@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR82_HUMAN: (2016-01-10 )
MNNNTTCIQPSMISSMALPIIYILLCIVGVFGNTLSQWIFLTKIGKKTSTHIYLSHLVTANLLVCSAMPFMSIYFLKGFQWEYQSAQCRVVNFLGTLSMHASMFVSLLILSWIAISRYATLMQKDSSQETTSCYEKIFYGHLLKKFRQPNFARKLCIYIWGVVLGIIIPVTVYYSVIEATEGEESLCYNRQMELGAMISQIAGLIGTTFIGFSFLVVLTSYYSFVSHLRKIRTCTSIMEKDLTYSSVKRHLLVIQILLIVCFLPYSIFKPIFYVLHQRDNCQQLNYLIETKNILTCLASARSSTDPIIFLLLDKTFKKTLYNLFTKSNSAHMQSYG
Atome Classification :
(20 SA)
-----------------------.......-..10-......----------...20........30........40........50........60.....-.--..70........80........90........-100.--......110....---...120--........130----.......140..--.---...------------.150.......160.-------------.......170.-....--..-180--.....----..190----.-..--..--..200.......--------210--..----.....-220.......----230----------....--------------------------------------.-------------.------------------------------------------------------------------------------------------------------------------------------------------------------------..240......-----------------.250.......260.......270......----.280....-.----------..290.......----------300.......310......----------.320.......330....---------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------MNNNTTC-I
Q
P
--
S
M
I
S
S
M
----------
A
L
P
I
I
Y
I
L
L
C
I
V
G
V
F
G
N
T
L
S
Q
W
I
F
L
T
KIGKKTS
T
H
I
Y
L
S
H
L
V
T
A
N
L
L
V
C
S-A--
M
P
F
M
S
I
Y
F
LKG
F
Q
W
E
YQSA
Q
C
R
V
V
N
F
L
G
T
L
S
M
-
H
A
S
M
--
F
V
S
L
L
I
L
S
W
I
A
I
S
---
R
Y
A
T
L
---
M
QKDSSQ
E
T
T
S
----
C
Y
E
K
I
F
Y
G
H
L
L
K
--
K
---
F
RQ------------P
N
F
A
R
K
L
C
I
Y
I
W
-
G
V
-------------
V
L
G
I
I
I
P
V
T
V
Y
-
Y
S
V
I
--EA-TEG--E
E
S
L
C
----
Y
N
R
Q
M
----
E
-
L
G
--
A
M
--
I
S
Q
I
A
G
L
I
G
T
T
F
--------
I
G
F
--
S
F
----
L
V
V
L
T
-
S
Y
Y
S
F
V
S
H
L
R
----
K
I
-----------
R
T
C
T
--------------------------------------
S
-------------
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
KDL
T
Y
S
S
V
K
-----------------
R
H
L
L
V
I
Q
I
L
L
I
V
C
FL
P
Y
S
I
F
K
P
I
F
Y
V
LHQR----D
N
C
Q
Q
L
N
Y
-
L
----------
I
E
T
K
N
I
L
T
C
L
A
S
----------ARSSTD
P
I
I
F
L
L
L
D
K
T
F
K
K
----------
T
L
Y
N
L
FTKSNSAHMQSYG---------------------------------------------------------------------------------
39
Fugue
87.64
22%
-133
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------------------
S
F
K
C
A
L
T
K
--
T
G
F
Q
F
Y
----------
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
--
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
----
F
-
H
V
N
L
--
Y
G
S
I
L
F
L
T
C
I
S
A
H
---
R
Y
S
G
V
---
V
Y
P
K
S
--------------------
L
G
--
R
---
L
K
K
------------
K
N
-
A
I
C
I
S
V
L
V
W
-
L
I
-------------
V
V
V
A
I
S
P
-
I
L
F
-
Y
S
G
T
--
G
V
-
R
K
N
--
K
T
I
T
C
----
Y
D
T
T
S
----
D
-
E
Y
--
L
R
--
S
Y
F
I
Y
S
M
C
T
T
V
A
--------
M
F
C
--
V
P
----
L
V
L
I
L
-
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
-----------
Y
T
C
T
VCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
-------------
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
E
P
L
R
R
K
S
I
Y
-----------------
L
V
I
I
V
L
T
V
F
A
V
S
-
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
FQTP
A
M
C
A
F
N
D
R
-
V
----------
Y
A
T
Y
Q
V
T
R
G
L
A
S
----------
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
----------
R
--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.79
22%
-139
- C3 -
5C1M
7
?
