@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O12D3_HUMAN: (2016-01-11 )
MENVTTMNEFLLLGLTGVQELQPFFFGIFLIIYLINLIGNGSILVMVVLEPQLHSPMYFFLGNLSCLDISYSSVTLPKLLVNLVCSRRAISFLGCITQLHFFHFLGSTEAILLAIMAFDRFVAICNPLRYTVIMNPQVCILLAAAAWLISFFYALMHSVMTAHLSFCGSQKLNHFFYDVKPLLELACSDTLLNQWLLSIVTGSISMGAFFLTLLSCFYVIGFLLFKNRSCRILHKALSTCASHFMVVCLFYGPVGFTYIRPASATSMIQDRIMAIMYSAVTPVLNPLIYTLRNKEVMMALKKIFGRKLFKDWQQHH
Atome Classification :
(20 SA)
-.....----....10...------.....20...---------------.----------------.---...---30........40........50.-.......60........70-.....-....80.....---...90........100---.......-..110......------.120.......130-.......140.......150...----------....-160...-----...----------------.170.......180.......190-.-...-...200.......210.--......--------------220----------.----......230------------------.--------........240.-----......250-.....----------....260--.---.---.-.---.-.---------------.--270.......280.......290.......300..--...-----..310....-------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MEN
V
T
----
T
M
N
E
F
L
L
L
G
------LT
G
V
Q
E
L
Q
P
F
---------------
F
----------------
F
---
G
I
F
---
L
I
I
Y
L
I
N
L
IGNG
S
I
L
V
M
V
V
LEPQ-LHS
P
M
Y
F
FLGN
L
S
C
L
D
IS--YSSV
T
-
L
P
K
L
L
V
N
L
V
C
S
---
R
R
A
I
S
F
L
G
C
I
T
Q
L
H
-----
F
F
H
F
LGS-
T
E
A
I
L
L
A
I
M
A
F
------
D
R
F
V
A
I
CNP
L
R
Y
T
V
-
I
MNP
Q
V
C
I
L
L
A
A
A
A
W
L
I
S
F
F
Y
A
L
----------
M
H
S
V
-
M
T
A
H
L
S
-----
F
CG----------------SQ
K
L
N
H
F
F
Y
D
V
K
P
L
L
E
LAC
S
D
T
L
L
-
N
-
Q
W
L
-
L
S
I
VTGS
I
S
M
G
A
F
F
L
T
L
--
L
S
C
F
Y
V
--------------
I
G
F
----------
L
----
L
FKNR
S
C
--------------------
R
--------
I
L
H
K
A
L
S
T
C
A
S
H
-----
F
M
V
V
C
L
F
---YGPV
G
----------
F
T
Y
IRPA--
S
---
A
---
T
-
S
---
M
-
I
---------------
Q
--
D
R
I
M
A
I
M
Y
S
A
V
T
P
V
L
N
P
L
I
Y
T
LR
N
K
E
V
M
M
A
L
K
K
I
F
--
G
R
K
-----
L
F
K
D
W
Q
QHH-------------
11
PsiBlast_PDB
92.54
21%
-149
- C4 -
2YDV
6
?
A:
[9-312]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
K
E
-
G
K
A
H
S
Q
-----
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
K
Q
----------
M
ESQ----------------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
R
Q
Q
E
P
F
K
-------------
10
PsiBlast_PDB
91.82
21%
-147
- C4 -
2YDO
3
?
A:
[9-312]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
K
E
-
G
K
A
H
S
Q
-----
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S--------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
R
Q
Q
E
P
F
K
-------------
13
PsiBlast_PDB
91.23
21%
-148
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[9-312]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
K
E
-
G
K
A
--------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
-------
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
R
Q
Q
E
P
F
K
-------------
12
PsiBlast_PDB
90.18
21%
-152
- C4 -
4UG2
3
?
A:
[9-309]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
A
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TPMLGWNNCG
Q
P
K
E
-
G
K
A
H
S
Q
-----
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
----------------------
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
R
-------------------
6
PsiBlast_PDB
89.85
21%
-150
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[9-308]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
--------
S
Q
-----
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
Q
P
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
--------------------
5
PsiBlast_PDB
88.21
21%
-152
- C4 -
3VG9
8
?
