@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10J6_HUMAN: (2016-01-11 )
MRRKNLTEVTEFVFLGFSRFHKHHITLFVVFLILYTLTVAGNAIIMTIICIDRHLHTPMYFFLSMLASSKTVYTLFIIPQMLSSFVTQTQPISLAGCTTQTFFFVTLAINNCFLLTVMGYDHYMAICNPLRYRVITSKKVCVQLVCGAFSIGLAMAAVQVTSIFTLPFCHTVVGHFFCDILPVMKLSCINTTINEIINFVVRLFVILVPMGLVFISYVLIISTVLKIASAEGWKKTFATCAFHLTVVIVHYGCASIAYLMPKSENSIEQDLLLSVT
Atome Classification :
(20 SA)
-------------------------------------------------------------.........10.....-----------.--..20........30........40........50...--.....60........70......-..80.....-...90.......-.100.......110.......120---......---------...130...---....-------140.......150....-...160.----.....---------.170..----------.....180.-....-----------------------.-----.-----190--.......-------------200.----...--...210.--...--...220......---------.--------------------230...-----....240.......250----........-260....----...---270....------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------------------------------MRRK
N
L
T
E
V
T
E
F
V
F
L
G
-----------
F
--
S
R
F
H
K
H
H
I
T
L
F
V
V
F
L
I
L
Y
T
L
T
VAG
N
A
I
I
M
T
I
I
C
IDRH--LH
T
P
M
Y
F
F
L
S
M
L
ASSK
T
V
Y
T
L
F
I
-
I
P
Q
M
L
S
S
F
V-TQTQ
P
I
S
L
AGCT-
T
Q
T
F
F
F
V
T
L
AIN
N
C
F
L
L
T
VMGY-----
D
H
Y
M
A
I
---------CNP
L
R
Y
R
V
I---TS
K
K
-------
V
C
V
Q
L
V
C
G
A
F
S
I
G
L
A
M
A
-
A
V
Q
V
T
S
I
----
F
T
L
P
F
---------
C
H
T
V
V
G
----------
H
F
F
C
D
I
L
P
V
-
M
K
L
S
-----------------------
C
-----
I
-----
N
T
T
--
I
N
E
I
I
N
F
-------------
V
V
R
L
----
F
V
I
--
L
V
P
M
G
L
V
--
F
I
S
--
Y
V
L
I
I
S
T
V
L
K
I
A---------S--------------------AE
G
W
K
K
-----
T
F
A
T
C
A
F
H
L
T
V
V
I
V
HY-----G
C
A
S
I
A
Y
L-MPKSENS----I
E
Q
---
D
L
L
L
SVT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
78.77
19%
-167
- C7 -
2KS9
1
NK1R_HUMAN
A:
[33-274]
--------------------------------------------------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
--
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
-
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
-----
D
R
Y
M
A
I
---------
I
H
P
L
Q
P
R
L
-----
S
A
T
-------
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
-
F
P
Q
G
Y
Y
S
----
T
T
E
T
-------------
M
P
S
----------
R
V
V
C
M
I
E
W
P
-
E
H
P
------------------------------------
N
K
I
--
Y
E
K
V
Y
H
I
-------------
C
V
T
V
----
L
I
Y
--
F
L
P
L
L
V
I
--
G
Y
A
--
Y
T
V
V
G
I
T
L
W
A
S
E
---------
I
PGDSSDRYH
E
Q
---------
V
S
A
K
R
K
-----
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
-----
L
P
F
H
I
F
F
L
-
L
P
Y
I
N
P
D
----
L
Y
L
---
K
K
F
I
Q
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
78.23
13%
-125
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
--
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
-
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
-----
D
R
Y
F
A
I
---------
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-------
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
----
W
Y
R
A
T
---------
H
Q
E
A
I
N
----------
C
Y
A
E
E
T
C
C
D
-
F
F
T
N
-----------------------
Q
-----
A
-----
Y
A
I
--
A
S
S
I
V
S
F
-------------
Y
V
P
L
----
V
I
M
--
V
F
V
Y
S
R
V
--
F
Q
E
--
A
K
R
Q
L
N
I
F
E
M
L
R
---------
I
--------------------
D
E
G
L
R
L
-----
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
-----
L
L
T
K
-
S
P
S
-
L
N
A
A
K
S
E
----
L
D
K
---
A
I
G
R
N
T
N
GVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
39
Fugue
77.27
17%
-121
- C7 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----------------------------------------------MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
-----------
L
--
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
-
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
-----
E
R
Y
V
V
V
---------
C
K
P
M
S
N
F
------------------------
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
----
M
A
L
A
C
---------
A
A
P
P
L
V
----------
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------------
C
G
I
DYY
T
-----
P
H
E
--
E
T
N
N
E
S
F
-------------
V
I
Y
M
----
F
V
V
HF
I
I
P
L
I
V
I
--
F
F
C
--
Y
G
Q
L
V
F
T
V
K
E
A
A
AQQQESA
T
T
Q
--------------------
K
A
E
K
E
V
-----
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
-----
P
Y
A
G
V
A
F
Y
-
I
F
T
H
Q
G
S
----
D
F
G
---
P
I
F
M
T
I
P
A
F
F
A
KTSAV
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------
44
Fugue
75.89
16%
-180
- C3 -
4RNZ
9
?
