@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPC5D_HUMAN: (2016-01-10 )
MYKDCIESTGDYFLLCDAEGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQWNVLPTQLLFLLSVLGLFGLAFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVKLVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGMMFVNMTPCQLNVDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNPQFQRQPQWDDPVVCIALVTNAWVFLLLYIVPELCILYRSCRQECPLQGNACPVTAYQHSFQVENQELSRARDSDGAEEDVALTSYGTPIQPQTVDPTQECFIPQAKLSPQQDAGGV
Atome Classification :
(14 SA)
-----.........10.......--.20...---.....30--------------..------......40....--.----------...50.----.......--60........70....-----------------..----..80.---..---------------.....90.-.......100..---....-----.110---------------.......120...----.--.--..130.......---140-----......----.150----------.........------160........170....------...-----.180..------------------------.....190..-------------.....200-.------...-------------...210.......220...---....230.......240.-------------------......250........260........270...-....280.....----..290.......-300.......310..---....-.320-.........330......--.340...-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
Y
K
D
C
I
ESTG
D
Y
F
L
L
CDA--EG
P
W
G
I
---
I
L
E
S
L
A
I
--------------
L
G
------
I
V
V
T
I
L
L
L
L
A
F
L
--
F
----------
L
M
R
K
I
Q
----
D
C
SQWNV--
L
P
T
Q
L
L
F
L
L
S
V
L
G
L
F
G
-----------------
L
A
----
F
A
F
I
I
---EL---------------NQQT
A
P
V
R
-
Y
F
L
F
G
V
L
F
A
L
C
F
---
S
C
L
L
-----
A
H
A
S
---------------
N
L
V
K
L
V
R
G
C
VSFS----
W
--
T
--
T
I
L
C
I
A
I
G
C
S
L
L
---
Q
I
I
-----
I
A
T
E
Y
V
----
T
L
------------
I
MTR
G
M
M
F
V
------N-MTP
C
Q
L
N
V
D
F
-
V
V
L
L
V
------
Y
V
L
-----
F
L
M
A
L
T
------------------------
F
F
V
SKATFCG-------------P
C
E
N
W
K
QH-G------
R
L
I
-------------
F
I
T
V
L
F
S
I
I
I
W
V
V
W
I
S
M
L
L---RGNPQFQRQPQWDD
P
V
V
C
-------------------
I
A
L
V
T
N
A
W
-
V
F
L
L
L
Y
I
V
P
E
-
L
C
I
L
Y
R
S
C
R
Q
ECPL-QGNACPVT
A
Y
Q
H
----
S
F
QV
E
N
Q
E
L
S
RA-RDSDGAEE
D
V
A
LTSY---GTPI-QP---QTVDP
T
Q
E
CFIPQAKLSP--QQDAGGV-----------------
10
Fugue
73.67
17%
-136
* C3 *
4MFL
7
?
A:
[23-345]
-----
M
D
P
E
T
V
R
I
A
L
G
---
L
E
E
R
--
T
A
A
W
L
T
---
E
L
D
E
L
G
P
--------------
P
A
------
E
P
V
R
L
P
R
G
E
E
A
R
--
D
----------
L
L
R
R
L
E
VP
E
L
D
A
E
E
I
V
A
--
A
A
P
D
P
D
R
D
P
A
L
W
W
L
L
E
-----------------
R
T
----
H
H
A
I
V
---
R
H
MGDHRAKPRGGPPLP
Y
E
G
G
A
A
A
R
-
Y
F
H
V
Y
V
F
L
A
T
V
P
---
A
V
R
R
-----
F
H
A
E
---------------
R
G
I
P
-----
D
E
V
G
----
W
--
E
--
T
L
T
Q
L
G
E
L
V
A
I
H
---
R
R
K
YG
Q
G
G
M
N
M
Q
W
W
----
T
T
------------
Y
H
L
R
G
I
L
Y
R
LGR
L
Q
F
S
-
L
A
T
G
K
D
G
T
P
H
-
L
G
L
A
V
P
EWGGP
L
L
P
-----
K
A
Y
D
E
S
------------------------
L
H
R
A
R
P
F
F
D
R
-------------
H
---
F
P
E
H
-
G
-------------------------------
A
R
V
A
W
G
S
S
W
M
---
L
-
D
P
Q
L
E
E
Y
L
T
E
D
S
N
I
I
Q
-------------------
L
A
---
R
F
W
-
T
L
T
-----------------
D
S
A
P
E
-
P
G
N
A
--------------------------
D
G
D
S
S
I
L
E
F
V
F
R
Y
N
---
G
Q
P
L
-
D
E
L--
P
Q
R
S
S
L
E
R
A
V
I
A
H
L
K
A
G
R
H
W
H
M
R
T
G
F
V
K
L
P--------------
7
Fugue
67.85
13%
-137
- C4 -
4O5J
3
?
