@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NMBR_HUMAN: (2016-01-11 )
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100...-....110.......120.......130.......140......---.150.--.---.....160.......170.......180....-....190........200.----......-210.......220.......230.......240.......--------------------------------250------------------------------------------------------------------------------------------------------------------------------------.------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------.---------------.--------.....260...-....270.......280.......290....-----....300..--...-..310.-......320.......330.......-340-.------........350.......360........370.......380.........390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPSKSLS
N
L
S
V
TTGANESGSVPEGWERDFLPASDG
T
T
T
E
L
V
I
R
C
V
I
P
S
L
Y
L
L
I
I
T
V
G
L
LG
N
I
M
L
V
K
I
F
IT
N
S
A
M
R
S
V
P
N
I
F
I
S
NLAAG
D
L
L
L
L
L
T
CVPVD
A
S
R
Y
F
-
F
D
E
W
M
F
GKVG
C
K
L
I
P
V
I
Q
L
TSVG
V
S
V
F
T
L
T
ALSA
D
R
Y
R
A
IVNP---MDMQT--S---
G
A
L
L
R
T
C
V
K
A
M
G
I
W
V
V
S
V
L
L
AV
P
E
A
V
F
-
S
E
V
A
-
R
I
S
SL-DNSS
F
T
A
CIPYPQ----TD
E
L
H
P
-
K
I
H
S
V
L
I
F
L
V
Y
F
L
I
P
L
A
I
I
S
I
Y
Y
Y
H
I
A
K
T
L
I
K
S
A
HNLPGE--------------------------------
Y
--------------------------------------------------------------------------------------------------------------------------------------
N
------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------
H
---------------
T
--------
K
K
Q
M
E
T
R
K
R
L
A
-
K
I
V
L
V
F
V
G
C
F
I
F
C
WFPN
H
I
L
Y
M
Y
RSF-NYNE-----IDP
S
L
G
H
M
I
--
V
T
L
-
V
A
R
V
L
S
-
F
G
N
SC
V
N
P
F
A
L
Y
L
L
S
E
S
F
R
R
HFNSQL-C---C------G
R
K
S
Y
Q
ERGT
S
Y
L
LSSS
A
V
-
R
M
T
S
LKSN
A
K
N
MVT
N
S
V
L
LN--G
H
S
M
K
Q
E
MAL
4
PsiBlast_PDB
89.93
27%
-133
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[95-406]
-------------
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
--
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
A
K
---
A
K
L
I
N
I
C
-----
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-----
V
T
R
P
-
R
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
Y
W
D
-
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
S
--------
K
E
K
D
R
S
L
R
R
I
T
-
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
-----
R
D
P
L
V
V
A
A
L
--
H
L
C
-
I
A
--
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-
Q
L
-
C
--------------------------------------------------------------
5
PsiBlast_PDB
89.28
28%
-141
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[118-414]
-----------------------------------
S
A
S
S
L
A
L
A
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
VKA
L
D
F
R
T
P
A
K
---
A
K
L
I
N
I
C
-----
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-----
V
T
R
P
-
R
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
Y
W
D
-
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
L
L
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
S
--------
K
E
K
D
R
S
L
R
R
I
T
-
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
-----
R
D
P
L
V
V
A
A
L
--
H
L
C
-
I
A
--
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-
Q
L
-
C
R
K
P
C
------
G
---------------------------------------------------
3
PsiBlast_PDB
89.23
27%
-138
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[95-406]
-------------
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
G
A
R
S
A
S
S
L
A
L
A
I
--
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
A
K
---
A
K
L
I
N
I
C
-----
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
-----
V
T
R
P
-
R
D
G
A
V
V
C
M
L
Q
F
P
S
----
P
S
W
Y
W
D
-
T
V
T
K
I
C
V
F
L
F
A
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
---------------
S
--------
K
E
K
D
R
S
L
R
R
I
T
-
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
-----
R
D
P
L
V
V
A
A
L
--
H
L
C
-
I
A
--
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
-
Q
L
-
C
--------------------------------------------------------------
1
PsiBlast_PDB
88.57
27%
-131
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[121-405]
--------------------------------------
P
L
G
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
-
L
P
F
Q
G
T
D
I
L
-
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-------
T
--
S
---
S
---
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-
G
S
-----
A
Q
V
-
E
D
E
E
I
E
C
L
V
E
I
P
T
----
P
Q
D
Y
W
G
-
P
V
F
A
I
C
I
F
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-
R
G
V
R
L
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------
R
E
K
D
R
N
L
R
R
I
T
-
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
-
G
--------
V
Q
P
S
S
E
T
