@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10Q1_HUMAN: (2016-01-11 )
MPVGKLVFNQSEPTEFVFRAFTTATEFQVLLFLLFLLLYLMILCGNTAIIWVVCTHSTLRTPMYFFLSNLSFLELCYTTVVVPLMLSNILGAQKPISLAGCGAQMFFFVTLGSTDCFLLAIMAYDRYVAICHPLHYTLIMTRELCTQMLGGALGLALFPSLQLTALIFTLPFCGHHQEINHFLCDVPPVLRLACADIRVHQAVLYVVSILVLTIPFLLICVSYVFITCAILSIRSAEGRRRAFSTCSFHLTVVLLQYGCCSLVYLRPRSSTSEDEDSQIALVYTFVTPLLNPLLYSLRNKDVKGALRSAIIRKAASDAN
Atome Classification :
(20 SA)
----------.........10........20........30........40........50........60---........70........80-........90........100.......110..--.----....120.......130....-...140.---......--150.......160.......170...---....180--.......---.190...-------.--...200.........210...--......220.......230---------...-------.----..--------------------.--------.-.240-----.......250--........------260...---------....----270--.---..-.-.--...280.-----......290.......300.......310---------------........------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MPV
G
K
L
V
FNQSE
P
T
E
F
V
F
R
A
FT
T
A
T
E
F
Q
V
L
L
F
L
L
F
L
L
L
Y
L
M
I
L
CGN
T
A
I
I
W
V
V
CTHSTLR
T
---
P
M
Y
F
F
L
SN
L
S
F
L
E
L
C
Y
T
T
V
V
-
V
P
L
M
L
S
N
I
LGAQK
P
I
S
L
AGCG
A
Q
M
F
F
F
V
T
LGST--
D
----
C
F
L
L
A
I
M
A
YD
R
Y
V
A
I
C
H
P
L
H
Y
-
T
L
I
M
T
R
E
---
L
C
T
Q
M
L
--
G
G
A
L
G
L
A
LFPSL
Q
L
T
A
L
I
F
TLPFCG
H
---
H
Q
E
I
N
H
---
F
LCDV
P
P
---
V
L
R
L
A
C
A
-------
D
--
I
R
V
H
--
Q
A
V
L
Y
V
V
S
I
L
--
V
L
T
--
I
P
F
L
L
I
C
V
S
Y
V
F
I
T
C
A
I
-----------
L
S
I-------R----SA--------------------E--------G-R
R
R
A
-----
F
ST
C
S
F
H
L
T
---
V
V
L
L
QYGC------
C
S
L
V
Y
L
---------RPRS----ST---S---ED-E-D--S
Q
I
A
L
V
Y
-----
T
F
V
T
P
L
L
N
P
L
L
Y
S
L
RNK
D
V
K
G
A
L
R
S
A
I
I
----------------
R
K
AASDAN------------
33
HHSearch
88.90
17%
-162
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-334]
------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
---
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
--
S
----
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
-
S
K
K
M
S
H
R
---
R
A
F
I
M
I
--
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
---
Y
T
-----
L
E
G
V
L
---
C
N
C
S
F
D
Y
---
I
S
------------
R
--
D
S
T
T
--
R
S
N
I
L
C
M
F
I
L
--
G
F
F
--
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
-----------
S
N
H
-------
E
----
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
-
E
M
R
L
-----
A
K
I
S
I
V
I
V
S
---
Q
F
L
L
S
W
S
P
------
Y
A
V
V
A
L
---------
L
A
Q
F
----
G
P
LEW
V
---
T
P
-
Y
-
A
--
A
Q
L
P
V
M
F
-----
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
----------------
W
V
L
T
C
C
Q
F
------------
40
Fugue
87.74
17%
-137
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
------------
R
F
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
---
S
R
----------
Y
I
P
E
---
G
M
Q
C
S
C
G
I
DYYTPH
E
--
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
AASATTQ
K
----
A
E
--------------------
K
--------
E
-
V
T
R
M
-----
V
I
I
M
V
I
A
F
L
---
I
C
W
L
P
Y
A
G
------
V
A
F
Y
I
F
---------
T
H
Q
G
----
S
D
---
F
---
G
P
-
I
-
F
--
M
T
I
P
A
F
F
-----
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
----------------
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A
13
PsiBlast_PDB
86.60
21%
-153
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[125-405]
-------------------------------------
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
---
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
T
L
V
L
L
T
-
L
P
F
Q
G
T
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
--
S
----
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------------
T
S
S
K
--
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
G
S
A
Q
V--
E
D
E
E
I
E
---
C
L
V
E
I
P
T
---
P
-----------------
Q
D
Y
--
W
G
P
V
F
A
I
C
I
F
--
L
F
S
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-----------
R
G
V
-------
R
LLSG
S
R
--------------------