A:
[11-294]
--------------------------------
S
P
--
S
M
V
T
A
I
----------
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
V
N
Y
L
M
G
-
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
-----
Y
Y
N
M
--
F
T
S
I
F
T
L
C
T
M
S
V
D
---
R
Y
I
A
V
---
C
H
P
V
K
A
L
D
-------------------------
F
R
T
------------
P
R
N
A
K
I
V
N
V
C
N
W
-
I
L
-------------
S
S
A
I
G
L
P
V
-
M
F
-
M
A
T
T
--
K
Y
-
R
Q
G
SI
D
C
T
L
T
----
F
S
H
P
T
----
W
-
Y
W
--
E
N
--
L
L
K
I
C
V
F
I
--------------
F
--
A
F
I
M
P
V
L
I
I
T
V
-
C
Y
G
L
M
I
L
R
L
K
----
S
V
-----------
R
M
L
S
--------------------------------------
G
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
N
L
R
R
I
T
-----------------
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
----
I
Y
V
I
I
K
A
L
----
I
T
I
P
E
T
T
F
-
Q
----------
T
V
S
W
H
F
C
I
A
L
G
Y
----------
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
----------
C
F
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.03
25%
-139
- C3 -
4N6H
23
C562_ECOLX (first)
A:
[121-411]
------------------------------------
S
L
A
L
A
I
----------
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
-----
L
S
I
D
Y
Y
N
M
--
F
T
S
I
F
T
L
T
M
M
S
V
D
---
R
Y
-------------------------
I
A
V
C
H
P
V
K
AL
D
---
F
R
T
------------
P
A
K
A
K
L
I
N
I
C
I
W
-
V
L
-------------
A
S
G
V
G
V
P
I
M
V
--
M
A
V
T
--
R
P
-
R
D
G
----
A
V
V
----
C
M
L
Q
F
----
P
-
S
P
--
S
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
--------
F
A
F
V
V
P
I
----
L
I
I
T
V
-
C
Y
G
L
M
L
L
R
L
R
----
S
V
-----------
R
L
L
S
--------------------------------------
G
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
R
R
I
T
-----------------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
-
I
V
W
T
L
V
D
I
----
D
R
R
D
P
L
---
V
----------
V
A
A
L
H
L
C
I
A
L
G
Y
----------
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
----------
C
F
R
Q
L
C
R
K
P
C
G
----------------------------------------------------------------------------------------
5
PsiBlast_PDB
85.01
25%
-143
- C3 -
4RWD
7
C562_ECOLX (first)
A:
[118-406]
------------------------------------
S
L
A
L
A
I
----------
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
-----
L
S
I
D
Y
Y
N
M
--
F
T
S
I
F
T
L
T
M
M
S
V
D
---
R
Y
-------------------------
I
A
V
C
H
P
V
K
A
L
D
---
F
R
T
------------
P
A
K
A
K
L
I
N
I
C
I
W
-
V
L
-------------
A
S
G
V
G
V
P
I
M
V
--
M
A
V
T
--
R
P
-
R
D
G
----
A
V
V
----
C
M
L
Q
F
----
P
-
S
P
--
S
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
--------
F
A
F
V
V
P
I
----
L
I
I
T
V
-
C
Y
G
L
M
L
L
R
L
R
----
S
V
-----------
R
L
L
S
--------------------------------------
G
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
R
R
I
T
-----------------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
-
I
V
W
T
L
V
D
I
----
D
R
R
D
P
L
---
V
----------
V
A
A
L
H
L
C
I
A
L
G
Y
----------
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
----------
C
F
R
Q
L
C
---------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.57
25%
-143
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[118-406]
------------------------------------
S
L
A
L
A
I
----------
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
-
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-
T
W
P
F
G
E
L
L
C
K
A
V
-----
L
S
I
D
Y
Y
N
M
--
F
T
S
I
F
T
L
T
M
M
S
V
D
---
R
Y
-------------------------
I
A
V
C
H
P
V
K
A
L
D
---
F
R
T
------------
P
A
K
A
K
L
I
N
I
C
I
W
-
V
L
-------------
A
S
G
V
G
V
P
I
M
V
--
M
A
V
T
--
R
P
-
R
D
G
----
A
V
V
----
C
M
L
Q
F
----
P
-
S
P
--
S
W
--
Y
W
D
T
V
T
K
I
C
V
F
L
--------
F
A
F
V
V
P
I
----
L
I
I
T
V
-
C
Y
G
L
M
L
L
--------------------------------------------------------------
G
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
D
R
S
L
R
R
I
T
-----------------
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
-
I
V
W
T
L
V
D
I
----
D
R
R
D
P
L
---
V
----------
V
A
A
L
H
L
C
I
A
L
G
Y
----------
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
----------
C
F
R
Q
L
C
---------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.79
24%
-145
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[131-401]
