@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O14J1_HUMAN: (2016-01-11 )
MVNLTSMSGFLLMGFSDERKLQILHALVFLVTYLLALTGNLLIITIITVDRRLHSPMYYFLKHLSLLDLCFISVTVPQSIANSLMGNGYISLVQCILQVFFFIALASSEVAILTVMSYDRYAAICQPLHYETIMDPRACRHAVIAVWIAGGLSGLMHAAINFSIPLCGKRVIHQFFCDVPQMLKLACSYEFINEIALAAFTTSAAFICLISIVLSYIRIFSTVLRIPSAEGRTKVFSTCLPHLFVATFFLSAAGFEFLRLPSDSSSTVDLVFSVFYTVIPPTLNPVIYSLRNDSMKAALRKMLSKEELPQRKMCLKAMFKL
Atome Classification :
(20 SA)
.........10.----------------.-.----------------...-..20........30........40........50.........60...-.....70....-....80........90........100.......110.......120.......130.......140.......150.......-.-160...----....170.......180...----..-------..190-------.......200....-...210-.-......220--.--------....----.-------.-----------..-----------230------------------.-........240......--.250.......260-.---------...---.----...--.270......--.280....--------...290.......300...---....310..-.....320-----------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MVNLTSMS
G
F
L
L
----------------M-G----------------FSD-
E
R
K
L
Q
I
L
H
A
L
V
F
L
V
T
Y
L
L
A
LTG
N
L
L
I
I
T
I
I
T
VD-RRLHS
P
M
Y
Y
F
L
K
H
L
-
S
L
L
D
L
C
F
I
S
V
T-
V
P
Q
S
I
A
N
S
L
MG
N
G
Y
I
S
L
V
Q
C
I
L
Q
V
F
F
F
I
A
LASS
E
V
A
I
L
T
V
MSY
D
R
Y
A
A
I
CQPL
H
Y
ETIM
D
P
R
A
C
R
H
A
V
I
A
V
W
I
A
G
G
-
L
S
G
L
M
H
A
-
A
-INFSIP----LC
G
K
R
V
I
H
Q
F
F
CD
V
P
Q
M
L
K
L
----
A
C
-------
S
Y
E
F
I
-------
N
E
I
A
L
A
A
F
T
T
S
A
A
F
-
I
C
L
I
S
I
-
V
-
L
S
Y
I
R
I
F
----
S
--------
T
V
L
R----I-------P-----------SA-----------E--------------------G-
R
T
K
V
F
S
T
C
L
P
H
L
F
V
A
T
F
--
F
L
S
AAG
F
E
F
L
RL---P---------SDS---S----
S
T
V
--
D
L
V
F
S
V
F
Y
T
V--IPPT
L
N
P
V
--------
I
Y
S
LRN
D
S
M
K
A
A
L
R
K
M
L
S
K
---
E
EL
P
Q
R
K
M
C
-
L
K
A
M
FKL------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
89.81
22%
-148
- C2 -
2YCW
7
ADRB1_MELGA
A:
[3-299]
---------
A
E
L
----------------
L
-
S
----------------
Q
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
--------
I
S
A
-
L
-
V
S
F
-
L
P
----
I
----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-
D
F
V
-------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
I
R
K
----
I
-------
D
-----------
R
A
-----------
S
--------------------
K
-
R
K
R
V
M
-
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
V
F
T
L
C
W
L
---
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
--
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
--------
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.00
22%
-152
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-299]
------------------------------------------------
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
--------
I
S
A
-
L
-
V
S
F
-
L
P
----
I
----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-
D
F
V
-------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
I
R
K
----
I
-------
D
-----------
R
A
-----------
S
--------------------
K
-
R
K
R
V
M
-
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
V
F
T
L
C
W
L
---
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
--
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
--------
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
87.38
22%
-145
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
------------------------------------------------
Q
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
--------
I
S
A
-
L
-
V
S
F
-
L
P
----
I
----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-
D
F
V
-------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
I
R
K
----
I
-------
D
-----------
R
A
-----------
S
--------------------
K
-
R
K
R
V
M
-
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
V
F
T
L
C
W
L
---
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
--
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
--------
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
86.78
17%
-125
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
PFSNKTGVVRSPFEAP
Q
-
Y
----------------
Y
L
A
-
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
--------------------
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
----
S
C
-------
G
I
D
Y
Y
TPHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
I
-
F
-
F
C
Y
G
Q
L
V
----
F
--------
T
V
K
E
----
A
AASATTQ
