@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O13J1_HUMAN: (2016-01-11 )
MEPLNRTEVSEFFLKGFSGYPALEHLLFPLCSAMYLVTLLGNTAIMAVSVLDIHLHTPVYFFLGNLSTLDICYTPTFVPLMLVHLLSSRKTISFAVCAIQMCLSLSTGSTECLLLAITAYDRYLAICQPLRYHVLMSHRLCVLLMGAAWVLCLLKSVTEMVISMRLPFCGHHVVSHFTCKILAVLKLACGNTSVSEDFLLAGSILLLPVPLAFICLSYLLILATILRVPSAARCCKAFSTCLAHLAVVLLFYGTIIFMYLKPKSKEAHISDEVFTVLYAMVTTMLNPTIYSLRNKEVKEAARKVWGRSRASR
Atome Classification :
(20 SA)
-----------........--.10...-------------.-------....20........30........---40---.....-----...50...---.....60........70......-..--------------------------80........90.........100....----..-----.110.......120.......130.....---..140.......150.......160..----...-----..170.......180.......190-----....-.-....200----------........210----......--------------...220......-..-------.-----------230----------.--------------------......----------------.240----------.......250.......260---.----.-.--------.-.--..270.......280--.....-----------..290.......300---..----.-----------....310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MEPL
N
R
T
E
--
V
S
E
F
F
L
-------------
K
-------GFSG
Y
P
A
L
E
H
L
L
F
P
L
C
S
A
M
Y
L
V
T
L
---LG---N
T
A
I
M
-----
A
V
S
V
L
D
I
H
---LHT
P
V
Y
F
F
LGNL
S
T
L
D
I
CYTP
T
F
-
V
P
--------------------------
L
M
L
V
H
L
LSSRK-T
I
S
F
A
V
C
A
I
Q
M
C
L
SLS----TG-----S
T
E
C
L
L
L
A
I
T
A
Y
D
R
Y
L
A
I
C
Q
P
L
R
Y
H
V
L
M
S
---
H
R
L
C
V
L
L
M
G
A
A
W
V
L
C
L
L
K
S
V
T
E
M
V
I
S
M----RLP-----FC
G
H
H
V
V
S
H
F
T
C
K
I
L
A
V
L
K
LACG-------NTSV-S-ED
F
L
LA-----------G
S
I
L
L
LPV
P
------
L
A
F
I
C
L
--------------
S
Y
L
L
--
I
L
A
T
I
L-RV-------P-----------
S
A
-----------
A
--------------------
R
C
C
K
A
F
----------------
S
T
C
L
----------
A
H
L
A
V
V
L
L
F
Y
G
T
I
I
F
M
Y
LKP---K----S-K--------E-A--HI
S
D
E
V
F
T
V
L
Y
A
M
V
T
--
T
ML
N
P
-----------
T
I
Y
S
L
R
N
K
E
V
K
E
A
A
R
---
K
V
----W-----------GRSRASR-----------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
92.04
18%
-139
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------
M
N
G
T
E
--
G
P
N
F
Y
V
PFSNKTGVVRSPF
E
-------
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---
L
G
---
F
P
I
N
F
-----
L
T
L
Y
V
T
V
Q
H
KK
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--------------------------
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
----
G
G
-----
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
----
R
Y
I
-----
P
E
G
--------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
F
V
I
Y
-----------
M
F
V
V
H
F
I
I
P
------
L
I
V
I
F
F
--------------
C
Y
G
Q
--
L
V
F
T
V
K
-
E
A
AASATTQ
K
-----------
A
E
-----------
K
--------------------
E
V
T
R
M
V
----------------
I
I
M
V
----------
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
---
Q
----
G
-
S
--------
D
-
F
--
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
-----------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
---
T
T
----
L
-----------
C
C
G
K
N
P
S
TTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
85.79
18%
-145
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
---
G
G
---
N
G
I
V
I
-----
Y
L
F
T
K
T
K
S
---
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
--------------------------
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
----
F
G
-----
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
---
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
----
A
Y
--------
T
L
-
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
-
T
-
R
S
N
I
L
C
-----------
M
F
I
L
G
F
F
G
P
------
I
L
I
I
F
F
--------------
C
Y
F
N
--
I
V
M
S
V
S
-
N
H
-------
E
-----------
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
----------------
K
I
S
I
----------
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
---
Q
----
F
-
G
PLE-----
W
-
V
--
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
--
A
I
H
N
P
-----------
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
---
Q
T
----
F
-----------
P
W
V
L
T
C
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
84.94
18%
-112
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
--
V
R
S
P
F
E
-------------
A
-------
P
Q
Y
-
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
---
L
G
F
P
I
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--------------------------
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
----
G
G
-----
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
----
R
Y
I
-----
P
E
G
--------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
-
N
-
E
S
F
V
I
Y
-----------
M
F
V
V
H
F
I
I
P
------
L
I
V
I
F
F
--------------
C
Y
G
Q
--
L
V
F
T
V
K
-
E
A
-------
A
AQQQESA
T
T
Q
K
A
E
-----------
K
--------------------
E
V
T
R
M
V
----------------
I
I
M
V
----------
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
---
Q
----
G
-
S
--------
D
-
F
--