--------------------------------------------------------
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
-
T
--
L
P
F
Q
G
T
D
I
L
L
G
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
-----
Y
Y
N
M
--
F
T
S
T
F
T
L
T
A
M
S
V
D
---
R
Y
V
A
I
---
C
H
P
--------------------------------
T
------------
S
S
K
A
Q
A
V
N
V
A
I
W
-
A
L
-------------
A
S
V
V
G
V
P
V
A
I
M
-
G
S
A
----
Q
-
V
E
D
--
E
E
I
E
C
----
L
---
V
----
E
-
I
P
--
T
P
--
Q
D
Y
W
G
P
V
F
A
I
C
I
--------
F
L
F
--
S
F
I
V
P
V
L
V
I
S
V
-
C
Y
S
L
M
I
R
R
L
R
----
G
V
-----------
R
L
L
S
--------------------------------------
G
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
D
R
N
L
R
R
I
T
-----------------
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
-----
V
L
A
Q
G
----
L
G
V
Q
P
S
S
E
T
A
----------
V
A
I
L
R
F
C
T
A
L
G
Y
----------
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
----------
C
F
R
------------------------------------------------------------------------------------------------
28
HHSearch
79.73
18%
-137
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
-------
T
A
S
I
W
N
L
C
A
I
S
I
D
---
R
Y
T
A
V
---
V
M
P
V
H
--------------------
Y
Q
--
H
G
T
G
Q
S
S
------------
C
R
R
V
A
L
M
I
T
A
V
W
-
V
L
-------------
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
-------
G
--
D
P
T
V
C
----
S
I
S
N
P
----------------
D
F
V
I
Y
S
S
V
V
S
--------
F
Y
L
--
P
F
----
G
V
T
V
L
-
V
Y
A
R
I
Y
V
V
L
K
----
Q
R
-----------
R
R
K
N
--------------------------------------
I
-------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
G
V
P
L
R
E
K
K
A
T
-----------------
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
----------
H
V
-
S
----------
P
E
L
Y
S
A
T
T
W
L
G
Y
----------
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
----------
A
F
L
K
I
L
S
C
-------------------------------------------------------------------------------------------
21
HHSearch
79.02
20%
-130
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-499]
------------------------------------
A
N
F
N
K
I
----------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
-------
Y
S
S
V
W
I
L
A
F
I
S
L
D
---
R
Y
L
A
I
---
V
H
A
T
--------------------
N
S
Q
--
R
---
P
R
K
------------
L
L
A
E
K
V
V
Y
V
G
V
W
-
I
P
-------------
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
--
E
---
A
D
--
D
R
Y
I
C
----
D
R
F
Y
P
----
N
-
D
L
--
W
---
V
V
V
F
Q
F
Q
H
I
M
V
G
--------
L
I
L
--
P
G
----
I
V
I
L
S
-
C
Y
C
I
I
I
S
K
L
S
----
H
S
-----------
G
S
N
I
--------------------------------------
F
-------------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
G
S
K
G
H
Q
K
R
K
A
L
-----------------
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
-
Q
G
C
E
F
E
N
T
-
V
----------
H
K
W
I
S
I
T
E
A
L
A
F
----------
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
----------
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
----------------------------------------------------------------------------------
25
HHSearch
76.95
17%
-132
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------
V
V
----------
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
--
V
P
F
G
A
A
H
I
L
M
K
-
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
-------
T
A
S
I
E
T
L
C
V
I
A
V
D
---
R
Y
F
A
I
---
T
S
P
F
--------------------
K
Y
Q
--
S
---
L
L
T
------------
K
N
K
A
R
V
I
I
L
M
V
W
-
I
V
-------------
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
---
A
T
-
H
-
Q
--
E
A
I
N
C
----
Y
A
E
E
T
----
C
C
D
F
--
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
--------
F
Y
V
--
P
L
----
V
I
M
V
F
-
V
Y
S
R
V
F
Q
E
A
K
----
R
Q
-----------
L
N
I
F
--------------------------------------
E
-------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
K
F
C
L
K
E
H
K
A
L
-----------------
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-----------
L
I
-
R
----------
K
E
V
Y
I
L
L
N
W
I
G
Y
----------
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
----------
A
F
Q
E
L
L
C
L
-------------------------------------------------------------------------------------------
45
Fugue
76.33
18%
-116
* C4 *
4US3
13
?