A
V
--
A
I
L
R
F
C
T
A
L
G
-
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------------------------------------
25
HHSearch
87.20
24%
-121
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-496]
----------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
---
T
N
S
Q
R
--
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
S
-
E
------
A
D
D
R
Y
I
C
D
R
F
Y
P
----
N
D
L
-
W
V
-
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
--------------------------------
L
--------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-------------------------------------------------------------------------------------------------
A
---------------
Y
--------
G
S
K
G
H
Q
K
R
K
A
L
-
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
-
I
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
--
W
I
S
-
I
T
E
A
L
A
-
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
-
T
---
S
------
G
R
P
L
E
V
L
F
Q
-------------------------------------------
27
HHSearch
87.02
19%
-122
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
---
L
R
Y
L
K
--
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
-----------
R
R
E
D
K
C
E
T
D
F
Y
----
D
V
-----
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
--------------------------------------------------------------------------------------------------------------------------------------
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
--------------------------------------------------
T
P
------------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTWD
A
--------
Y
L
H
M
N
R
E
R
K
A
A
-
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
-
C
K
N
C
------
C
N
----
E
H
--
L
H
M
-
F
T
I
W
L
G
-
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
-
H
---
I
----------------------------------------------------------
26
HHSearch
87.00
23%
-119
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
---
F
K
Y
Q
S
--
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
-
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
---------
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
--------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
A
K
R
V
I
T
T
F
R
TGTW-----------------------------------------------------------------------------------
D
---------------
A
--------
Y
K
F
C
L
K
E
H
K
A
L
-
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
-
Q
D
N
L
------
I
----
R
K
E
--
V
Y
I
-
L
L
N
W
I
G
-
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
-
C
---
L
----------------------------------------------------------
28
HHSearch
86.51
22%
-117
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-471]
-------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
---
L
R
Y
N
G
--
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
C
-
G
Q
--------
S
Q
G
C
G
E
G
Q
V
ACLF
E
D
V
V
P
M
-
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
--------------------------------
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW---------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
A
---------------
Y
--------
R
S
T
L
Q
K
E
V
H
A
A
-
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-
C
P
D
C
-------
S
H
-
A
P
L
W
--
L
M
Y
-
L
A
I
V
L
S
-
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-
R
---
S
------
H
V
L
R
Q
-----------------------------------------------
24
HHSearch
85.49
20%
-112
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
---
L
T
Y
P
V
--
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
-
V
G
V
---
R
T
V
E
D
G
E
C
Y
I
Q
F
F
----
S
----
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
--------------------------------
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKS----------------------------------------------------------------------------------------------------------
P
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
-------------------------------------------------------------------------------------------------------------------------------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
---------------
A
--------
Y
P
P
P
S
R
E
K
K
V
T
-
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
-
C
A
P
C
------
I
P
----
N
T
--
V
W
T
-
I
G
Y
W
L
C
-
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
-
M
--------------------------------------------------------------
34
HHSearch
82.92
21%
-125
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
---
V
H
Y
Q
H
--
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
T
-
G
--------
D
P
T
V
C
S
I
S
N
P
------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
