@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10A5_HUMAN: (2016-01-11 )
MAIGNWTEISEFILMSFSSLPTEIQSLLFLTFLTIYLVTLKGNSLIILVTLADPMLHSPMYFFLRNLSFLEIGFNLVIVPKMLGTLLAQDTTISFLGCATQMYFFFFFGVAECFLLATMAYDRYVAICSPLHYPVIMNQRTRAKLAAASWFPGFPVATVQTTWLFSFPFCGTNKVNHFFCDSPPVLKLVCADTALFEIYAIVGTILVVMIPCLLILCSYTRIAAAILKIPSAKGKHKAFSTCSSHLLVVSLFYISSSLTYFWPKSNNSPESKKLLSLSYTVVTPMLNPIIYSLRNSEVKNALSRTFHKVLALRNCIP
Atome Classification :
(20 SA)
------.........10........20--------------.........30........40........50........60.......---.70.......-.80........-90..--......100.......110------.......120--.........130....----...140..-.....150...--------------..-..160.------.....-----.170.......180...-.....----190.........200------.......210..----.----....220......---------.230-----------.--------------------..----------....240.......250---.-------...-----....260.....---.----.270....--...280---...--....290.......300.......310.....----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MAIG
N
W
T
E
I
S
E
F
I
L
M
S
F
SSL---------------
P
T
E
I
Q
S
L
L
F
L
T
F
L
T
I
Y
L
V
T
LKG
N
S
L
I
I
L
V
TLA
D
P
M
LHS
P
M
Y
F
F
L
RN
L
S
---
F
L
E
IG
F
N
L
V
I
-
V
P
K
M
L
G
T
L
LAQ-DT
T
I
--
S
F
L
G
C
A
T
Q
M
Y
F
F
F
F
F
G
V
A
E
------
C
F
L
L
A
T
M
A
----YD
R
Y
V
A
I
CSPLHYP
V
I
----MNQR
T
R
A
K
-
L
AAASWFPGF
P
--------------
V
A
-
T
V
Q
T
T
W
------
L
F
SFP-----FCGTNKV
N
H
F
FCD-SP
P
-
V
L
K
L
V
----C--A
D
T
A
L
F
E
I
Y
A
I
V
------
G
T
I
L
V
V
M
I
P
C
L
L
----
I
----
L
C
S
Y
T
R
I
A
A
A
I
L
K---------IPSA-----------K--------------------GK----------
H
K
A
F
S
T
C
S
S
H
L
L
V
V
S
L
----
F
-------
Y
IS-----SS
L
T
Y
F
WPKSNN---S----PES
K
K
L
L
S
--
L
S
Y
T
V
V
---
T
P
M
--
L
N
P
I
I
Y
S
LR
N
S
E
V
K
N
A
L
S
R
T
F
H
K
V
L
A
L
R
NCIP----------------------------------
7
PsiBlast_PDB
90.90
22%
-148
- C1 -
3VGA
1
AA2AR_HUMAN
A:
[6-303]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
-------
S
Q
-
G
C
G
-
E
G
Q
V
A
----
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
------------------------------------
9
PsiBlast_PDB
90.79
21%
-145
- C1 -
2YDV
6
?
A:
[3-303]
------------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
-
E
G
Q
V
A
----
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ---------------------------------------S
T
L
-------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
11
PsiBlast_PDB
90.59
21%
-143
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[6-303]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
----
G
C
G
-
E
G
Q
V
A
----
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
-
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
8
PsiBlast_PDB
89.88
21%
-140
- C1 -
2YDO
3
?
A:
[6-303]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
-
E
G
Q
V
A
----
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S----------------------------------------T
L
--------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
----------------------------------
6
PsiBlast_PDB
89.83
22%
-150
- C1 -
3VG9
8
?
A:
[6-303]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
A
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
-------
S
Q
-
G
C
G
-
E
G
Q
V
A
----
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------
4
PsiBlast_PDB
89.73
22%
-144
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[7-303]
----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
A
G
-
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
L
T
P
M
L
G
W
NNCGQP----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
-
M
N
Y
M
V
-----------
Y
F
N
F
F
A
------------
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
A
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
---------------------------------------
1
PsiBlast_PDB
89.60
22%
-138
- C1 -
3PWH
1
?
A:
[7-303]
----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
A
G
-
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
L
T
P
M
L
G
W
NNCGQP----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
-
M
N
Y
M
V
-----------
Y
F
N
F
F
A
------------
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
A
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
---------------------------------------
2
PsiBlast_PDB
89.51
22%
-143
- C1 -
3REY
1
AA2AR_HUMAN
A:
[7-303]
----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
A
G
-
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
L
T
P
M
L
G
W
NNCGQP----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
-
M
N
Y
M
V
-----------
Y
F
N
F
F
A
------------
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
A
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
---------------------------------------
10
PsiBlast_PDB
89.40
21%
-145
- C1 -
4UG2
3
?
