@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPC5C_HUMAN: (2016-01-10 )
MAIHKALVMCLGLPLFLFPGAWAQGHVPPGCSQGLNPLYYNLCDRSGAWGIVLEAVAGAGIVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLAAHVFALNFLARKNHGPRGWVIFTVALLLTLVEVIINTEWLIITLVRGSGEGGPQGNSSAGWAVASPCAIANMDFVMALIYVMLLLLGAFLGAWPALCGRYKRWRKHGVFVLLTTATSVAIWVVWIVMYTYGNKQHNSPTWDDPTLAIALAANAWAFVLFYVIPEVSQVTKSSPEQSYQGDMYPTRGVGYETILKEQKGQSMFVENKAFSMDEPVAAKRPVSPYSGYNGQLLTSVYQPTEMALMHKVPSEGAYDIILPRATANSQVMGSANSTLRAEDMYSAQSHQAATPPKDGKNSQVFRNPYVWD
Atome Classification :
(20 SA)
------------------------------------------------------.........10........20------........30........-40........50..-......----------60...--.....------------70........80.......-----.90........100.......110.......120..----.....130.......140.......150.......160---------.........170.......180...-------------....190.....--...200--------.........210.......220-........230.......240-----.......250.......----260..---.....--------270..---......280.......290...--.....----300.......310.......320.......330..-------------.....340...-------....350.......360..---.....370.......380......------.390.....-----..400.......410.......420-.........430.......440----------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------M
A
I
H
K
A
L
V
M
C
LG
L
P
L
F
LFPGA------WAQGHVPPGCSQGL
N
P
L
Y
-
Y
N
LCDRSGA
W
G
I
V
L
-
E
A
VAG
A
----------
G
I
V
T
T
--
F
V
L
T
I
------------
I
L
V
ASLPF
V
Q
D
T
K
K
R
S
L
L
G
-----
T
Q
V
F
F
L
L
G
T
L
G
L
F
C
L
V
F
A
C
V
VKP
D
F
S
T
C
A
S
R
R
F
L
F
G
----
V
L
F
A
I
C
F
S
C
L
A
A
H
V
F
A
L
N
F
L
A
RKNHGPR
G
W
V
I
F
T
V
A
-----------
L
L
L
T
L
V
E
V
I
INT
E
W
L
I
I
T
L
V
RGSGE-------------GGPQGN-SSAG
W
--
A
VAS----------
P
C
AI
A
N
M
D
F
V
M
A
L
I
Y
V
M
L
L
L
L
--
G
A
F
L
G
A
W
P
A
L
C
G
R
Y
K
R
W
R
KH
G
-----
V
F
V
L
L
TTA
T
S
V
A
I
W
V
V
W
----
I
V
M
YT---YGNKQ--------HN-SP---TWDDP
T
L
A
I
A
L
AANA
W
A
F
-
V
L
F
--YVIP
E
----
V
S
Q
V
TKSSPEQSYQGDMYPTRGV
G
Y
E
T
I
L
K
E
QKGQ-------------
S
M
F
V
ENKAFSM-------DEPVAAKRPVSPYSGYNG
Q
---
L
L
T
S
VYQP
T
E
M
A
L
M
HKVPSEGA
Y
D
------
I
I
L
PRATAN-----S
Q
V
MGSANS
T
L
R
A
E
D
MYSAQSHQ---AATPPKDGKNS
Q
V
FRNPYVWD-----------------------------------------------
33
Fugue
73.08
15%
-88
* C5 *
3JA7
-
?