A:
[27-400]
---------
L
K
N
L
N
E
K
Y
E
Q
L
S
Q
Y
--
L
N
Q
V
A
S
---
L
K
Q
S
I
Q
N
--------------
A
N
------
N
I
E
L
V
N
S
S
L
N
Y
L
K
S
F
----------
T
N
N
N
Y
N
----
S
T
T
Q
S
P
I
--
F
N
A
V
Q
A
V
I
T
S
V
L
G
F
W
S
-----------------
L
Y
AGNY
F
T
F
F
V
GKK
V
D
---------------
S
G
Q
P
A
S
V
Q
G
N
P
P
F
K
T
I
I
E
N
C
S
GIE
N
C
A
M
D
Q
T
T
Y
D
K
M
K
---------------
K
L
A
E
D
L
Q
A
A
Q
T
N
S
----
A
--
T
KG
N
N
L
C
A
L
S
G
C
A
A
T
---
S
N
P
------
P
N
S
T
V
----
S
N
------------
A
L
N
L
A
Q
Q
L
M
------
D
-
L
I
A
N
T
K
-----
T
A
M
M
W
------
K
N
I
-----
V
I
S
G
V
S
------------------------
N
T
S
G
A
I
T
S
T
N
-------------
Y
P
T
Q
Y
A
V
F
-
N
------
N
I
K
-------------
A
M
I
P
I
L
Q
Q
A
V
T
L
S
Q
S
N
H
T
L
---
S
A
S
L
Q
A
Q
A
T
G
S
Q
T
N
P
K
F
A
-------------------
K
D
I
Y
T
F
A
Q
N
Q
K
Q
V
I
S
Y
A
Q
D
-
I
F
N
L
F
N
S
I
----
P
A
-
E
Q
Y
K
Y
L
E
K
A
Y
L
K
----
I
P
N
A
G
S
T
P
T
N
P
Y
-
R
Q
V
V
N
L
N
Q
E
V
Q
T
I
K
N
---
N
V
S
Y
-
Y
G
---
N
R
V
D
A
A
L
S
V
A
R
D
V
Y
N
L
K
S
--
N
Q
A
E
I
V
T
A
Y
N
D
A
K
T
L
S
E
E
I
S
K
LPH
15
Fugue
67.20
18%
-106
- C2 -
4RGL
1
?
