@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O10W1_HUMAN: (2016-01-11 )
MEFVFLAYPSCPELHILSFLGVSLVYGLIITGNILIVVSIHTETCLCTSMYYFLGSLSGIEICYTAVVVPHILANTLQSEKTITLLGCATQMAFFIALGSADCFLLAAMAYDRYVAICHPLQYPLLMTLTLCVHLVVASVISGLFLSLQLVAFIFSLPFCQAQGIEHFFCDVPPVMHVVCAQSHIHEQSVLVAAILAIAVPFFLITTSYTFIVAALLKIHSAAGRHRAFSTCSSHLTVVLLQYGCCAFMYLCPSSSYNPKQDRFISLVYTLGTPLLNPLIYALRNSEMKGAVGRVLTRNCLSQNS
Atome Classification :
(20 SA)
------------------...----..----------------....10...------------------.....20--------......----..30..------......40........50.....-...60..--.....-.70-------........80.......----------------.90........100.......110......--.120.......130.......140.......150-----.......160-......-----------.-.170.......180------........190.-----......------200.......210-....-----------...220-----------.--------------------..--------.------------...230-----.....------...240---.....--------..250...----.----.---.----.260.--.-------......270---...----......280.......290....----------------...--300...---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------M
E
F
----
V
F
----------------
L
AYPSCP
E
L
------------------
H
I
L
S
F
L
G
--------
V
S
L
V
Y
G
----
L
I
I
TG
N
------
I
L
I
V
V
S
IHT
E
T
C
L
C
T
S
M
Y
Y
F
L
GS-LS
G
I
E
I
C
--
Y
T
A
V
V
-
V
P
H
-------
I
L
A
N
T
L
QSEK
T
I
T
L
L
G
C
----------------
A
T
Q
M
A
F
F
I
A
LGS
A
D
C
F
L
L
A
A
M
A
YDR
Y
V
A
I
C--HPLQ
Y
P
L
L
M
T
L
T
L
C
V
H
L
V
V
A
S
V
I
S
G
L
F
L
S
L
Q
L
V
A
-----
F
I
F
SLP
F
C
Q--AQGI
E
H
-----------F-FCDV
P
P
V
M
H
V
V
C
A
-------
Q
S
HI
H
E
Q
S
V
L
V
A
-----
A
I
L
A
I
A
------
V
P
F
F
L
IT
T
S
Y
T
F
I
-
V
A
A
L
-----------
L
K
I
H
SA-----------A--------------------GR--------
H
------------
R
A
F
S
T
------
C
S
S
H
L
------
T
V
V
L
L
Q---YG
C
C
A
--------
F
M
Y
LCPSS----S----Y---N----PK-
Q
D
--
R
-------
F
I
S
L
V
Y
T
-----LG
T
----
P
L
L
N
P
L
I
Y
A
LRNS
E
M
K
G
A
V
G
R
V
L
----------------
T
R
N
--
C
LSQNS---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.26
23%
-163
- C10 -
3VGA
1
AA2AR_HUMAN
A:
[19-308]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
Q-------SQGCGEGQ
V
A
C
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
K
Q
M
-----------
E
--------------------
S
Q
PLPG----
E
------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.05
22%
-167
- C10 -
2YDV
6
?
A:
[19-312]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
-------
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP
K
E
G
K
A
H
S
Q
GCGEGQVAC
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
K
Q
M
-----------
E
--------------------
S
Q
------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
91.41
23%
-166
- C10 -
3VG9
8
?
A:
[19-309]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
Q-------SQGCGEGQV
A
C
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
K
Q
M
-----------
E
--------------------
S
Q
PLPG----
E
------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.97
22%
-164
- C10 -
2YDO
3
?
A:
[19-312]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
-------
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP
K
E
G
K
A
H
S
Q
GCGEGQVAC
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
K
Q
M
-----------
E
--------------------
S
--------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
87.37
22%
-171
- C10 -
4UG2
3
?