E
--------
K
-
D
R
N
L
-----
R
R
I
T
R
L
V
L
V
---
V
V
A
V
F
V
G
C
------
W
T
P
V
Q
V
F
V
L
A
Q
G
L
GV
Q
P
S
S
----
E
T
---
A
-------------
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
----------------------------------------
6
PsiBlast_PDB
84.89
20%
-147
- C2 -
4GRV
3
ENLYS_BPT4 (first)
A:
[32-317]
-------------------------------------
K
V
L
V
T
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
----
S
LQ
S
T
V
H
Y
H
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
-
M
P
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
----
A
L
N
V
A
S
L
S
V
A
R
Y
L
A
I
C
H
P
F
K
A
-
K
T
L
M
S
R
S
---
R
T
K
K
F
I
--
S
---
A
I
W
L
A
S
A
L
L
A
I
P
M
L
F
T
M
G
L
Q
N
R
---
S
A
D
G
T
H
PGG
L
V
C
--
T
P
---
I
V
D
T
A
T
V
-------
K
V
V
I
Q
V
N
--
T
F
M
S
F
L
F
P
M
L
--
V
I
S
--
I
L
N
T
V
I
A
N
K
L
T
V
M
V
N
I
F
-----------
E
M
L
-------
R
----
I
D
--------------------
E
--------
G
L
R
L
K
I
-----
Y
K
D
T
E
G
Y
Y
T
---
I
-----
G
I
------
G
H
L
L
T
K
---------
S
P
S
L
----
N
A
---
A
---
K
S
-
E
L
D
--
K
---
R
N
T
-----
N
G
V
--
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
-
G
I
L
----------------
R
N
A
K
L
K
P
V
------------
31
HHSearch
83.84
16%
-155
- C2 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
----------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
---
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
--
S
----
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
-
R
L
--
S
A
T
---
A
T
K
V
V
I
--
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
--
T
-
E
-----
T
M
P
S
R
---
V
V
C
M
I
E
W
---
P
E
H
P
----------
N
--
K
I
Y
E
--
K
V
Y
H
I
C
V
T
V
L
--
I
Y
F
--
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
-----------
W
A
S
-------
E
----
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
-
K
R
K
V
-----
V
K
M
M
I
V
V
V
C
---
T
F
A
I
C
W
L
P
------
F
H
I
F
F
L
---------
L
P
Y
I
----
N
P
---
D
LYL
K
K
F
I
-
Q
Q
V
Y
L
A
I
M
W
L
-----
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
----------------
C
C
P
F
I
S
A
G
------------
9
PsiBlast_PDB
81.82
22%
-171
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-224]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
---
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
----
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
-
Q
S
L
M
T
R
A
---
R
A
K
V
I
I
--
C
T
V
W
A
--------
I
S
A
L
V
S
F
L
P
I
M
M
H
WWR
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
-------
G
C
C
-------
D
--
F
V
T
N
--
R
A
Y
A
I
A
S
S
I
I
--
S
F
Y
--
I
P
L
L
------
I
M
I
F
V
A
L
-----------
R
V
Y
-------
R
----
E
A
--------------------
K
--------
E
-
Q
I
R
K
-----
I
D
R
A
S
K
R
K
R
---
V
M
L
M
R
E
H
K
------
A
L
K
T
L
G
---------
I
I
M
G
----
V
F
---
T
---
L
C
-
W
-
L
--
P
F
F
L
V
N
I
-----
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
----------------
P
I
I
Y
C
R
S
P
------------
7
PsiBlast_PDB
81.24
22%
-172
- C2 -
2YCW
7
ADRB1_MELGA
A:
[7-224]
---------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
---
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
----
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
-
Q
S
L
M
T
R
A
---
R
A
K
V
I
I
--
C
T
V
W
A
--------
I
S
A
L
V
S
F
L
P
I
M
M
H
WWR
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
-------
G
C
C
-------
D
--
F
V
T
N
--
R
A
Y
A
I
A
S
S
I
I
--
S
F
Y
--
I
P
L
L
------
I
M
I
F
V
A
L
-----------
R
V
Y
-------
R
----
E
A
--------------------
K
--------
E
-
Q
I
R
K
-----
I
D
R
A
S
K
R
K
R
---
V
M
L
M
R
E
H
K
------
A
L
K
T
L
G
---------
I
I
M
G
----
V
F
---
T
---
L
C
-
W
-
L
--
P
F
F
L
V
N
I
-----
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
----------------
P
I
I
Y
C
R
S
P
------------
39
Fugue
80.44
17%
-121
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
------------
R
F
G
--
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
---
S
R
Y
----------
I
P
E
---
G
M
Q
C
S
C
G
I
DYYTPH
