@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPC5B_HUMAN: (2016-01-10 )
MFVASERKMRAHQVLTFLLLFVITSVASENASTSRGCGLDLLPQYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVRLPFIKEKEKKSPVGLHFLFLLGTLGLFGLTFAFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHGTGPAGWQLVGLALCLMLVQVIIAVEWLVLTVLRDTRPACAYEPMDFVMALIYDMVLLVVTLGLALFTLCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGDAWNDPTLAITLAASGWVFVIFHAIPEIHCTLLPALQENTPNYFDTSQPRMRETAFEEDVQLPRAYMENKAFSMDEHNAALRTAGFPNGSLGKRPSGSLGKRPSAPFRSNVYQPTEMAVVLNGGTIPTAPPSHTGRHLW
Atome Classification :
(18 SA)
-.........10.......-.20........30........40-.----------..-......50.--.......60----........70..--------......--80........90........100--........110.-----.....--.120.......130.......140.......----------------------150........160.......170.-----------------------------......----180..---------.----------....190..-....--.200.......210.---......220-.......--.230.......---240.......250......-----.260----.........270....--------...280..---.-----..--..290-.....-------------------------..300....-...310....------.-------.--.320.......330..-------.--....340.......----350-------..-.....-.360.......370........380----.......390--------.....---....400.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MFVA
S
E
R
K
M
R
A
H
Q
V
L
T
F
L
-
L
L
F
V
I
T
S
V
ASENASTSRGC
G
L
D
--
L
----------
L
P
-
Q
Y
V
S
L
C
D
L
D
--
A
I
W
G
I
V
V
E
A
----VAG
A
G
A
L
I
T
L
L
L
--------
M
L
I
L
L
V
--RLPFIKEKEKKSP
V
G
L
H
F
L
F
L
L
---
G
T
L
G
L
F
G
L
T
F
A
F
-----
I
IQE
D
--
E
T
I
C
S
V
R
R
F
L
W
G
V
L
F
A
L
C
F
S
C
L
L
S
Q
A
W
R
V
R
R
----------------------
L
V
-RHGTGP
A
G
W
Q
L
V
G
L
A
L
C
L
M
L
V
Q
-----------------------------
V
I
I
A
V
E
----
W
L
V
L
T
---------
V
----------
L
RDTRPACA-Y
E
P
M
--
D
F
V
M
A
L
I
Y
D
M
V
L
L
V
V
---
T
L
G
L
A
L
F
T
--
L
CGKF
K
R
--
W
KLN
G
A
F
L
L
I
T
---
A
F
L
S
V
L
I
W
V
A
W
M
T
M
Y
L
FGN-----
V
K
------
L
QQGDAWND
P
T
L
A
I
T
L
--------AAS
G
W
V
F
V
---
I
-----FH--AIP
E
I
-
H
C
T
L
L
-------------------------
P
A
L
QENTPN-YFDTSQP
R
M
R
------
E
-------
T
--
A
F
E
E
DVQ
L
P
R
A
Y
M
ENK-------A--FSMDEHN
A
A
LRTAG----FP--------NG-SLGKR-PSGSLGKRPSAPF-RSNVYQP
T
E
M
A
----
V
V
LNGGTI----------PTAPP---SHTGRHLW
16
Fugue
83.19
17%
-141
- C2 -
2W3P
4
?