A:
[19-309]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
-------
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP
K
E
G
K
A
H
S
Q
GCGEGQVAC
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
-----------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
87.13
22%
-163
- C10 -
4UHR
1
AA2AR_HUMAN
A:
[19-312]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
-------
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP
K
E
G
K
A
-GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
-----------
R
Q
L
K
Q
M
-----------
E
--------------------
S
Q
PLPG----
E
------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
------
A
I
I
V
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---------
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
S
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
--
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.89
23%
-169
- C10 -
3REY
1
AA2AR_HUMAN
A:
[19-305]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP------GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
-------------------
L
R
I
F
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
A
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.78
23%
-165
- C10 -
3RFM
1
AA2AR_HUMAN
A:
[19-305]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP------GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
-------------------
L
R
I
F
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
A
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.59
23%
-166
- C10 -
3UZA
1
AA2AR_HUMAN
A:
[19-305]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP------GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
-------------------
L
R
I
F
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
A
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.36
23%
-166
- C10 -
3UZC
1
AA2AR_HUMAN
A:
[19-305]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP------GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
-------------------
L
R
I
F
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
A
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.35
23%
-162
- C10 -
3PWH
1
?
A:
[19-305]
-----------------------------------------------------------------------------------------------
L
A
I
L
G
N
------
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
-
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
---------
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
----------------
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
--
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
--------
M
L
G
W
N
N
C
G
QP------GCGEGQVAC--
L
-
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-------
N
--------
F
F
A
-----
C
V
L
---------
V
P
L
L
L
M
L
G
V
Y
-------------------
L
R
I
F
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
------
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
---
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----
S
----
H
---
A
----
P
L
-
W
L
--
M
-------
Y
L
A
I
V
L
A
-----
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
80.66
18%
-147
* C11 *
2KS9
1
NK1R_HUMAN
A:
[35-325]
-------------------------------------------------------------------------
W
A
A
A
--------
Y
T
V
I
V
V
----
T
S
V
V
G
N
------
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
-
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
-------
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
----------------
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
--
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-----
Y
S
T
T
-
E
------
T
M
P
S
R
-----------
V
-
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
E
K
V
Y
H
I
C
V
-----
T
V
L
I
Y
F
------
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-
G
I
T
L
-----------
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
--------
R
------------
K
V
V
K
M
------
M
I
V
V
V
------
C
T
F
A
I
C
---
W
L
P
F
H
--------
I
F
F
L
L
P
Y
I
----
N
PD--
L
---
Y
L---
K
K
F
I
Q
--
Q
V
Y
-----
L
A
I
M
W
L
A
-----
M
S
S
----
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
C
C
--