K
-----------
A
E
-----------
K
--------------------
E
-
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--
P
Y
A
G
V
A
F
Y
I
F
T
H
---
Q
---------
G
S
D
---
F
----
G
P
I
--
F
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---
G
K
N
P
S
T
T
V
S
-
K
T
E
T
S
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.20
22%
-157
- C2 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
-------------------------------------------------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
--------
I
S
A
-
L
-
V
S
F
-
L
P
----
I
----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-
D
F
V
-------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
I
R
----------------------------------------------------------------------
E
H
K
A
L
K
T
L
--
G
I
I
M
G
V
F
T
L
C
W
L
---
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
--
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
--------
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
84.84
22%
-152
- C2 -
2YCY
6
ADRB1_MELGA
A:
[10-299]
-------------------------------------------------
W
-
E
A
G
M
S
L
L
M
A
L
V
V
L
----
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
-
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
-
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
--------
I
S
A
-
L
-
V
S
F
-
L
P
----
I
----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-
D
F
V
-------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
-
I
-
F
V
A
L
R
V
Y
R
E
A
K
E
--------
Q
I
R
-------------
D
-----------
R
A
-----------
S
--------------------
K
-
R
K
R
V
M
-
L
M
R
E
H
K
A
L
K
T
L
--
G
I
I
M
G
V
F
T
L
C
W
L
---
P
F
F
L
V
N
I
V
N
V
F
N
R
---
D
----
L
V
P
--
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
--------
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
82.44
17%
-140
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
--------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
-
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
-
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
-
L
L
A
F
P
Q
G
-
Y
-
Y
S
T
-
T
E
--------
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
--------------
N
K
I
Y
-------
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
-
L
P
L
L
V
I
-
G
-
Y
A
Y
T
V
V
G
----
I
--------
T
L
W
A
----
S
-------
E
-----------
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
-
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
--
C
W
L
P
F
H
I
F
F
L
L
P
---
Y
---------
I
N
P
---
D
LYLK
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
--
S
S
T
M
Y
N
P
I
--------
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
---
C
P
F
I
S
A
G
D
Y
-
E
G
L
E
M
K
S
------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
80.74
19%
-127
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
-
Q
-
M
H
W
Y
R
A
-------
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
----
F
T
-------
N
Q
A
Y
A
-------
I
A
S
S
I
V
S
F
-----
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
----
Q
-------
L
-----------
N
I
-----------
F
--------------------
E
-
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
GY
Y
T
I
G
I
G
H
L
L
T
K
S
---
P
---------
S
L
N
---
A
----
A
K
S
--
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
--------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
---
A
K
L
K
P
V
Y
D
S
-
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
43
Fugue
79.26
18%
-124
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------
P
C
----------------
F
-
R
----------------
E
E
N
-
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
-
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
-
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
A
N
W
Y
F
-
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
-
L
L
T
I
P
D
F
-
I
F
A
N
V
S
E
A
DD
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
V
F
Q
F
Q
H
I
----
M
V
-------
G
L
I
L
P
-------
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
-
L
S
H
S
G
S
N
I
-
F
E
M
L
R
I
D
----
E
--------
G
-
L
R
----
L
-------
K
-----------
I
Y
-----------
K
--------------------
D
-
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
--
S
L
N
A
A
K
S
E
L
D
K
A
IGR
N
---------
T
N
G
---
V
----
I
T
K
--
D
E
A
E
K
L
F
N
Q
D
--
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
