@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NPY5R_HUMAN: (2016-01-11 )
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
Atome Classification :
(20 SA)
.........10........20........30........40........50.....---...60........70........80........90...-.....100.......110.......120.......130.......140.....--.--.-150--.-........160....-...170........180.--.......190........----200..---.---.--...210.......220.........230.......240.......250-----........260...------....270.........280-------------...------------------....290.....------..300....---------...310---------...--......320-------........---------330..------.....340.......350-----------.........360---------.-----------........370.......380.......390----..-------.------....------.400...-....410.......420.......430.......440----.....----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDL
E
L
D
E
Y
Y
N
K
TLATENNTAATRNSDFPV
W
D
D
Y
KS
S
V
D
D
L
Q
Y
F
L
I
G
L
Y
T
F
V
S
L
L
G
F
---
M
G
N
L
L
I
L
M
A
L
M
K
KRNQK
T
T
V
N
F
L
I
G
N
L
A
F
S
D
I
L
V
V
L
FC-S
P
F
T
L
T
S
V
L
L
D
Q
W
M
F
G
K
V
M
C
H
I
M
P
F
L
Q
C
V
S
V
L
V
S
T
L
I
L
I
S
I
A
I
V
R
Y
H
M
I
KHPI--S--N-N----L-TANH
G
Y
F
L
I
A
T
V
W
T
L
-
G
F
A
IC-S
P
L
P
V
F
H
S
L
-
V
E
--
L
Q
E
T
F
G
S
A
L
-
L
SS
R
Y
L
C
V
----ESWPS---D---
S
--
Y
R
I
A
F
T
I
S
L
L
L
V
Q
Y
--
I
L
P
L
V
C
L
TV
S
H
T
S
V
C
R
S
I
SCGLSNKENRLEE------N
E
M
I
N
L
T
LHPSKKS------G
P
Q
V
K
--
L
SGSHKW
S
Y
S
F
I
-------------
K
K
H
------------------
R
R
R
YSKK
T
A
C
V
L------PAPERPSQE---------NHSR-----------IL
P
--
E
N
F
G
S
V
R
S
--------
Q
LSSSSKF---------IPGVP------
T
C
F
E
IKPEENS
D
V
H
E
L
-------------
R
V
K
R
S
V
T
R
I
K
-----------
K
-----------
R
S
R
S
V
F
Y
R
L
T
I
L
I
L
V
F
A
V
S
W
M
P
L
H
L
F
H
V
V
T-----DF-------N------DNLI------SNRH
F
K
L
-
V
Y
C
I
C
H
L
L
G
M
M
S
C
C
L
N
P
I
L
Y
G
F
L
NNG
I
K
A
D
L
V
S
L
I
------
H
C
LHM----------------------
7
PsiBlast_PDB
89.12
20%
-122
- C9 -
3PDS
8
ADRB2_HUMAN (first)
A:
[6-430]
----------------------------------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-
L
P
I
Q
M
H
W
Y
R
-
A
T
--
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
----
D
F
F
T
N
---
Q
---
A
--
Y
A
I
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
YYTIGI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYKFCL-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
----
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------
L
--------------------------
20
PsiBlast_PDB
88.63
20%
-134
- C9 -
3OE8
1
CXCR4_HUMAN (first)
A:
[50-479]
------------------------------------------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
---
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
-
P
F
W
A
V
D
A
V
A
--
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
--
S
-
Q
R
P
R
K
L
-
L
A
E
K
V
V
Y
V
--
G
V
W
I
P
-
A
L
L
L
T
-
I
P
D
F
I
F
A
N
V
-
S
E
--
A
D
D
----------
R
Y
I
C
D
----
R
F
Y
P
N
---
D
---
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
--
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
YYTIGI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYH----
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
-----
S
F
I
L
L
EIIK
Q
------
G
C
E
F
------
E
N
T
V
H
K
W
-
I
-
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
---------------------------------------------
4
PsiBlast_PDB
88.24
20%
-120
- C9 -
3NY8
7
ENLYS_BPT4
A:
[40-462]
------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
-
G
L
T
-
S
F
L
P
I
--
Q
M
-
H
W
--
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----
D
F
F
T
N
---
Q
---
A
--
Y
A
I
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYKFCL-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
----
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------
L
--------------------------
3
PsiBlast_PDB
88.13
20%
-125
- C9 -
3D4S
6
ENLYS_BPT4
A:
[40-462]
------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
-
G
L
T
-
S
F
L
P
I
--
Q
M
-
H
W
--
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----
D
F
F
T
N
---
Q
---
A
--
Y
A
I
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
YYTIGI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYKFCL-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
----
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------
L
--------------------------
6
PsiBlast_PDB
87.45
20%
-123
- C9 -
3NYA
3
ADRB2_HUMAN (first)
A:
[40-462]
------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
-
G
L
T
-
S
F
L
P
I
--
Q
M
-
H
W
--
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----
D
F
F
T
N
---
Q
---
A
--
Y
A
I
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYKFCL-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
----
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------
L
