@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10J5_HUMAN: (2016-01-11 )
MKRKNFTEVSEFIFLGFSSFGKHQITLFVVFLTVYILTLVANIIIVTIICIDHHLHTPMYFFLSMLASSETVYTLVIVPRMLLSLIFHNQPISLAGCATQMFFFVILATNNCFLLTAMGYDRYVAICRPLRYTVIMSKGLCAQLVCGSFGIGLTMAVLHVTAMFNLPFCGTVVDHFFCDIYPVMKLSCIDTTINEIINYGVSSFVIFVPIGLIFISYVLVISSILQIASAEGRKKTFATCVSHLTVVIVHCGCASIAYLKPKSESSIEKDLVLSVTYTIITPLLNPVVYSLRNKEVKDALCRVVGRNIS
Atome Classification :
(20 SA)
------------------------------------------------------------------...--....--------..10........20........30.......--------.40.------.......50...--....----------------.60......----..70-------------..---.....-..80.....-.----..90-...--......100-----.......110-------------........120.-----------------------......130...---....140.......150.......160.......170..------.....---180-----......-.190...-.-....--.200....--.-------.--.210....-----.---...220......--------------.230------------------.--------....---------....240.......--------250--.......260---..----.---.---.---.-----------.-------.270------------.....---.-------.--.280.......290..--------.....300.......-------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------MKR--K
N
F
T
--------
E
V
S
E
F
I
F
L
GFSSFGK
H
Q
I
T
L
F
V
V
F
L
T
V
Y
I
L
T
--------
L
V
A
N
------
I
I
I
V
T
I
I
C
IDHH--LH
T
P
----------------
M
Y
F
F
L
S
M
LA----SSE--------------
T
V
---
Y
T
L
V
I
-
V
P
R
M
L
L
S
L
I
-F----HNQ--PI
S
--
L
A
G
C
A
T
Q
M
F
-----
F
F
V
I
L
ATN
N
--------------
C
F
L
L
T
AMGY
D
R
Y
-----------------------
V
A
I
CRP
L
R
Y
T
V
I
---MSK
G
L
C
A
Q
L
V
C
GSF
G
I
G
L
T
M
A
V
L
H
V
T
A
MFNLP
F
C
G
T
V
V
D
------
H
F
F
C
D
---
I
Y
P
-----
V
M
K
L
S
C
-
I
D
--
T
T
I
-
N
-
E
I
I
N
--YGV
S
S
F
V
I
--
F
-------
V
--
P
I
G
-
L
I
F
I
-----
S
---
Y
V
L
V
I
S
S
I
L
Q
I
A--------------SA--------------------E--------GR
K
K
---------
T
F
A
T
C
V
S
H
L
T
V
V
I
V
--------HCG--CA
S
I
A
Y
LKP----KS----E---S---S---I-----------E-------K
D
-
L
------------
V
L
S
V
T
---
Y
-------
T
--
I
I
T
P
L
L
N
P
V
V
Y
S
LRN
K
--------
E
V
K
D
A
L
C
R
V
VGRNIS-------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
86.67
16%
-155
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-332]
---------------------------------------------------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
--------
C
G
G
N
------
G
I
V
I
Y
L
F
T
K
T
K
S
--
L
Q
T
P
----------------
A
N
M
F
I
I
N
L
A
----
F
S
D
--------------
F
T
---
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
----
K
K
W
--
I
F
G
--
F
A
A
C
K
V
Y
G
F
-----
I
G
G
I
F
G
F
M
S
--------------
I
M
T
M
A
M
I
S
I
D
R
Y
-----------------------
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
--
Y
-
T
L
E
G
V
------
L
C
N
C
S
---
F
D
Y
-----
I
S
R
--------
D
S
T
-
T
-
R
S
N
I
--
L
C
M
F
I
L
G
F
--
F
-------
G
--
P
I
L
-
I
I
F
F
-----
C
---
Y
F
N
I
V
M
S
V
S
N
H
E
--------------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
---------
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
--------
S
W
S
--
P
Y
A
V
V
A
L
L
A
----
Q
F
----
G
---
P
L--
E
---
W
-----------
V
-------
T
P
-
Y
------------
A
A
Q
L
P
---
V
-------
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
--------
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
86.34
16%
-149
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-323]
-----------------------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
--------
V
V
G
N
------
V
V
V
M
W
I
I
L
A
H
K
R
--
M
R
T
V
----------------
T
N
Y
F
L
V
N
L
A
----
F
A
E
--------------
A
S
---
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
----
N
E
W
--
Y
Y
G
--
L
F
Y
C
K
F
H
N
F
-----
F
P
I
A
A
V
F
A
S
--------------
I
Y
S
M
T
A
V
A
F
D
R
Y
-----------------------
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
-
E
---
T
M
P
S
------
R
V
V
C
M
---
I
E
W
-----
P
E
H
P
----
N
--
K
I
Y
-
E
-
K
V
Y
H
--
I
C
V
T
V
L
I