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
87
Fugue
78.62
16%
-138
- C11 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------MN
G
T
E
G
P
N
F
----
Y
V
PFSNKTGVVRSPFEAP
Q
Y
Y
L
A
E
P
W
Q
------------------
F
S
M
L
A
A
Y
--------
M
F
L
L
I
M
----
L
G
F
P
I
N
------
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
-------
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
S
N
---------
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-----
A
C
A
A
P
P
L
--------
V
G
-----------
W
-
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
-----
F
V
V
H
F
I
------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
-----------
K
E
A
A
A
S
-----------
A
--------------------
T
T
--------
Q
------------
K
A
E
K
E
------
V
T
R
M
V
------
I
I
M
V
I
A
---
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
----
Y
----
I
---
F
----
T
H
-
Q
G
--
S
DFGPIFM
T
I
P
A
F
F
A
-----
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
--
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
89
Fugue
77.77
17%
-146
- C11 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------
D
E
V
W
------------------
V
V
G
M
G
I
V
--------
M
S
L
I
V
L
----
A
I
V
F
G
N
------
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
-------
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
----------------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-----
M
H
W
Y
R
A
--
T
--
H
Q
E
A
I
N
-----------
C
-
Y
A
E
E
T
C
-----
C
D
-------
F
F
-
T
N
Q
A
Y
A
I
A
S
-----
S
I
V
S
F
Y
------
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
-----------
K
R
Q
--
L
-----------
N
--------------------
I
F
--------
E
------------
M
L
R
I
D
------
E
G
L
R
L
------
K
I
Y
K
D
T
---
E
G
Y
Y
T
--------
I
G
I
G
H
L
L
T
----
K
----
S
---
P
----
S
L
-
N
A
--
A
-------
K
S
E
L
D
K
A
-----
I
G
R
NTNG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
----------------
R
N
A
--
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
80
HHSearch
77.10
13%
-139
- C11 -
2Z73
5
OPSD_TODPA
A:
[34-333]
----------------------------------------------------------------------
Y
Y
S
L
G
I
F
--------
I
G
I
C
G
I
----
I
G
C
G
G
N
------
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
-
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
-------
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
----------------
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
--
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-----
G
W
G
A
Y
---
T
---
L
E
G
V
L
-----------
C
-
N
C
S
F
D
Y
I
S
------------
R
D
S
T
T
R
S
N
I
L
C
M
-----
F
I
L
G
F
F
------
G
P
I
L
I
I
F
F
C
Y
F
N
I
-
V
M
S
V
-----------
S
N
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--------
M
------------
R
L
A
K
I
------
S
I
V
I
V
------
S
Q
F
L
L
S
---
W
S
P
Y
A
--------
V
V
A
L
L
A
Q
F
----
G
----
P
LEW
V
----
T
P
-
Y
A
--
A
-------
Q
L
P
V
M
F
A
-----
K
A
S
----
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
--
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
90
Fugue
76.69
18%
-122
- C11 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------------MN
G
T
E
G
P
N
F
----
Y
V
----------------
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
--------
L
L
I
M
L
G
----
F
P
I
N
F
L
------
T
L
Y
V
T
V
Q
H
K
K
--
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
-------
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
S
N
F
---------
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-----
A
C
A
A
P
P
L
-----
V
G
W
S
R
-----------
Y
----
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
-----
F
V
V
H
F
I
------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
KEAAAQQQESA
T
T
Q
K
A
E
-----------
K
--------------------
E
V
--------
T
------------
R
M
V
I
I
------
M
V
I
A
F
------
L
I
C
W
L
P
---
Y
A
G
V
A
--------
F
Y
I
F
T
H
Q
G
----
S
----
D
---
F
----
G
P
-
I
F
--
M
-------
T
I
P
A
F
F
A
-----
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
--
E
T
S
Q
V
A
PA-------------------------------------------------------------------------------------------------------------------------------------------------------
75
HHSearch
73.20
17%
-125