A:
[6-303]
---------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
A
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
----
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
----
L
T
P
------
M
L
G
W
N
-----
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
-
E
G
Q
V
A
----
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
------
N
F
F
A
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L-------------------------------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
S
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
H
V
L
R
-----------------------------------
3
PsiBlast_PDB
89.09
22%
-142
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[7-303]
----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
A
G
-
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
L
T
P
M
L
G
W
NNCGQP----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
-
M
N
Y
M
V
-----------
Y
F
N
F
F
A
------------
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
A
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
---------------------------------------
5
PsiBlast_PDB
89.00
22%
-144
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[7-303]
----------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
---
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
-
G
F
C
A
--
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
------
I
F
S
L
L
A
I
A
----
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
----
V
T
G
T
R
A
A
G
-
I
I
A
I
C
W
V
L
S
F
A
--------------
I
G
L
T
P
M
L
G
W
NNCGQP----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
-
V
V
P
-
M
N
Y
M
V
-----------
Y
F
N
F
F
A
------------
C
V
L
V
P
L
L
L
----
M
----
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-------
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
----
F
A
L
C
W
L
P
L
H
I
I
-----
N
C
F
T
F
F
C
P
D
C
S
H
---
A
----
P
L
W
L
M
Y
L
A
--
I
V
L
A
H
T
---
N
S
V
--
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
R
S
---------------------------------------
20
PsiBlast_PDB
85.38
24%
-135
- C1 -
2Y01
12
ADRB1_MELGA
A:
[3-297]
----------------------
A
E
L
L
---------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
---
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
-
G
T
W
L
WG
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
------
I
E
T
L
C
V
I
A
----
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
----
M
T
-
R
A
R
A
K
-
V
---------------------------
I
I
C
T
V
W
------
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
H
W
W
R
D
-
E
D
P
Q
A
L
K
C
Y
Q
D
PG
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
------
S
S
I
I
S
F
Y
I
P
L
L
I
----
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------S
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
-------
F
L
V
-----
N
I
V
N
V
F
-----
N
---
R
----
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------
19
PsiBlast_PDB
85.20
24%
-138
- C1 -
2Y00
13
ADRB1_MELGA
A:
[3-297]
----------------------
A
E
L
L
---------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
---
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
-
G
T
W
L
WG
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
------
I
E
T
L
C
V
I
A
----
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
----
M
T
-
R
A
R
A
K
-
V
---------------------------
I
I
C
T
V
W
------
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
H
W
W
R
D
-
E
D
P
Q
A
L
K
C
Y
Q
DPG
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
------
S
S
I
I
S
F
Y
I
P
L
L
I
----
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
--------------------------------------------------S
R
V
M
L
M
R
E
--
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
-------
F
L
V
-----
N
I
V
N
V
F
-----
N
---
R
----
D
L
V
P
D
W
L
F
--
V
A
F
N
W
L
G
Y
A
N
S
A
--
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------
33
HHSearch
80.99
18%
-123
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
---
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
-
E
W
Y
Y
--
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
------
I
Y
S
M
T
A
V
A
----
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
------
S
A
T
A
T
K
V
-
V
I
C
V
I
W
V
L
A
L
L
--------------
L
A
-
F
P
Q
G
Y
Y
-------
S
T
T
--------
E
T
-
M
P
S
R
V
V
C
M
-
I
E
W
-
P
E
H
P
---------
N
K
I
Y
E
K
V
Y
H
I
C
------
V
T
V
L
I
Y
F
L
P
L
L
V
----
I
----
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
----------
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
----
C
-------
W
L
P
-----
F
H
I
F
F
L
L
P
Y
I
N
P
---
D
LYLK
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
---
S
T
M
--
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
----------------------------------
35
HHSearch
77.00
18%
-119
- C1 -
2Z73
5
OPSD_TODPA
A:
[32-334]
-------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
---
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
-
K
W
I
F
--
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
------
I
M
T
M
A
M
I
S
----
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
----
M
S
H
R
R
A
F
I
-
M
I
I
F
V
W
L
W
S
V
L
--------------
W
A
-
I
G
P
I
F
G
------
W
G
A
Y
--------
T
L
-
E
G
V
L
C
N
C
S
-
F
D
Y
-
I
S
-----------
R
D
S
T
T
R
S
N
I
L
C
------
M
F
I
L
G
F
F
G
P
I
L
I
----
I
----
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
----------
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
----
S
-------
W
S
P
-----
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
----
T
P
Y
A
A
Q
L
P
--
V
M
F
A
K
A
---
S
A
I
--
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
----------------------------------
41
Fugue
76.87
16%
-126
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
---
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
-
Y
F
V
F
--
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
------
L
W
S
L
V
V
L
A
----
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
--------------
A
A
-
P
P
L
V
G
W
------
S
R
Y
I
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
-
H
E
E
----------------
T
N
N
E
S
F
V
I
Y
------
M
F
V
V
H
F
I
I
P
L
I
V
----
I
----
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
S
-----------
A
--------------------
T
T
----------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
----
A
-------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
---
S
----
D
F
G
P
I
F
M
T
--
I
P
A
F
F
A
---
K
T
S
AV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A------------------------
13
PsiBlast_PDB
74.38
25%
-149
- C1 -
2YCW
7
ADRB1_MELGA
A:
[3-243]
----------------------
A
E
L
L
---------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
---
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
-
G
T
W
L
WG
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
------
I
E
T
L
C
V
I
A
----
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
----
M
T
-
R
A
R
A
K
-
V
---------------------------
I
I
C
T
V
W
------
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
-
A
L
K
C
Y
Q
D
P
G
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
------
S
S
I
I
S
F
Y
I
P
L
L
I
----
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
--------------------------------
S
K
----------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
-------
I
I
M
-----
G
V
F
T
L
C
W
L
P
F
F
L
---
V
----
N
I
V
N
V
F
N
R
--
D
L
V
P
D
W
---
L
F
V
--
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------------------------
44
Fugue
74.03
20%
-150
- C1 -
4PG7
9
?