Y
--
F
-------
L
--
P
L
L
-
V
I
G
Y
-----
A
---
Y
T
V
V
G
I
T
L
W
A
S
E
--------------
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
---------
V
V
K
M
M
I
V
V
V
C
T
F
A
I
--------
C
W
L
--
P
F
H
I
F
F
L
L
P
----
Y
I
----
N
---
P
---
D
LYL
K
-----------
K
F------
I
Q
-
Q
------------
V
Y
L
A
I
---
M
-------
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
--------
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
86.06
16%
-142
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------------------------------------------------------MN
G
T
E
G
--
P
N
F
Y
VPFSNKTG
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--------
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
----------------
L
N
Y
I
L
L
N
L
A
----
V
A
D
--------------
L
F
---
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
--
V
F
G
--
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
I
A
--------------
L
W
S
L
V
V
L
A
I
E
R
Y
-----------------------
V
V
V
C
K
P
M
S
N
F
-----------------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
R
Y
---
I
P
E
-----
G
M
Q
C
S
C
-
G
I
--
D
Y
Y
-
T
-
P
H
E
E
--
T
N
N
E
S
F
V
I
--
Y
M
F
V
VHF
I
I
--
P
L
I
-
V
I
F
F
-----
C
---
Y
G
Q
L
V
F
T
V
K
E
A
A
--------------
A
S
--------------------
A
--------
T
T
Q
K
---------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
--------
A
F
L
--
I
C
W
L
P
Y
A
G
V
----
A
F
----
Y
---
I
---
F
---
T
-----------
H
QGSDFGP
I
F
-
M
------------
T
I
P
A
F
---
F
-------
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
--------
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------
42
Fugue
79.88
17%
-114
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------------------------------------------MN
G
T
E
G
--
P
N
F
Y
VPFSNKTG
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--------
L
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
----------------
L
N
Y
I
L
L
N
L
A
----
V
A
D
--------------
L
F
---
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
--
V
F
G
--
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
I
A
--------------
L
W
S
L
V
V
L
A
I
E
R
Y
-----------------------
V
V
V
C
K
P
M
S
N
F
-----------------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
------
G
W
S
R
Y
---
I
P
E
-----
G
M
Q
C
S
C
G
I
D
YY
T
P
H
-
E
-
E
T
N
N
--
E
S
F
V
I
Y
M
F
--
V
VHF
I
---
I
--
P
L
I
-
V
I
F
F
-----
C
---
Y
G
Q
L
V
F
T
V
K
E
A
A
--------------
A
Q
--------------------
Q
--------
Q
E
S
A
---------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
--------
I
M
V
--
I
A
F
L
I
C
W
L
P
----
Y
A
----
G
---
V
---
A
---
F
Y
I
F
T
H
QGSDFG
P
-------
I
F
-
M
------------
T
I
P
A
F
---
F
-------
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
--------
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------
29
HHSearch
76.57
13%
-135
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
---------------------------------------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
--------
L
L
G
N
------
S
L
V
M
L
V
I
L
Y
S
R
V
--
G
R
S
V
----------------
T
D
V
Y
L
L
N
L
A
----
L
A
D
--------------
L
L
---
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
------
N
G
W
--
I
F
G
--
T
F
L
C
K
V
V
S
L
-----
L
K
E
V
N
F
Y
S
G
--------------
I
L
L
L
A
C
I
S
V
D
R
Y
-----------------------
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
-
Q
-
A
Y
-
H
P
N
N
S
------
S
P
V
C
Y
---
E
V
L
-----
G
N
D
----
T
---
A
K
W
-
R
-
M
V
L
R
--
I
L
P
H
T
F
G
F
--
I
-------
V
--
P
L
F
-
V
M
L
F
-----
C
---
Y
G
F
T
L
R
T
L
F
K
A
H
---------------
M
--------------------
G
--------
Q
K
H
R
---------
A
M
R
V
I
F
A
V
V
L
I
F
L
L
--------
C
W
L
--
P
Y
N
L
V
L
L
A
D
----
T
L
M
RTQ
V
IQE
S
C
E
R
R
---
N
-----------
N
-------
I
G
-
R
------------
A
L
D
A
T
---
E
I
L
-----
G
--
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
--------