- C11 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------
L
N
------------------
K
Y
V
V
I
I
A
--------
Y
A
L
V
F
L
----
L
S
L
L
G
N
------
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
-
L
A
L
A
D
L
L
--
F
A
L
-
T
-
L
P
I
-------
W
A
A
S
K
V
-
N
G
W
I
F
G
T
F
L
C
----------------
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
--
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-----
F
R
Q
A
--
Y
-
H
--
P
-
N
N
S
S
-----------
P
-
V
C
Y
E
V
L
G
N
----
D
-------
T
A
K
W
R
M
V
L
R
I
L
P
-----
H
T
F
G
F
I
------
V
P
L
F
V
M
L
F
C
Y
G
F
T
-
L
R
T
L
-----------
F
K
A
H
-
M
-----------
G
--------------------
Q
K
--------
H
------------
R
A
M
R
V
------
I
F
A
V
V
------
L
I
F
L
L
C
---
W
L
P
Y
N
--------
L
V
L
L
A
D
T
L
M
RTQ
V
I---
Q
E--
S
C
E
R
R
N
N
-
I
G
R
A
L
-------
D
A
T
E
I
L
G
-----
F
L
H
----
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
----------------
A
M
H
--
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Fugue
69.22
24%
-193
- C2 -
3GRE
-
VPS15_YEAST
A:
[1031-1454]
ESIEKFLSTFILPPLRDY
K
E
F
GPIQ
E
I
----------------
V
R
S
P
N
M
G
N
L
RG----------------
K
L
I
A
T
L
M
ENEPNSIT
S
S
A
V
S
P
G
E
T
P
Y
L
I
T
G
S
DQG
V
I
K
I
W
N
L
K
E
I
I
V
G
E
V
Y
S
S
S
L
T
Y
D
C
S
S
T
V
T
Q
I
T
M
I
PN
F
D
A
F
A
-
V
S
S
KDG
Q
I
I
V
L
K
V
N
H
Y
Q
Q
E
S
E
V
K
F
L
N
C
ECI
R
K
I
N
LKNFGKNEY
A
V
R
M
R
A
F
V
---
N
E
E
K
S
L
L
V
A
L
T
N
L
S
R
V
I
I
F
D
I
R
T
L
E
R
L
Q
I
I
E
N
S
P
R
H
G
A
V
S
S
I
C
I
D
E
E
C
C
V
L
I
L
G
T
TRG
I
I
D
I
W
D
I
R
F
----
N
V
L
I
R
S
-----------
W
S
F
G
D
H
A
P
I
T
H
V
E
V
C
-------
Q
F
Y
-
G
K
N
S
V
I
V
V
G
GSSK
T
F
L
T
I
W
NFVKGH
C
Q
Y
A
F
I
N
S
D
E
Q
P
S
-
M
E
H
F
-----------
L
P
I
E
K
G
-----------
L
--------------------
E
E
LNFCGIRS
L
------------
N
A
L
S
T
------
I
S
V
S
N
------
D
K
I
L
L
T
D
EA
T
S
S
I
V
--------
M
F
S
L
N
E
L
S
----
S
SKAV
I
---
S
----
P
F
-
S
D
--
V
-------
F
I
P
T
Q
V
T
AN
L
T
M
L
L
R
----
K
M
K
H
D
I
I
N
S
I
S
T
C
E
V
D
E
T
P
L
L
V
A
----------------
C
D
N
SG
L
I
G
I
F
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
77
HHSearch
68.44
14%
-128
- C11 -
1U19
14
OPSD_BOVIN
A:
[41-327]
-----------------------------------------------------------------------
S
M
L
A
A
Y
--------
M
F
L
L
I
M
----
L
G
F
P
I
N
------
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
-
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
-------
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
----------------
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-----
G
W
S
R
--
Y
-
I
--
P
-
E
G
M
Q
-----------
C
-
S
C
G
I
D
Y
Y
T
P
---
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
-----
F
V
V
H
F
I
------
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-
V
F
T
V
-----------
K
E
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
--------
K
------------
E
V
T
R
M
------
V
I
I
M
V
------
I
A
F
L
I
C
---
W
L
P
Y
A
--------
G
V
A
F
Y
I
F
T
----
H
QGS-
D
---
F
----
G
P
-
I
F
--
M
-------
T
I
P
A
F
F
A
-----
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
--
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
70
HHSearch
65.36
21%
-153
- C11 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
-----------------------------------------------------------------------
V
G
M
G
I
V
--------
M
S
L
I
V
L
----
A
I
V
F
G
N
------
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
-
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
-------
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
----------------
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-----
M
H
W
Y
-
R
A
-----
T
H
Q
E
A
-----------
I
-
N
C
Y
A
----
E
E
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
-----
S
I
V
S
F
Y
------
V
P
L
V
I
M
V
F
V
Y
S
R
V
-
F
Q
E
A
-----------
K
R
Q
L
N
I
-----------
F
--------------------
E
M
--------
L
------------
R
I
D
E
G
------
L
R
L
K
I
------
Y
K
D
T
E
G
---
Y
Y
T
I
G
--------
I
G
H
L
L
T
K
S
----
P
----
S
---
L
----
N
A
-
A
K
--
S
-------
E
L
D
K
A
I
G
-----
R
N
T
----
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
----------------
I
L
R
--
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------