A:
[9-309]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
TPMLGWNNCG
Q
--------
S
Q
-----
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
L
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
Q
P
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
L
-----
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
H
-----
V
L
R
-------------------
15
PsiBlast_PDB
86.96
20%
-154
- C4 -
3REY
1
AA2AR_HUMAN
A:
[9-305]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
--------------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
A
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-----
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------
18
PsiBlast_PDB
86.41
20%
-154
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[9-305]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
--------------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
A
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-----
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------
16
PsiBlast_PDB
86.31
20%
-153
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[9-305]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
--------------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
A
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-----
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------
17
PsiBlast_PDB
86.16
20%
-153
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[9-305]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
--------------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
A
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-----
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------
14
PsiBlast_PDB
86.12
20%
-148
- C4 -
3PWH
1
?
A:
[9-305]
--------------------------------------------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
--
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
PMLGWNNCG
Q
P
--------------
G
C
G
----------------
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
F
A
-
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
--
A
A
A
R
R
Q
--------------
L
K
Q
----------
M
E
S
QP
L
P
G
E
R
A
R
--------------------
S
--------
T
L
Q
K
E
V
H
A
A
K
S
A
-----
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
------
F
T
F
F
C
P
D
--
C
---
S
---
H
-
A
---
P
-
L
---------------
W
--
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
--
R
S
----------------------------
35
HHSearch
77.53
14%
-139
- C4 -
2Z73
5
OPSD_TODPA
A:
[34-334]
--------------------------------
Y
Y
S
---------------
L
----------------
G
---
I
F
I
---
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
-
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
---
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
-----
I
G
G
I
F
G
F
-
M
S
I
M
T
M
A
M
I
S
I
------
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
-
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
----------
G
P
I
F
-
G
-
W
G
-------
A
Y
T
-----------------
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
T
-
T
-
R
S
N
-
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
--
F
C
Y
F
N
I
--------------
V
-
M
----------
S
----
V
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
--------
A
E
M
R
L
A
K
I
S
I
V
I
-----
V
S
Q
F
L
L
S
---
W
S
P
Y
A
----------
V
V
A
L
L
A
Q
--
F
---
G
PLE
W
-
V
---
T
-
P
---------------
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
--
P
W
V
-----
L
T
C
C
Q
F
D
D
K
-------------
41
Fugue
73.39
14%
-126
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--
M
N
G
T
----
E
G
P
N
F
Y
V
P
F
------
S
N
K
T
G
V
V
R
S
P
---------------
F
EAPQYYLAE
P
W
Q
F
S
M
L
A
---
A
Y
M
---
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
------
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
----------
P
P
L
V
-
G
W
S
R
Y
I
-----
P
E
G
MQC-------------
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
-
V
-
H
F
I
-
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--
K
E
------------------
A
A
A
----------
S
----
A
T
T
Q
K
A
E
--------------------
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
-----
F
L
I
C
W
L
P
---
Y
A
G
V
A
----------
F
Y
I
F
T
H
Q
--
G
---
S
---
D
-
F
---
G
-
P
---------------
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
-----
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A----
42
Fugue
71.98
15%
-116
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-
M
N
G
T
E
----
G
P
N
F
Y
V
P
F
S
------
N
K
T
G
V
V
R
S
P
F
EAPQYYLAE
P
W
Q
F
S
M
L
----------------
A
---
A
Y
M
---
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
------
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
-
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