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
-----------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
---
T
T
----
L
C
CGKNPLGDDE
A
S
T
T
V
S
K
TETSQVAPA--------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
82.51
17%
-139
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
-----------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
---
V
G
---
N
V
V
V
M
-----
W
I
I
L
A
H
K
R
---
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
--------------------------
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
----
A
V
-----
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
---
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-----
T
T
--------
E
T
-
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
I
Y
-
E
-
K
V
Y
H
I
C
-----------
V
T
V
L
I
Y
F
L
P
------
L
L
V
I
G
Y
--------------
A
Y
T
V
--
V
G
I
T
L
W
-
A
S
-------
E
-----------
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
R
K
V
V
----------------
K
M
M
I
----------
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
---
Y
I
N--
P
D
L
--------
Y
L
K
KF
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
--
T
M
Y
N
P
-----------
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
---
H
A
----
F
-----------
R
C
C
P
F
I
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
77.78
16%
-125
- C3 -
1U19
14
OPSD_BOVIN
A:
[42-326]
----------------------------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
---
N
F
L
T
L
-----
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
--------------------------
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
----
G
G
-----
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
---
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
----
R
Y
--------
I
P
-
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
-------
E
E
T
N
-
N
-
E
S
F
V
I
Y
-----------
M
F
V
V
H
F
I
I
P
------
L
I
V
I
F
F
--------------
C
Y
G
Q
--
L
V
F
T
V
K
-
E
A
-------
A
-----------
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
K
E
V
T
----------------
R
M
V
I
----------
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
----
G
-
S
--------
D
-
F
--
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
--
A
V
Y
N
P
-----------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
---
T
T
----
L
-----------
C
C
G
K
N
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
75.99
17%
-127
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
----------------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
--------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
NG
V
I
T
K
D
-----------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
---
G
I
----
L
-----------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
50
Fugue
71.93
16%
-139
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-------------
P
C
F
R
E
E
--
N
A
N
F
------------------------------
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
---
V
G
---
N
G
L
V
I
-----
L
V
M
G
Y
Q
K
K
---
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
--------------------------
F
W
A
V
D
A
V
A
N
W
--
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
----
N
L
-----
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
---
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
----
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
-------
L
I
L
P
-
G
-
I
V
I
L
S
C
-----------
Y
C
I
I
I
S
K
L
S
HSGSN
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
--
G
I
G
H
L
L
T
K
S
-------
P
-----------
S
L
-----------
N
--------------------
A
A
K
S
E
L
----------------
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
---
N
----
A
-
K
--------
L
-
K
--
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
--
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
---
N
L
A
K
S
R
W
-----------
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ--------------------------------------
35
HHSearch
71.25
18%
-128
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
--------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
---
L
G
---
N
S
L
V
M
-----
L
V
I
L
Y
S
R
V
---
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
--------------------------
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
----
N
F
-----
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
---
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
----
A
Y
--------
H
-
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
-----------
T
A
K
W
-
R
-
M
V
L
R
I
L
-----------
P
H
T
F
G
F
I
V
P
------
L
F
V
M
L
F
--------------
C
Y
G
F
--
T
L
R
T
L
F
-
K
A
-------
H
-----------
M
------------
G
--------------------
Q
K
H
R
A
M
----------------
R
V
I
F
----------
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
---
T
L
M
RT
Q
-
V
IQE
S
C
E
R
R
N
-
N
--
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