A:
[10-450]
-------------------GREQ
W
A
S
R
L
G
F
-
I
L
A
--
A
M
G
S
A
V
----------
G
L
G
N
I
W
R
F
S
Y
V
T
G
E
N
G
G
A
A
F
L
L
V
Y
L
G
F
I
A
L
-
I
G
I
P
I
V
L
A
E
F
T
I
G
R
R
A
Q
S
D
-
A
----------
V
G
S
F
E
K
L
A
P
G
K
P
W
K
V
A
G
L
M
G
V
A
A
G
-
F
L
I
L
--
S
F
Y
G
V
I
A
G
W
I
L
F
Y
---
L
F
N
Y
I
T
GQ
L
W
S
A
P
A
E
G
F
G
G
----
F
F
E
G
F
I
A
N
P
T
L
P
--
L
---
F
W
Q
------------
A
L
F
M
I
A
T
I
W
I
V
A
I
G
V
KKGIERSN
K
I
L
M
P
L
L
G
V
L
L
I
A
L
A
I
-
Y
S
L
T
LG
G
A
-
K
E
G
--
L
A
F
L
F
SPD-
W
S
A
L
K
----
D
-
P
G
--
V
Y
--
L
A
A
I
S
Q
A
F
F
T
L
S
--------
L
G
M
--
G
A
----
L
I
T
Y
G
-
S
Y
V
S
K
D
S
R
L
P
----
G
-------------
A
A
V
--------------------------------------
S
-------------
V
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
L
D
T
A
F
A
-
I
I
-----------------
A
G
I
M
I
F
P
A
V
F
A
L
G
L
S
P
S
G
G
P
G
L
V
F
V
V
L
P
D
I
----
F
D
S
I
R
L
G
P
-
I
----------
V
G
I
A
F
F
I
L
L
G
A
A
----------
A
L
S
S
A
V
S
L
L
E
V
P
V
A
Y
F
M
R
K
F
DWS
R
K
Q
A
A
I
T
L
G
V
I
I
T
L
L
G
I
P
S
S
L
S
F
G
VLGEVTIIPGLN
I
F
D
S
V
D
F
I
A
SSV
F
L
P
L
G
G
M
I
I
A
L
F
I
G
WGWK
T
S
D
A
L
A
E
S
DLTDS
V
W
G
K
L
W
I
L
S
L
R
F
I
A
P
I
A
I
L
I
V
F
L
S
A
F
42
Fugue
73.95
16%
-108
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRSP
F
E
A
P
Q
Y
Y
-
L
A
E
--
P
W
Q
F
S
M
----------
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
-
E
I
A
L
--
W
S
----
L
V
V
L
A
I
E
---
R
Y
V
V
V
---
C
K
P
M
S
N
F
R
F
--------------------------
G
------------
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
-------------
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
---
Y
I
-
P
E
G
--
M
Q
C
S
C
G
I
DY
Y
T
P
H
E
----
E
-
T
N
---------
N
E
S
F
V
I
Y
M
F
--------
V
V
H
--
F
I
----
I
P
L
I
V
-
I
F
F
C
Y
G
Q
L
V
F
----
T
V
-----------
K
E
A
A
--------------------------------------
A
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
-----------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
--
A
F
Y
I
F
T
H
Q
----
G
S
----
D
F
-
G
----------
P
I
F
M
T
I
P
A
F
F
A
K
----------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
----------
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A------------------------------------------------------------------------
23
HHSearch
73.84
17%
-126
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------
V
V
----------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
N
L
Y
T
L
Y
T
V
I
G
-
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
-------
N
A
S
V
M
N
L
L
I
I
S
F
D
---
R
Y
F
C
V
---
T
K
P
L
--------------------
T
Y
P
--
V
---
K
R
T
------------
T
K
M
A
G
M
M
I
A
A
A
W
-
V
L
-------------
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
--
V
G
V
R
T
V
--
E
D
G
E
C
----
Y
I
Q
F
F
----
S
-
N
--------
A
A
V
T
F
G
T
A
I
A
A
--------
F
Y
L
--
P
V
----
I
I
M
T
V
-
L
Y
W
H
I
S
R
A
S
K
----
S
R
-----------
I
N
I
F
--------------------------------------
E
-------------
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
P
P
P
S
R
E
K
K
V
T
-----------------
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-----------
C
I
-
P
----------
N
T
V
W
T
I
G
Y
W
L
C
Y
----------
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
----------
T
F
K
H
L
L
M
--------------------------------------------------------------------------------------------
24
HHSearch
72.81
19%
-135
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-----------------------------------------
M
----------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
--
M
P
M
N
I
L
Y
L
L
M
S
-
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
-------
T
A
S
I
F
S
V
F
I
L
C
I
D
---
R
Y
R
S
V
---
Q
Q
P
L
--------------------
R
Y
L
--
K
---
Y
R
T
------------
K
T
R
A
S
A
T
I
L
G
A
W
-
F
L
-------------
S
F
L
W
V
I
P
I
L
G
--
W
N
H
--------
R
--
R
E
D
K
C
----
E
T
D
F
Y
----
D
-
V
T
--------
W
F
K
V
M
T
A
I
I
N
--------
F
Y
L
--
P
T
----
L
L
M
L
W
-
F
Y
A
K
I
Y
K
A
V
R
----
Q
H
-----------
C
N
I
F
--------------------------------------
E
-------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