A:
[10-556]
P
V
D
Y
R
T
D
P
S
Q
Y
K
H
W
K
L
S
F
N
G
P
V
A
T
L
G
I
D
I
A
E
D
G
G
I
R
D
G
Y
K
L
K
--
L
NSYD
L
G
V
D
I
E
L
H
-
D
A
I
Q
R
I
R
F
E
HP
E
V
R
T
V
V
L
T
S
LKDR
V
F
C
S
G
A
N
I
F
M
L
G
L
ST
H
A
W
K
V
N
F
C
K
F
T
--
N
E
T
R
N
G
L
E
D
S
S
R
H
S
G
L
K
F
L
A
A
V
N--
G
A
C
A
G
G
G
Y
E
L
A
L
A
CD
E
I
Y
L
V
D
D
R
S
S
S
V
S
L
P
E
V
P
L
L
G
V
L
P
G
T
G
G
L
T
R
V
T
D
K
R
K
V
R
H
D
R
A
D
I
F
C
T
VVEGVRG
E
R
A
K
A
W
R
L
V
-
D
E
V
V
K
P
N
Q
F
D
Q
A
I
Q
A
R
A
L
E
L
A
A
Q
SDRPAH
A
Q
G
V
P
L
T
R
I
E
R
T
D
R
ED
G
L
T
Y
KT
L
D
V
T
I
D
RAKR
I
A
T
F
T
---------
A
K
A
PQTEPPAS
I
D
A
I
V
A
A
G
A
N
W
W
P
L
--
K
F
A
R
E
F
D
D
A
I
L
S
M
R
T
NEL
A
V
G
T
W
V
F
R
--
T
E
G
D
A
R
H
--
L
L
A
A
D
A
S
L
M
Q
H
KDH
W
F
V
R
E
T
I
G
L
L
R
R
T
L
A
R
I
D
V
-----
S
S
R
S
L
F
A
L
I
E
P
G
S
C
F
A
G
T
F
A
E
L
A
F
--------
A
A
D
-
R
T
Y
M
---
A
A
LPAN
E
D
--
E
E
P
A
I
-
T
L
S
E
V
NFGLYPMVTHQS
R
L
A
R
R
F
YEE
T
E
P
L
D
A
V
R
S
R
I
G
Q
-
A
I
K
P
V
E
A
E
R
L
GLVTAS
P
-------
D
--
D
I
D
W
A
D
E
I
R
I
A
L
E
E
R
A
-------
A
--
M
S
P
D
A
L
T
G
L
E
A
N
L
R
----
F
N
--------
G
P
E
T
M
E
T
R
-
I
F
G
R
L
T
A
W
Q
N
W
I
F
N
R
P
N
A
V
G
E
K
G
A
L
----
K
V
Y
G
K
G
S
K
----------
A
Q
F
D
V
---
S
R
V
-----
18
Fugue
80.20
16%
-121
* C5 *
2IQH
-
?
A:
[21-489]
---
N
A
T
E
I
R
A
S
V
G
K
M
I
D
G
I
-
G
R
F
Y
I
Q
M
C
T
E
L
K
L
S
D
Y
E
G
---
R
--
L
----------
I
Q
-
N
S
L
--------
T
I
E
R
M
V
L
S
A
----
F
D
T
G
G
P
I
Y
R
R
---------------
V
--
D
G
K
W
R
R
E
L
I
L
Y
D
K
E
E
I
R
R
I
W
R
Q
A
N
N
G
D
D
A
T
A
G
L
T
H
M
M
-----
I
W
H
S
N
--
L
N
D
A
T
Y
Q
R
--
T
R
A
L
V
R
T
G
M
D
P
R
M
C
S
L
M
Q
G
S
T
----------------------
L
P
-
R
R
-
S
G
A
A
G
A
A
V
K
G
V
G
T
M
V
M
E
L
I
-----------------------------
R
M
I
K
R
G
----
I
N
R
R
T
---------
R
----------
I
A
Y
E
R
M
C
N
I
-
L
K
G
K
FQ
T
A
A
Q
R
T
M
V
D
Q
V
R
E
S
R
---
N
P
G
N
A
E
F
E
--
D
L
I
F
L
A
R
S
A
L
I
L
R
G
S
V
A
H
K
S
---
C
L
P
A
C
V
Y
G
S
A
V
A
S
G
Y
D
F
E
R
EGYSL
V
G
------
I
D
P
F
R
L
L
Q
N
S
Q
V
-
Y
S
L
I