--
S
C
L
N
P
-----------
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
---
K
I
----
L
-----------
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
68.59
21%
-146
- C3 -
4LDL
3
ADRB2_HUMAN (first)
A:
[158-377]
---------------
N
R
A
K
R
V
I
T
T
F
R
T
-------------
G
-------
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
L
K
E
H
K
----------------
A
L
K
T
----------
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---
V
----
H
-
V
--------
I
-
Q
--
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
--
G
Y
V
N
S
-----------
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
---
A
F
----
Q
-----------
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
68.32
21%
-145
- C3 -
4LDO
3
ENLYS_BPT4
A:
[158-377]
---------------
N
R
A
K
R
V
I
T
T
F
R
T
-------------
G
-------
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
L
K
E
H
K
----------------
A
L
K
T
----------
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---
V
----
H
-
V
--------
I
-
Q
--
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
--
G
Y
V
N
S
-----------
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
---
A
F
----
Q
-----------
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
68.03
21%
-145
- C3 -
4LDE
3
ENLYS_BPT4
A:
[158-377]
---------------
N
R
A
K
R
V
I
T
T
F
R
T
-------------
G
-------
T
W
D
A
Y
A
A
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
T
K
T
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
L
K
E
H
K
----------------
A
L
K
T
----------
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
---
V
----
H
-
V
--------
I
-
Q
--
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
--
G
Y
V
N
S
-----------
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
---
A
F
----
Q
-----------
E
L
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
66.26
20%
-141
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
--------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
----
Y
R
-------
A
T
H
--
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
64.79
20%
-141
- C3 -
3NYA
3
ADRB2_HUMAN (first)
A:
[49-236]
----------------------------------------------------------------
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
64.36
22%
-150
- C3 -
3SN6
1
ENLYS_BPT4
R:
[158-377]
---------------
N
R
A
K
RV
I
T
T
F
R
T
-------------
G
-------
T
W
D
A
----
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
AIV
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
T
--
K
-
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
VLCV
T
A
-----
S
I
E
T
L
--
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
---
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
Q
K
-----------
I
--------------------
D
K
S
E
G
R
----------------
C
L
K
E
----------
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
---
F
----
F
-
I
--------
V
-
N
--
I
V
H
V
I
Q
D
N
L
I
R
K
E
V
Y
--
I
L
L
N
W
-----------
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
---
S
P
----
D
-----------
F
R
I
A
F
Q
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
64.07
20%
-142
- C3 -
3D4S
6
ENLYS_BPT4
A:
[49-236]
----------------------------------------------------------------
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
64.03
20%
-142
- C3 -
3NY9
4
ADRB2_HUMAN (first)
A:
[49-236]
----------------------------------------------------------------
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
63.52
20%
-142
- C3 -
3NY8
7
ENLYS_BPT4
A:
[49-236]
----------------------------------------------------------------
S
L
I
V
L
A
I
V
---
F
G
---
N
V
L
V
I
-----
T
A
I
A
K
F
E
R
---
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
--------------------------
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
----
C
V
-----
T
A
S
I
W
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
------------
L
P
-----
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
F
T
-
N
-
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
------
L
V
I
M
V
F
--------------
V
Y
S
R
--
V
F
Q
E
A
K
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
62.90
20%
-158
- C3 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
----------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
---
I
G
---
N
I
L
V
M
-----
V
S
I
K
V
N
R
H
---
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
--------------------------
L
Y
T
L
Y
T
V
I
G
Y
W
-
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
----
V
S
-----
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
---
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
----
F
I
V
-------
G
V
R
T
V
E
D
G
E
C
Y
I
Q
F
----------------
F
S
-
N
-
A
A
V
T
F
G
-----------
T
A
I
A
A
F
Y
L
P
------
V
I
I
M
T
V
--------------
L
Y
W
H
--
I
S
R
A
S
K
-
S
R
-------
I
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
62.12
14%
-162
- C1 -
3IF5
-
?
