@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR12_HUMAN: (2016-01-10 )
MNEDLKVNLSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLIIFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSVSFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLAQRARSPSDV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90....-----..-..100.-----..---....110.......120..---------.....130.......140.......150--........160.......170....-.--..---------180.-----..------....190------...-.-----.-.-..200---...--......210---------........220.......230-...--.-------.-----------------------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------..240.....--..250.......260....------...270.----.....-----.-----280-.......290.......300---........310.......320.......330..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNE
D
L
K
V
NLSGL
P
R
D
Y
L
D
A
A
A
A
E
N
I
S
A
A
V
SSRVPAVEPEP
E
L
V
VNP
W
D
I
V
L
CTSG
T
L
I
SCE
N
A
I
V
V
L
I
I
FHNPSLR
A
P
M
F
L
L
I
G
S
L
A
L
A
D
L
L
A
G
I
-----
G
L
-
I
T
N
F
V
F
-----
A
Y
---
L
L
Q
SEA
T
K
L
V
T
I
G
L
I
V
A
S
F
---------
S
A
S
V
C
S
L
L
A
I
T
V
D
R
Y
L
S
L
Y
Y
A
L
T
YHSE---
R
T
V
T
F
T
Y
V
M
L
V
M
L
WG
T
S
I
C
L
G
L
L
P
V-M--GW---------NCLR-----DE------ST
C
S
V
V-------RPL-T-----K-N-
N
A
A
-----
I
L
S
--
V
S
F
L
F
M
F
A
----------
L
M
L
Q
L
Y
I
Q
I
C
K
I
V
M
R
H
A
H
Q
I
--
A
L
Q
--
H
-------
H
-----------------------------------------------------------------------------------------------------------------------------------------------------
F
------------------------------------------------------------------------------------------------LAT
S
H
Y
V
TTR--KG
V
S
T
L
A
I
I
L
G
T
F
A
A
C
W
M
P
------
F
T
L
Y
S
L
I
----
A
D
YTY-----P-----
S
I
Y
-
T
Y
A
T
LL
P
A
T
Y
N
S
I
I
N
P
V
I
Y
----
A
F
R
N
Q
E
I
Q
K
A
L
C
L
I
C
CGC
I
P
S
S
L
A
Q
RARSPSDV
42
HHSearch
87.34
25%
-139
- C8 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
-----
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
---
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
---------
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
-
F
--
G
F
---------
N
T
T
G
-----
D
P
------
T
V
C
S
I
S
-------
N
P
--------
D
-
F
-
V
I
Y
-----
S
S
V
--
V
S
F
Y
L
P
F
G
----------
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
--
I
F
E
--
M
-------
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
----------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW-------------------------------------------------------------------------------
D
A
Y
G
V
P
L
R
E
K
--
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
------
F
F
L
T
H
V
L
----
N
T
H
C
Q
TCHV-
S
-----
P
E
L
-
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
----
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
----------------
40
HHSearch
84.43
24%
-144
- C8 -
3EML
13
ENLYS_BPT4
A:
[22-472]
--------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
F
A
I
T
-----
I
S
TG-
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
---------
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
---------
N
N
C
G
-----
Q
S
------
Q
G
C
G
E
G
QVACLFE
D
V
V
-
P
-----
M
N
Y
M
V
Y
F
-----
N
F
F
--
A
C
V
L
V
P
L
L
----------
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
--
E
M
L
--
R
-------
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
------------------------------------------------------------------------------------------------
A
Y
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
------
L
H
I
I
N
C
F
----
T
F
F
C
P
DCSHA
P
-----
L
W
L
-
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-----------
35
HHSearch
82.12
24%
-132
- C8 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
---
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
-
Q
M
-
H
W
---------
Y
R
A
T
H
Q
---
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
-------
F
T
N
-
Q
-----
A
-
Y
-
A
I
A
-----
S
S
I
--
V
S
F
Y
V
P
L
V
----------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
--
E
M
L
--
R
-------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT-
W
------------------------------------------------------------------------------------------------
D
A
Y
K
F
C
L
K
E
H
--
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
------
F
F
I
V
N
I
V
----
H
V
I
Q
D
NLI--
R
-----
K
E
V
-
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