L
H
M
N
R
E
R
K
A
A
-----------------
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
-----------
C
-
N
----------
E
H
L
H
M
F
T
I
W
L
G
Y
----------
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
----------
T
F
K
R
I
L
H
I
-------------------------------------------------------------------------------------------
32
HHSearch
70.87
18%
-124
- C3 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
-----------------------------------------
V
----------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
--
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
-------
F
A
S
I
Y
S
M
T
A
V
A
F
D
---
R
Y
M
A
I
---
I
H
P
L
Q
--------------------
P
R
--
L
-----
S
------------
A
T
A
T
K
V
V
I
C
V
I
W
-
V
L
-------------
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
----
E
-
T
M
P
--
S
R
V
V
C
----
M
I
E
W
P
----
E
-
H
P
--
N
K
IY
E
K
V
Y
H
I
C
V
T
V
L
I
--------
Y
F
L
--
P
L
----
L
V
I
G
Y
-
A
Y
T
V
V
G
I
T
L
W
----
A
S
-----------
E
I
P
G
--------------------------------------
D
-------------
S
SDRY--------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Q
V
S
A
K
R
K
V
V
-----------------
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
L
----
Y
---
L
K
K
F
-
I
----------
Q
Q
V
Y
L
A
I
M
W
L
A
M
----------
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
----------
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
---------------------------------------------------------------------------------
30
HHSearch
70.86
15%
-136
- C3 -
3EML
13
ENLYS_BPT4
A:
[20-472]
---------------------------------------
G
S
S
----------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
--
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
-------
Q
S
S
I
F
S
L
L
A
I
A
I
D
---
R
Y
I
A
I
---
R
I
P
L
--------------------
R
Y
N
--
G
---
L
V
T
------------
G
T
R
A
K
G
I
I
A
I
C
W
-
V
L
-------------
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
--
G
Q
-------
S
Q
G
C
----
G
E
G
Q
V
ACLF
E
-
D
V
--
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
--------
V
L
V
--
P
L
----
L
L
M
L
G
-
V
Y
L
R
I
F
L
A
A
R
----
R
Q
-----------
L
N
I
F
--------------------------------------
E
-------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
-
R
S
T
L
Q
K
E
V
H
A
A
-----------------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---------
S
H
A
-
P
----------
L
W
L
M
Y
L
A
I
V
L
S
H
----------
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
----------
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------------------------------------------------------------------------
40
Fugue
70.55
17%
-92
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
-
V
R
S
--
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-
G
--
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
-
E
I
A
L
--
W
S
----
L
V
V
L
A
I
E
---
R
Y
V
V
V
---
C
K
P
M
S
N
F
R
F
--------------------------
G
------------
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
-------------
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
---
I
-
P
E
G
--
M
Q
C
S
C
G
I
DY
Y
T
P
H
E
----
E
-
T
N
------
N
E
S
F
V
I
Y
M
F
V
V
H
--------
F
I
I
--
P
L
----
I
V
I
F
F
-
C
Y
G
Q
L
V
F
T
V
K
----
E
A
-----------
A
A
Q
Q
Q-------------------------------------
E
-------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
-----------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
--
A
F
Y
I
F
T
H
Q
----
G
S
----
D
F
-
G
----------
P
I
F
M
T
I
P
A
F
F
A
K
----------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
----------
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------
26
HHSearch
69.54
16%
-123
* C3 *
2Z73
5
OPSD_TODPA
A:
[31-334]
-------------------------------------
D
A
V
Y
Y
----------
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
-------
F
M
S
I
M
T
M
A
M
I
S
I
D
---
R
Y
N
V
I
---
G
R
P
M
--------------------
A
A
S
--
K
---
K
M
S
------------
H
R
R
A
F
I
M
I
I
F
V
W
-
L
W
-------------
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
---
T
-
L
E
G
--
V
L
C