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
75.37
14%
-137
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-325]
----------------------------------------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
--------
F
P
I
N
------
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
----------------
L
N
Y
I
L
L
N
L
A
----
V
A
D
--------------
L
F
---
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
----
G
Y
F
--
V
F
G
--
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
I
A
--------------
L
W
S
L
V
V
L
A
I
E
R
Y
-----------------------
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
-
I
P
E
G
M
------
Q
C
S
C
G
---
I
D
Y
-----
Y
T
P
----
H
E
--
E
T
N
-
N
-
E
S
F
V
--
I
Y
M
F
V
V
H
F
--
I
-------
I
--
P
L
I
-
V
I
F
F
-----
C
---
Y
G
Q
L
V
F
T
V
K
E
A
A
--------------
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
---------
V
T
R
M
V
I
I
M
V
I
A
F
L
I
--------
C
W
L
--
P
Y
A
G
V
A
F
Y
I
----
F
T
----
H
---
Q
---
G
---
S
-----------
D
-------
F
G
P
I
------------
F
M
T
I
P
A
F
-
F
-------
A
--
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
--------
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
73.08
18%
-153
* C5 *
4QLA
1
HYEP_BOMMO
A:
[19-442]
LDLEEWWGPPELKQKQDT
S
I
K
P
F
E
I
T
FS
E
T
M
V
K
E
L
K
E
R
I
K
K
RRPFAPPLEGVGFKYGFNSKQ
L
D
S
W
L
K
Y
W
A
E
E
Y
P
--------
F
A
E
R
Q
K
F
L
N
Q
Y
P
H
F
K
T
N
I
Q
G
L
N
I
H
F
M
R
I
T
P
K
--------
V
P
K
G
------
V
E
I
V
P
L
L
L
L
H
G
W
--
P
G
S
V
----------------
R
E
F
Y
E
A
I
P
H
L
T
AV
S
K
D
--------------
R
N
---
F
A
L
E
I
-
I
A
P
S
L
P
G
Y
G
-
F
----
S
D
A
--
A
V
R
PG
L
A
A
A
E
V
A
V
I
-----
F
K
N
L
M
A
R
L
----------------------
G
Y
K
Q
Y
-----------------------
Y
V
Q
G
G
--
D
W
G
A
L
---
I
G
S
A
M
A
T
F
F
P
K
E
I
I
G
F
H
S
N
M
A
L
T
L
S
P
A
A
T
F
L
E
F
V
G
A
L
F
P
------
S
L
I
V
E
PEL
A
N
R
-----
L
Y
P
L
S
E
-
K
Y
--
S
T
L
-
L
-
E
E
L
G
--
Y
M
H
I
Q
A
T
K
--
P
-------
D
--
T
V
G
-
I
G
L
T
D
----
S
---
P
A
G
L
L
A
Y
I
L
E
K
F
--------------
S
T
WTNP----------------
D
--------
L
R
S
K
EDGGLSYRW
T
K
D
Q
L
I
D
N
L
M
L
Y
W
S
--------
T
K
S
--
I
V
T
S
M
R
L
Y
A
----
E
S
----
F
---
S
---
S
---
R
-----------
H
-------
F
D
-
L
KLDEIQVQ
V
P
T
W
V
L
Q
A
K
---
H
EL
A
Y
Q
P
P
C
--
I
L
K
M
K
Y
P
K
L
V
N
A
S
V
I
E
DGGHFLAF
E
L
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.26
22%
-155
- C4 -
2YCY
6
ADRB1_MELGA
A:
[21-219]
-------------------------------------------------------------------------------------------------------------
V
V
L
L
I
--------
V
A
G
N
------
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
----------------
T
N
L
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
----
G
T
W
--
L
W
G
--
S
F
L
C
E
L
W
T
S
-----
L
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
I
D
R
Y
-----------------------
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------------
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-
C
D
--
F
V
T
-
N
-
R
--
A
--
Y
A
I
A
S
S
I
I
S
F
Y
-------
I
--
P
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
--------------
R
A
--------------------
S
--------
K
R
K
R
---------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
--------
I
I
M
--
G
V
F
T
L
C
W
L
P
----
F
F
----
L
---
V
---
N
---
I
-----------
V
-------
N
V
-
F
------------
N
R
D
L
V
---
P
-------
D
--
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
--------
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.19
22%
-151
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[21-219]
-------------------------------------------------------------------------------------------------------------
V
V
L
L
I
--------
V
A
G
N
------
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
----------------
T
N
L
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
----
G
T
W
--
L
W
G
--
S
F
L
C
E
L
W
T
S
-----
L
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
