@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10A6_HUMAN: (2016-01-11 )
MERQNQSCVVEFILLGFSNYPELQGQLFVAFLVIYLVTLIGNAIIIVIVSLDQSLHVPMYLFLLNLSVVDLSFSAVIMPEMLVVLSTEKTTISFGGCFAQMYFILLFGGAECFLLGAMAYDRFAAICHPLNYQMIMNKGVFMKLIIFSWALGFMLGTVQTSWVSSFPFCGLNEINHISCETPAVLELACADTFLFEIYAFTGTFLIILVPFLLILLSYIRVLFAILKMPSTTGRQKAFSTCAAHLTSVTLFYGTASMTYLQPKSGYSPETKKVMSLSYSLLTPLLNLLIYSLRNSEMKRALMKLWRRRVVLHTI
Atome Classification :
(20 SA)
------------.........10...-.....-20--.--........30........40........50........60........70......-..80........90....------....100.......110.......120.......130.......140.......150....-...160.......170.......180.......--190..--.....200.......210.......220.....---------..230-----------.-----------------.---.....240.......250------....------.--...260.---.---..---...270-----------.......280.-...--...290.......300.....---------------..310..---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MERQ
N
Q
S
C
V
V
E
F
I
L
-
L
GFSN-
Y
---
P
--
E
L
Q
G
Q
L
F
V
A
F
L
V
I
Y
L
V
T
L
IGN
A
I
I
I
V
I
V
SLDQSLH
V
P
M
Y
L
F
L
L
N
L
S
V
V
DL
S
F
S
A
V
I
-
M
P
E
M
L
V
V
L
STEK
T
T
I
SF
G
------
G
C
F
A
Q
M
Y
F
I
L
L
FGG
A
E
C
F
L
L
G
A
M
A
Y
D
R
F
A
A
I
CHPL
N
Y
Q
M
I
MNK
G
V
F
M
K
L
I
I
F
S
W
A
L
G
F
M
L
G-T
V
Q
T
S
W
VSSFPFCGLNEINHISCET
P
A
V
L
E
L
AC--A
D
T
F
L
--
F
E
I
Y
AF
T
G
T
F
L
I
I
L
V
P
F
L
L
I
L
L
S
Y
I
R
V
L
F
A
I
LK---------MPSTT-----------G-----------------
R
---
Q
K
A
F
S
T
C
A
A
H
L
T
S
V
T
L
F
-------
Y
GTA------
S
--
M
T
Y
LQPK---S---GY---SP
E
T
K
K
-----------
V
M
S
L
S
Y
S
L
L
T
P
-
L
L
N
--
L
L
I
Y
S
LR
N
S
E
M
K
R
A
L
M
K
L
W
R
R
---------------
R
V
VLHTI---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
98.78
22%
-155
- C4 -
2YDV
6
?
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ------------------------------------S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
98.05
22%
-156
- C4 -
4UG2
3
?
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L-----------------------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.66
22%
-152
- C4 -
2YDO
3
?
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S-------------------------------------T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.70
22%
-163
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.61
22%
-163
- C4 -
3VG9
8
?
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
93.29
22%
-154
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-307]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
----
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
S
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.34
21%
-164
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
91.09
21%
-161
- C4 -
3PWH
1
?
