@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O2T27_HUMAN: (2016-01-11 )
MEQSNYSVYADFILLGLFSNARFPWLLFALILLVFLTSIASNVVKIILIHIDSRLHTPMYFLLSQLSLRDILYISTIVPKMLVDQVMSQRAISFAGCTAQHFLYLTLAGAEFFLLGLMSYDRYVAICNPLHYPVLMSRKICWLIVAAAWLGGSIDGFLLTPVTMQFPFCASREINHFFCEVPALLKLSCTDTSAYETAMYVCCIMMLLIPFSVISGSYTRILITVYRMSEAEGRGKAVATCSSHMVVVSLFYGAAMYTYVLPHSYHTPEQDKAVSAFYTILTPMLNPLIYSLRNKDVTGALQKVVGRCVSSGKVTTF
Atome Classification :
(20 SA)
--------------.........10........20....---....30........40........50........60........70......-..80........-------90........100-----........110........120-------.........130----.........140--------.......150....--------...160.......170.......180........----------190-----.........200.....--..210.......220------....-..-..230-----------------.-----.-----------.----...-.240------.......250-------.-------........260--.---.----.---...-------.--.---270-------.......280.------......290.......300...------------....310.....----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MEQSN
Y
S
V
Y
A
D
F
I
L
L
G
L
FSNAR
F
P
W
---
L
L
F
A
L
I
L
L
V
F
L
T
S
I
A
S
N
V
V
K
I
I
L
I
H
IDSRL
H
T
P
M
Y
F
L
L
S
Q
LS
L
R
D
I
L
Y
I
S
T
I
-
V
P
K
M
L
V
D
Q
V
M
S
Q
-------R
A
I
S
FAGCTA
Q
H
------
F
L
Y
L
T
LA
G
A
-
E
F
F
L
L
G
L
MSY---------D
R
Y
V
AICNPL------H
Y
P
V
L
M
SR
K
I
C
W
--------
L
I
V
A
A
A
W
LGGSID
G
--------
F
L
LT
P
V
T
M
QFPFCASRE
I
N
H
F
F
CE-V
P
A
L
L
K
L
SC----------T-------DT
S
A
Y
E
T
A
M
Y
V
C
C
I
M
M
L
--
L
I
P
F
S
V
ISGS
Y
T
R
I
-------
L
I
T
V
-
Y
R
-MSEAE-----------------G-----R-----------G----
K
A
V
-
A
TCS------S
H
M
V
V
V
S
L
---------
F
-------YG
A
A
M
Y
T
Y
VL---P---H----S---YHT-------P--
E
---
Q
D
K
-------
A
V
S
A
F
Y
T
I
L
T
P
------
M
L
N
P
L
I
Y
S
LRNK
D
V
T
G
A
L
Q
K
V
V
------------
G
R
C
VSSGKVTTF----------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
94.03
20%
-140
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
-------
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPG
E
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
A
A
I
I
A
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
93.84
21%
-132
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------------
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
----
G
C
G
E
G
Q
V
A
C
LF--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
L
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPG
E
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
L
A
I
I
V
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
----
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
93.72
21%
-129
- C2 -
2YDO
3
?
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------------
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
E
G
Q
V
A
C
LF--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
L
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
------T
L
---------
Q
----
K
E
V
-
H
A
A
K
------
S
L
A
I
I
V
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
93.67
20%
-142
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
-------
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPG
E
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
A
A
I
I
A
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
93.46
20%
-143
- C2 -
3PWH
1
?
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
-------
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
LF--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPGE
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
A
A
I
I
A
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
93.20
20%
-141
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
-------
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPG
E
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
A
A
I
I
A
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.13
20%
-142
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
-------
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
A
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
A
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
A
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
PLPGE
R
A
R
S
T
L
Q
----
K
E
V
-
H
A
A
K
------
S
A
A
I
I
A
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
A
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
92.61
21%
-129
- C2 -
2YDV
6
?
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------------
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
E
G
Q
V
A
C
LF--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
L
A
A
-
R
R
Q
L
K
Q
M
E
-----------------
S
-----
Q
S
T
L
--------
Q
----
K
E
V
-
H
A
A
K
------
S
L
A
I
I
V
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
Q
Q
E
P
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
91.79
21%
-131
- C2 -
4UG2
3
?