I
D
R
Y
-----------------------
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------------
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-
C
D
--
F
V
T
-
N
-
R
--
A
--
Y
A
I
A
S
S
I
I
S
F
Y
-------
I
--
P
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------
R
A
--------------------
S
--------
K
R
K
R
---------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
--------
I
I
M
--
G
V
F
T
L
C
W
L
P
----
F
F
----
L
---
V
---
N
---
I
-----------
V
-------
N
V
-
F
------------
N
R
D
L
V
---
P
-------
D
--
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
--------
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.86
22%
-152
- C4 -
2YCW
7
ADRB1_MELGA
A:
[21-219]
-------------------------------------------------------------------------------------------------------------
V
V
L
L
I
--------
V
A
G
N
------
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
----------------
T
N
L
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
----
G
T
W
--
L
W
G
--
S
F
L
C
E
L
W
T
S
-----
L
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
I
D
R
Y
-----------------------
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------------
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-
C
D
--
F
V
T
-
N
-
R
--
A
--
Y
A
I
A
S
S
I
I
S
F
Y
-------
I
--
P
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------
R
A
--------------------
S
--------
K
R
K
R
---------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
--------
I
I
M
--
G
V
F
T
L
C
W
L
P
----
F
F
----
L
---
V
---
N
---
I
-----------
V
-------
N
V
-
F
------------
N
R
D
L
V
---
P
-------
D
--
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
--------
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
70.55
11%
-131
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
--------
V
F
G
N
------
V
L
V
I
T
A
I
A
K
F
E
R
--
L
Q
T
V
----------------
T
N
Y
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
----
K
M
W
--
T
F
G
--
N
F
W
C
E
F
W
T
S
-----
I
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
V
D
R
Y
-----------------------
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
------
C
Y
A
E
E
---
T
C
C
-----
D
F
F
T
N
Q
-
A
Y
--
A
I
A
-
S
-
S
I
V
S
--
F
Y
V
P
L
V
I
M
--
V
-------
F
--
V
Y
S
-
R
V
F
Q
-----
E
---
A
K
R
Q
L
N
I
F
E
M
L
R
--------------
I
D
--------------------
E
--------
G
L
R
L
---------
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
--------
G
H
L
--
L
T
K
-
S
P
S
L
N
----
A
A
----
K
---
S
---
E
---
L
-----------
D
-------
K
A
-
I
GRNTNGVI----
T
K
D
E
A
---
E
-------
K
--
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
--------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
18
PsiBlast_PDB
70.19
22%
-149
- C4 -
2YCX
3
ADRB1_MELGA
A:
[21-219]
-------------------------------------------------------------------------------------------------------------
V
V
L
L
I
--------
V
A
G
N
------
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
----------------
T
N
L
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
----
G
T
W
--
L
W
G
--
S
F
L
C
E
L
W
T
S
-----
L
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
I
D
R
Y
-----------------------
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------------
H
W
W
R
D
---
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-
C
D
--
F
V
T
-
N
-
R
--
A
--
Y
A
I
A
S
S
I
I
S
F
Y
-------
I
--
P
L
L
I
M
I
F
V
-----
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
--------------
R
A
--------------------
S
--------
K
R
K
R
---------
V
M
L
M
R
E
H
K
A
L
K
T
L
G
--------
I
I
M
--
G
V
F
T
L
C
W
L
P
----
F
F
----
L
---
V
---
N
---
I
-----------
V
-------
N
V
-
F
------------
N
R
D
L
V
---
P
-------
D
--
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
--------
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
68.95
14%
-140
- C2 -
4KPP
4
?
