@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MAS1L_HUMAN: (2016-01-11 )
MVWGKICWFSQRAGWTVFAESQISLSCSLCLHSGDQEAQNPNLVSQLCGVFLQNETNETIHMQMSMAVGQQALPLNIIAPKAVLVSLCGVLLNGTVFWLLCCGATNPYMVYILHLVAADVIYLCCSAVGFLQVTLLTYHGVVFFIPDFLAILSPFSFEVCLCLLVAISTERCVCVLFPIWYRCHRPKYTSNVVCTLIWGLPFCINIVKSLFLTYWKHVKACVIFLKLSGLFHAILSLVMCVSSLTLLIRFLCCSQQQKATRVYAVVQISAPMFLLWALPLSVAPLITDFKMFVTTSYLISLFLIINSSANPIIYFFVGSLRKKRLKESLRVILQRALADKPEVGRNKKAAGIDPMEQPHSTQHVENLLPREHRVDVET
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100--.......110.......120....-...130.......140....-.--..150.......160.......170.......180..---.....190.......200.......210......-----.------.220-------.--------------......230.......240....-----------...250...-------------------------------------------------------------------------------------------------------------------------------------------------------------------....260..-.....270.......280......-.-------------290----------.--.....-----------...300-...-.....310.......320........330.......340.......350.......360.......370......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVW
G
K
I
C
W
F
SQRA
G
W
T
V
F
A
E
S
Q
I
S
L
S
C
S
L
C
LHSGDQEAQN
P
N
L
V
S
Q
L
C
G
V
F
L
QNETN
E
T
I
H
M
Q
M
S
M
AVGQQAL
P
L
N
IIA
P
K
A
V
L
V
S
L
C
G
V
L
LNG
T
V
F
W
L
L
C
C--GATN
P
Y
M
V
Y
I
L
H
L
V
A
A
D
V
I
Y
L
C
C
S
-
A
V
G
F
L
Q
V
T
L
L
TYH
G
V
V
F
F
I
P
-
D
--
F
L
A
I
LSP
F
S
F
E
V
C
L
C
L
L
V
A
ISTE
R
C
V
C
V
L
F
P
I
W
Y
R
CH---RPKYTSN
V
V
C
T
L
I
WG
L
P
F
C
I
N
I
V
K
S
L
F
-
L
T
Y
W
K
H
-----
V
------
K
A
C
V
-------
I
--------------
F
L
K
L
S
G
L
F
H
A
I
L
S
L
V
M
C
V
S
S
L
T
L
-----------
L
I
R
F
L
CCSQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------QQKA
T
R
V
Y
A
-
V
V
Q
ISA
P
M
F
L
L
WAL
P
L
S
V
A
P
L
I
T
D
-
F
-------------
K
------------
M
--
F
V
T
T
S
-----------
Y
L
I
S
L
--
F
L
I
-INSSAN
P
I
I
Y
F
F
V
G
S
L
R
-
K
K
R
L
K
E
S
L
R
V
I
L
Q
R
ALADKPEVGRNKKAAGIDPMEQPH
S
T
Q
H
V
E
N
LLPREHRVDVET
9
HHSearch
84.62
19%
-154
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
--------------------------------------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
NR
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
-
G
Y
W
-
P
L
G
P
V
-
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
VRTVE
D
------
G
E
C
Y
-------
I
QFFSN
A
A
V
------
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
S
R
E
K
K
V
T
R
-
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
-
F
CAP----------
C
------------
I
--
P
N
T
V
W
-----------
T
I
G
Y
W
--
L
C
Y
-
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
-
K
K
T
F
K
H
L
L
M
------------------------------------------------
16
HHSearch
81.74
18%
-147
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
--------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
-
A
A
C
H
G
-
C
L
-
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-----
S
------
Q
G
C
G
EGQVACL
F
EDVVP
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----------
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
Q
K
E
V
H
A
A
K
-
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
-
F
CPDCS--------
H
------------
A
--
P
L
W
L
M
-----------
Y
L
A
I
V
--
L
S
H
-
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
-
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------
12
HHSearch
79.13
15%
-146
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-498]
------------------------------------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
QK
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
--
A
N
W
-
Y
F
G
N
F
-
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
E
A
-----
D
D
R
----
Y
I
C
D
-------
R
F
Y
PN
D
L
W
V
V
V
F
---
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
-----------
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
-
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
-
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
------------
T
--
V
H
K
W
I
-----------
S
I
T
E
A
--
L
A
F
-
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
-
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------------
19
HHSearch
78.10
16%
-152
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-325]
--------------------------------------------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
-
G
Y
F
-
V
F
G
P
T
-
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
-----
E
GMQ---
C
S
C
G
-------
I
DYYTPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----------
V
F
T
V
K
E
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-
T
H
QGS---------
