@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10H5_HUMAN: (2016-01-11 )
MQGLNHTSVSEFILVGFSAFPHLQLMLFLLFLLMYLFTLLGNLLIMATVWSERSLHMPMYLFLCALSITEILYTVAIIPRMLADLLSTQRSIAFLACASQMFFSFSFGFTHSFLLTVMGYDRYVAICHPLRYNVLMSLRGCTCRVGCSWAGGLVMGMVVTSAIFHLAFCGHKEIHHFFCHVPPLLKLACGDDVLVVAKGVGLVCITALLGCFLLILLSYAFIVAAILKIPSAEGRNKAFSTCASHLTVVVVHYGFASVIYLKPKGPQSPEGDTLMGITYTVLTPFLSPIIFSLRNKELKVAMKKTCFTKLFPQNC
Atome Classification :
(20 SA)
-----------.........10.....----------------...20-.....--------....30........40........50.......--.60........70......-..80........90........100..-.....110.-----.....----.120.......130.......---140.......150......----------.160......-.170.......180.......190-......--.200.......210------.......220.....-----------..230.--------------------.--------......240...-....250.......260.-----------...-------.---.-------.270--........280.......----290.......300.-----......310...------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MQGLNHT
S
V
S
E
F
I
L
V
G----------------FSA
F
--
P
H
L
Q
L
--------
M
L
F
L
L
F
L
L
M
Y
L
F
T
L
L
G
N
L
L
I
M
A
T
VWSERSLH
M
P
--
M
Y
L
F
L
C
A
L
S
I
T
E
I
L
Y
T
V
A
I
-
I
P
R
M
L
A
D
L
L
S
T
Q
R
S
I
A
F
L
A
C
A
S
Q
M
F
F
S
-
F
SFG
F
T
H
S
F
-----
L
L
T
V
M----GYD
R
Y
V
A
I
CH
P
L
R
Y
N
V
L
M
SLR---G
C
T
C
R
VGCSWA
G
G
L
V
M
G
M
V
----------
V
T
S
A
I
F
H
L
A
F-CG
H
K
E
I
H
H
F
F
CHVP
P
L
L
K
LACGD
D
-
V
L
V
V
AK--G
V
G
L
V
C
I
T
A
L
L
G
C
F
------
L
L
I
L
L
S
Y
A
F
I
V
A
A
I
L
-----------KIP-SA--------------------E--------GR
N
K
A
F
S
T
C
A
S
H
-
L
T
V
V
V
V
HYG
F
A
S
V
I
Y
L
KP-----------KGP-------Q---S-------PE-G--
D
T
L
M
G
I
T
Y
T
V
L
T
P
F
L
S
P
I
----
I
F
S
LRN
K
E
L
K
V
A
M
K
-----
K
T
C
F
T
K
LFPQNC------------------
38
HHSearch
85.57
15%
-161
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------------------
A
V
Y
Y
--------
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
--
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
-
G
I
F
G
F
M
S
I
M
-----
T
M
A
M
I
----
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
---
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
----------
P
I
F
G
W
G
A
Y
T
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
-
S
-
T
T
R
S
--
N
I
L
C
M
F
I
L
G
F
F
G
P
I
------
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
-----------
N
H
E
-
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
I
S
I
V
I
-
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
-----------
Q
F
G
-------
P
LEW
V
-------
T
P
-
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
----
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
-----
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------
45
Fugue
79.96
16%
-139
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
----------------
Q
Y
Y
L
AE
P
W
Q
F
S
--------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
--
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
----
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
---
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------------------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----------
E
A
A
-
A
Q
--------------------
Q
--------
Q
E
S
A
T
T
Q
K
A
E
K
E
-
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
---
F
-------
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
44
Fugue
77.32
16%
-134
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
SNKTGVVRSPFEAPQY
Y
L
A
E
--
P
W
Q
F
S
--------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
--
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
----
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
---
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------------------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
-
Y
Y
T
P
H
E
ET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
------
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
FTVKEAAASAT
T
Q
K
-
A
E
--------------------
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
-
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
-----------
Q
G
S
-------
D
---
F
-------
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------
33
HHSearch
72.85
14%
-157
* C4 *
2KS9
1
NK1R_HUMAN
A:
[33-325]
-----------------------------------------------------
V
--------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
--
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
-
I
A
A
V
F
A
S
I
Y
-----
S
M
T
A
V
----
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
---
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
----------
Q
G
Y
Y
S
-
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---
P
N
K
-
I
-
Y
E
K
V
--
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
------
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
-----------
A
S
E
-
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
M
M
I
V
V
-
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
-----------
Y
I
N
-------
P
---
D
LYL----
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
----
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
-----
H
A
F
R
C
C
P
F
I
S
A
G
------------------
47
Fugue
71.49
19%
-166
- C3 -
4NWV
2
?