A:
[1-447]
-----------------------------------------------------------------------------------------
N
W
I
S
E
L
I
D
T
Y
-
R
N
L
M
N
N
Y
E
V
D
N
A
V
S
-
E
I
V
S
D
A
-----------
I
V
Y
E
--
D
D
T
E
V
------------
V
A
L
N
L
D
K
S
K
F
S
P
K
I
K
N
M
M
L
-----
D
E
F
S
D
V
L
N
H
L
S
---------
F
Q
R
K
G
S
D
H
F
R
R
W
Y
V
D
S
----
R
I
F
F
H
K
I
I
D
P
K
R
P
K
E
G
I
K
E
L
R
R
L
D
P
R
Q
V
Q
Y
V
Y
F
I
Y
D
T
A
H
ESYACDGR
M
Y
E
A
G
T
K
I
K
I
P
K
A
A
V
V
Y
A
---
H
S
G
L
-------------
V
D
C
C
G
K
-
N
I
I
G
Y
LH
R
A
V
K
----------
P
A
N
Q
L
K
L
L
E
D
A
V
V
I
Y
R
I
T
R
A
P
--
D
R
R
V
W
Y
V
D
T
G
N
M
P
A
R
K
A
A
E
H
M
-----
Q
H
V
M
N
T
M
K
N
R
V
---
V
Y
D
----
A
S
T
G
K
---
I
K
N
Q
Q
--------
H
N
-
M
S
---
M
T
E
D
Y
W
L
Q
---
R
R
D
G
K
A
V
-
T
E
V
--
D
T
L
P
G
----
A
D
N
T
G
N
M
E
D
I
R
W
F
R
Q
A
L
Y
M
A
L
R
V
P
L
S
R
I
P
Q
D
Q
Q
G
G
-------------
V
M
F
D
S
G
T
S
I
T
R
-------
D
E
L
T
F
A
K
F
-
I
R
E
L
Q
H
K
F
E
E
---
V
F
L
D
P
L
K
-
T
N
L
L
L
K
G
I
I
T
E
D
E
W
N
D
E
I
NNI
K
I
E
F
H
R
D
S
Y
F
-----
A
E
L
K
E
A
E
I
L
E
R
R
I
N
M
L
T
M
A
E
P
F
I
---
G
K
Y
I
S
H
R
T
A
M
K
D
I
L
Q
M
T
D
E
E
I
E
Q
E
A
K
Q
I
E
EESKEARFQD-----------------------------
36
Fugue
63.00
18%
-104
- C2 -
4LDV
13
ARFA_ARATH
A:
[16-356]
-----------------------------------------------------S
D
A
L
C
R
E
L
W
H
A
C
A
G
P
L
V
T
L
P
R
E
G
E
R
V
Y
Y
F
P
E
G
H
M
E
Q
L
E
A
S
M
H
Q
G
L
E
-
Q
Q
M
P
S
F
N
L
P
S
K
I
L
C
-
K
V
I
N
I
Q
----------
R
R
A
E
T
D
E
V
Y
A
Q
I
------------
T
L
L
P
E
L
D
Q
S
E
P
T
S
P
D
A
P
V
Q
-----
E
T
V
H
S
F
C
K
T
L
T
----------
A
S
D
T
S
T
H
G
G
----------------
F
S
V
L
R
R
H
A
D
D
C
L
P
P
L
D
M
S
Q
Q
P
P
W
Q
E
L
V
A
T
D
-----------
L
H
--------
N
S
E
W
H
F
R
H
I
F
R
G
Q
P
--------------------------------------------------------
R
R
H
L
L
T
T
--
G
-----
W
S
V
F
V
S
S
-
K
K
L
V
A
G
D
-----
A
F
I
F
L
R
G
E
N
E
-------------
E
L
R
---
V
G
V
R
R
--------
H
M
P
S
S
---
V
I
S
S
H
S
M
H
I
G
V
L
A
T
A
A
H
A
-
I
T
T
--------------------------------
G
T
I
F
S
V
F
Y
K
P
R
T
S
R
-------------
S
E
F
----
I
V
S
V
-------
N
R
Y
L
E
A
K
T
----------------------------
Q
K
L
S
V
G
M
R
F
K
------
M
R
F
K
R
F
S
G
T
-----
I
V
G
V
Q
E
N
K
S
S
V
W
H
D
S
E
W
R
S
L
K
V
Q
---
W
D
E
P
S
S
V
F
R
P
E
R
V
--
S
P
W
E
L
E
P
L
N--------------------------------------------
30
Fugue
59.96
16%
-93
* C4 *
3O6X
6
?