A:
[2-396]
-----------DF
T
K
E
K
F
Q
L
L
A
I
S
S
L
T
L
P
W
L
I
S
L
A
F
N
Y
H
H
P
A
L
T
Q
T
L
L
S
G
L
A
V
V
S
A
S
F
L
I
S
W
A
A
E
T
A
E
M
--
D
V
P
R
--------
S
F
S
L
A
I
V
A
L
L
A
V
L
P
E
Y
A
V
D
G
Y
F
A
W
K
A
G
S
V
G
G
--------
E
Y
V
H
------
Y
A
T
A
N
M
T
G
A
N
R
L
--
L
I
G
I
----------------
G
W
S
L
V
A
F
I
A
----
F
R
T
L
KSK
E
V
E
L
D
DGI
R
L
E
I
---
F
F
L
F
L
-
A
T
L
Y
A
F
T
L
P
-
L
----
K
G
H
IS
P
F
D
--
A
L
V
F
V
S
L
Y
A
-----
I
Y
I
Y
L
S
T
K
A
ER
E
E
V
E
V
G
G
V
P
A
Y
L
C
S
L
K
T
E
T
R
R
L
S
V
-----------------------
V
V
L
F
L
F
A
G
F
T
I
L
---
M
S
V
E
A
F
S
E
G
L
L
E
T
A
R
I
A
G
I
D
E
F
L
A
V
Q
--
W
I
A
P
L
A
S
E
S
P
E
------
L
I
V
A
----
I
Y
F
-----
V
R
R
F
R
--
V
S
--
A
S
M
-
N
-
A
L
I
S
--
S
K
V
N
Q
W
T
L
--
L
-------
I
--
G
T
I
-
A
I
I
Y
-----
S
---
I
S
A
F
K
L
Q
S
L
P
L
D
--------------
A
R
--------------------
Q
--------
S
E
E
V
---------
L
L
T
A
A
Q
S
L
F
A
V
A
I
L
L
DLKIS
W
K
E
A
S
--
A
L
F
L
L
F
I
V
Q
----
L
L
----
F
---
P
---
G
---
V
-----------
E
-------
V
R
-
Y
------------
I
I
S
A
I
---
Y
-------
I
--
I
L
S
---
L
P
I
L
F
A
-
K
R
K
--------
E
I
V
E
S
F
-
R
T
V
K
R
L
I
S
LE-----------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
67.36
18%
-164
- C4 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
----------------------------------------------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
--------
V
F
G
N
------
V
L
V
I
T
A
I
A
K
F
E
R
--
L
Q
T
V
----------------
T
N
Y
F
I
T
S
L
A
----
C
A
D
--------------
L
V
---
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
----
K
M
W
--
T
F
G
--
N
F
W
C
E
F
W
T
S
-----
I
D
V
L
C
V
T
A
S
--------------
I
E
T
L
C
V
I
A
V
D
R
Y
-----------------------
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
---
H
Q
E
------
A
I
N
C
Y
---
A
---------
E
E
T
C
-
C
D
--
F
F
T
-
N
-
Q
A
Y
A
--
I
A
S
S
I
V
S
F
--
Y
-------
V
--
P
L
V
-
I
M
V
F
-----
V
---
Y
S
R
V
F
Q
E
A
K
R
Q
L
--------------
N
I
--------------------
F
--------
E
M
L
R
---------
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
--------
G
Y
Y
--
T
I
G
I
G
H
L
L
T
----
K
S
----
P
---
S
---
L
---
N
-----------
A
-------
A
K
-
S
------------
E
L
D
K
A
---
I
-------
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
66.59
14%
-163
- C3 -
3ZPJ
-
?