----------
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
C
G
-------------------
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
-
V
-
H
F
I
-
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--
K
E
A
A
A
Q
--------------
Q
Q
E
----------
S
----
A
T
T
Q
K
A
E
--------------------
K
--------
E
V
T
R
M
V
I
I
M
V
I
A
-----
F
L
I
C
W
L
P
---
Y
A
G
V
A
----------
F
Y
I
F
T
H
Q
--
G
---
S
---
D
-
F
---
G
-
P
---------------
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-----
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
32
HHSearch
71.65
14%
-131
* C4 *
2KS9
1
NK1R_HUMAN
A:
[35-326]
--------------------------------------------------
W
----------------
A
---
A
A
Y
---
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
-
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
---
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
-----
F
P
I
A
A
V
F
-
A
S
I
Y
S
M
T
A
V
A
F
------
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
---
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
----------
P
Q
G
Y
-
Y
--
S
-
T
-----
T
-
E
-----------------
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
Y
-
E
-
K
V
Y
-
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
--
Y
A
Y
T
V
V
--------------
G
-
I
----------
T
----
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
---------
S
--------
A
K
R
K
V
V
K
M
M
I
V
V
-----
V
C
T
F
A
I
C
---
W
L
P
F
H
----------
I
F
F
L
L
P
Y
--
I
NP-
D
---
L
-
Y
L--
K
-
K
FI
Q
------------
Q
--
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
--
R
C
C
-----
P
F
I
S
A
G
D
Y
E
-------------
31
HHSearch
70.56
16%
-128
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
--------------------------------
K
Y
V
---------------
V
----------------
I
---
I
A
Y
---
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
-
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
-
T
-
L
P
I
W
A
A
S
K
V
-
N
---
G
W
I
F
G
T
F
L
C
K
V
V
S
L
-----
L
K
E
V
N
F
Y
-
S
G
I
L
L
L
A
C
I
S
V
------
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
--
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
----------
P
F
F
L
-
F
-
R
Q
-
A
-----
Y
-
H
----------------
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
---
T
-
A
K
W
-
R
-
M
V
L
-
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
--
F
C
Y
G
F
T
--------------
L
-
R
----------
T
----
L
F
K
A
H
-
M
--------------------
G
--------
Q
K
H
R
A
M
R
V
I
F
A
V
-----
V
L
I
F
L
L
C
---
W
L
P
Y
N
----------
L
V
L
L
A
D
T
--
L
M
RT
Q
VI-
Q
E
S
C
E
R
R
N
N
---------------
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
--
A
M
H
-----
G
---------------------
33
HHSearch
67.47
13%
-134
- C4 -
1U19
14
OPSD_BOVIN
A:
[42-328]
----------------------------------
M
---------------
L
----------------
A
---
A
Y
M
---
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
---
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
-----
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
------
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
--
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
----------
P
P
L
V
-
G
-
W
S
-
R
-----
Y
-
I
----------------
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
N
-
N
-
E
S
F
-
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
--
F
C
Y
G
Q
L
--------------
V
-
F
----------
T
----
V
K
E
A
A
A
Q
--------------------
Q
QESA
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
-----
V
I
A
F
L
I
C
---
W
L
P
Y
A
----------
G
V
A
F
Y
I
F
T
H
Q
---
G
---
S
D
F
---
G
-
P
---------------
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--
C
C
G
-----
K
N
P
L
G
D
D
E
A
-------------
50
Fugue
66.52
10%
-165
- C3 -
1JQ5
3
GLDA_GEOSE
A:
[2-367]
A
A
E
R
V
F
----
I
S
P
A
K
Y
V
Q
G
------
K
N
V
I
T
K
I
A
N
Y
---------------
L
----------------
E
GIG
N
K
T
---
V
V
I
A
D
E
I
V
W
K
I
A
G
H
T
I
V
N
E
L
K
K
G
N
I
A
A
E
E
V
V
F
S
G
E
A
S
R
N
E
V
E
--
R
I
A
N
I
-
A
R
K
A
E
A
A
I
V
I
G
V
G
G
G
K
T
L
D
T
A
K
A
V
A
D
E
L
D
A
Y
I
V
I
V
P
T
A
A
S
-
T
D
A
P
T
S
A
L
S
V
I
Y
S
DDGV
F
E
S
Y
R
F
Y
K
K
N
P
D
L
V
-
L
V
D
T
K
I
I
A
N
A
P
P
R
L
L
A
S
G
I
A
D
A
L
----------
A
T
W
V
-
E
A
R
S
V
I
-----
K
S
G
GKTMAGGIPT
I
A
A
E
A
I
A
E
K
C
E
Q
T
L
F
K
Y
G
K
L
A
Y
E
S
V
K
A
K
V
V
-
T
-
P
A
L
-
E
A
V
V
E
A
N
T
L
L
S
G
L
G
F
E
S
G
G
L
A
A
A
H
A
--------------
I
H
N
----------
G
----
F
T
A
L
E
G
E
--------------------
I
--------
H
H
L
T
H
G
E
K
V
A
F
G
-----
T
L
V
Q
L
A
L
---
E
E
H
S
Q
----------
Q
E
I
E
R
Y
I
--
E
---
L
---
Y
-
L
---
C
-
L
DLPVTLEDIKLKDAS
R
--
E
D
I
L
K
V
A
K
A
A
T
A
E
--
G
E
T
I
H
N
A
F
N
V
T
A
D
D
V
A
D
A
I
F
--
A
A
D
-----
Q
Y
A
K
A
Y
K
E
K
-------------
43
Fugue
65.67
19%
-152
- C2 -
4RNZ
9
?