A:
[3-728]
K
M
R
F
F
A
L
Q
E
L
SNRKP
L
E
I
T
T
PSNKLSDYYASHVFDRKKMQEYLP
K
E
A
Y
K
A
V
V
D
A
T
E
K
G
T
P
I
S
R
E
M
A
D
L
I
A
N
G
M
K
S
------
W
A
K
S
L
N
V
T
H
Y
T
H
W
F
Q
P
L
T
K
H
D
G
F
I
E
F
G
E
D
G
E
V
I
-
E
R
F
S
G
K
LLTAWDGS
S
P
A
F
V
V
D
--
T
T
L
C
I
PTIFIEALD
Y
K
T
P
L
L
K
A
L
A
A
V
D
K
A
A
T
E
V
C
Q
L
F
DKNI
T
R
V
F
T
N
L
G
W
E
Q
E
Y
F
L
V
D
T
S
L
Y
N
A
R
P
D
L
R
L
T
G
R
T
L
M
G
HSIP
P
R
V
T
A
F
M
K
E
L
E
I
E
C
H
K
L
G
I
P
V
K
T
R
H
N
E
V
A
P
N
Q
F
E
L
A
-----------
P
I
F
E
N
C
N
L
A
N
D
H
N
Q
L
V
M
D
L
M
K
R
I
A
R
K
H
H
F
A
V
L
FHEKPY
N
G
V
N
G
S
G
K
H
N
N
W
--
S
L
C
T
DTGINLFAPG
K
N
P
K
G
N
M
L
F
L
T
F
L
V
N
V
L
M
M
V
H
K
N
Q
D
L
L
R
A
S
I
M
S
A
G
N
S
H
R
L
G
A
N
E
A
P
P
A
I
L
S
I
F
L
G
S
Q
L
S
A
T
L
D
E
I
R
NRTS
P
F
A
F
T
---
G
N
R
F
E
--------
F
R
-
A
A
---
G
S
S
A
N
C
A
A
A
M
I
A
I
N
A
A
M
A
-
N
Q
L
--
N
E
F
K
A
S
V
DK
D
E
A
I
F
R
I
L
K
E
N
I
I
A
S
E
L
I
R
F
E
G
D
G
Y
S
E
E
W
K
Q
E
A
A
R
R
GL
T
N
I
C
H
V
P
E
A
L
M
H
Y
M
D
N
Q
S
R
A
V
LIGERIF
N
E
T
E
L
A
C
R
L
E
V
E
L
E
K
Y
T
M
K
---
V
Q
I
E
S
R
V
L
G
D
L
A
I
N
H
I
V
P
I
A
V
S
Y
Q
------
N
R
L
L
E
N
L
C
R
M
K
E
I
F
S
E
E
E
Y
E
V
M
S
A
D
R
K
E
L
I
K
E
I
S
H
R
V
---
S
A
I
K
V
L
V
R
D
M
T
E
A
R
K
V
A
N
H
K
E
N
F
K
E
K
A
F
A
Y
E
E
TVRPY
L
E
S
I
R
D
H
I
D
H
L
E
M
E
IDDEIWPLPK
Y
R
E
L
L
FT
8
PsiBlast_PDB
44.48
27%
-43
- C3 -
1M57
1
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
14
PsiBlast_PDB
43.98
27%
-38
- C3 -
3OMA
7
?
B:
[31-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
7
PsiBlast_PDB
43.72
27%
-46
- C3 -
1M56
1
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
11
PsiBlast_PDB
43.59
27%
-35
- C3 -
3FYE
6
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
12
PsiBlast_PDB
43.57
27%
-35
- C3 -
3FYI
6
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
13
PsiBlast_PDB
43.51
27%
-33
- C3 -
3OM3
8
?