A:
[1-356]
---------------------------------------M
T
T
L
E
E
I
N
L
L
V
E
R
GY
Y
E
E
A
L
A
K
V
YEIE
D
P
I
--
E
Q
V
Q
--------
V
L
T
K
I
V
V
T
I
Y
Q
H
D
G
P
M
E
W
I
P
S
I
M
E
D
A
M
Y
I
A
K
K
LRD
P
A
N
K
A
V
A
Y
------
S
I
I
A
S
T
L
A
I
M
E
Y
--
E
E
D
A
----------------
M
D
F
F
N
R
A
I
D
----
E
A
N
--------------
E
I
---
E
S
P
I
E
-
K
G
M
V
L
S
T
L
A
-
Y
----
H
L
A
--
I
A
G
--
Y
P
D
N
A
L
E
I
F
N
I
A
--
F
D
T
I
I
G
A
E
T
--------------
S
Y
T
H
K
V
D
G
I
L
R
I
-----------------------
G
D
L
L
E
K
A
G
D
T
L
P
---
S
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
H
V
N
Q
R
A
A
I
V
E
K
K
I
E
L
A
K
T
V
Y
D
------
V
G
L
P
Q
---
I
R
A
-----
A
L
L
K
G
K
-
N
H
--
Y
A
L
-
A
-
I
I
K
K
K
Y
S
G
V
M
R
L
I
G
--
E
-------
L
--
E
V
A
-
L
W
M
K
R
V
NNM
E
---
Y
L
D
V
V
D
K
A
F
E
C
C
------------------------------------
E
--------
S
P
R
F
---------
T
-
D
V
N
V
Q
H
I
A
R
L
L
T
--------
E
L
G
N
L
R
R
A
L
K
F
A
K
E
IQN
I
H
K
----
R
---
S
---
E
---
A
-----------
L
-------
K
A
-
I
------------
A
L
E
L
V
---
R
-------
R
--
K
K
F
E
E
V
K
K
I
I
E
S
I
P
D
P
--------
K
I
R
E
E
A
L
N
E
I
G
-
T
I
E
-------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
64.63
12%
-169
- C1 -
2W7O
3
POLK_HUMAN
A:
[15-501]
--------------------------------------------KEK
I
N
K
I
I
M
E
A
T
KGS
R
F
Y
G
N
E
L
K
K
E
--
K
Q
V
N
--------
Q
R
I
E
N
M
M
Q
Q
K
A
Q
I
T
S
Q
Q
L
R
K
A
Q
L
Q
V
D
R
F
A
M
E
--------
L
E
Q
S
RNLS
N
T
I
V
H
I
D
M
D
A
F
Y
A
A
--
V
E
M
R
D
N
PELKD
K
P
I
A
V
G
S
MS
M
L
S
T
S
N
Y
H
A
----
R
R
F
--------------
G
V
RAA
M
P
G
F
I
-
A
K
R
L
C
P
Q
L
I
-
I
V
P
PN
F
D
K
--
Y
R
A
--
V
S
K
E
V
K
E
I
L
A
D
Y
DP
N
F
M
A
M
S
L
D
E
--------------
A
Y
L
N
I
T
K
H
L
E
E
R
Q
NWPEDKRRYFIKQN
S
V
V
F
G
TS
A
Q
E
V
V
K
E
I
R
F
R
I
E
---
Q
K
T
T
L
T
-----
A
S
A
G
I
A
P
N
T
M
L
A
K
V
C
S
D
K
N
K
P
N
G
Q
Y
Q
I
L
PN
R
Q
A
V
M
D
F
I
K
---
D
L
P
-----
I
R
K
V
S
G
-
I
G
--
K
V
T
-
E
-
K
M
L
K
A
-
L
G
I
I
T
C
T
E
--
L
-------
Y
Q
Q
R
A
L
-
L
S
L
L
-----
F
---
S
E
T
S
W
H
Y
F
L
H
I
S
L
GLGST
H
L
T
R
DGER
K
S
--------------------
M
--------
S
V
E
R
---------
T
F
S
E
I
N
K
A
E
E
Q
Y
S
L
--------
C
Q
E
--
L
C
S
E
L
A
Q
D
L
----
Q
K
----
E
---
R
---
L
---
K
-----------
G
-------
R
T
-
V
------------
T
I
K
L
K
N
VN
F
-------
E
--
V
K
T
R
A
S
T
V
S
S
V
V
S
T
A
E
--------
E
I
F
A
I
A
K
E
L
L
K
T
E
I
D
ADFPHPLRLR
L
M
G
V
R
I
SSFPNE---------------------------------------------------------------------------------------------------------------------------
24
HHSearch
63.98
17%
-160
- C4 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-200]
-----------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
--------
V
G
L
N
------
L
L
V
L
Y
A
V
R
S
E
R
K
--
L
H
T
V
----------------
G
N
L
Y
I
V
S
L
S
----
V
A
D
--------------
L
I
---
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
----
S
K
W
--
S
L
G
--
R
P
L
C
L
F
W
L
S
-----
M
D
Y
V
A
S
T
A
S
--------------
I
F
S
V
F
I
L
C
I
D
R
Y
-----------------------
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
-------
R
R
------
E
D
K
C
-------------------
E
T
--
D
F
Y
-
D
V
T
W
F
K
--
V
M
T
A
I
I
N
F
--
Y
-------
L
--
P
T
L
-
L
M
L
W
-----
F
---
Y
A
K
I
Y
K
A
V
R
Q
H
C
--------------
N
I
--------------------
F
--------
E
M
L
R
---------
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
--------
G
Y
Y
--
T
I
G
I
G
H
L
L
T
----
K
S
----
P
---
S
---
L
---
N
-----------
A
-------
A
K
-
S