A:
[1-448]
-----------
M
R
H
P
I
P
D
Y
--
L
A
S
L
V
T
-------------
E
L
G
AVN
P
G
E
T
A
Q
Y
I
P
V
L
A
E
A
D
P
D
R
F
G
I
A
L
A
T
P
---
T
G
---
R
L
H
C
A
G
DADV
E
F
T
I
Q
S
A
S
---
K
P
F
T
Y
A
A
A
L
V
D
R
G
F
A
A
V
D
R
Q
V
G
L
-
N
P
S
G
EAFNELSLEAESHRPDNAMI
N
A
G
A
L
A
V
H
Q
L
L
V
G
P
E
A
S
R
K
E
R
L
D
R
A
V
E
I
M
S
L
L
----
A
G
RRLSV
D
W
E
T
Y
E
S
E
M
A
V
S
D
R
N
L
S
L
A
H
M
L
R
S
Y
G
V
L
Q
DS
A
E
E
I
V
A
G
Y
V
A
Q
C
A
V
L
V
T
V
K
D
L
A
V
M
G
A
C
L
A
T
GG
I
H
P
-----
M
T
G
E
R
M
L
P
S
I
V
A
R
R
V
V
S
V
M
T
S
S
G
-------
M
Y
D
A
-
A
-
G
Q
W
L
A
D
VGIP
A
K
S
G
VAG
G
V
L
G
A
L
P
G
R
------
V
G
I
G
V
F
--------------
S
P
R
L
D
E
V
G
N
S
A
R
-
G
V
-------
L
-----------
A
C
-----------
R
--------------------
R
L
S
E
D
F
RLHLMDGDSLGGTAVR
F
V
E
R
----------
E
G
D
R
V
F
L
H
L
Q
G
V
I
R
F
G
G
A
E
A
---
V
----
L
-
D
--------
A
-
L
T
D
L
R
T
G
I
R
T
V
V
L
N
L
A
R
V
--
D
R
I
D
D
-----------
V
G
R
R
L
I
A
E
G
V
R
R
L
Q
A
D
G
V
R
V
----
E
-----------
V
E
D
P
E
R
I
L----------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
62.00
21%
-144
- C3 -
3EML
8
ENLYS_BPT4
A:
[22-222]
---------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
---
N
V
L
V
C
-----
W
A
V
W
L
N
S
N
---
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
--------------------------
F
A
I
T
I
S
T
--
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
----
L
T
-----
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
----
N
C
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
-------
F
E
D
V
V
P
M
N
Y
M
V
Y
F
-----------
N
F
F
A
C
V
L
V
P
------
L
L
L
M
L
G
--------------
V
Y
L
R
--
I
F
L
A
A
R
-
R
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
M
L
R
I
D
----------------
E
G
L
R
----------
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
---
K
----
S
-
P
--------
S
-
L
--
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
-----------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
---
V
R
----
G
-----------
I
L
R
N
A
K
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------