--------------------------
5
PsiBlast_PDB
86.60
20%
-124
- C9 -
3NY9
4
ADRB2_HUMAN (first)
A:
[40-462]
------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
-
G
L
T
-
S
F
L
P
I
--
Q
M
-
H
W
--
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
----
D
F
F
T
N
---
Q
---
A
--
Y
A
I
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
-
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
YYTIGI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
TP
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYKFCL-
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
----
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
------
L
--------------------------
19
PsiBlast_PDB
86.46
20%
-131
- C9 -
3ODU
6
CXCR4_HUMAN (first)
A:
[50-484]
------------------------------------------
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
---
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
L
-
P
F
W
A
V
D
A
V
A
--
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
--
S
-
Q
R
P
R
K
L
-
L
A
E
K
V
V
Y
V
--
G
V
W
I
P
-
A
L
L
L
T
-
I
P
D
F
I
F
A
N
V
-
S
E
--
A
D
D
----------
R
Y
I
C
D
----
R
F
Y
P
N
---
D
---
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
--
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
GI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
------------------
I
G
R
N
T
N
G
V
I
T
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
-----------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
-----------
V
A
G
F
T
------
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
-----
S
F
I
L
L
EI
I
K
Q
------
G
C
E
F
------
E
N
T
V
H
K
W
-
I
-
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
------
T
S
G
R
P
----------------------
85
Fugue
85.01
20%
-116
- C8 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-----------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
---
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
-
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
NS
Q
--
R
-
P
----
R
-
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
-
A
L
L
L
T
-
I
P
D
F
I
F
A
N
V
-
S
E
--
A
D
----------
D
R
Y
I
C
D
----
R
F
Y
P
N
---
D
---
L
--
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
--
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
------
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
GI
G
H
L
L
T
--
K
S
P
S
L
N
A
A
K
S
E
L
-------------
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
L
D
A
V
---------
R
R
A
A
-----------
L
I
N
--
M
V
F
Q
M
G
E
T
--------
G
V
A
G
F
T
N
S
---------
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
-------------
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
-----------
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
-----
S
F
-------
I
L
L
EI
I
K
Q
G
C
E
------
F
E
N
T
V
H
K
-
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
TSGRPL
E
V
L
F
Q
----------------------
15
PsiBlast_PDB
81.52
19%
-108
- C9 -
4IAR
2
C562_ECOLX
A:
[20-396]
----------------------------------------
K
V
L
L
V
M
L
L
A
L
I
T
L
A
T
T
---
L
S
N
A
F
V
I
A
T
V
Y
R
T
R
K
L
H
T
P
A
N
Y
L
I
A
S
L
A
V
T
D
L
L
V
S
I
L
V
-
M
P
I
S
T
M
Y
T
V
T
G
R
W
T
L
G
Q
V
V
C
D
F
W
L
S
S
D
I
T
C
C
T
A
S
I
W
H
L
C
V
I
A
L
D
R
Y
W
A
I
T
D
A
V
E
Y
S
--
A
-
K
----
R
-
T
P
K
R
A
A
V
M
I
A
L
V
W
V
F
-
S
I
S
I
S
-
L
P
-
P
F
F
W
R
Q
-
A
--------
S
E
C
V
-
V
N
T
D
H
------------------------
I
L
Y
T
V
Y
S
T
V
G
A
F
--
Y
F
P
T
L
L
L
I
A
L
Y
G
R
I
Y
V
E
A
R
S
R
I
A
D
L
E
D
N
W
E
T
L
-----
N
D
--
N
L
K
V
I
E
K
A
D
N
------
A
A
Q
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
-------------
K
A
T
------------------
P
P
K
L
E
D
K
S
------------
P
D
S
P
E
M
K
---------
D
F
R
H
-----------
G
F
D
--
I
L
V
G
Q
I
D
D
A
L
------
K
L
A
N
E
G
K
V
---------
K
E
A
Q
A
------
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
---------------------
L
A
-----------
A
-----------
R
E
R
K
A
T
K
T
L
G
I
I
L
G
A
F
I
V
C
W
L
P
F
F
I
I
S
L
V
M
-----
P
I
---------------------------
W
F
H
L
A
I
F
D
F
F
T
W
L
G
Y
L
N
S
L
I
N
P
I
I
Y
T
M
S
N
E
D
F
K
Q
A
F
H
K
L
I
------
R
F
K
------------------------
8
PsiBlast_PDB
80.17
17%
-104
- C9 -
4U15
6
ACM3_RAT
A:
[14-398]
------------------------------------------
F
I
A
F
L
T
G
F
L
A
L
V
T
I
---
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
--
T
YR
A
-
K
----
R
-
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
-
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
-
F
V
--
G
K
R
T
V
P
P
G
E
-
C
F
I
Q
F
L
-------
S
E
P
T
---
I
---
T
--
F
G
T
A
------
I
A
A
F
--
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GGGSGG
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
------
V
R
G
I
L
--
R
N
A
K
L
K
P
V
Y
D
S
L
-------------
D
A
V
------------------
R
R
A
A
L
I
N
M
V
F
Q
M
------
G
E
T
G