A:
[1-369]
-------------------------------------------------------------
M
E
R
L
V
W
D
K
L
T
L
L
G
F
L
E
K
N
HIPQ
K
L
Y
Y
N
L
--
S
S
Q
D
K
E
L
S
A
E
I
Q
S
N
V
T
Y
Y
T
L
R
D
A
N
N
T
L
I
Q
A
L
I
P
I
S
Q
D
--
L
Q
I
H
I
Y
K
K
-------
G
E
D
Y
F
L
D
F
-
I
P
----
I
I
F
-
T
R
K
E
K
T
L
L
L
S
L
Q
-
T
S
P
Y
Q
D
I
I
K
A
T
N
D
P
L
L
A
N
Q
L
M
N
A
Y
K
KS
V
P
F
K
R
L
---------
V
K
N
D
K
I
A
I
V
---
Y
T
R
D
-------
Y
R
V
G
Q
A
F
G
Q
P
T
I
K
M
A
M
V
-
S
S
R
S
N
Q
Y
----
Y
L
F
S
H
SNG
H
Y
Y
D
SK
A
Q
E
V
A
G
----------
F
L
L
E
T
P
V
K
Y
-
T
R
I
S
SPFSYGRFHRPHY
G
V
D
Y
A
A
K
HGS
L
-----
I
-----
H
S
A
--
S
D
G
R
V
G
F
-------------
M
G
V
K
AGYG
K
V
V
--
E
I
H
L
N
E
L
--
R
L
V
--
Y
A
H
M
S
A
F
A
N
G
L
K
---------
K
--------------------
G
S
F
V
K
K
GQII
G
R
V
G
S
T
G
P
H
L
H
F
G
V
Y
K
N
-----
S
R
P
I
N
P
L
G
-
Y
I
R
T
A
K
S
K
L
H
G
K
Q
R
---
E
V
F
L
E
K
A
Q
R
S
K
Q
K
L
E
E
L
L
K
T
H
SFEKNSFYLLEGFLEHHHH---------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
75.33
16%
-159
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------------------------------------MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
-----------
Q
--
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
-
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
-----
E
R
Y
V
V
V
---------
C
K
P
M
S
N
F
------------------------
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
----
M
A
L
A
C
---------
A
A
P
P
L
V
----------
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
-----------------------
C
-----
G
I
DYYT
P
H
E
--
E
T
N
N
E
S
F
-------------
V
I
Y
M
----
F
V
V
HF
I
I
P
L
I
V
I
--
F
F
C
--
Y
G
Q
L
V
F
T
V
K
E
A
A
---------
A
--------------------
S
A
T
T
Q
K
-----
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
-
I
F
T
H
Q
G
S
----
D
F
G
---
P
I
F
M
T
I
P
A
F
F
A
K
TSAVY
N
P
V
I
Y
I
M
MN
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
74.39
14%
-175
* C7 *
2Z73
5
OPSD_TODPA
A:
[32-288]
-----------------------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
--
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
-
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
-----
D
R
Y
N
V
I
---------
G
R
P
M
A
A
S
K
K
---
M
S
H
R
-------
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
W
----
G
A
Y
T
L
------------
E
G
V
----------
L
C
N
C
S
F
D
Y
I
-
S
R
--------------------------------------
D
S
--
T
T
R
S
N
I
L
-------------
C
M
F
I
----
L
G
F
--
F
G
P
I
L
I
I
--
F
F
C
--
Y
F
N
I
V
M
S
V
S
N
H
E
---------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
-----
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
-----
S
P
Y
A
V
V
A
L
-
L
A
Q
F
G
P
L
----
E
W
V
---
T
P
Y
A
A
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
72.27
17%
-172
- C7 -
3EML
8
ENLYS_BPT4
A:
[21-222]
-------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
--
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
-
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
-----
D
R
Y
I
A
I
---------
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
-------
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
-
L
T
P
M
L
G
W
----
N
N
C
G
Q
-------------------------
S
Q
G
C
G
E
G
Q
----
V
A
-----------------------
C
-----
L
-----
F
E
D
VV
P
M
N
Y
M
V
Y
-------------
F
N
F
F
----
A
C
V
--
L
V
P
L
L
L
M
--
L
G
V
--
Y
L
R
I
F
L
A
A
R
R
Q
L
---------
N
--------------------
I
F
E
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
-----
Y
T
I
G
I
G
H
L
-
L
T
K
S
P
S
L
----
N
A
A
---
K
S
E
L
D
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
72.12
22%
-133
- C5 -
4PCH
2
?