-
L
R
M
L
Q
Q
K
RW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ------
31
HHSearch
77.72
17%
-127
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
-
A
C
A
A
P
P
L
-
V
-
G
W
S
R
Y
--------
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
--------------
H
E
E
T
N
-------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
I
-
F
-
F
C
Y
G
Q
L
V
----
F
--------
T
V
K
E
----
A
-------
A
-----------
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
-
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
--
C
W
L
P
Y
A
G
V
A
F
Y
I
---
F
---------
T
H
Q
GSD
F
----
G
P
I
--
F
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---
G
K
N
P
L
G
D
D
E
-
A
S
T
T
V
S
K
------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
77.03
18%
-105
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
----------------
F
-
S
NKTGVVRSPFEAPQYY
L
A
E
-
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
-
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
-
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
-----------
A
P
P
----
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
C
----
S
C
G
I
DYYTP
H
E
E
T
N
-------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
I
-
F
-
F
C
Y
G
Q
L
V
----
F
--------
T
V
K
E
----
A
-------
A
AQQQESA
T
T
Q
K
A
E
-----------
K
--------------------
E
-
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
--
P
Y
A
G
V
A
F
Y
I
F
T
H
---
Q
---------
G
S
D
---
F
----
G
P
I
--
F
M
T
I
P
A
F
F
A
K
--
T
S
A
V
Y
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
---
G
K
N
P
L
G
D
D
E
-
A
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.98
24%
-123
- C2 -
4U14
1
ENLYS_BPT4
A:
[24-288]
-------------------------------------------------------------------
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
-
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
-
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
-
I
S
F
V
L
W
A
P
A
-
I
L
F
W
Q
Y
----
F
V
G
K
R
T
-------
V
P
P
G
-------
E
C
-------
F
I
Q
F
L
-------
S
E
P
T
I
T
F
G
T
A
I
A
A
F
-
Y
M
P
V
T
I
-
M
T
I
L
Y
W
R
I
Y
----
K
E
T
E
K
M
N
C
F
E
M
L
R
----
I
-------
D
------------------------
E
--------------------
G
L
R
L
K
I
Y
K
D
C
------
E
G
Y
--
Y
T
I
G
I
G
H
L
L
T
K
S
---
P
---------
S
L
N
---
A
----
A
K
S
--
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
--------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
---
A
K
L
K
P
V
Y
D
S
-
L
D
A
V
R
R
C
------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.91
24%
-119
- C2 -
4DAJ
3
ACM3_RAT (first)
A:
[24-288]
-------------------------------------------------------------------
L
V
T
I
I
G
N
I
L
V
I
V
A
F
K
V
N
-
K
Q
L
K
T
V
N
N
Y
F
L
L
S
L
-
A
C
A
D
L
I
I
G
V
I
S
-
M
N
L
F
T
T
Y
I
I
M
N
R
W
A
L
G
N
L
A
C
D
L
W
L
S
I
D
Y
V
A
S
N
A
S
V
M
N
L
L
V
I
S
F
D
R
Y
F
S
I
T
R
P
L
T
Y
R
A
---
K
R
T
T
K
R
A
G
V
M
I
G
L
A
W
V
-
I
S
F
V
L
W
A
P
A
-
I
L
F
W
Q
Y
----
F
V
G
K
R
T
-------
V
P
P
G
-------
E
C
-------
F
I
Q
F
L
-------
S
E
P
T
I
T
F
G
T
A
I
A
A
F
-
Y
M
P
V
T
I
-
M
T
I
L
Y
W
R
I
Y
----
K
E
TE
K
M
N
I
F
E
M
L
R
----
I
-------
D
------------------------
E
--------------------
G
L
R
L
K
I
Y
K
D
------
T
E
G
Y
--
Y
T
I
G
I
G
H
L
L
T
K
S
---
P
---------
S
L
N
---
A
----
A
K
S
--
E
L
D
K
A
I
G
R
N
T
--
N
G
V
I
T
K
D
E
--------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
---
A
K
L
K
P
V
Y
D
S
-
L
D
A
V
R
R
A
------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
74.29
15%
-135
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
-
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
-
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
-
L
W
A
I
G
P
I
-
F
-
G
W
G
A
Y
--------
T
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
----------------
R
D
S
T
-------
T
R
S
N
I
L
C
M
F
I
L
G
F
F
-
G
P
I
L
I
I
-
F
-
F
C
Y
F
N
I
V
----
M
--------
S
V
S
N
----
H
-------
E
-----------
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
-
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
--
S
W
S
P
Y
A
V
V
A
L
L
A
---
Q
---------
F
G
P
LEW
V
----
T
P
Y
--
A
A
Q
L
P
V
M
F
A
K
--
A
S
A
I
H
N
P
M
--------
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
---
V
L
T
C
C
Q
F
D
D
-
K
E
T
E
D
D
K
------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
70.93
