@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O13D1_HUMAN: (2016-01-11 )
MYRFTDFDVSNISIYLNHVLFYTTQQAGDLEHMETRNYSAMTEFFLVGLSQYPELQLFLFLLCLIMYMIILLGNSLLIIITILDSRLHTPMYFFLGNLSFLDICYTSSSIPPMLIIFMSERKSISFIGCALQMVVSLGLGSTECVLLAVMAYDHYVAICNPLRYSIIMNGVLYVQMAAWSWIIGCLTSLLQTVLTMMLPFCGNNVIDHITCEILALLKLVCSDITINVLIMTVTNIVSLVILLLLIFISYVFILSSILRINCAEGRKKAFSTCSAHSIVVILFYGSALFMYMKPKSKNTNTSDEIIGLSYGVVSPMLNPIIYSLRNKEVKEAVKKVLSRHLHLLKM
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160---...---....170.......180.......190.-......-----200..----.......210.......220-.....--...230.......240.......250.......---------260------------------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------------------...---...270.....-------..280.------.....-------.290.....----..300.......310.......320.......330.......340....------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
R
FTDFDVS
N
I
S
I
Y
L
N
H
V
L
F
Y
TTQQAG
D
L
E
H
M
ETR
N
Y
S
A
M
T
E
F
F
L
V
G
L
SQYP
E
L
Q
L
F
L
F
L
L
C
L
I
M
Y
M
I
I
L
LGN
S
L
L
I
I
I
T
I
L
DSRLHT
P
M
Y
F
FLGN
L
S
F
L
D
I
C
YTSSSIP
P
M
L
I
I
F
MSERKS
I
S
F
I
G
C
A
L
Q
M
V
V
S
LGLG
S
T
E
C
V
L
L
A
V
M
A
YD
H
Y
V
A
I
C
N
P
L
---
R
Y
S
---
I
IMN
G
V
L
Y
V
Q
M
A
A
W
S
W
I
I
G
C
L
T
S
L
L
Q
T
V
-
L
T
M
M
L
P
-----F--CG----N
N
V
I
D
H
I
T
C
E
I
L
A
L
L
K
L
V
C--SD
I
T
I
--
N
V
L
I
M
T
V
T
N
I
V
S
L
V
I
L
L
L
L
I
F
I
S
Y
V
F
I
L
S
S
I
L
R
---------
I
NC------------------------------------------------------------------------------------------------------------------------------------------------------------------A-----------------------------------------------------------------------------------------------------------------------------------------------------------------EG
R
---
K
K
A
F
STCSA
H
S
-------
I
V
V
I
L
F
------YG
S
A
L
-------
F
M
Y
MKPKSK----NTNTSD
E
I
I
G
L
S
Y
G
V
V
S
P
M
L
N
P
I
I
Y
S
LR
N
K
E
V
K
E
A
V
K
K
V
L
S
R
H
L
H
L
LKM------------------
10
PsiBlast_PDB
87.73
21%
-148
- C4 -
3C9L
14
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
-------------------
28
HHSearch
87.49
19%
-140
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
---
K
Y
Q
---
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
---------------
T
H
Q
E
A
I
N
C
Y
A
E
----
E
T
C
--
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
---------
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC
L
K
E
---
H
K
A
L
K
T
L
G
I
I
M
-------
G
T
F
T
L
C
------
W
L
P
F
F
-------
I
V
N
I
V
H
V
I
Q
DN--
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------
15
PsiBlast_PDB
86.38
21%
-152
- C4 -
4J4Q
9
GNAT1_BOVIN (first)
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
12
PsiBlast_PDB
86.20
21%
-153
- C4 -
3DQB
6
GNAT1_BOVIN (first)
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
14
PsiBlast_PDB
85.99
21%
-154
- C4 -
3PXO
5
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
13
PsiBlast_PDB
85.96
21%
-157
- C4 -
3PQR
10
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
16
PsiBlast_PDB
85.72
21%
-151
- C4 -
4PXF
8
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
9
PsiBlast_PDB
84.98
21%
-154
- C4 -
3CAP
7
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
20
PsiBlast_PDB
84.76
21%
-145
- C4 -
2I36
2
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
ICWLP
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
18
PsiBlast_PDB
84.50
21%
-137
- C4 -
1GZM
15
OPSD_BOVIN
A:
[24-315]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
SNF
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
-------------------
17
PsiBlast_PDB
83.86
21%
-135
- C4 -
3OAX
16
OPSD_BOVIN
A:
[24-315]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
Q
---
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------
11
PsiBlast_PDB
82.88
21%
-150
- C4 -
1F88
8
OPSD_BOVIN
A:
[21-314]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
------------------
19
PsiBlast_PDB
82.03
21%
-138
- C4 -
1HZX
14
OPSD_BOVIN
A:
[24-315]
-----------------------------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
-
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
G
M
Q
C
-----
S
--
C
G
-------
I
D
Y
Y
T
P
H
------------
E
E
T
N
--
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------
5
PsiBlast_PDB
81.29
20%
-157
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----
F
A
I
G
-
L
T
P
M
L
G
-----
W
NN
C
G
----
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
-------
I
I
A
G
L
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
6
PsiBlast_PDB
81.12
20%
-158
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----
F
A
I
G
-
L
T
P
M
L
G
-----
W
NN
C
G
----
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
-------
I
I
A
G
L
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
3
PsiBlast_PDB
81.03
20%
-157
- C4 -
3PWH
1
?
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----
F
A
I
G
-
L
T
P
M
L
G
-----
W
NN
C
G
----
Q
P
--------
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
-------
I
I
A
G
L
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
46
Fugue
80.86
17%
-104
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
------
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
---
S
-
N
---
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
GMQC
S
--
C
G
I
DYY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
--
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
A
T
T
---------
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
---
T
R
M
V
I
I
M
V
I
A
F
-------
L
I
C
W
L
P
------
Y
A
G
V
A
-------
F
Y
I
F
T
H
Q
G
S
----
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA
4
PsiBlast_PDB
80.73
20%
-158
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----
F
A
I
G
-
L
T
P
M
L
G
-----
W
NN
C
G
----
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
-------
I
I
A
G
L
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
7
PsiBlast_PDB
79.53
20%
-159
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
--
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
-----
F
A
I
G
-
L
T
P
M
L
G
-----
W
NN
C
G
----
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
--
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
-------
I
I
A
G
L
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
----
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------------
32
HHSearch
78.69
18%
-148
- C4 -
3EML
13
ENLYS_BPT4
A:
[22-472]
--------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
---
R
Y
N
---
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
-----
Q
-------------
S
Q
G
C
G
E
G
Q
---
V
A
C
--
L
F
E
D
V
VP
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
---------
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
---
V
H
A
A
K
S
L
A
I
I
V
-------
G
L
F
A
L
C
------
W
L
P
L
H
-------
I
I
N
C
F
T
F
F
C
PDCS
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--------------------