D
------------
F
--
G
P
I
F
M
-----------
T
I
P
A
F
--
F
A
K
-
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
-
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------
14
HHSearch
77.66
16%
-143
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
---------------------------------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
-
S
K
W
-
S
L
G
R
P
-
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
----RR---
E
------
D
K
C
E
-------
T
DFYDV
T
W
F
------
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
-----------
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
N
R
E
R
K
A
A
K
-
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
-
F
CKN----------
C
------------
C
--
N
E
H
L
H
-----------
M
F
T
I
W
--
L
G
Y
-
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
-
K
K
T
F
K
R
I
L
H
I
-----------------------------------------------
13
HHSearch
77.54
15%
-156
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
--------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
FE
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
-
K
M
W
-
T
F
G
N
F
-
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
---
A
I
N
C
Y
A
E
E
T
C
C
-------
D
FFTN
Q
A
Y
-------
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-----------
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
L
K
E
H
K
A
L
K
-
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
-
I
QDN----------
L
------------
I
--
R
K
E
V
Y
-----------
I
L
L
N
W
--
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
-
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------
18
HHSearch
77.43
16%
-151
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
ER
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
-
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
G
D
-----
P
------
T
V
C
S
-------
I
SN
P
D
F
---------
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
-----------
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGV
P
L
R
E
K
K
A
T
Q
-
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
-
H
CQTC---------
H
------------
V
--
S
P
E
L
Y
-----------
S
A
T
T
W
--
L
G
Y
-
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
-
R
K
A
F
L
K
I
L
S
C
-----------------------------------------------
11
HHSearch
75.08
14%
-148
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-337]
-------------------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
TK
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
-
I
F
G
F
A
-
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
-----
E
GVL---
C
N
C
S
-------
F
DYISRD
S
T
T
R
S
N
--
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-----------
V
M
S
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
N
A
E
M
R
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
-
F
GPLE---------
W
------------
V
--
T
P
Y
A
A
-----------
Q
L
P
V
M
--
F
A
K
-
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
-
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---------------------
21
HHSearch
71.32
19%
-135
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[39-322]
--------------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
SR
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
L
-
P
I
W
-
A
A
S
K
V
--
N
G
W
-
I
F
G
T
F
-
L
CK
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
-
R
Q
A
Y
H
P
-----
N
NSS---
P
V
C
Y
-------
E
VLGNDTAKWRMVL-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-----------
L
R
T
L
F
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
K
H
R
A
M
R
-
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
-
L
M
------------
R
TQVIQE
S
C
E
R
R
N
N
--
I
G
R
A
L
-----------
D
A
T
E
I
--
L
G
F
-
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
-
R
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------
4
PsiBlast_PDB
68.58
19%
-173
- C2 -
4XT1
13
US28_HCMVA
A:
[78-318]
---------------------------------------------------------------------------------------------------------------
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
L
-
P
---
L
W
M
Q
Y
L
L
D
-----
S
V
P
C
T
--
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
----
Y
Y
A
I
V
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
--
I
F
A
V
I
I
A
I
P
H
F
-
M
V
V
T
K
K
-----
D
------
N
Q
C
M
-------
T
DYD-----------
Y
L
E
V
S
--
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
H
K
G
R
I
V
R
-
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
-
L
-------------
K
------------
L
L
K
W
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
--
L
A
F
-