A:
[8-335]
----------------------
Y
--
Q
P
P
Y
T
I
T
P
A
I
V
N
L
V
A
E
--------------
I
G
------
E
I
I
G
R
Y
T
V
L
A
E
Q
--
N
----------
L
T
P
R
L
R
----
R
E
N
R
I
R
T
--
I
Q
A
S
L
A
I
E
N
N
T
L
-----------------------------------
T
L
---------------
E
Q
V
T
A
V
I
D
-
G
--------------
K
R
V
L
-----
G
H
P
R
---------------
E
I
Q
E
V
R
N
A
F
A
T
Y
E
A
MED
W
DA
S
--
V
E
G
D
L
L
A
A
H
E
L
L
M
--
R
G
L
-----
V
D
E
T
G
R
YRS
G
G
V
------------
G
I
F
R
G
E
Q
L
V
------
H
M
A
P
P
A
D
R
V
P
K
L
M
A
D
L
L
D
------
W
L
E
N
TNEH
P
L
V
A
S
C
------------------------
I
F
H
Y
E
F
E
F
I
H
-------------
P
F
A
D
G
N
G
R
M
G
------
R
L
W
-------------
Q
T
L
I
L
R
N
---
W
K
P
L
L
A
Y
L
P
---
V
E
T
V
I
R
D
R
Q
E
D
Y
Y
R
V
L
A
V
-------------------
A
D
S
Q
A
D
A
------
T
P
F
V
E
F
M
L
G
A
L
R
D
A
V
R
E
A
V
S
T
D
H
Q
V
T
D
Q
V
A
A
L
I
R
----
A
I
G
G
G
E
L
S
S
N
D
L
M
Q
A
L
G
L
S
H
R
P
T
F
R
N
N
Y
---
L
N
P
A
M
E
D
---
E
W
I
E
R
T
Q
----
P
D
S
P
R
S
P
--
T
Q
R
Y
R
L
T
GKGQR------------
8
Fugue
64.55
14%
-132
- C4 -
4Q2E
5
CDSA_THEMA
A:
[29-290]
-----
I
T
A
S
V
V
A
P
F
V
V
L
C
F
V
----------------
S
Y
E
S
L
--------------
I
G
------
L
V
S
A
I
L
I
L
A
G
Y
E
--
L
----------
I
T
L
E
M
K
----
E
---------
R
D
A
R
F
F
Y
V
I
L
L
A
L
Y
P
-----------------
V
L
----
Y
G
L
V
F
---
E
E
---------------
P
---------------------------------------------------------------------------------------------------
T
Q
P
L
----
S
I
------------
L
F
I
T
G
V
V
F
S
------
L
-
I
T
D
K
D
P
S
Q
V
F
-
K
T
V
A
A
------
F
S
I
-----
A
L
I
Y
V
T
------------------------
F
F
L
S
F
--
F
L
P
-------------
I
Y
R
D
F
G
A
A
-
N
------
A
L
L
-------------
V
L
T
S
T
W
V
F
D
S
F
A
Y
F
T
G
L
K
F
GRT
R
I
S
P
R
Y
S
P
R
K
S
L
E
G
V
I
G
G
-------------------
F
L
G
V
V
I
Y
T
-
F
L
Y
R
L
V
V
N
D
L
-
L
S
V
N
V
I
C
F
R
T
F
L
P
F
-
A
A
T
V
A
I
M
D
T
F
G
D
----
I
F
E
C
A
L
K
R
H
Y
G
V
-
K
D
S
G
K
-------
T
L
P
---
G
H
G
G
-
M
L
---
D
R
I
D
G
L
L
F
V
-
A
P
V
S
Y
I
V
F
--
K
I
L
E
G
V
V
R----------------
14
Fugue
62.28
12%
-149
- C3 -
1VA6
7
GSH1_ECOLI
A:
[1-515]
-----
M
I
P
D
V
S
Q
A
L
A
W
L
E
K
H
P
Q
A
LK
G
I
Q
R
G
L
---
E
R
E
T
L
R
V
N
ADGTLATTGHPEA
L
G
SALTHK
W
I
T
T
D
F
A
E
A
L
L
E
--
F
I
T
P
VDGD
I
E
H
M
L
T
F
M
R
----
D
L
H
R
Y
T
A
R
N
M
G
D
E
R
M
W
P
L
S
M
P
S
Y
I
A
EGQDIE
L
A
Q
Y
G
TS
N
T
G
R
F
K
----
T
L
Y
R
E
---
G
L
---------------
K
N
R
Y
G
A
L
M
-
Q
T
I
S
G
V
H
Y
N
F
S
L
---
P
M
A
F
-----
W
Q
A
K
SGDIS
G
A
D
A
K
E
K
I
S
A
G
Y
F
R
V
I
R
N
Y
Y
R
F
G
----
W
------
V
I
P
Y
L
F
G
A
S
P
A
ISS
S
F
L
-----
T
S
L
P
F
E
----
K
T
ESG
M
Y
Y
L
PYATS
L
R
L
S
D
L
G
Y
T
------
N
-
K
S
Q
S
N
L
G
I
T
F
-
N
D
L
Y
E
------
Y
V
A
-----
G
L
K
Q
A
I
K
TPS
E
E