R
PNEN
P
A
H
K
S
Q
L
V
W
M
---
A
-----
C
H
SA
A
F
E
D
L
-
R
V
S
S
F
-------------------------
I
R
G
T
K
V
V
P
R
G
K
L
S
T
R
G
V
Q
I
A
------
S
-------
N
--
E
N
M
E
T
M
E
S
S
T
L
E
L
R
S
R
-------
Y
--
W
A
I
R
T
R
S
G
G
N
T
S
S
G
QI
S
I
Q
P
--------
T
F
-
S
V
Q
R
N
L
P
F
D
R
P
T
I
M
A
A
S
D
M
-
R
T
E
I
I
R
L
M
E
S
A
RPED
V
S
F
Q
G
R
G
V
F
E
LSDEKAT
S
P
I
V
P
S
FDM
S
N
E
G
S
Y
F
F
1
PsiBlast_PDB
75.01
22%
-169
- C4 -
4OR2
9
C562_ECOLX (first)
A:
[93-341]
----------------------------
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
----------
I
P
V
R
Y
L
E
W
S
N
I
E
--
S
I
I
A
I
---
A
----
F
S
C
L
G
I
L
V
T
L
F
V
--------
T
L
I
F
V
L
Y
R
D
T
P
V
V
K
S
S
S
R
E
----
L
C
Y
I
I
L
A
---
G
I
F
L
G
Y
V
C
P
F
T
L
-----
I
A
K
P
T
--
T
T
S
C
Y
L
Q
R
L
L
V
G
L
S
S
A
M
C
Y
S
A
L
V
T
K
T
N
R
I
A
R
----------------------
I
L
A
R
K
P
R
F
M
S
A
W
A
Q
V
I
I
A
S
I
L
I
S
V
Q
-----------------------------
L
T
L
V
V
T
----
L
I
I
M
E
P
P
M
P
I
L
S
Y
P
S
----------
I
K
E
V
Y
L
I
C
N
-
T
S
N
L
--
G
V
V
A
P
L
G
Y
N
G
L
L
I
M
S
---
C
T
Y
Y
A
F
K
T
R
N
V
P
A
N
F
N
E
--
A
K
----
Y
I
A
F
T
---
M
Y
T
T
C
I
I
W
L
A
F
V
P
I
Y
F
G
S
N
-----
Y
K
------
I
I
T
T
C
F
A
V
S
L
S
V
T
V
A
L
--------
G
C
M
F
T
P
K
M
---
Y
-----
I
I
--
I
A
K
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
Fugue
34.93
5%
76
- C4 -
1U97
-
COX17_YEAST
A:
[1-69]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------
T
E
T
D
K
K
Q
E
Q
-
E
N
H
A
E
C
E
D
K
P
------
K
-------
P
CC
V
C
K
P
E
K
E
E
R
D
T
C
I
L
F
N
GQDSEKC
K
--
E
F
I
E
K
Y
K
E
C
M
K
G
Y
G
----
F
E
--------
V
P
-
S
A
N
------------------------------------------------------------------
2
PsiBlast_PDB
34.07
32%
139
- C3 -
5CCU
2
?
A:
[400-455]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
G
----
E
P
G
R
M
I
F
D
AD
N
G
-
D
F
A
Y
R
-
F
T
P
R
A
A
T
R
P
T
E
I
F
-
V
S
D
L
H
Y
P
D
G
Y
A
----
V
Q
V
D
G
G
Q
V
----------
T
S
A
P
G
---
A
R
I
V
T
V
V
A
8
HHSearch
33.54
15%
115
- C3 -
3E19
1
?