V
A
G
F
T
---------
N
S
L
R
-----------
M
L
Q
--
Q
K
R
W
D
E
A
A
--------
V
N
L
A
K
S
R
W
---------
Y
N
Q
T
P
------
N
----------------------------
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYL
I
---
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
-----
T
F
-------
C
------
D
S
C
I
------
P
K
T
Y
W
N
L
-
G
Y
W
L
C
Y
I
----
N
S
T
V
N
P
V
C
Y
A
L
C
N
K
T
F
R
T
T
F
K
T
L
----------------------------------
72
HHSearch
80.09
23%
-146
- C8 -
2KS9
1
NK1R_HUMAN
A:
[35-323]
-------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
---
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
--
P
-
R
----
L
-
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
-
A
L
L
L
A
-
F
P
Q
G
Y
Y
S
T
T
-
E
T
------------
M
P
S
R
V
V
C
M
----
I
E
W
P
E
---
H
PNK
I
--
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
-----------------------------------------------------------------------------------------
I
P
G
-
D
------------------
S
----------------------------------------------------------------------------------------------------------
S
D
R
Y
H
E
Q
V
-----------
S
-----------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
-----
Y
I
-------
N
------
P
D
L
Y
------
L
K
K
F
I
Q
Q
-
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
------
R
C
C
P
F
----------------------
84
Fugue
77.44
21%
-137
- C8 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------
S
F
K
C
A
L
T
K
T
G
F
------------
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
---
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
--
S
L-
G
-
R
----
L
-
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
-
V
V
V
A
I
-
S
P
I
L
F
Y
S
G
T
-
G
V
--
R
K
---------
N
K
T
I
T
C
Y
----
D
T
T
S
D
---
E
---
Y
--
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
MF
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
L
I
-----
Y
K
M
K
K
Y
T
------
C
T
V
C
G
Y
I
Y
N
P
--
E
D
------
G
D
---------------------------------------------------------------------
P
D
N
G
V
N
P
G
T
---------
D
F
K
D
-----------
I
V
C
--
P
L
C
G
V
G
K
D
--------
Q
F
E
E
V
E
E
-----------------------------------------------------------------------
P
-----------
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
-------
Q
TP----
A
M
C
A
------
F
N
D
R
V
Y
A
-
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
--------------------------------------
86
Fugue
76.90
18%
-121
- C8 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
----
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
--
N
F
R
----
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
D
Y
-
Y
T
P
------------
H
E
---
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
T
T
Q
K
A
E
------
K
E
V
T
R
M
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-----
F
T
-------
H
------
Q
G
---------
S
D
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A------
87
Fugue
76.50
19%
-123
* C8 *
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
---
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
--
N
F
R
----
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
G
I
D
Y
-
Y
T
P
H
------------
E
---
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
--------------------------------------------------------------------------------------------------------
V
F
T
V
------
K
E
A
A
A
Q
Q
Q
E
---------
S
A
--------------------------------------------------------------------------------------------------
T
T
Q
-----------
K
-----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-----
F
T
-------
H
------
Q
G
---------
S
D
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA
83
Fugue
75.66
16%
-105
- C8 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
--
Y
-
Q
SL--
L
-
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
-
S
G
L
T
S
-
F
L
-
P
I
Q
M
H
W
-
Y
R
--
A
T
H
Q
E
A
I
N
C
-
Y
A
E
E
T
C
C
D
FFTN
Q
A
Y
A
I
---
A
---
S
--
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
--
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
------
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
------
T
K
S
P
S
--
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
------------------
F
N
Q
D
V
D
A
A
V
R
G
I
------
L
R
N
A
K
L
K
P
V
---------
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
--
M
G
E
T
G
V
A
G
--------
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
------
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
-------------
T
F
R
T
G
T
W
D
A
Y
-----------
K
FCL--------
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
-----
V
I
-------
Q
------
D
N
L
I
------
R
K
E
V
Y
I
L
-
L
N
----
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
--
S
P
D
F
R
I
A
F
Q
E
L
------
L
C
L
------------------------
9
PsiBlast_PDB
74.71
17%
-108
- C9 -
4U16
2
?