A:
[14-303]
------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
---------------
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
-
S
I
F
S
L
L
A
I
A
I
---------
D
R
Y
I
A
I
R
I
P
L
------
R
Y
N
G
L
V
T
G
T
R
A
K
--------
G
I
I
A
I
C
W
V
L
S
F
A
I
G
----------
L
T
P
M
-
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-
G
C
G
E
G
Q
V
A
C
LF--------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-------
F
L
A
A
-
R
R
Q
L
----------------------------A
R
S
T
L
------
Q
----
K
E
V
-
H
A
A
K
------
S
L
A
I
I
V
G
L
---------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
---
P
---
D
----
C
---
S
H
A
-------
P
--
L
---
W
L
M
-------
Y
L
A
I
V
L
S
H
T
N
S
------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
------------
R
S
H
V
L
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
86.52
17%
-142
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-333]
------------------------------------
V
Y
Y
---
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
-------
W
I
F
G
F
A
A
C
K
V
Y
G
------
F
I
G
G
I
F
G
F
M
-
S
I
M
T
M
A
M
I
S
I
---------
D
R
Y
N
V
I
G
R
P
M
------
A
A
S
K
K
M
S
H
R
R
A
F
--------
I
M
I
I
F
V
W
L
W
S
V
L
W
A
--------
I
G
P
I
F
---
G
W
G
A
-
Y
T
L
E
G
V
L
C
N
C
S
-
F
D
Y
I
S
----------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
-------
V
M
S
V
-
S
N
-
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----
A
-----------
N
----
A
E
M
-
R
L
A
K
------
I
S
I
V
I
V
S
Q
---------
F
-------
L
L
S
W
S
P
Y
A
V
V
---
A
L
L
A
Q
----
F
GPL
E
W
V
-------
T
--
P
---
Y
A
A
-------
Q
L
P
V
M
F
A
K
A
S
A
------
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
------------
P
W
V
L
T
C
C
Q
F
D
D
K
----------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
85.08
17%
-139
* C2 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
-------
W
Y
Y
G
L
F
Y
C
K
F
H
N
------
F
F
P
I
A
A
V
F
A
-
S
I
Y
S
M
T
A
V
A
F
---------
D
R
Y
M
A
I
I
H
P
L
------
Q
P
R
L
--
S
A
T
A
T
K
--------
V
V
I
C
V
I
W
V
L
A
L
L
L
A
--------
F
P
Q
G
---
Y
Y
S
T
T
--
E
T
M
P
S
R
V
V
C
M
-
I
E
W
P
E
H
P
--------------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-------
G
I
T
L
-
W
A
-
S
E
I
P
G
DSSDRYH
E
---------
Q
-----
V
-----------
S
----
A
K
R
-
K
V
V
K
------
M
M
I
V
V
V
C
T
---------
F
-------
A
I
C
W
L
P
F
H
I
F
F
L
L
P
---
Y
----
I
---
N
P
D
LYL----
K
--
K
FI
Q
Q
V
Y
-------
L
A
I
M
W
L
A
M
S
S
T
------
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
------------
R
C
C
P
F
I
S
A
G
D
Y
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
82.68
17%
-129
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
---
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-------
F
V
F
G
P
T
G
C
N
L
E
G
------
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
---------
E
R
Y
V
V
V
C
K
P
M
------
S
-
N
F
R
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
A
L
A
C
A
-----------
A
P
P
L
V
G
W
----
S
R
-------
Y
-
I
P
E
G
M
Q
C
S
C
----------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
-
K
E
-
A
A
A
S
A
-----------------
T
-----
T
-----------
Q
----
K
A
E
-
K
E
V
T
------
R
M
V
I
I
M
V
I
---------
A
-------
F
L
I
C
W
L
P
Y
A
G
---
V
---
A
----
F
---
Y
I
F
-------
T
--
H
---
Q
G
S
DFGPIFM
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
77.95
14%
-117
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
---
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
-------
W
T
F
G
N
F
W
C
E
F
W
T
------
S
I
D
V