------------
E
L
D
K
A
---
I
-------
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
62.51
16%
-167
* C4 *
3PBL
1
DRD3_HUMAN (first)
A:
[41-226]
------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
--------
V
F
G
N
------
G
L
V
C
M
A
V
L
K
E
R
A
--
L
Q
T
T
----------------
T
N
Y
L
V
V
S
L
A
----
V
A
D
--------------
L
L
---
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
----
G
V
W
--
N
F
S
--
R
I
C
C
D
V
F
V
T
-----
L
D
V
M
M
C
T
A
S
--------------
I
W
N
L
C
A
I
S
I
D
R
Y
-----------------------
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
--
T
---
T
G
D
------
P
T
V
C
-------------------
S
I
--
S
N
P
---
D
-
F
V
--
I
Y
S
S
V
V
S
F
--
Y
-------
L
--
P
F
G
-
V
T
V
L
-----
V
---
Y
A
R
I
Y
V
V
L
K
Q
R
R
--------------
R
K
--------------------
N
--------
I
F
E
M
---------
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
--------
T
E
G
--
Y
Y
T
I
G
I
G
H
L
----
L
T
----
K
---
S
---
P
---
S
-----------
L
-------
N
A
-
A
------------
K
S
E
L
D
---
K
-------
A
--
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
--------
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
62.42
17%
-172
- C4 -
3EML
8
ENLYS_BPT4
A:
[21-221]
---------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
--------
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
--
L
Q
N
V
----------------
T
N
Y
F
V
V
S
L
A
----
A
A
D
--------------
I
A
---
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-------
G
F
--
C
A
A
--
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
S
S
--------------
I
F
S
L
L
A
I
A
I
D
R
Y
-----------------------
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
------------
S
Q
G
C
G
---
E
G
--------
Q
V
A
C
-
L
F
--
E
D
V
V
P
M
N
Y
M
V
--
Y
F
N
F
F
A
C
V
--
L
-------
V
--
P
L
L
-
L
M
L
G
-----
V
---
Y
L
R
I
F
L
A
A
R
R
Q
L
--------------
N
I
--------------------
F
--------
E
M
L
R
---------
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
--------
G
Y
Y
--
T
I
G
I
G
H
L
L
T
----
K
S
----
P
---
S
---
L
---
N
-----------
A
-------
A
K
-
S
------------
E
L
D
K
A
---
I
-------
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
62.03
15%
-168
- C4 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
-----------------------------------------------------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
--------
I
I
G
N
------
I
L
V
M
V
S
I
K
V
N
R
H
--
L
Q
T
V
----------------
N
N
Y
F
L
F
S
L
A
----
C
A
D
--------------
L
I
---
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
----
G
Y
W
--
P
L
G
--
P
V
V
C
D
L
W
L
A
-----
L
D
Y
V
V
S
N
A
S
--------------
V
M
N
L
L
I
I
S
F
D
R
Y
-----------------------
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
R
T
V
E
------
D
G
------------------
E
C
-
Y
I
--
Q
F
F
-
S
N
A
A
V
T
--
F
G
T
A
I
A
A
F
--
Y
-------
L
--
P
V
I
-
I
M
T
V
-----
L
---
Y
W
H
I
S
R
A
S
K
S
R
I
--------------
N
I
--------------------
F
--------
E
M
L
R
---------
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
--------
G
Y
Y
--
T
I
G
I
G
H
L
L
T
----
K
S
----
P
---
S
---
L
---
N
-----------
A
-------
A
K
-
S
------------
E
L
D
K
A
---
I
-------
G
--
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
--------
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
-------------------------------------------------------------------------------------------------------------------------------------------------