B:
[31-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
15
PsiBlast_PDB
43.26
27%
-37
- C3 -
3OMI
7
?
B:
[31-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
16
PsiBlast_PDB
43.25
27%
-35
- C3 -
3OMN
7
?
B:
[31-131]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
10
PsiBlast_PDB
43.19
27%
-39
- C3 -
3DTU
3
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
9
PsiBlast_PDB
43.17
27%
-37
- C3 -
2GSM
3
COX2_RHOSH
B:
[35-135]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
L
V
I
I
A
-
A
I
T
I
F
V
T
L
----
L
I
L
Y
A
V
W
R
F
H
E
K
R
NK
V
P
A
R
F
T
H
N
-
S
P
L
E
I
A
W
T
I
V
P
I
V
I
L
V
A
I
G
A
F
S
L
P
V
L
F
N
Q
Q
E
I
P
E
----
A
D
V
T
V
K
V
T
G
Y
Q
W
Y
W
G
Y
E
Y
P
D
E
E
I
S
F
E
S
Y
M
I
G
S
P
A
T
-------------
G
G
D
N
R
M
S
P
E
V
E
-------
Q
Q
L
I
E
A
G
Y
S
R
D
E
F
L
L
A
T
D
T
---
A
M
V
V
P
V
N
K
T
V
V
V
Q
V
T
G
A
D
V
I
H
S
W
T
------
V
P
A
F
G
V
K
Q
D
-----
A
V
P
G
R
L
A
Q
L
W
F
R
A
E
R
E
G
I
F
F
G
Q
C
---
S
E
L
C
G
I
S
H
A
Y
M
P
I
T
V
K
V
V
S
E
E
-----------------------------------------------
6
PsiBlast_PDB
35.12
27%
36
- C3 -
2AGS
1
?
A:
[355-423]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
G
Y
S
S
V
---
L
----
Y
K
D
D
K
L
Y
S
L
H
E
I
N
T
N
D
V
Y
S
------
L
V
F
V
R
L
I
G
E
-----
L
Q
L
M
K
S
V
V
R
T
W
K
E
E
D
N
H
L
A
S
I
C
T
PVV
P
A
T
P
P
S
K
G
G
C
G
A
A
V
P
T
A
G
L
V
G
-----------------------------------------------
4
PsiBlast_PDB
33.01
34%
-32
- C3 -
3RO6
-
KRDE_METCA
B:
[105-147]
------------------------------------------------------
M
A
L
H
D
L
V
A
Q
C
L
G
L
P
L
V
E
I
L
G
-------
R
A
H
D
S
L
P
T
S
V
T
I
G
I
K
P
V
E
-
E
T
L
A
E
A
R
E
H
L
A
L
G
F
-
R
V
L
K
V
K
----------
L
C
G
D
E
--
E
Q
D
F
E
------------
R
L
R
R
L
H
E
T
L
A
G
R
A
V
V
R
V
D
P
-----
N
Q
S
Y
D
R
D
G
L
L
R
L
D
R
L
V
Q
E
L
G
I
E
F
I
E
Q
P
F
P
A
G
R
T
D
W
L
----
R
A
L
P
K
A
I
R
R
R
I
A
A
D
E
S
L
L
G
P
A
D
A
F
A
L
A
A
P
P
A
A
C
G
I
F
-----------
N
I
K
L
M
K
C
G
G
L
A
P
A
R
R
I
A
T
I
A
E
T
A