L
C
V
T
A
-
S
I
E
T
L
C
V
I
A
V
---------
D
R
Y
F
A
I
T
S
P
F
------
K
Y
Q
S
L
L
T
K
N
K
A
R
--------
V
I
I
L
M
V
W
I
V
S
G
L
T
S
--------
F
--
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
------
E
T
C
C
----------
D
-------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
---
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
-
K
R
-
Q
L
N
I
F
-----------------
E
-----
M
-----------
L
----
R
I
D
-
E
G
L
R
------
L
K
I
Y
K
D
T
E
------------------
G
Y
Y
T
I
G
I
G
H
---
L
---
L
----
T
---
K
S
P
-------
S
--
L
---
N
A
A
-------
K
S
E
L
D
K
A
I
G
R
N
------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
------------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
20
PsiBlast_PDB
76.94
20%
-120
- C2 -
4BEZ
3
OPSD_BOVIN
A:
[37-313]
-------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
D
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-------
F
V
F
G
P
T
G
C
N
L
E
G
------
F
-
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
---------
E
R
Y
V
V
V
C
K
P
M
SNFRFG
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-----------------------------
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
GIDYYTPHEE
T
-------
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
-----
K
E
A
A
-----------------
A
-----
Q
-----------
Q
----
Q
E
S
-
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-------
A
G
V
A
F
Y
I
F
T
H
---
Q
---
G
----
S
---
C
F
G
-------
P
------
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
76.82
16%
-122
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
--------------------------------------
Y
---
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
-
V
N
G
-------
W
I
F
G
T
F
L
C
K
V
V
S
------
L
L
K
E
V
N
F
Y
S
-
G
I
L
L
L
A
C
I
S
V
---------
D
R
Y
L
A
I
V
H
A
T
------
R
T
L
T
-
Q
K
R
H
L
V
K
--------
F
V
C
L
G
C
W
G
L
S
M
N
L
S
--------
L
P
F
F
---
L
F
R
Q
A
Y
H
P
-
N
N
S
S
P
V
C
Y
-
E
V
L
G
N
D
---------------------
T
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
--
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
-------
L
R
T
L
-
F
K
-
A
H
M
G
------------------
Q
-----
K
-----------
H
----
R
A
M
-
R
---------
V
I
F
A
V
V
L
I
---------
F
-------
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
---
T
L
M
RT
Q
---
V
I
Q
E
S
C
E
R
R
-
N
N
I
G
---
R
A
L
-------
D
A
T
E
I
L
G
F
L
H
S
------
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
------------
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
76.68
16%
-111
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
---
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-------
F
V
F
G
P
T
G
C
N
L
E
G
------
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
---------
E
R
Y
V
V
V
C
K
P
M
------------------------------
S
N
F
R
F
G
E
N
H
A
--------
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYY-----
T
-------
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
-
K
E
-
A
A
A
Q
Q
-----------------
Q
-----
E
-----------
S
A
T
T
Q
K
A
E
-
K
E
V
T
------
R
M
V
I
I
M
V
I
---------
A
-------
F
L
I
C
W
L
P
Y
A
G
---
V
---
A
----
F
---
Y
I
F
T
H
QGSDF
G
--
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
APA-------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
75.68
17%
-114
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
---
L
P
-
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
K
T
D
-------
W
I
F
G
D
A
M
C
K
L
Q
R
------
F
I
F
H
V
N
L
Y
G
-
S
I
L
F
L
T
C
I
S
A
---------
H