A:
[14-305]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
91.05
21%
-164
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
90.84
21%
-162
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
90.58
21%
-162
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
--
S
T
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
-----------
A
-----------------
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
------
C
--
F
T
F
F
C
P
D
---
C
---
S
H
---
A
P
L
W
L
M
-----------
Y
L
A
I
V
L
A
H
T
N
S
-
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
84.18
15%
-119
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
---
E
--
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
------
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
--
D
F
F
-
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
I
F
-----------
E
-----------------
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
IG
H
L
L
T
K
S
P
---
S
---
L
N
---
A
A
K
S
E
L
-----------
D
K
A
I
G
R
N
T
N
G
V
-
I
T
K
--
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
---------------
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
39
Fugue
83.85
16%
-138
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
-
E
A
P
Q
Y
-
Y
LAE
P
--
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
----
Q
C
S
C
G
I
D
Y
---
Y
T
P
--
H
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
S
A
-----------
T
-----------------
T
---
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
-------
F
L
I
C
W
L
P
Y
A
G
V
--
A
F
Y
I
F
T
H
---
Q
---
G
S
---
D
F
G
P
I
F
-----------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
--
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---------------
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
83.00
17%
-141
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-326]
--------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
------
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
Y
S
T
T
E
---
T
--
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
-----
N
K
I
Y
--
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
---------
S
E
I
P
G
DSSDRYH
E
Q
V
S
A
-----------------
K
---
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-------
W
L
P
F
------
H
--
I
F
F
L
L
P
Y
I
NP
D
---
L
Y
LKK
F
I
Q
Q
V
Y
-----------
L
A
I
M
W
L
A
M
S
S
T
-
M
Y
N
--
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
---------------
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
82.06
17%
-144
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-333]
----------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
W
G
A
Y
---
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
-------
R
D
S
T
--
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-------
W
S
P
Y
------
A
--
V
V
A
L
L
A
Q
---
F
GPL
E
W
---
V
T
P
Y
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
A
-
I
H
N
--
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
---------------
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
77.14
15%
-127
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
-
E
---
P
--
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
----
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
--
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
F
---
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
---------
A
A
A
Q
Q
-----------
Q
-----------------
E
---
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
-------
M
V
I
A
------
F
--
L
I
C
W
L
P
Y
---
A
---
G
V
---
A
F
Y
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
--
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
GKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
APA------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
75.93
22%
-181
- C4 -
3EML
8
ENLYS_BPT4
A:
[21-222]
------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
------
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
--
L
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
-----------
E
-----------------
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
--
I
G
H
L
L
T
K
---
S
---
P
S
---
L
N
A
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
---------------
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
74.79
25%
-182
- C4 -
3EML
8
ENLYS_BPT4
A:
[29-222]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
-----------
E
-----------------
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
--
I
G
H
L
L
T
K
---
S
---
P
S
---
L
N
A
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
---------------
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.25
25%
-180
- C4 -
3QAK
1
ENLYS_BPT4
A:
[29-222]
--------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
--------
T
I
S
T
G
FCAA
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
----
C
G
---------
Q
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
-----------
E
-----------------
M
---
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-------
Y
Y
T
I
------
G
--
I
G
H
L
L
T
K
---
S
---
P
S
---
L
N
A
A
K
S
-----------
E
L
D
K
A
I
G
R
N
T
N
-
G
V
I
--
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
---------------
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
73.81
20%
-129
- C4 -
4Y7L
5
?
A:
[2-240]
------T
P
A
A
E
S
L
N
A
R
W
R
T
A
V
V
D
G
W
N
-
N
A
F
S
G
R
Y
---
P
FK
N
V
S
S
D
A
S
L
P
L
L
A
K
Y
L
N
T
D
T
G
R
I
A
R
F
L
Q
N
N
L
S
G
V
L
H
R
E
G
S
R
W
V
P
D
---
T
G
L
T
F
N
P
A
F
-
L
K
A
I
N
T
L
S
E
I
A
D
V
A
F
T
T
G
------
N
--
A
G
L
H
F
E
L
R
P
G
T
A
A
G
V
M
Q
T
T
L
I
T
D
N
----------
Q
K
L
I
Y
V
N
Q
M
P
V
W
K
R
F
T
W
P
A
D
T
E
A
P
-
G
A
S
L
S
W
V
S
T
Q
A
--
G
T
R
Q
Y
A
D
L
P
---------------------------
G
S
W
------------
G
L
I
R
L
L
E
M
-------------------------------------------------------------
A
R
R
K
A
A
-------
P
G
V
A
------
S
--
G
W
S
L
S
W
Q
---
A
---
Q
D
---
G
R
-----------------
M
L
N
Y
T
L
R
T
E
-
A
G
E
G
P
L
V
L
L
K
L
R
N
F
V
L
P
E
T
V
F
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------