A:
[30-384]
----SVAPVAK
A
N
A
L
R
T
T
S
S
N
S
I
L
L
K
G
----------------
C
D
R
I
--
V
T
V
V
D
ASTYDAGS
A
I
V
S
I
P
I
T
P
D
I
A
Y
R
L
G
S
T
A
R
T
F
Q
R
I
K
Y
R
S
L
K
F
R
--
V
N
A
Q
-
C
A
T
T
-
T
A
G
G
Y
V
A
G
F
-
V
K
D
A
A
D
V
L
P
T
G
T
A
S
I
P
Y
L
M
S
N
T
G
S
F
T
Q
P
W
W
K
S
T
V
H
N
V
K
I
P
Q
K
L
F
Y
T
E
APTR
G
A
D
A
V
R
E
Y
C
-
P
G
Q
F
H
V
L
V
D
S
K
PSQ
I
C
P
V
T
V
D
L
E
W
V
V
E
L
H
-
D
A
T
----------
F
R
K
E
S
D
Q
T
A
I
-
S
A
I
V
A
D
H
T
L
N
V
Y
G
L
P
A
T
S
N
R
V
G
H
I
-
L
I
S
P
I
G
--
Q
T
P
K
D
L
T
P
T
R
F
A
T
F
------
F
G
F
L
P
D
D
K
F
C
V
R
I
P
T
-----------
P
V
D
V
V
L
--------------------
T
--------
G
D
N
V
Y
Q
S
V
E
A
T
H
-
I
R
A
Y
L
V
N
G
G
L
G
I
D
F
H
L
A
A
-----------
Y
N
D
-------
T
---
T
H
T
I
Q
P
II
P
T
-
L
--
W
N
V
Y
D
V
T
G
A
V
T
A
P
F
T
S
A
I
Y
D
N
H
V
W
T
H
K
D
K
F
V
P
V
S
F
Q
DEPIP
G
T
V
F
D
Y
L
Y
P
R
S
-------------------
36
HHSearch
71.49
14%
-155
- C4 -
1U19
14
OPSD_BOVIN
A:
[40-328]
----------------------------------------------------
F
S
--------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
--
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
-
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
----
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
---
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
----------
P
L
V
G
W
S
R
Y
I
P
-----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
-
T
-
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----------
E
A
A
-
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
-
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
-----------
F
T
H
-------
Q
---
G
SDF----
G
P
-
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
----
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
P
L
G
D
------------------
30
HHSearch
67.45
23%
-184
- C4 -
3EML
8
ENLYS_BPT4
A:
[22-221]
-----------------------------------------------------
S
--------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
T
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
----------
P
M
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
Y
--
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
------
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
-
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----------
K
S
P
-------
S
---
L
-------
N
A
-
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
----
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
N
A
K
L
K
P
------------------
35
HHSearch
65.20
15%
-139
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------
L
N
K
Y
--------
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
--
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
-
E
V
N
F
Y
S
G
I
L
-----
L
L
A
C
I
----
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
---
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
----------
F
F
L
F
R
Q
A
Y
H
-----
P
N
N
S
S
P
V
C
Y
E
V
L
G
-----
N
D
T
-
A
K
W
R
M
V
--
L
R
I
L
P
H
T
F
G
F
I
V
P
L
------
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
-----------
K
A
H
-
M
---------------------
G
--------
Q
K
H
R
A
M
R
V
I
F
A
V
-
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
-----------
T
L
M
RTQVIQE
S
C
E
R
R
-------
N
N
-
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
----
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
-----
K
I
L
A
M
H
G
-----------------------
27
HHSearch
65.10
21%
-172
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[9-200]
-----------------------------------------------------
M
--------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
--
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
-
Y
V
A
S
T
A
S
I
F
-----
S
V
F
I
L
----
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
---
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
----------
I
L
-
G
W
N
H
---------
R
R
E
D
K
C
E
T
D
F
----------
Y
-
D
V
T
W
--
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
------
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
-----------
Q
H
C
-
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
-
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
-----------
K
S
P
-------
S
---
L
-------
N
A
-
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
----
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----
V
R
G
I
L
R
N
A
K
L
K
P
------------------
18
PsiBlast_PDB
63.95
25%
-162
- C4 -
4UG2
3
?