E
--
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
KEAAAQQQESA
T
T
Q
-------
K
----
A
E
--------------------
K
--------
E
-
V
T
R
M
-----
V
I
I
M
V
I
A
F
L
---
I
C
W
L
P
Y
A
G
------
V
A
F
Y
I
F
---------
T
H
Q
G
----
S
D
---
F
---
G
P
-
I
-
F
--
M
T
I
P
A
F
F
-----
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
PA----------
8
PsiBlast_PDB
79.28
22%
-172
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-224]
-----------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
---
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
----
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
-
Q
S
L
M
T
R
A
---
R
A
K
V
I
I
--
C
T
V
W
A
--------
I
S
A
L
V
S
F
L
P
I
M
M
H
WWR
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
-------
G
C
C
-------
D
--
F
V
T
N
--
R
A
Y
A
I
A
S
S
I
I
--
S
F
Y
--
I
P
L
L
------
I
M
I
F
V
A
L
-----------
R
V
Y
-------
R
----
E
A
--------------------
K
--------
E
-
Q
I
R
K
-----
I
D
R
A
S
K
R
K
R
---
V
M
L
M
R
E
H
K
------
A
L
K
T
L
G
---------
I
I
M
G
----
V
F
---
T
---
L
C
-
W
-
L
--
P
F
F
L
V
N
I
-----
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
----------------
P
I
I
Y
C
R
S
P
------------
30
HHSearch
77.09
16%
-130
- C2 -
1U19
14
OPSD_BOVIN
A:
[40-328]
-------------------------------------
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
---
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
--
A
----
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
F
-
G
E
N
---
H
A
I
M
G
V
--
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
--
Y
-
I
-----
P
E
G
M
Q
---
C
S
C
G
I
D
Y
---
Y
T
P
---
H
-------
E
--
E
T
N
N
--
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
-----------
K
E
A
-------
A
----
A
Q
--------------------
Q
QESA
T
T
Q
K
A
-
E
K
E
V
-----
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
W
L
P
------
Y
A
G
V
A
F
---------
Y
I
F
T
H
Q--
G
S
---
D
---
F
G
P
I
-
F
--
M
T
I
P
A
F
F
-----
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
----------------
C
G
K
N
P
L
G
D
------------
10
PsiBlast_PDB
74.96
22%
-168
- C2 -
2YCY
6
ADRB1_MELGA
A:
[10-224]
------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
---
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
--
S
----
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
-
Q
S
L
M
T
R
A
---
R
A
K
V
I
I
--
C
T
V
W
A
--------
I
S
A
L
V
S
F
L
P
I
M
M
H
WWR
D
E
D
P
Q
A
---
L
K
C
Y
Q
D
P
-------
G
C
C
-------
D
--
F
V
T
N
--
R
A
Y
A
I
A
S
S
I
I
--
S
F
Y
--
I
P
L
L
------
I
M
I
F
V
A
L
-----------
R
V
Y
-------
R
----
E
A
--------------------
K
--------
E
-
Q
I
R
-------
D
R
A
S
K
R
K
R
---
V
M
L
M
R
E
H
K
------
A
L
K
T
L
G
---------
I
I
M
G
----
V
F
---
T
---
L
C
-
W
-
L
--
P
F
F
L
V
N
I
-----
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
----------------
P
I
I
Y
C
R
S
P
------------
23
HHSearch
74.19
20%
-169
- C2 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-235]
-------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
----
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
---
K
A
R
V
I
I
--
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
---
A
-----
T
H
Q
E
A
---
I
N
C
Y
A
-------
E
E
T
C
C
-------
D
--
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
21
HHSearch
73.63
19%
-173
- C2 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
---------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
---
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
--
S
----
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
-
P
V
K
R
T
T
K
---
M
A
G
M
M
I
--
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
--
I
V
G
V
----
R
T
V
E
D
---
G
E
C
-------------
Y
-------
I
--
Q
F
F
S
N-
A
A
V
T
F
G
T
A
I
A
--
A
F
Y
--
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
-----------
K
S
R
-------
I
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
29
HHSearch
73.36
17%
-137