Y
A
K
I
GIEKDGKRLQINSN
V
L
Q
I
E
N
E
L
Y
A
P
I
R
P
K
R
VTRSGES
P
S
D
A
L
L
R
G
-
G
IE
Y
I
E
V
R
S
L
DINPFSPIGVD
E
Q
Q
V
R
F
L
D
L
F
M
V
W
C
A
L
A
D
A
P
E
---
M
S
S
S
E
L
A
C
T
R
V
N
W
N
R
V
I
L
EGRKPG
L
T
L
G
IGCETAQFP
L
P
Q
V
G
K
D
L
-
F
R
D
L
K
R
V
A
Q
T
-
L
D
S
I
N
G
G
E
A
Y
Q
K
V
C
-
D
E
L
V
A
C
F
D
N
P
D
L
----
T
F
S
A
R
I
L
R
S
M
I
D
-
T
T
G
K
A
F
A
E
A
Y
R
N
L
L
R
---
E
E
P
L
-
E
I
LR
E
E
D
F
V
A
E
R
E
A
S
E
R
R
Q
Q
E
M
E
--
A
A
D
T
E
P
F
A
V
W
L
E------------
13
Fugue
47.04
10%
-92
- C1 -
4BB7
3
RSC2_YEAST
A:
[16-251]
HMD
E
V
I
V
N
N
I
S
Y
H
V
G
D
W
A
L
L
R
N
Q
--
N
D
P
Q
K
P
---
I
V
G
Q
I
F
R
--------------
L
W
------
K
T
P
D
G
K
Q
W
L
N
A
C
--
W
----------
Y
Y
R
P
E
Q
----
T
V
H
R
V
D
--------------------------------------------------------------------------
R
-
L
F
Y
K
N
----------------------------------------------------------------------------
E
V
M
-----
K
T
G
Q
Y
R
----
D
H
------------
L
V
S
N
-------------------
L
V
G
K
-
C
Y
V
I
H
------
F
T
R
-----
Y
Q
R
G
N
P
------------------------
D
M
K
E
G
P
L
F
V
C
-------------
E
F
R
Y
N
E
S
D
-
K
------
I
F
N
-------------
K
I
R
T
---------
W
K
A
C
L
P
---
E
E
I
R
D
L
D
E
A
T
I
P
V
N
G
R
K
F
-------------------
F
K
Y
P
S
P
------
I
R
H
L
L
P
A
-
N
A
T
P
H
D
R
V
P
E
P
T
M
G
-
S
P
D
A
P
P
L
V
G
A
V
Y
----
M
R
P
-
K
M
Q
R
D
D
L
G
-
E
Y
A
T
S
D
D
C
P
R
Y
I
I
R
P
---
N
D
S
P
-
E
E
---
G
Q
V
D
I
E
T
G
T
I
T
T
--------------------------------
1
HHSearch
33.13
19%
-193
- C4 -
2Z73
3
OPSD_TODPA
A:
[36-62]
---------------------------
S
L
G
I
---
F
I
G
I
C
G
I
--------------
I
G
------
C
G
G
N
G
I
V
I
Y
L
F
T
--
K
----------
T
K
S
L
Q
T
----
P
A
N
M
F
I
I
--
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
-----------------
L
M
----
T
I
S
C
F
---
L
K
---------------
K
W
I
F
G
F
A
A
-
C
K
V
Y
G
F
I
G
G
I
F
G
---
F
M
S
I
-----
M
T
M
A
---------------
M
I
S
I
D
R
Y
N
V
I
G
R
P
----
M
--
A
--
A
S
K
K
M
S
H
R
R
A
F
I
---
M
I
I
-----
F
V
W
L
W
S
----
V
L
------------
W
A
I
G
P
I
F
G
W
------
G
-
A
Y
T
L
E
G
V
L
C
N
-
C
S
F
D
Y
------
I
S
R
-----
D
S
T
T
R
S
------------------------
N
I
L
C
M
F
I
L
G
F
-------------
F
G
P
I
L
I
I
F
-
F
------
C
Y
F
-------------
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
R
---
L
N
A
K
E
L
R
K
A
Q
A
G
A
N
A
E
M
R
-------------------
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
-
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
-
W
V
T
P
Y
A
A
Q
L
P
V
M
----
F
A
K
A
S
A
I
H
N
P
M
I
-
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
---
F
P
W
V
-
L
T
---
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
--
I
P
A
G
E
-------------------
3
HHSearch
30.54
7%
