@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O4A15_HUMAN: (2016-01-11 )
MELLTNNLKFITDPFVCRLRHLSPTPSEEHMKNKNNVTEFILLGLTQNPEGQKVLFVTFLLIYMVTIMGNLLIIVTIMASQSLGSPMYFFLASLSFIDTVYSTAFAPKMIVDLLSEKKTISFQGCMAQLFMDHLFAGAEVILLVVMAYDRYMAICKPLHELITMNRRVCVLMLLAAWIGGFLHSLVQFLFIYQLPFCGPNVIDNFLCDLYPLLKLACTNTYVTGLSMIANGGAICAVTFFTILLSYGVILHSLKTQSLEGKRKAFYTCASHVTVVILFFVPCIFLYARPNSTFPIDKSMTVVLTFITPMLNPLIYTLKNAEMKSAMRKLWSKKVSLAGKWLYHS
Atome Classification :
(20 SA)
.........10....---....20........30......-----..40........50........60.....-...70......---------..80........-----------90........100.-----------..-..----..110..-.....----120.......130...---------....140.......150......--.160.---...-...170.......---180..-.....-190....-----....200.......210.......--220.......230.......240....--------...250....--..--------------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------------260.......270.......280...------------------....290--------------.--------------....---------..300.......310.......320.......-------------330.......340..-------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MELLTNN
L
K
FIT
D
P
F
---
V
C
R
L
RHLSPT
P
S
E
E
H
MKNKNNV-----
T
E
F
I
L
L
GLTQNPEG
Q
K
V
L
F
V
T
F
L
L
I
Y
M
V
T
-
I
MG
N
L
L
I
I
V
T
I
---------MASQSLG
S
P
M
Y
F
-----------
F
L
A
S
L
S
F
I
D
T
V
Y
ST-----------AF-
A
P
----
K
M
I
V
D
L
L
-SEKKT----
I
S
F
Q
G
C
M
A
Q
L
F
M
D
H
L
F---------A
G
A
E
V
I
L
L
V
V
M
A
Y
D
R
Y
M
A
I
C
K
P
L
--
H
E
L
I
T---M
N
R
-
R
V
C
V
L
M
L
L
A
A
W
I
G
---
G
F
L
H
S
-
L
V
Q
F
L
-
F
-
I
YQLP-----FC
G
P
N
V
I
D
N
F
L
C
D
L
Y
P
L
L
K
L
ACTN--
T
Y
V
T
G
L
S
M
IANGGA
I
C
A
V
T
F
F
T
I
L
L
S
Y
--------
G
V
I
L
H
S
LKTQ--SL--------------------------------------------------------------------------------------------------------------------------------------------------------------------E--------------------------------------------------------------------------------------------------------------------------------------------------------------------GK
R
K
A
F
Y
T
C
A
S
H
V
T
V
V
I
L
F
F
V
P
C
I
F
L------------------YARPNST--------------F--------------PIDK---------S
M
T
V
V
L
T
F
I
T
P
M
L
N
P
L
I
Y
T
LK
N
A
E
M
K
S
A
M
R
K
L
-------------
W
S
K
K
V
S
LA
G
K
WLYHS-------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
91.39
21%
-149
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-----------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
Q
S
L
---
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
H
W
Y
R
A
T
-----
H
-----
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
--------
S
R
V
F
Q
E
A
K
R
Q
--
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
------------------
N
I
V
H
V
I
Q
DNLI----------
R
--------------
K
E
V
Y
---------
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
-------------
L
C
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
90.70
21%
-148
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
-
V
F
G
N
G
L
V
C
M
A
V
---------
L
K
E
R
A
L
Q
T
T
T
N
Y
-----------
L
V
V
S
L
A
V
A
D
L
L
V
A
T
-----------
L
V
-
M
P
----
W
V
V
Y
L
E
V
T
G
G
V
W
N
----
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
---------
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
--
H
Y
Q
H
G
T
G
Q
S
S
C
-
R
R
V
A
L
M
I
T
A
V
W
V
L
---
A
F
A
V
S
-
C
P
L
L
F
-
G
-
F
N
T
T
------------
G
D
P
T
V
C
S
I
S
N
------------
P
--
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
--------
A
R
I
Y
V
V
L
K
Q
R
--
R
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
------------------
H
V
L
N
T
H
C
QTCHV---------
S
--------------
P
E
L
Y
---------
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
-------------
L
S
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
88.96
19%
-150
* C1 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
-
I
I
G
N
I
L
V
M
V
S
I
---------
K
V
N
R
H
L
Q
T
V
N
N
Y
-----------
F
L
F
S
L
A
C
A
D
L
I
I
G
V
-----------
F
S
-
M
N
----
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
----
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
---------
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
--
T
Y
P
V
K
---
R
T
T
-
K
M
A
G
M
M
I
A
A
A
W
V
L
---
S
F
I
L
W
-
A
P
A
I
L
-
F
-
W
Q
F
I
V
-----
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
--------
W
H
I
S
R
A
S
K
S
R
--
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