A:
[1-369]
-
M
E
R
L
V
W
D
KL
T
L
L
G
F
L
E
K
N
HIPQ
K
L
Y
Y
N
L
S
S
Q
D
K
E
---------------
L
----------------
S
---
A
E
I
QSN
V
T
Y
Y
T
L
R
D
A
N
N
T
L
I
Q
A
L
I
P
I
S
Q
D
-
L
Q
I
H
I
Y
K
K
-
G
E
D
Y
F
L
D
F
I
P
I
I
F
T
R
K
-
E
K
T
L
L
L
S
L
Q
T
S
---
P
Y
Q
D
I
I
K
A
T
N
D
P
L
L
-----
A
N
Q
L
M
N
A
Y
K
K
S
V
P
F
K
R
L
V
K
------
N
D
K
I
A
I
V
Y
T
R
D
Y
R
V
G
Q
A
F
G
Q
P
T
I
K
M
A
M
V
S
S
R
S
N
Q
Y
Y
L
F
----------
S
H
S
------------------------------------
N
G
H
Y
Y
D
S
K
A
Q
E
V
---
A
G
F
L
L
-
E
-
T
P
V
K
Y
T
R
I
S
S
P
F
S
Y
G
R
F
H
R
P
H
--
Y
G
V
D
Y
A
A
K
HGS
L
I
H
S
A
S
D
G
R
V
G
F
M
G
V
K
AGYG
K
V
V
----
E
I
H
L
N
E
L
--------------------
R
--------
L
V
Y
A
H
M
S
A
F
A
N
G
LKKG
S
F
V
K
K
G
Q
I
---
I
G
R
V
G
STG
P
H
L
H
F
G
V
Y
K
N
S
R
P
I
--
N
---
P
---
L
-
G
---
Y
-
I
---------------
R
--
T
A
K
S
K
L
H
G
K
Q
R
E
V
F
L
E
K
A
---
Q
R
S
K
Q
K
L
E
E
L
L
K
T
H
--
S
F
E
KNSFY
L
L
E
G
F
L
E
H
H
HH-----------
27
HHSearch
62.28
18%
-160
- C4 -
3EML
8
ENLYS_BPT4
A:
[22-221]
---------------------------------
S
V
---------------
Y
----------------
I
---
T
V
E
---
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
-----
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
------
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
-
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
----------
T
P
M
L
-
G
W
N
N
C
G
-----
Q
-----------------------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
-
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
--
G
V
Y
L
R
I
--------------
F
-
L
----------
A
----
A
R
R
Q
L
N
I
--------------------
F
--------
E
M
L
R
I
D
E
G
L
R
L
K
-----
I
Y
K
D
T
E
G
---
Y
Y
T
I
G
----------
I
G
H
L
L
T
K
--
S
---
P
---
S
-
L
---
N
-
A
---------------
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
--
I
L
R
-----
N
A
K
L
K
P
V
Y
D
-------------