25%
-138
- C2 -
3SN6
1
R:
[199-388]
------------------------------------------------------------------------
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
--------
P
I
Q
----
M
H
W
Y
R
---
Q
E
A
I
N
C
--
Y
A
E
E
----
T
C
-------
C
D
F
F
T
-------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
QLQK
I
-------
D
-----------
K
S
-----------
E
--------------------
G
-
R
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
--
T
F
T
L
C
W
L
P
F
F
I
V
---
N
---------
I
V
H
---
V
----
I
Q
D
--
N
L
I
R
K
E
V
Y
I
L
--
L
N
W
I
G
Y
V
N
--------
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
---
E
L
L
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
70.89
17%
-158
- C1 -
4G3A
-
CLASP_DROME
A:
[5-231]
--
K
P
S
D
L
D
G
F
I
Q
----------------
Q
M
P
----------------
K
A
D
M
R
V
K
V
Q
L
A
E
D
L
V
T
F
L
S
D
D
--------
T
N
S
I
V
C
T
D
M
G
-------
F
L
I
D
G
L
M
P
W
L
T
-------------------
G
S
H
F
K
I
A
Q
K
S
L
E
A
F
S
E
L
I
K
R
L
G
-------
S
D
F
N
A
Y
T
A
T
V
L
P
H
V
I
D
R
L
G
D
S
R
D
T
V
R
E
K
A
Q
L
L
L
R
D
L
M
E
H
R
V
L
P
----------------
P
Q
A
L
I
D
K
L
A
T
S
C
F
K
H
K
N
A
----
K
V
-------
R
E
E
F
L
-------
Q
T
I
V
N
A
L
H
E
Y
G
T
Q
Q
-
L
S
-----
V
-
R
V
Y
I
P
P
V
----
C
--------
A
L
L
G
----
D
-------
P
-----------
T
V
-----------
N
--------------------
V
-
R
E
A
A
I
Q
T
L
V
E
I
Y
K
H
V
----------------------------------------------------------------------------------
G
D
R
L
R
P
D
L
R
R
M--
D
D
V
P
A
S
K
L
A
M
L
E
Q
K
F
D
Q
V
K
L
E--------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
70.76
25%
-137
- C2 -
4LDL
3
ADRB2_HUMAN
A:
[199-377]
------------------------------------------------------------------------
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
--------
P
I
Q
----
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
--
Y
A
E
E
----
T
C
-------
C
D
F
F
T
-------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
----
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
--
T
L
C
W
L
P
F
F
I
V
N
I
---
V
---------
H
V
I
---
Q
----
D
N
L
--
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
--------
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.57
25%
-135
- C2 -
4QKX
2
ADRB2_HUMAN
A:
[199-377]
------------------------------------------------------------------------
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
C
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
--------
P
I
Q
----
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
--
Y
A
E
E
----
T
C
-------
C
D
F
F
T
-------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
----
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
--
T
L
C
W
L
P
F
F
I
V
N
I
---
V
---------
H
V
I
---
Q
----
D
N
L
--
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
--------
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
70.56
25%
-137
- C2 -
4LDO
3
A:
[199-377]
------------------------------------------------------------------------
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
--------
P
I
Q
----
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
--
Y
A
E
E
----
T
C
-------
C
D
F
F
T
-------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
----
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
--
T
L
C
W
L
P
F
F
I
V
N
I
---
V
---------
H
V
I
---
Q
----
D
N
L
--
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
--------
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.08
25%
-133
- C2 -
4LDE
3
A:
[199-377]
------------------------------------------------------------------------
G
N
V
L
V
I
T
A
I
A
K
F
-
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
-
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
-
L
T
S
F
L
--------
P
I
Q
----
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
--
Y
A
E
E
----
T
C
-------
C
D
F
F
T
-------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
-
V
-
F
V
Y
S
R
V
F
----
Q
--------
E
A
K
R
----
Q
-------
L
-----------
Q
K
-----------
F
--------------------
A
-
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
--
T
L
C
W
L
P
F
F
I
V
N
I
---
V
---------
H
V
I
---
Q
----
D
N
L
--
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
--------
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
---
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------