
E
L
A
E
V
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------