A:
[8-271]
-----------------------------------------------------------E
V
L
D
T
V
P
L
T
E
D
T
Q
Y
K
V
E
A
-----------
V
L
L
P
N
F
G
K
A
A
F
Q
S
R
G
L
P
Y
T
M
S
D
T
L
G
P
G
A
A
L
C
Y
S
V
A
V
I
N
----
L
P
E
I
M
I
V
W
E
A
Y
R
L
E
T
E
L
L
F
A
-----
P
Q
M
A
S
S
G
Y
-
Q
R
A
N
G
-
T
L
A
G
I
E
G
T
Q
L
Y
F
W
A
C
G
G
G
P
----
L
D
V
I
G
I
---------------------
N
P
D
P
E
R
L
K
---
V
N
E
----------------------
A
L
E
-
G
P
G
N
S
D
V
----
A
S
L
Q
A
---------
L
R
K
Q
V
N
----------
A
---
A
N
F
P
V
--
E
L
W
-----------------------
V
-----
A
-----
D
P
T
--
K
N
D
N
-----------------
T
R
Y
----
F
G
R
--
V
V
G
G
G
V
T
P
P
V
V
S
--
Y
G
N
Q
S
T
T
P
L
I
D
E
---------
N
--------------------
G
V
G
I
L
C
-----
T
F
G
S
V
Y
L
T
S
A
D
M
V
G
M
T
-----
G
L
P
G
L
P
T
L
S
A
D
Y
S
N
Q
R
----
T
V
Q
A
G
Y
G
R
F
F
R
V
H
C
R
Q
R
R
I------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
72.12
16%
-136
- C7 -
1U19
10
OPSD_BOVIN
A:
[38-277]
-----------------------------------------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
-
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
-----
E
R
Y
V
V
V
---------
C
K
P
M
S
N
F
R
F
----
G
E
N
-------
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
W
----
S
R
Y
I
P
------------
E
G
M
----------
Q
C
S
C
G
I
D
Y
Y
-
T
P
H
------------------------------------
E
E
T
--
N
N
E
S
F
V
I
-------------
Y
M
F
V
----
V
H
F
--
I
I
P
L
I
V
I
--
F
F
C
--
Y
G
Q
L
V
F
T
V
K
E
A
A
---------
A
QQQESA
T
T
------------
Q
K
A
E
K
E
-----
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
-----
L
P
Y
A
G
V
A
F
-
Y
I
F
T
H
Q
G
----
S
D
F
---
G
P
I
F
M
T
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
72.01
19%
-164
- C7 -
3UON
2
ACM2_HUMAN (first)
A:
[24-215]
--------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
--
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
-
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
-----
D
R
Y
F
C
V
---------
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
-------
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
W
----
Q
F
I
V
G
---------
V
R
-
T
V
E
----------
D
G
E
C
Y
I
Q
F
F
---------------------------------------------
S
N
A
A
V
T
F
-------------
G
T
A
I
----
A
A
F
--
Y
L
P
V
I
I
M
--
T
V
L
--
Y
W
H
I
S
R
A
S
K
S
R
I
---------
N
--------------------
I
F
E
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
-----
Y
T
I
G
I
G
H
L
-
L
T
K
S
P
S
L
----
N
A
A
---
K
S
E
L
D
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
68.27
16%
-160
- C7 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
-------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
--
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
-
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
-----
D
R
Y
F
A
I
---------
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-------
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
----
W
Y
R
A
T
------------
H
Q
E
----------
A
I
N
C
Y
A
E
-----
E
T
-----------------------
C
-----
C
-----
D
F
F
--
T
N
Q
A
Y
A
I
-------------
A
S
S
I
----
V
S
F
--
Y
V
P
L
V
I
M
--
V
F
V
--
Y
S
R
V
F
Q
E
A
K
R
Q
L
---------
N
--------------------
I
F
E
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
-----
Y
T
I
G
I
G
H
L
-
L
T
K
S
P
S
L
----
N
A
A
---
K
S
E
L
D
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
67.63
16%
-149
- C7 -
3RZE
2
ENLYS_BPT4 (first)
A:
[10-201]