A:
[34-73]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
L
T
P
G
A
T
I
-
Q
V
L
E
S
--
M
G
-
P
----
I
I
I
S
V
G
G
V
----------
R
F
A
I
G
---
K
G
L
A
G
R
V
M
20
Fugue
33.35
12%
30
- C5 -
4WFC
2
RRP6_YEAST
A:
[7-110]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
P
D
V
L
L
S
R
V
I
N
V
V
R
--------
A
A
S
S
L
A
S
Q
---
D
-----
V
D
--
F
Y
K
N
L
-
D
R
G
F
S
-------------------------
K
D
L
K
S
K
A
D
K
-
L
A
D
M
A
N
E
I
I
L
------
S
I
D
EHHES
D
--
L
W
N
N
F
G
N
I
M
D
N
L
L
E
M
S
-------
D
--
H
S
L
D
K
L
N
C
A
I
N
S
K
---------------------------------------------------------------------------------------
12
Fugue
32.65
17%
-31
- C4 -
2HJQ
-
YQBF_BACSU
A:
[1-111]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
F
T
-----
A
K
------
L
I
K
G
K
T
Y
N
V
--
M
G
I
T
F
--------
R
A
G
V
S
Q
T
V
P
K
K
L
-----
Y
E
--
Y
L
N
E
N
P
Y
F
I
L
T
-------------------------
Q
E
L
N
N
Q
K
D
D
-
P
I
N
Y
T
E
S
E
L
K
------
G
-------
M
--
N
K
A
E
H
E
S
I
I
S
N
L
G
R
N
P
-------
S
DF
K
N
A
D
E
R
I
A
Y
I
L
K
Q
I
----
D
N
--------
K
G
-
E
L
E
H
H
-
H
H
H
H
-----------------------------------------------------------
11
Fugue
30.99
14%
143
- C4 -
1DH3
1
CREB1_MOUSE
A:
[1-55]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
R
E
V
R
L
M
K
N
-
R
E
A
A
R
E
S
R
R
K
------
K
-------
K
--
E
Y
V
K
S
L
E
N
R
V
A
V
L
E
N
Q
-------
N
--
K
T
L
I
E
E
L
K
A
L
K
D
L
Y
----
S
H
--------
K
-----------------------------------------------------------------------
3
HHSearch
30.83
12%
-102
- C4 -
2Z73
3
OPSD_TODPA
A:
[36-61]
----------------------------------------------------------------------
S
L
G
I
F
I
G
I
----
C
G
I
I
G
C
G
G
N
G
I
V
--------
I
Y
L
F
T
K
--
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
---
S
L
V
N
G
F
P
L
M
T
I
S
-----
C
F
L
K
K
--
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
----------------------
D
R
-
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
-----------------------------
I
I
F
V
W
L
----
W
S
V
L
W
---------
A
----------
I
G
P
I
F
G
W
G
A
-
Y
T
L
E
--
G
V
L
C
N
C
S
F
D
Y
I
S
R
D
S
---
T
T
R
S
N
I
L
C
--
M
F
I
L
G
F
F
--
G
P
I
L
I
I
F
F
C
Y
F
---
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
-----
L
N
------
A
K
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
--------
L
A
K
I
S
I
V
I
---
V
-----
S
Q
--
F
L
L
S
W
-
S
P
Y
A
V
-------------------------
V
A
L
L
A
Q
F
G
P
-
L
E
W
V
T
P
Y
A
A
Q
------
L
-------
P
--
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
-------
V
--
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
----
W
V
--------
L
T
-
C
C
Q
F
D
-
D
K
E
T
E
D
D
K
D
A
E
T
E
-
I
P
A
G
E
--------------------------------------------
5
HHSearch
29.97
7%
-144
- C4 -
3VW7
2
ENLYS_BPT4
A:
[21-47]