R
Y
S
G
V
V
Y
P
-------
K
S
L
G
R
L
K
K
K
N
A
I
--------
C
I
S
V
L
V
W
L
I
V
V
V
A
-----------
I
S
P
-
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
-
D
T
T
----
S
D
----------
E
-------
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
--
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
-------
V
R
A
L
I
Y
K
-
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDG----
D
-----
P
-----------
D
----
N
G
V
-
N
P
G
T
------
D
F
K
D
I
V
C
P
---------
L
-------
C
G
V
G
K
D
Q
F
E
E
---
V
---
E
----
E
---
P
L
R
-------
R
--
K
---
S
I
Y
-------
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
------------
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-----------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
74.66
15%
-118
- C2 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------
S
---
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-------
F
V
F
G
P
T
G
C
N
L
E
G
------
F
F
A
T
L
G
G
E
I
-
A
L
W
S
L
V
V
L
A
I
---------
E
R
Y
V
V
V
C
K
P
M
------
S
N
F
R
-
F
G
E
N
H
A
I
--------
M
G
V
A
F
T
W
V
M
A
L
A
C
A
--------
A
P
P
L
V
---
G
W
S
R
-
Y
I
P
E
G
M
Q
C
S
C
G
-
I
D
Y
Y
T
P
-------------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
-
K
E
-
A
A
A
Q
Q
-----------------
Q
ESA
T
T
Q
-----------
K
----
A
E
K
-
E
V
T
R
------
M
V
I
I
M
V
I
A
---------
F
-------
L
I
C
W
L
P
Y
A
G
V
---
A
F
Y
I
F
T
---
H
---
Q
G
S
DF-----
G
--
P
---
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
P
L
G
D
D
E
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
73.40
20%
-119
- C2 -
2X72
5
GNAT1_BOVIN (first)
A:
[37-313]
-------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
-------
F
V
F
G
P
T
G
C
N
L
Q
G
------
F
-
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
---------
E
R
Y
V
V
V
C
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
A
L
A
-----------------------------
C
A
A
P
P
L
V
G
W
S
R
Y
-
I
P
E
G
M
Q
C
S
C
GIDYYTPHEE
T
-------
N
N
E
S
F
V
I
Y
M
F
V
---
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
-----
K
E
A
A
-----------------
A
-----
Q
-----------
Q
----
Q
E
S
-
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
-------
A
G
V
A
F
Y
I
F
T
H
---
Q
---
G
----
S
---
C
F
G
-------
P
------
I
F
M
-------
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
------------
C
C
G
K
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
72.08
15%
-130
- C1 -
3HGU
-
?
A:
[2-354]
-----------------
K
D
Y
S
L
E
I
D
A
V
M
K
A
A
Q
I
N
-
D
T
N
N
---
F
V
Q
A
L
M
R
W
H
F
S
K
E
T
G
S
---
P
F
W
L
G
M
R
E
Q
L
N
F
D
P
I
K
D
V
K
T
I
N
D
L
R
Q
F
S
D
I
S
H
C
-
L
R
Q
E
P
V
A
N
L
V
P
Q
GLPADS
H
P
Q
V
Y
E
S
G
G
A
P
K
Y
------
V
V
A
Y
D
A
W
I
E
-
A
L
I
S
W
R
M
S
G
Y
QHRPG
R
P
S
G
N
T
L
A
A
I
P
T
G
P
------
H
I
V
G
A
I
N
K
E
R
A
L
R
L
G
G
M
F
F
S
I
D
I
D
P
R
W
V
K
R
S
L
S
E
GD
T
A
T
V
R
K
Y
T
H
H
L
V
D
Q
V
Q
N
T
L
M
N
Q
D
I
R
F
L
V
T
T
-
P
P
V
L
R
E
L
L
K
----------
R
-------
P
E
V
V
L
Q
M
K
Q
S
L
A
Q
I
T
L
G
--
G
T
E
L
N
L
D
E
I
K
F
I
A
S
EILPD
C
E
F
S
A
S
-
Y
G
-
S
T
S
A
L
-----------------
G
-----
V
-----------
S
----
R
S
L
L
I
T
S
E
------
S
Q
Q
V
I
Y
D
S
---------
F
-------
S
P
F
I
T
Y
D
V
V
D
---
S
---
I
----
T
---
A
Q
T
-------
V
--
E
---
Y
G
E
-------
R
G
N
V
I
V
T
H
L
S
P
------
W
--
A
F
Y
P
R
V
A
E
R
D
T
A
I
R
L
P
G
V
S
------------
G
F
--
A
G
D
R
L
A
D
I
EPLK------------------------------------------------------------------------------------------------------------------------------------------------------