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
-
R
Q
E
L
H
C
L
L
A
E
F
R
---------------------------------------------
20
HHSearch
67.84
15%
-143
- C2 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
--------------------------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
-
Y
Y
G
L
F
Y
C
K
-
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
M
-----
P
SR----
V
V
C
M
-------
I
EWPEHPNKIY
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-----------
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
A
K
R
K
V
V
K
-
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
-
I
N------------
P
DLYLKK------
F
--
I
Q
Q
V
Y
-----------
L
A
I
M
W
--
L
A
M
-
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
-
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----
5
PsiBlast_PDB
65.78
19%
-161
- C2 -
4XT3
2
US28_HCMVA
A:
[78-316]
---------------------------------------------------------------------------------------------------------------
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
L
-
P
---
L
W
M
Q
Y
L
L
D
H
---
A
S
V
P
C
T
--
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
----
Y
Y
A
I
V
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
F
S
I
F
W
W
--
I
F
A
V
I
I
A
I
P
H
F
-
M
V
V
T
K
K
-----
D
------
N
Q
C
M
-------
T
DYD-----------
Y
L
E
V
S
--
Y
P
I
I
L
N
V
E
L
M
L
G
A
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
R
I
S
R
I
V
A
V
S
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
H
K
G
R
I
V
R
-
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
T
L
F
V
D
T
-
L
-------------
K
------------
L
L
K
W
I
S
S
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
--
L
A
F
-
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
-
R
Q
E
L
H
C
L
L
A
E
-----------------------------------------------
10
HHSearch
59.72
13%
-147
- C2 -
3V2Y
1
ENLYS_BPT4
A:
[62-495]
-------------------------------------------------------------------------
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
TK
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
-
K
L
T
P
A
Q
W
F
-
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
G
-
W
N
C
I
S
A
-----
L
------
S
S
C
S
-------
T
VLPLYH
K
H
------
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
-----------
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
--
S
S
E
N
V
A
L
L
K
-
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
-
G
CKVKT--------
C
------------
D
--
I
L
F
R
A
-----------
E
Y
F
L
V
--
L
A
V
-
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
-
R
R
A
F
I
R
I
M
G
R
P
L
---------------------------------------------
7
PsiBlast_PDB
46.92
28%
-67
- C2 -
4S0V
1
A:
[451-542]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
M
S
F
S
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
R
A
R
R
K
T
A
R
M
L
M
V
V
L
L
V
F
A
I
C
Y
L
P
I
S
I
L
N
V
L
K
R
V
F
-------------
G
------------
M
--
F
A
H
--DR
E
T
V
Y
A
W
---
F
T
F
S
H
--
W
L
V
Y
A
N
S
A
A
N
P
I
I
Y
N
F
L
S
G
K
F
-
R
E
E
F
K
A
A
F
S
C
-----------------------------------------------
34
Fugue
43.56
18%
-28
- C2 -
1YKH
-
MED7_YEAST
A:
[111-205]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Y
K
I
Q
E
L
R
K
-
L
L
K
S
L
L
L
N
Y
L
E
L
I
G
V
L
S
I
N
P
D
M
Y
E
-
R
-------------
K
------------
V
--
E
N
I
R
T
-----------
I
L
V
N
I
--
H
H
L
-
L
N
E
------------
Y
R
-
P
H
Q
S
R
E
S
L
I
M
L
L
E
E
Q
L
E
Y
K
R
G
E
I
R
E
I
E
Q
V
C
K
Q
V
H
D
K
L
T
S
------------------
33
Fugue
40.37
16%
-13
- C1 -
2K5N
-
?
A:
[1-74]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------
A
------------
M
--
N
G
T
I
T
-----------
T
W
F
K
D
K
G
F
G
F
-
I
K
D
E
N
G
D
N
R
Y
F
H
V
I
K
V
A
N
P
D
L
I
K
K
D
A
A
V
T
F
E
P
T
T
N
N
K
G
L
S
A
Y
A
V
K
V
V
P
L
E
H
H
H
H
H
H
-------------------
31
Fugue
37.98
21%
226
* C2 *
1W5K
-
GCN4_YEAST
A:
[2-34]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
M
R
Q
I
E
D
R
L
E
E
I
L
S
K
L
H
H
I
C
N
E
L
A
R
I
R
R
L
L
G
E
R
-------------------------
30
Fugue
37.21
28%
178
- C2 -
1ZTA
-
?
?:
[1-35]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
R
-
M
K
Q
L
E
D
K
V
E
E
L
L
S
K
N
Y
H
L
E
N
E
V
A
R
L
K
K
L
V
G
E
R
-------------------------
28
Fugue
36.36
23%
201
- C2 -
1IHQ
-
GCN4_YEAST (first)
A:
[1-38]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
G
S
S
S
-
L
E
A
V
R
R
K
I
R
S
L
Q
E
Q
N
Y
H
L
E
N
E
V
A
R
L
K
K
L
V
G
E
R
-------------------------
35
Fugue
35.21
17%
169
- C2 -
3EAB
-
CHM1B_HUMAN
G:
[148-196]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
D
M
L
L
Q
E
M
A
D
E
A
G
L
D
T
G
S
V
G
T
S
V
A
S
A
E
Q
D
E
L
S
Q
R
L
A
R
L
R
----------