---------------------------------------------------------------------
L
F
V
P
S
V
Y
T
G
----
V
F
V
V
S
L
P
L
N
I
M
A
--------
I
V
V
F
I
L
--
K
M
K
V
K
K
P
A
V
V
Y
M
L
H
L
A
T
A
D
V
L
F
---
V
S
V
L
P
F
K
I
S
Y
Y
F
-----
S
G
S
D
W
--
Q
F
G
S
E
L
C
R
F
V
T
A
A
F
Y
C
N
M
Y
A
S
I
L
L
M
T
V
I
S
I
D
----------------------
R
F
-
L
A
V
V
Y
P
M
R
T
L
G
R
A
S
F
T
C
L
A
I
W
A
-----------------------------
L
A
I
A
G
V
----
V
P
L
L
L
---------
K
----------
E
Q
T
I
Q
V
P
G
L
-
G
I
T
T
--
C
H
D
V
L
S
E
T
L
L
E
G
Y
Y
A
---
Y
Y
F
S
A
F
S
A
--
V
F
F
F
V
P
L
--
I
I
S
T
V
C
Y
V
S
I
I
---
R
C
L
S
S
S
A
N
I
F
E
M
L
R
I
D
E
G
L
-----
R
L
------
K
I
Y
K
N
T
E
G
Y
Y
T
I
G
I
G
H
--------
L
L
T
K
S
P
S
L
---
N
-----
A
A
--
K
S
E
L
D
-
K
A
I
G
R
-------------------------
N
T
N
G
V
I
T
K
D
-
E
A
E
K
L
F
N
Q
D
V
------
D
-------
A
--
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-------
S
--
L
D
A
V
R
R
A
A
L
I
N
M
V
F
----
Q
M
--------
G
E
-
T
G
V
A
G
-
F
T
N
S
L
R
M
L
Q
Q
K
R
W
-
D
E
A
A
V
N
L
A
K
S
R
----
W
Y
N
Q
T
P
N
R
----------
A
K
R
V
I
---
T
T
F
R
T
G
T
W
7
HHSearch
29.27
17%
112
* C3 *
2H3J
-
?
A:
[30-70]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
L
L
P
G
A
A
L
-
R
V
V
R
I
A
P
L
G
D
P
----
I
Q
V
E
T
R
Q
T
----------
S
L
A
L
R
---
R
K
D
L
A
L
L
T
17
Fugue
29.02
17%
213
- C4 -
1KD8
1
?
A:
[1-35]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
K
Q
------
L
-------
E
--
A
E
V
E
E
I
E
S
E
V
W
H
L
E
N
E
-------
V
--
A
R
L
E
K
E
N
A
E
C
E
A
----------------------------------------------------------------------------------------
10
HHSearch
27.65
7%
99
- C3 -
2K4Y
-
?
A:
[33-74]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
M
G
I
V
R
G
T
E
I
-
Y
I
E
G
K
A
P
M
G
D
P
----
I
A
L
R
L
R
G
Y
----------
S
L
S
L
R
---
K
S
E
A
K
D
I
L
9
HHSearch
25.94
12%
143
- C4 -
3V2Y
-
ENLYS_BPT4
A:
[66-90]
-----------------------------------------------------------------------
T
S
V
V
F
I
L
----
I
C
C
F
I
I
L
E
N
I
F
V
--------
L
L
T
I
W
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
23.86
12%
108
- C4 -
3ODU
-
CXCR4_HUMAN (first)
A:
[50-75]
----------------------------------------------------------------------
F
L
P
T
I
Y
S
I
----
I
F
L
T
G
I
V
G
N
G
L
V
--------
I
L
V
M
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
22.65
56%
1339
- C1 -
1G70
-
?
B:
[7-14]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
P
S
G
A
E
-
R
R
R
R
R
A
A
A
A
----------------------------------------
13
Fugue
20.41
11%
195
* C4 *
2KY5
-
PECA1_HUMAN
A:
[677-711]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
K
K
D
T
------
E
-------
T
--
V
Y
S
E
V
R
K
A
V
P
D
A
V
E
S
R
-------
Y
--
S
R
T
E
G
S
L
D
G
T
------------------------------------------------------------------------------------------