N
C
----
S
F
D
Y
I
----
S
-
R
D
--
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
--------
F
F
G
--
P
I
----
L
I
I
F
F
-
C
Y
F
N
I
V
M
S
V
S
----
N
H
-----------
E
K
E
M
--------------------------------------
A
A
M
A
K
RLNAKE
L
R
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
G
A
N
A
E
M
R
L
A
-----------------
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
----------
W
V
-
T
----------
P
Y
A
A
Q
L
P
V
M
F
A
K
----------
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
----------
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
---------------------------------------------------------------------------------
43
Fugue
67.76
16%
-133
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------------------------
P
C
-
F
R
E
E
N
A
N
F
N
K
I
----------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
--
L
P
F
W
A
V
D
A
V
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
-
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
HAT
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
--
A
---
N
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
-
H
I
-------------
M
V
G
L
I
L
P
G
I
V
I
-
L
S
C
Y
--
C
I
-
I
I
S
--
K
L
S
H
-------
S
G
S
----
N
-
I
F
--
E
M
--
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
I
--
G
H
----
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
----
K
A
IGRNTNGVIT
K
D
E
A
E
--------------------------------------
K
-------------
L
------------------------------------------------------------------------------------------------------------------------------------------------------------
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
----
R
W
D
E
A
A
V
N
-
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
----------
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ---------------------
27
HHSearch
65.21
16%
-133
- C3 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
------------------------------------
K
E
N
S
I
K
----------
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
-
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
-------
S
A
S
V
F
S
L
L
A
I
A
I
E
---
R
Y
I
T
M
---
L
K
---------------------------------
N
------------
N
F
R
L
F
L
L
I
S
A
C
W
-
V
I
-------------
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
I
-------
S
--
A
L
S
S
C
----
S
T
V
L
P
----
L
-
Y
H
--------
K
H
Y
I
L
F
C
T
T
V
--------
F
T
L
--
L
L
----
L
S
I
V
I
-
L
Y
C
R
I
Y
S
L
V
R
----
T
R
-----------
N
I
F
E
--------------------------------------
M
-------------
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
A
S
R
S
S
E
N
V
A
L
L
-----------------
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
---------
T
C
D
-
I
----------
L
F
R
A
E
Y
F
L
V
L
A
V
----------
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
----------
A
F
I
R
I
M
G
R
P
L
-----------------------------------------------------------------------------------------
31
HHSearch
64.21
17%
-89
- C3 -
1U19
14
OPSD_BOVIN
A:
[39-328]
---------------------------------------
Q
F
S
----------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
--
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
-------
E
I
A
L
W
S
L
V
V
L
A
I
E
---
R
Y
V
V
V
---
C
K
P
M
S
--------------------
N
F
--
R
---
F
-
G
------------
E
N
H
A
I
M
G
V
A
F
T
W
-
V
M
-------------
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
--
I
--
P
E
G
--
M
Q
C
S
C
----
G
I
D
Y
Y
----
T
-
P
H
EE
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
--------
F
I
I
--
P
L
----
I
V
I
F
F
-
C
Y
G
Q
L
V
F
T
V
K
----
E
A
-----------
A
A
Q
Q
--------------------------------------
Q
-------------
E
S-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
V
T
-----------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
----------
S
D
F
-
G
----------
P
I
F
M
T
I
P
A
F
F
A
K
----------
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
----------
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
---------------------------------------------------------------------------------