G
I
-------------
D
L
M
W
G
C
-
M
D
E
S
R
--
I
S
I
A
----------
A
A
L
H
A
A
L
A
C
P
A
T
R
Y
L
D
L
D
G
S
F
--
D
L
A
R
D
V
A
E
G
G
F
I
L
E
D
G
R
L
R
V
T
-----
E
R
P
G
L
G
L
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
32.62
13%
62
- C4 -
4V0C
1
KCNQ1_HUMAN
A:
[7-108]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
H
H
H
G
S
D
Y
D
D
I
F
T
T
E
S
A
L
K
V
Q
Q
K
-------------------
Q
R
Q
K
H
F
N
R
-------
Q
I
P
A
A
A
S
L
I
Q
T
A
W
R
C
Y
A
A
E
-------------------
N
P
D
S
S
T
W
K
------
I
Y
I
E
F
S
Q
L
R
-----
E
H
H
R
A
T
I
K
V
I
R
R
M
Q
Y
F
V
A
K
K
K
F
Q
---
Q
A
R
K
P
---------------------------------------------------------------
5
PsiBlast_PDB
31.63
25%
67
- C3 -
1T47
-
HPPD_STRAW
A:
[16-81]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
F
P
V
K
G
M
D
A
V
V
F
A
V
G
N
A
K
Q
-------------
A
A
H
Y
Y
S
T
A
F
G
M
Q
L
V
A
Y--
S
G
P
E
N
G
S
R
E
T
A
S
Y
V
L
T
N
G
S
A
R
F
V
L
T
S
V
I
K
P
A
T
P
W
G
H
F
L
A
D
H
V
A
E
H
G
------
D
G
V
V
D
L
A
I
E
-----
V
P
D
A
R
A
A
H
A
Y
A
I
E
H
G
A
R
S
V
A
E
P
Y
---
E
L
K
D
E
H
G
T
V
V
L
A
A
I
A
T
Y
G
K
T
R
-----------------------------------------------
3
PsiBlast_PDB
31.39
34%
-42
- C3 -
3RIT
2
KRDE_METCA
A:
[105-147]
------------------------------------------------------
M
A
L
H
D
L
V
A
Q
C
L
G
L
P
L
V
E
I
L
G
-------
R
A
H
D
S
L
P
T
S
V
T
I
G
I
K
P
V
E
-
E
T
L
A
E
A
R
E
H
L
A
L
G
F
-
R
V
L
K
V
K
----------
L
C
G
D
E
--
E
Q
D
F
E
------------
R
L
R
R
L
H
E
T
L
A
G
R
A
V
V
R
V
D
P
-----
N
Q
S
Y
D
R
D
G
L
L
R
L
D
R
L
V
Q
E
L
G
I
E
F
I
E
Q
P
F
P
A
G
R
T
D
W
L
----
R
A
L
P
K
A
I
R
R
R
I
A
A
D
E
S
L
L
G
P
A
D
A
F
A
L
A
A
P
P
A
A
C
G
I
F
-----------
N
I
K
L
M
K
C
G
G
L
A
P
A
R
R
I
A
T
I
A
E
T
A
G
I
-------------
D
L
M
W
G
C
-
M
D
E
S
R
--
I
S
I
A
----------
A
A
L
H
A
A
L
A
C
P
A
T
R
Y
L
D
L
D
G
S
F
--
D
L
A
R
D
V
A
E
G
G
F
I
L
E
D
G
R
L
R
V
T
-----
E
R
P
G
L
G
L
V
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
29.28
29%
-79
- C3 -
3KAL
-
?