A:
[14-388]
------------------------------------------
F
I
A
F
L
T
G
F
L
A
L
V
T
I
---
I
G
N
I
L
V
I
V
A
F
K
V
N
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
--
T
YR
A
-
K
----
R
-
T
T
K
R
A
G
V
M
I
G
L
A
W
V
I
-
S
F
V
L
W
-
A
P
A
I
L
F
W
Q
Y
-
F
V
--
G
K
R
T
V
P
P
G
E
-
C
F
I
Q
F
L
-------
S
E
P
T
---
I
---
T
--
F
G
T
A
------
I
A
A
F
--
Y
M
P
V
T
I
M
T
I
L
Y
W
R
I
Y
K
E
T
E
K
M
N
I
F
E
M
L
R
I
D
E
GGGSGG
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
------
V
R
G
I
L
--
R
N
A
K
L
K
P
V
Y
D
S
L
-------------
D
A
V
------------------
R
R
A
A
L
I
N
M
V
F
Q
M
------
G
E
T
G
V
A
G
F
T
---------
N
S
L
R
-----------
M
L
Q
--
Q
K
R
W
D
E
A
A
--------
V
N
L
A
K
S
R
W
---------
Y
N
Q
T
P
------
N
----------------------------
R
A
K
R
V
I
T
T
F
R
-----------
T
GTWDAYL
I
---
K
E
K
K
A
A
Q
T
L
S
A
I
L
L
A
F
I
I
T
W
T
P
Y
N
I
M
V
L
V
N
-----
T
F
-------
C
------
D
S
C
I
------
P
K
T
Y
W
N
L
-
G
Y
W
L
C
Y
I
----
N
S
T
V
N
P
V
C
Y
A
L
C
N
--------------------------------------------
76
HHSearch
72.75
20%
-144
- C8 -
1U19
14
OPSD_BOVIN
A:
[42-326]
------------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
--
N
-
F
R
---
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
-
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
-
Y
I
---
P
--------
E
G
M
Q
C
S
C
G
----
I
D
Y
Y
T
PHE
E
---
T
--
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
-----------------------------------------------------------------------------------------
Q
Q
-
Q
-------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
-----------
K
-----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-----
F
T
-------
H
------
Q
G
S
-------
D
--
F
G
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------
C
C
G
K
N
----------------------
78
HHSearch
72.73
17%
-147
- C8 -
2Z73
5
OPSD_TODPA
A:
[33-332]
---------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
---
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
--
A
--
A
-
S
K
K
--
M
-
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
-
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
-
Y
T
--
L
---------
E
G
V
L
C
N
C
S
----
F
D
Y
I
S
---
R
---
D
S
-
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
M
A
A
----------------------------------------------------------------
M
------------------
A
K
----
R
L
----------------
N
A
-------------------------------------------------------------------------------------------------------
K
E
L
R
K
A
Q
A
G
A
-----------
N
-----------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
-----
Q
F
-------
G
------
P
L
E
---------
W
V
T
P
Y
-
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
------
P
W
V
L
T
----------------------
77
HHSearch
68.91
22%
-153
- C8 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
----------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
---
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
--
R
--
T
-
L
----
T
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
-
S
M
N
L
S
-
L
P
F
F
L
F
R
Q
A
-
Y
H
---
P
--------
N
N
S
S
P
V
C
Y
----
E
V
L
G
N
---
D
---
T
AK
W
R
M
V
L
R
I
L
P
H
T
F
G
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
-----------
G
-----------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
-----
T
L
-------
M
------
R
T
Q
V
IQE
S
C
E
R
R
N
N
I
G
R
-
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
------
A
M
H
G
-----------------------
2
PsiBlast_PDB
65.86
27%
-169
- C9 -
4EA3
3
C562_ECOLX (first)
A:
[124-316]
---------------------------------------
L
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
---
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
L
--
P
F
Q
G
T
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
---------------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
-
A
S
V
V
G
-
V
P
V
A
I
M
G
S
A
Q
V
E
--
D
E
E
I
---------
E
C
L
V
E
----
I
P
T
P
Q
---
D
---
Y
--
W
G
P
V
F
A
I
C
I
F
L
F
S
F
--
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
R
G
V
R
L
L
S
G
S
R
E
K
D
------
R
N
L
R
R
I
T
R
L
V
L
V
V
V
------
A
V
F
V
G
--
C
W
T
P
V
Q
V
F
V
L
A
Q
-------------
G
L
G
------------------
V
Q
P
S
S
E
T
A
V
A
I
L
------
R
F
C
T
A
L
G
Y
V
---------
N
S
C
L
-----------
N
P
I
--
L
Y
A
F
L
D
E
N
--------
F
K
A
C
F
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------