----
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------
36
HHSearch
80.62
28%
-136
- C8 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
----------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
-----
A
Y
-
T
A
N
L
L
L
-----
S
G
ATT
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
---------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
-
M
--
G
W
---------
N
C
I
S
-----
A
L
------
S
S
C
S
T
V
-------
L
P
L
Y
H
-----
K
-
H
-
Y
I
L
-----
F
C
T
--
T
V
F
T
L
L
L
L
----------
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
--
M
L
R
--
I
-------
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
------------------------------------------------------------------------------------------------
A
Y
A
S
R
S
S
E
N
V
--
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
------
L
F
I
L
L
L
L
----
D
V
G
C
K
-----
V
KTC
D
I
L
F
R
-
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
----
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------
38
HHSearch
80.28
23%
-142
- C8 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
----------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
-----
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
K
---
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
---------
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
----
G
W
---------
N
H
--R----
R
E
------
D
K
C
E
T
D
-------
F
Y
D
-
V
-----
T
W
F
-
K
V
M
-----
T
A
I
--
I
N
F
Y
L
P
T
L
----------
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
--
E
M
L
--
R
-------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
---------------
N
R
A
K
R
V
I
T
T
F
R
TGTW----------------------------------------------------------------------------------
D
A
Y
L
H
M
N
R
E
R
--
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
------
Y
F
I
F
F
M
V
----
I
A
F
C
K
NCC--
N
-----
E
H
L
-
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
----
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------
34
HHSearch
79.36
22%
-138
- C8 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
----------------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
-----
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
---
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
---------
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
-
L
--
F
W
---------
Q
F
I
V
GVRTV
E
D
------
G
E
C
Y
I
Q
-------
F
F
S
-
N
A
----
A
-
V
-
T
F
G
-----
T
A
I
--
A
A
F
Y
L
P
V
I
----------
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
--
E
M
L
--
R
-------
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
-------------------------------------------------------------------------------------------------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
P
P
P
S
R
E
K
--
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
------
Y
N
V
M
V
L
I
----
N
T
F
C
A
PCI--
P
-----
N
T
V
-
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
----
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------
20
PsiBlast_PDB
77.29
27%
-135
- C8 -
2YCW
7
ADRB1_MELGA
A:
[24-293]
--------------------------------------------------------
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
-----
T
W
---
L
W
G
S
F
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
Y
Q
-----
D
P
------
G
C
C
D
F
V
-----------
T
-----
N
-
R
-
A
Y
A
-----
I
A
S
--
S
I
I
S
F
Y
I
P
----------
L
L
I
M
I
F
V
A
L
-
R
V
Y
R
E
A
K
E
Q
I
--
R
K
I
--
D
-------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
------------------------------------------------------------------------------------------------
S
K
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
------
F
F
L
V
N
I
V
----
N
V
F
N
R
DLV--
P
-----
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
----
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------
7
PsiBlast_PDB
75.77
26%
-152
- C8 -
3UZC
1
AA2AR_HUMAN
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
---------------------
G
C
-
G
-----
E
-
G
-
Q
V
A
CL
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------
5
PsiBlast_PDB
75.74
26%
-148
- C8 -
3RFM
1
AA2AR_HUMAN
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
---------------------
G
C
-
G
-----
E
-
G
-
Q
V
A
CL
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------
3
PsiBlast_PDB
75.47
26%
-146
- C8 -
3PWH
1
?