A:
[76-147]
------------------------------------------------------------------
L
P
L
S
L
L
P
G
P
------
F
P
E
S
H
W
K
Q
G
C
E
--
L
A
P
I
F
-
N
E
L
V
D
R
V
S
L
D
G
K
F
L
Q
E
S
L
S
R
T
----------
K
N
A
D
E
--
F
T
S
R
L
------------
L
D
I
H
S
-
K
M
L
Q
I
N
K
K
E
D
I
R
M
-----
G
I
V
R
S
D
Y
M
I
D
E
K
T
K
S
L
L
Q
I
E
M
N
T
I
S
T
S
F
A
L
I
G
C
L
M
T
----
G
L
H
K
S
L
L
S
Q
Y
G
K
F
L
G
L
N
S
N
R
V
P
A
N
N
A
V
D
Q
S
A
E
A
L
A
K
-----------
A
W
S
E
Y
N
N
P
R
A
A
I
L
V
V
V
Q
V
E
E
R
N
M
Y
E
-------------
Q
H
Y
I
S
A
-
L
L
R
E
K
--
H
H
I
R
----------
S
I
R
K
T
L
T
E
I
D
Q
E
G
K
I
L
P
D
G
T
L
--
S
V
D
G
Q
A
I
S
V
V
Y
F
R
A
G
Y
T
P
K
D
Y
-----
P
S
E
S
E
W
R
A
R
L
L
M
E
Q
S
S
A
----
I
K
C
P
T
---
I
S
Y
H
L
--------
V
G
-
T
K
---
K
I
Q
Q
E
L
A
K
P
G
V
L
E
R
F
V
E
N
-
K
D
H
--
I
A
K
L
R
----
A
C
F
A
G
L
W
S
L
E
D
S
D
I
V
K
K
A
I
E
N
P
E
L
F
V
M
K
P
Q
R
E
G
G
G
-------------
N
N
I
Y
G
D
E
L
R
E
T
-------
L
L
K
L
Q
E
D
A
A
Y
I
L
M
Q
R
I
F
P
A
---
T
S
P
A
I
L
V
R
D
G
N
W
D
T
G
H
V
I
S
E
A
G
I
F
------
G
T
Y
L
R
N
K
D
K
-----
I
I
I
N
N
E
S
G
Y
M
V
R
T
K
I
S
S
S
Y
E
G
G
V
---
L
P
G
F
G
V
V
D
T
V
Y
L
T
-------------------------------------------------------
1
PsiBlast_PDB
28.58
29%
-84
- C3 -
3KAJ
-
?
A:
[76-147]
------------------------------------------------------------------
L
P
L
S
L
L
P
G
P
------
F
P
E
S
H
W
K
Q
G
C
E
--
L
A
P
I
F
-
N
E
L
V
D
R
V
S
L
D
G
K
F
L
Q
E
S
L
--------------
N
A
D
E
--
F
T
S
R
L
------------
L
D
I
H
S
-
K
M
L
Q
I
N
K
K
E
D
I
R
M
-----
G
I
V
R
S
D
Y
M
I
D
E
K
T
K
S
L
L
Q
I
E
M
N
T
I
S
T
S
F
A
L
I
G
C
L
M
T
----
G
L
H
K
S
L
L
S
Q
Y
G
K
F
L
G
L
N
S
N
R
V
P
A
N
N
A
V
D
Q
S
A
E
A
L
A
K
-----------
A
W
S
E
Y
N
N
P
R
A
A
I
L
V
V
V
Q
V
E
E
R
N
M
Y
E
-------------
Q
H
Y
I
S
A
-
L
L
R
E
K
--
H
H
I
R
----------
S
I
R
K
T
L
T
E
I
D
Q
E
G
K
I
L
P
D
G
T
L
--
S
V
D
G
Q
A
I
S
V
V
Y
F
R
A
G
Y
T
P
K
D
Y
-----
P
S
E
S
E
W
R
A
R
L
L
M
E
Q
S
S
A
----
I
K
C
P
T
---
I
S
Y
H
L
--------
V
G
-
T
K
---
K
I
Q
Q
E
L
A
K
P
G
V
L
E
R
F
V
E
N
-
K
D
H
--
I
A
K
L
R
----
A
C
F
A
G
L
W
S
L
E
D
S
D
I
V
K
K
A
I
E
N
P
E
L
F
V
M
K
P
Q
N
I
Y
G
D
-------------
E
L
R
E
T
L
L
K
L
Q
Y
-------
I
L
M
Q
R
I
F
P
A
T
S
P
A
I
L
V
R
D
G
---
N
W
D
T
G
H
V
I
S
E
A
G
I
F
G
T
Y
L
R
N
K
D
K
I
------
I
I
N
N
E
S
G
Y
M
-----
V
R
T
K
I
S
S
S
Y
E
G
G
V
L
P
G
F
G
V
V
D
T
V
---
Y
L
T
-----------------------------------------------------------------