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
---
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
--
G
----
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
-
L
T
Q
-
K
R
H
---
L
V
K
F
V
C
--
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
--
Y
-
H
-----
P
N
N
S
S
---
P
V
C
Y
E
V
L
---
G
N
---
D
T
----------
A
K
W
R
--
M
V
L
R
I
L
P
H
T
F
--
G
F
I
--
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
-----------
F
K
A
-------
H
-----
M
--------------------
G
--------
Q
-
K
H
R
A
-----
M
R
V
I
F
A
V
V
L
---
I
F
L
L
C
W
L
P
------
Y
N
L
V
L
L
---------
A
D
T
L
M
RTQ
V
I
QE-
S
C
E
R
R
N
N
I
-
G
R
A
L
D
A
T
E
I
L
-----
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
----------------
M
H
G
-----------------
20
PsiBlast_PDB
72.84
23%
-169
- C2 -
3NYA
3
ADRB2_HUMAN (first)
A:
[50-227]
----------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
---
Q
E
A
I
N
C
---
Y
A
E
E
T
----------
C
C
-------
D
--
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
17
PsiBlast_PDB
72.39
23%
-171
- C2 -
3D4S
6
ENLYS_BPT4
A:
[50-227]
----------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
---
Q
E
A
I
N
C
---
Y
A
E
E
T
----------
C
C
-------
D
--
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
26
HHSearch
72.13
20%
-183
- C2 -
3EML
8
ENLYS_BPT4
A:
[23-221]
---------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
---
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
--
S
----
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
-
N
G
L
V
T
G
T
---
R
A
K
G
I
I
--
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-----------
S
---
Q
G
C
G
E
G
------
Q
V
A
C
L
-------
F
--
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
--
C
V
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
-----------
R
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
18
PsiBlast_PDB
71.54
23%
-163
- C2 -
3NY8
7
ENLYS_BPT4
A:
[50-227]
----------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
---
Q
E
A
I
N
C
---
Y
A
E
E
T
----------
C
C
-------
D
--
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------
48
Fugue
71.50
16%
-155
- C1 -
2Y23
4
A:
[6-312]
-------------------
T
K
E
V
V
V
N
V
D
D
D
G
V
I
S
L
N
F
E
C
D
K
-----------
M
T
P
K
S
E
F
S
W
S
K
D
Y
V
S
T
E
D
S
---
P
R
L
E
V
E
S
K
G
N
K
T
K
M
T
F
-----------------
K
D
L
G
M
D
D
L
G
---
I
Y
S
C
D
V
T
D
T
--
D
G
I
A
S
S
Y
L
I
D
E
E
E
L
K
R
L
L
A
L
S
H
E
H
K
F
P
T
V
P
V
K
S
E
---
L
A
V
E
I
L
EK
G
Q
V
R
F
W
M
Q
A
E
K
L
S
G
N
A
K
V
N
Y
I
F
N
E
K
E
---
I
F
E
G
P
K
---
Y
K
M
H
I
D
R
NTG
I
I
E
M
F
M
E
-------
K
--
L
Q
D
E
--
D
E
G
T
Y
T
F
Q
L
Q
D
G
K
A
T
--
N
H
S
T
V
V
L
V
G
D
V
F
K
K
L
Q
K
-----------
E
A
E
-------
F
----
Q
R
--------------------
Q
--------
E
-
W
I
R
K
Q
G
PHF
V
E
Y
L
S
W
E
V
T
G
EC
N
V
L
L
K
C
K
V
A
NIKKE
T
H
I
V
W
Y
---------
K
D
E
R
----
E
I
---
S
---
V
D
-
E
-
K
--
H
G
I
C
T
L
L
-----
I
T
E
F
S
K
K
D
A
G
I
Y
E
V
I
L
K
D
D
R
G
K
D
K
S
R
L
K
----------------
L
V
D
E
A
---------------
19
PsiBlast_PDB
71.30
23%
-168
- C2 -
3NY9
4
ADRB2_HUMAN (first)
A:
[50-227]
----------------------------------------------
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
---
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
--
S
----
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
-
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
--
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
-----
H
---
Q
E
A
I
N
C
---
Y
A
E
E
T
----------
C
C
-------
D
--
F
F
T
N
--
Q
A
Y
A
I
A
S
S
I
V
--
S
F
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
-----------
K
R
Q
-------
L
----
N
I
--------------------
F
--------
E
-
M
L
R
I
-----
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
G
Y
Y
T
------
I
G
I
G
H
L
---------
L
T
K
S
----
P
S
---
L
---
N
A
-
A
-
K
--
S
E
L
D
K
A
I
-----
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
----------------
L
R
N
A
K
L
K
P
------------