---------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
--
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
-
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
-----
D
R
Y
R
S
V
---------
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
-------
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
-
I
P
I
L
G
-
W
----
N
H
----------------
R
R
----------
E
D
K
C
E
T
D
F
Y
-
D
--------------------------------------------
V
T
W
F
K
V
-------------
M
T
A
I
----
I
N
F
--
Y
L
P
T
L
L
M
--
L
W
F
--
Y
A
K
I
Y
K
A
V
R
Q
H
C
---------
N
--------------------
I
F
E
M
L
R
-----
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
-----
Y
T
I
G
I
G
H
L
-
L
T
K
S
P
S
L
----
N
A
A
---
K
S
E
L
D
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
65.42
24%
-139
- C7 -
4GPO
-
ADRB1_MELGA
A:
[6-139]
----------------------------------------------------------------------------------------
L
--
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
-
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
-----
D
R
Y
L
A
I
---------
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
-------
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
L
P
I
M
M
H
----
W
W
R
D
E
---------
D
P
Q
A
L
K
----------
C
Y
Q
D
P
G
C
C
D
-
F
V
T
N
-----------------------
R
-----
A
-----
Y
A
I
--
A
S
S
I
I
S
F
-------------
Y
I
P
L
----
L
I
M
--
I
F
V
A
L
R
V
--
Y
R
E
--
A
K
E
Q
V
M
L
M
R
E
H
K
---------
A
--------------------
L
K
T
L
G
I
-----
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
-----
I
V
N
V
F
N
R
D
-
L
V
P
D
W
L
F
----
V
A
F
---
N
W
L
G
Y
A
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
65.18
16%
-174
- C7 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-227]
----------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
--
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
-
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
-----
D
R
Y
T
A
V
---------
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
-------
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
G
F
----
N
T
T
---------------
G
D
----------
P
T
V
C
S
I
S
N
------------------------------------------------
P
D
F
V
I
-------------
Y
S
S
V
----
V
S
F
--
Y
L
P
F
G
V
T
--
V
L
V
--
Y
A
R
I
Y
V
V
L
K
Q
R
R
---------
R
--------------------
K
N
I
F
E
M
-----
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
-----
G
Y
Y
T
I
G
I
G
-
H
L
L
T
K
S
P
----
S
L
N
---
A
A
K
S
E
L
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.10
24%
-151
- C7 -
2Y03
4
ADRB1_MELGA
A:
[6-139]
----------------------------------------------------------------------------------------
L
--
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
-
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
-----
D
R
Y
L
A
I
---------
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
-------
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
L
P
I
M
M
H
----
W
W
R
D
E
---------
D
P
Q
A
L
K
----------
C
Y
Q
D
P
G
C
C
D
-
F
V
T
N
-----------------------
R
-----
A
-----
Y
A
I
--
A
S
S
I
I
S
F
-------------
Y
I
P
L
----
L
I
M
--
I
F
V
A
L
R
V
--
Y
R
E
--
A
K
E
Q
I
R
S
R
V
M
L
M
---------
R
--------------------
E
H
K
A
L
K
-----
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
-----
F
L
V
N
I
V
N
V
-
F
N
R
D
L
V
P
----
D
W
L
---
F
V
A
F
N
W
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
64.74
13%
-171
- C4 -
3LDF
1
?