--------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW---------------------------------------------------------------------------------
D
---------------
A
--------
Y
G
V
P
L
R
E
K
K
A
T
-
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
-
C
Q
T
C
-------
H
--
V
S
P
E
--
L
Y
S
-
A
T
T
W
L
G
-
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
-
S
---
C
----------------------------------------------------------
19
PsiBlast_PDB
82.03
23%
-129
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
18
PsiBlast_PDB
81.69
23%
-130
- C2 -
2Y04
13
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
20
PsiBlast_PDB
81.57
23%
-129
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
45
Fugue
81.19
21%
-96
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------
S
F
K
C
A
L
T
K
T
G
F
---------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
---
K
S
L
G
R
--
L
---
K
K
K
N
A
I
C
I
S
V
L
-
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
-----
T
G
V
-
R
K
N
K
T
I
T
C
Y
D
T
T
S
----
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
T
--------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------
C
------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------
Y
---------------
I
Y
N
PEDGDP
D
N
G
V
N
P
G
T
D
F
K
-
D
I
V
C
P
L
C
G
--------------
V
G
K
D
-
Q
F
E
E
-----
V
E
E
P
L
R
R
K
S
--
I
Y
L
-
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
-
M
---
C
------
A
F
N
--
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
-
S
L
N
S
C
V
--------
N
P
I
L
Y
F
LA
G
D
T
F
R
R
R
---
15
PsiBlast_PDB
81.13
23%
-128
- C2 -
2Y01
12
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
14
PsiBlast_PDB
81.11
23%
-130
- C2 -
2Y00
13
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
6
PsiBlast_PDB
81.09
27%
-139
- C2 -
5C1M
7
?
A:
[13-296]
--------------------------------------
S
M
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
T
S
T
-
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
R
T
P
R
N
---
A
K
I
V
N
V
C
N
-----
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-
A
T
T
K
Y
R
Q
G
S
I
-
D
C
T
-----
L
T
F
S
H
----
P
T
W
Y
W
E
-
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
L
-
K
S
V
R
M
L
S
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------
K
E
K
D
R
N
L
R
R
I
T
-
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
---
I
T
-----
I
P
E
T
T
F
Q
T
V
--
S
W
H
-
F
C
I
A
L
G
-
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------------------------------------
16
PsiBlast_PDB
81.08
23%
-130
- C2 -
2Y02
13
ADRB1_MELGA
A:
[17-300]
------------------------------------------------
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
---
F
R
Y
Q
S
--
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
R
-
D
-----
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C---
C
D
F
V
T
N
-
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
-
N
R
D
L
-----
V
P
D
W
L
-------
F
V
-
A
F
N
W
L
G
-
Y
A
N
S
A
M
N
P
I
-
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
-
A
--------------------------------------------------------------
9
PsiBlast_PDB
80.90
24%
-102
- C2 -
2KSB
1
NK1R_HUMAN
A:
[56-362]
------------------------------------------------------------------
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
---
L
Q
P
R
L
--
S
---
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
-
T
M
P
-----
S
R
V
V
C
M
I
E
W
P
E
H---
P
N
K
I
Y
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--
E
I
P
G
D
--------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
R
---------------
Y
--------
H
E
Q
V
S
A
K
R
K
V
V
-
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
-
P
Y
I
N
-----
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
-
A
I
M
W
L
A
-
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
---
C
PFISAG
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------
8
PsiBlast_PDB
80.90
24%
-102
- C2 -
2KSA
1
NK1R_HUMAN
A:
[56-362]
------------------------------------------------------------------
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
---
L
Q
P
R
L
--
S
---
A
T
A
T
K
V
V
I
C
V
--
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
-
T
M
P
-----
S
R
V
V
C
M
I
E
W
P
E
H---
P
N
K
I
Y
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--
E
I
P
G
D
--------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------
S
------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------
R
---------------
Y
--------
H
E
Q
V
S
A
K
R
K
V
V
-
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
---
L
-
P
Y
I
N
-----
P
D
L
Y
L
K
K
F
I
Q
Q
V
Y
L
-
A
I
M
W
L
A
-
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
---
C
PFISAG
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------