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
T
A
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
K
E
G
K
A
H
S
Q
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
L
A
R
S
T
L
Q
K
E
V
-----------
H
A
A
-
K
S
--------------------
L
--------
A
I
I
V
G
L
F
A
L
C
W
L
-
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
-----------
P
L
W
-------
L
---
M
-------
Y
L
-
A
--
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
----
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----
H
V
L
R
--------------------------
1
PsiBlast_PDB
63.94
31%
-173
- C4 -
4EA3
3
C562_ECOLX (first)
A:
[124-273]
---------------------------------------------------
L
K
V
--------
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
L
L
T
----
L
P
F
Q
G
T
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
-
Y
Y
N
M
F
T
S
T
F
-----
T
L
T
A
M
----
S
V
D
R
Y
V
A
I
C
H
P
------
T
S
S
K
---
A
Q
A
V
N
V
A
I
-
W
A
L
A
S
V
V
G
V
P
----------
V
--
A
I
M
G
S
A
Q
-
V
E
D
E
E
I
E
C
L
V
E
I
P
T
P
Q
D
Y
W
G
P
V
F
A
-
I
C
I
F
L
F
--
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
------
L
M
I
R
R
L
R
G
V
R
L
L
S
G
S
-----------
R
E
K
-
D
R
--------------------
N
--------
L
R
R
I
T
R
L
V
L
V
V
V
-
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
-----------
L
G
V
-------
Q
---
P
-------
S
S
-
E
--
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
----
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
-----
A
C
F
R
--------------------------
19
PsiBlast_PDB
63.89
25%
-162
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
T
A
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
K
E
G
K
A
---
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
-----
F
R
Q
T
F
R
K
I
I
R
S
H
------------------
17
PsiBlast_PDB
63.40
25%
-163
- C4 -
2YDV
6
?
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
T
A
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
K
E
G
K
A
H
S
Q
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
S
T
L
-----------
Q
K
E
-
V
H
--------------------
A
--------
A
K
S
L
A
I
I
V
G
L
F
A
-
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-----------
C
S
H
-------
A
---
P
-------
L
W
-
L
--
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
----
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
-----
I
I
R
S
H
V
L
R
Q
Q
E
P
------------------
9
PsiBlast_PDB
63.18
25%
-167
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
A
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
--------
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-----
E
F
R
Q
T
F
R
K
I
I
R
S
------------------
8
PsiBlast_PDB
63.05
25%
-165
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
A
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
--------
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-----
E
F
R
Q
T
F
R
K
I
I
R
S
------------------
52
Fugue
63.03
16%
-141
- C1 -
1B12
1
LEP_ECOLI
A:
[2-248]
---------------
R
S
F
I
Y
E
P
F
Q
I
P
S
----------------
G
S
M
M
--
P
------------------------
T
L
L
I
G
D
F
I
L
V
E
K
F
----------------
A
Y
G
I
K
D
P
I
Y
Q
K
T
L
-
I
E
T
G
-----
H
P
K
R
G
-------
D
I
V
V
F
K
-
Y
P
E
D
P
K
L
D
Y
-----
I
K
R
A
V
----
G
L
P
G
D
K
V
T
Y
D
P
V
S
K
E
L
T
I
Q
-
P
---
G
C
S
S
G
Q
A
C
E
N
A
L
P
V
T
Y
S
N
V
----------
E
P
S
D
F
V
Q
T
F
S
R
R
N
G
G
E
A
T
S
G
F
F
E
V
P
K
N
E
T
K
E
----------
N
--
G
I
R
L
S
E
R
K
E
T
L
G
----------------
D
V
T
H
R
I
L
-----------
T
V
P
-
I
A
--------------------
Q
--------
D
Q
V
G
M
Y
Y
Q
Q
P
G
Q
Q
L
A
T
W
I
V
P
P
G
Q
Y
F
M
M
----------------------------------------
G
--
D
N
R
D
N
S
A
D
S
R
Y
W
G
F
V
P
E
A
----
N
L
V
G
R
A
T
A
I
W
M
S
F
D
-----
G
L
R
L
S
R
I
G
G
I
H
-------------------
7
PsiBlast_PDB
62.93
25%
-162
- C4 -
3PWH
1
?
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
A
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
--------
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-----
E
F
R
Q
T
F
R
K
I
I
R
S
------------------
10
PsiBlast_PDB
62.91
25%
-164
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
A
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
--------
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-----
E
F
R
Q
T
F
R
K
I
I
R
S
------------------
16
PsiBlast_PDB
62.58
25%
-159
- C4 -
2YDO
3
?
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
T
A
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
K
E
G
K
A
H
S
Q
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
------
A
A
R
R
Q
L
K
Q
M
E
S
T
L
Q
K
-----------
E
V
H
-
A
A
--------------------
K
--------
S
L
A
I
I
V
G
L
F
A
L
C
-
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-----------
H
A
P
-------
L
---
W
-------
L
M
-
Y
--
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
----
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
-----
R
S
H
V
L
R
Q
Q
E
P
F
K
------------------
11
PsiBlast_PDB
62.46
25%
-166
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-174]
--------------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
--
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-
L
V
L
A
Q
S
S
I
F
-----
S
L
L
A
I
----
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
---
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCGQ
P
--------
G
-
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
-
F
A
C
V
L
V
--
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------
G
E
R
-
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
-----------
C
F
T
-------
F
---
F
-------
C
P
-
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-----
E
F
R
Q
T
F
R
K
I
I
R
S
------------------