A:
[20-446]
H
M
K
K
L
N
I
A
L
L
G
L
G
T
V
G
S
G
V
V
K
I
I
E
E
N
---------------
R
Q
Q
I
Q
D
T
L
N
-
K
D
I
V
I
K
H
I
L
V
R
D
K
S
K
K
R
P
L
N
I
S
Q
Y
H
L
T
E
D
V
N
E
I
L
N
D
D
S
LD
I
I
V
E
V
M
G
G
I
E
P
-
T
V
D
W
L
R
T
A
L
K
N
K
K
H
V
I
--
T
A
N
K
D
L
L
A
V
H
L
K
L
L
E
D
L
A
E
E
N
G
V
A
L
K
F
E
A
S
V
A
G
GPNN
I
S
K
F
M
G
I
L
N
G
T
S
N
F
I
L
S
K
M
T
K
E
Q
T
T
F
E
E
-
A
L
D
E
A
K
R
L
G
F
A
EADP
T
D
D
V
E
G
V
D
A
A
R
K
-
V
V
I
T
S
Y
------
L
S
F
N
Q
-----
V
I
K
L
N
D
V
K
R
R
G
I
S
-
G
V
T
-
L
T
D
I
N
----
V
--
A
D
Q
L
G
Y
K
I
K
L
I
G
K
G
I
Y
E
N
G
K
V
N
A
S
V
E
P
T
L
I
DKKH
Q
----
L
A
A
V
E
D
E
Y
N
A
I
Y
V
---------
I
G
D
A
V
G
D
T
M
F
Y
G
K
G
-
A
--------------------
G
S
----------
L
A
T
G
S
A
V
V
S
D
L
L
N
V
A
L
----
F
-------
F
E
S
-----
T
L
P
P
H
F
E
L
K
T
D
K
---
T
----
R
E
M
E
K
--
S
--
N
F
F
V
V
V
---
N
H
V
--
K
G
----
S
I
E
N
F
E
N
E
L
K
A
I
L
P
F
H
R
S
L
R
V
A
N
Y
D
N
Q
S
Y
A
A
V
I
V
GLESSP
E
E
L
I
T
K
H
GYEVD
K
V
Y
P
V
E
GV
14
PsiBlast_PDB
73.19
25%
-150
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-243]
-------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
---
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
-
G
T
W
L
WG
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
------
I
E
T
L
C
V
I
A
----
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
----
M
T
-
R
A
R
A
K
-
V
---------------------------
I
I
C
T
V
W
------
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
-
A
L
K
C
Y
Q
DPG
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
------
S
S
I
I
S
F
Y
I
P
L
L
I
----
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
--------------------------------
S
K
----------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
----
G
-------
I
I
M
-----
G
V
F
T
L
C
W
L
P
F
F
L
---
V
----
N
I
V
N
V
F
N
R
--
D
L
V
P
D
W
---
L
F
V
--
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
--------------------------------------
17
PsiBlast_PDB
72.10
25%
-155
- C1 -
4BVN
11
ADRB1_MELGA
A:
[6-233]
-------------------------
L
---------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
---
C
A
D
L
V
V
G
L
L
V
-
V
P
-
F
G
A
T
L
V
V
R
-
G
T
W
L
WG
S
F
L
-
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
------
V
E
T
L
C
V
I
A
----
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
----
M
T
-
R
A
R
A
K
-
V
---------------------------
I
I
C
T
V
W
------
A
I
S
A
L
-----
V
S
F
L
P
I
M
M
H
W
W
R
D
-
E
D
P
Q
A
L
K
C
Y
Q
DPG
C
--
C
D
F
V
T
N
R
A
Y
A
I
A
------
S
S
I
I
S
F
Y
I
P
L
L
I
----
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------
K
R
KTS
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
----
C
-------
W
L
P
-----
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
K
W
L
F
V
--
A
F
N
W
L
G
---
Y
A
N
--
S
A
M
N
P
I
I
L
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-------------------------------------------