A:
[1-385]
M
I
K
L
M
V
G
S
F
A
E
K
K
L
K
R
GVQLLSSRDYPNLNLDN
Q
V
V
Q
L
Y
S
DADIFL
G
T
A
Y
L
S
K
Q
NKGVGWL
I
S
P
K
K
V
S
L
N
V
T
Y
F
I
K
L
-----------
F
--
Q
W
S
K
D
K
R
K
N
F
A
H
S
K
L
T
T
A
Y
R
L
F
N
Q
D
G
D
S
F
G
G
V
T
I
D
C
Y
--
G
D
----
F
V
L
F
S
W
Y
N
S
F
V
Y
Q
I
R
D
E
-
I
V
A
A
F
R
Q
V
Y
-
P
N
F
L
G
A
Y
E
K
I
R
F
-
N
V
S
A
H
L
Y
G
Q
E
A
P
E
Q
F
L
I
L
E
N
G
I
-----
S
Y
N
V
F
L
NDGLMTGIF
L
D
Q
R
Q
V
R
N
E
---
L
I
N
G
SAAG
K
T
V
L
N
L
F
S
Y
T
A
A
F
S
V
A
A
A
M
G
G
A
M
A
T
T
S
V
D
LAK
R
S
R
A
L
---------
S
L
A
H
F
E
A
N
HLDMAN
H
Q
L
V
V
M
D
V
F
D
Y
-
F
K
Y
A
-----------------------
R
-----
R
-----
H
H
L
--
T
Y
D
I
I
I
I
D
P
P
SFARNK
E
V
F
S
V
S
K
D
----
Y
H
K
--
L
I
R
Q
G
L
E
--
I
L
S
EN
G
L
I
I
A
S
T
N
A
A
N
M
---------
T
--------------------
V
S
Q
F
K
K
-----
Q
I
E
K
G
F
G
K
Q
K
H
T
Y
L
D
L
-----
Q
--
Q
L
P
S
D
-
F
A
V
N
V
Q
D
----
E
S
S
---
N
Y
L
K
V
F
T
I
K
V---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
64.65
24%
-148
- C7 -
4AMI
3
ADRB1_MELGA
A:
[6-139]
----------------------------------------------------------------------------------------
L
--
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
-
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
-----
D
R
Y
L
A
I
---------
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
-------
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
L
P
I
M
M
H
----
W
W
R
D
E
---------
D
P
Q
A
L
K
----------
C
Y
Q
D
P
G
C
C
D
-
F
V
T
N
-----------------------
R
-----
A
-----
Y
A
I
--
A
S
S
I
I
S
F
-------------
Y
I
P
L
----
L
I
M
--
I
F
V
A
L
R
V
--
Y
R
E
--
A
K
E
Q
L
M
R
E
H
K
A
L
---------
K
--------------------
T
L
G
I
I
M
-----
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-----
N
V
F
N
R
D
L
V
-
P
D
W
L
F
V
A
----
F
N
W
---
L
G
Y
A
N
S
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
64.50
24%
-151
- C7 -
4AMJ
5
ADRB1_MELGA
A:
[6-139]
----------------------------------------------------------------------------------------
L
--
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
-
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
-----
D
R
Y
L
A
I
---------
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
-------
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
L
P
I
M
M
H
----
W
W
R
D
E
---------
D
P
Q
A
L
K
----------
C
Y
Q
D
P
G
C
C
D
-
F
V
T
N
-----------------------
R
-----
A
-----
Y
A
I
--
A
S
S
I
I
S
F
-------------
Y
I
P
L
----
L
I
M
--
I
F
V
A
L
R
V
--
Y
R
E
--
A
K
E
Q
S
R
V
M
L
M
R
E
---------
H
--------------------
K
A
L
K
T
L
-----
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
-
R
D
L
V
P
D
W
----
L
F
V
---
A
F
N
W
L
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
64.49
24%
-150
- C7 -
3ZPQ
6
ADRB1_MELGA
A:
[6-139]
----------------------------------------------------------------------------------------
L
--
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
--
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
-
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
-----
D
R
Y
L
A
I
---------
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
-------
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
-
F
L
P
I
M
M
H
----
W
W
R
D
E
---------
D
P
Q
A
L
K
----------
C
Y
Q
D
P
G
C
C
D
-
F
V
T
N
-----------------------
R
-----
A
-----
Y
A
I
--
A
S
S
I
I
S
F
-------------
Y
I
P
L
----
L
I
M
--
I
F
V
A
L
R
V
--
Y
R
E
--
A
K
E
Q
S
R
V
M
L
M
R
E
---------
H
--------------------
K
A
L
K
T
L
-----
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
-----
V
N
I
V
N
V
F
N
-
R
D
L
V
P
D
W
----
L
F
V
---
A
F
N
W
L
G
Y
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
64.09
13%
-149
- C7 -
2LNL
-
CXCR1_HUMAN
A:
[38-268]
------------------------------------------------------------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
--
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
V
--
N
G
W
I
F
G
T
F
L
C
K
-
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
-----
D
R
Y
L
A
I
---------
V
H
A
T
R
T
L
T
Q
----
K
R
H
-------
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
-
L
P
F
F
L
F
R
----
Q
A
Y
H
P
------------
N
N
S
----------
S
P
V
C
Y
E
V
L
G
-
N
D
-------------------------------------
T
A
K
--
W
R
M
V
L
R
I
-------------
L
P
H
T
----
F
G
F
--
I
V
P
L
F
V
M
--
L
F
C
--
Y
G
F
T
L
R
T
L
F
K
A
H
------------------------------
M
G
Q
K
H
R
-----
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
-----
L
P
Y
N
L
V
L
L
-
A
D
T
L
M
R
T
----
Q
V
I
---
Q
E
S
C
E
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------