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
---------------------
G
C
-
G
-----
E
-
G
-
Q
V
A
CLFED
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------
6
PsiBlast_PDB
75.32
26%
-149
- C8 -
3UZA
1
AA2AR_HUMAN
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
---------------------
G
C
-
G
-----
E
-
G
-
Q
V
A
CL
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------
16
PsiBlast_PDB
75.17
28%
-170
- C8 -
4LDO
3
A:
[200-463]
-------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
-
F
G
A
-----
A
H
---
I
L
----
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
Y
A
-----
E
E
------
T
C
C
D
F
----------
F
-
T
-----
N
-
Q
-
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
V
P
L
V
----------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
--
E
-------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
------
F
F
I
V
N
I
V
H
V
IQ
D
N
L
I
R
-----
K
-----
E
V
Y
-
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
CRS
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------
4
PsiBlast_PDB
74.93
26%
-152
- C8 -
3REY
1
AA2AR_HUMAN
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
---------------------
G
C
-
G
-----
E
-
G
-
Q
V
A
CL
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------
15
PsiBlast_PDB
74.88
28%
-172
- C8 -
4LDL
3
ADRB2_HUMAN
A:
[200-463]
-------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
-
F
G
A
-----
A
H
---
I
L
----
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
Y
A
-----
E
E
------
T
C
C
D
F
----------
F
-
T
-----
N
-
Q
-
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
V
P
L
V
----------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
--
E
-------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
------
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
-----
K
-----
E
V
Y
-
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
C
RS
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------
14
PsiBlast_PDB
74.68
28%
-172
- C8 -
4LDE
3
A:
[200-463]
-------------------------------------------------------------
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----
A
V
-
V
P
-
F
G
A
-----
A
H
---
I
L
----
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
--
H
W
YRATH
Q
E
A
I
N
C
Y
A
-----
E
E
------
T
C
C
D
F
----------
F
-
T
-----
N
-
Q
-
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
V
P
L
V
----------
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
--KF
A
L
K
--
E
-------
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
------
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
R
-----
K
-----
E
V
Y
-
I
L
L
N
W
I
-
G
Y
V
N
S
G
F
N
P
L
I
Y
CRS
P
D
F
R
-
I
A
F
Q
E
L
L
C
L
--------------------
19
PsiBlast_PDB
74.51
27%
-137
- C8 -
2VT4
8
ADRB1_MELGA
A:
[24-293]
--------------------------------------------------------
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
-
T
L
V
V
R
G
-----
T
W
---
L
W
G
S
F
L
C
E
L
W
T
-
S
L
D
V
L
C
V
---------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
-
M
M
H
W
W
RDED
P
Q
A
L
-
K
C
Y
Q
-----
D
P
------
G
C
C
D
F
V
-----------
T
-----
N
-
R
-
A
Y
A
-----
I
A
S
--
S
I
I
S
F
Y
I
P
----------
L
L
I
M
I
F
V
A
L
-
R
V
Y
R
E
A
K
E
Q
I
--
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
------
F
F
L
V
N
I
V
----
N
V
F
N
R
DLV--
P
-----
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
----
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------
13
PsiBlast_PDB
72.07
26%
-155
- C8 -
3VGA
1
AA2AR_HUMAN
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
------------------
S
-------
Q
G
C
-
G
-----
E
-
G
-
Q
V
A
C
L
F
ED
V
V
P
--
M
N
Y
M
V
Y
F
N
FFACV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
PL
P
-------
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
------
P
D
C
S
H
-----
A
-----
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------
39
HHSearch
71.97
18%
-129
* C8 *
2Z73
5
OPSD_TODPA
A:
[29-335]
--------------------------------------
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-----
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
---
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
---------
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
-
F
--
G
W
---------
G
A
Y
T
L
E
G--
V
L
------
C
N
C
S
F
D
-------
Y
I
S
-
R
D
S
T
T
R
S
-
N
-
I
L
C
-----
M
F
I
--
L
G
F
F
G
P
I
L
----------
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
--
A
A
M
--
A
K
RLNAKE
L
-----------------------------------------------------------------------------------------------------------------------------------------------------
R
------------------------------------------------------------------------------------------------
K
A
Q
A
G
A
N
A
E
M
--
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
------
Y
A
V
V
A
L
L
----
A
Q
F
G
P
LEWV-
T
-----
P
Y
A
-
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
----
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
9
PsiBlast_PDB
71.91
26%
-140
- C8 -
2YDV
6
?
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
----
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
K
------
E
G
K
A
H
S
-------
Q
G
C
-
G
-----
E
-
G
-
Q
V
A
CLFED
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
--
E
S
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
10
PsiBlast_PDB
71.88
26%
-141
- C8 -
4UG2
3
?
A:
[24-297]
-------------------------------------------------------------
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
-----
L
A
-
I
P
---
F
-----
A
I
---
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
----
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
-
L
--
G
W
N--------
N
C
G
Q
-----
P
K
------
E
G
K
A
H
S
-------
Q
G
C
-
G
-----
E
-
G
-
Q
V
A
CLFED
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
----
C
S
H
A
------
P
-----
L
W
L
-
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
----
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------