-183
- C4 -
3VW7
2
ENLYS_BPT4
A:
[21-48]
--------------------------
L
F
V
P
S
---
V
Y
T
G
V
F
V
--------------
V
S
------
L
P
L
N
I
M
A
I
V
V
F
I
--
L
----------
K
M
K
V
K
K
----
P
A
V
V
Y
M
L
--
H
L
A
T
A
D
V
L
F
V
S
V
L
P
F
K
-----------------
I
S
----
Y
Y
F
S
G
---
S
D
---------------
W
Q
F
G
S
E
L
C
-
R
F
V
T
A
A
F
Y
C
N
M
Y
---
A
S
I
L
-----
L
M
T
V
---------------
I
S
I
D
R
F
L
A
V
V
Y
P
M
----
R
--
T
--
L
G
R
A
S
F
T
C
L
A
I
W
---
A
L
A
-----
I
A
G
V
V
P
----
L
L
------------
L
K
E
Q
T
I
Q
V
P
------
G
-
L
G
I
T
T
C
H
D
V
L
-
S
E
T
L
L
------
E
G
Y
-----
Y
A
Y
Y
F
S
------------------------
A
F
S
A
V
F
F
F
V
P
-------------
L
I
I
S
T
V
C
Y
-
V
------
S
I
I
-------------
R
C
L
S
S
S
A
N
I
F
E
M
L
R
I
D
E
G
L
---
R
L
K
I
Y
K
N
T
E
G
Y
Y
T
I
G
I
G
H
-------------------
L
L
T
K
S
P
S
L
-
N
A
A
K
S
E
L
D
K
A
-
I
G
R
N
T
N
G
V
I
T
K
D
E
A
-
E
K
L
F
N
Q
D
V
D
A
A
V
----
R
G
I
L
R
N
A
K
L
K
P
V
-
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
---
V
F
Q
M
-
G
E
---
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
--
D
E
A
A
V
N
L
-----------------
2
HHSearch
26.08
21%
72
- C4 -
3ODU
-
CXCR4_HUMAN (first)
A:
[49-76]
--------------------------
I
F
L
P
T
---
I
Y
S
I
I
F
L
--------------
T
G
------
I
V
G
N
G
L
V
I
L
V
M
G
--
Y
----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
24.46
20%
139
- C4 -
3KXY
-
?
T:
[17-81]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
A
V
G
H
F
-
E
G
R
S
V
T
R
A
A
V
R
G
EDRS
S
V
A
G
L
A
R
W
L
A
R
N
-
V
A
G
D
P
R
S
E
Q
A
L
Q
R
L
A
DGD
G
T
P
L
-
E
A
---
R
T
V
R
R
R
--------------------------------------
4
HHSearch
24.18
33%
329
- C4 -
1ZZA
-
SNN_HUMAN
A:
[20-34]
----------------------------------
I
L
I
A
I
A
A
--------------
L
G
------
A
L
I
L
G
C
W
C
Y
L
R
L
--
Q
----------
R
I
S
Q
S
E
----
D
E
E
S
I
V
G
--
D
G
E
T
K
E
P
F
L
L
V
Q
Y
S
A
K
-----------------
G
P
----
C
V
E
R
K
---
A
K
---------------
L
M
T
P
N
G
P
E
-
V
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
HHSearch
22.36
15%
68
- C4 -
3V2Y
-
ENLYS_BPT4
A:
[66-91]
----------------------------
T
S
V
---
V
F
I
L
I
C
C
--------------
F
I
------
I
L
E
N
I
F
V
L
L
T
I
W
--
K
----------
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
Fugue
17.52
23%
327
- C4 -
4MQV
-
SMAL1_HUMAN
B:
[1-26]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
E
E
Q
R
----
K
K
I
E
E
N
R
Q
K
A
L
A
-
R
R
A
E
K
L
L
A
----------------------------------------------------------------
16
Fugue
11.96
20%
372
* C4 *
2DOH
-
C:
[4-28]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
D
A
E
L
Q
R
L
-
K
N
E
R
H
E
E
A
E
L
E
R
L
S
----------------------------------------------------------