------------------
V
L
I
N
T
F
C
APCI----------
P
--------------
N
T
V
W
---------
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
-------------
L
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
88.82
19%
-147
- C1 -
3EML
13
ENLYS_BPT4
A:
[21-472]
-----------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
-
I
L
G
N
V
L
V
C
W
A
V
---------
W
L
N
S
N
L
Q
N
V
T
N
Y
-----------
F
V
V
S
L
A
A
A
D
I
A
V
G
V
-----------
L
A
-
I
P
----
F
A
I
T
I
S
T
---
G
F
C
----
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
---------
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
--
R
Y
N
G
L
---
V
T
G
-
T
R
A
K
G
I
I
A
I
C
W
V
L
---
S
F
A
I
G
-
L
T
P
M
L
-
G
-
W
N
N
C
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
--------
L
R
I
F
L
A
A
R
R
Q
--
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
------------------
N
C
F
T
F
F
C
PDCSHA--------
P
--------------
L
W
L
M
---------
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-------------
I
R
S
H
V
L
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
84.26
19%
-138
- C1 -
3ODU
6
CXCR4_HUMAN (first)
A:
[44-499]
-------------------------------------------------------
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
-
I
V
G
N
G
L
V
I
L
V
M
---------
G
Y
Q
K
K
L
R
S
M
T
D
K
-----------
Y
R
L
H
L
S
V
A
D
L
L
F
V
------------
I
T
-
L
P
----
F
W
A
V
D
A
V
--
A
N
W
Y
----
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
---------
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
S
Q
R
P
---
R
K
L
-
L
A
E
K
V
V
Y
V
G
V
W
I
P
---
A
L
L
L
T
-
I
P
D
F
I
-
F
-
A
N
V
S
E
----------
A
D
D
R
Y
I
C
D
R
F
Y
P
N
--------
D
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
--------
C
I
I
I
S
K
L
S
H
S
--
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
------------------
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
--------------
H
K
W
I
---------
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
-------------
L
T
S
G
R
P
L
E
V
L
F
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
84.25
21%
-147
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
-
V
G
L
N
L
L
V
L
Y
A
V
---------
R
S
E
R
K
L
H
T
V
G
N
L
-----------
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
-----------
V
V
-
M
P
----
M
N
I
L
Y
L
L
-
M
S
K
W
S
----
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
---------
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
--
R
Y
L
K
Y
---
R
T
K
-
T
R
A
S
A
T
I
L
G
A
W
F
L
---
S
F
L
W
V
-
I
P
I
L
G
-
W
--
N
H
-------------
R
R
E
D
K
C
E
T
D
F
Y
D
-----------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
--------
A
K
I
Y
K
A
V
R
Q
H
--
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
------------------
F
M
V
I
A
F
C
KNCC----------
N
--------------
E
H
L
H
---------
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
-------------
L
H
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
82.96
19%
-146
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
-------------------------------------------------------
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
-
I
L
E
N
I
F
V
L
L
T
I
---------
W
K
T
K
K
F
H
R
P
M
Y
Y
-----------
F
I
G
N
L
A
L
S
D
L
L
A
G
V
-----------
A
Y
-
T
A
----
N
L
L
L
S
G
A
--
T
T
Y
K
----
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
---------
L
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-------------
N
N
-
F
R
L
F
L
L
I
S
A
C
W
V
I
---
S
L
I
L
G
-
G
L
P
I
M
-
G
-
W
N
C
I
------------
S
A
L
S
S
C
S
T
V
L
P
L
-----------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
--------
C
R
I
Y
S
L
V
R
T
R
--
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
V
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
------------------
L
L
L
D
V
G
C
--------------
K
VKTC
D
I
--------
L
F
R
A
---------
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
-------------
M
G
R
P
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
79.33
15%
-119
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
---
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
--------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
---------
V
Q
H
K
K
L
R
T
P
L
N
Y
-----------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
-
R
---
F
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
A
P
P
L
V
G
-
W
-
S
R
Y
I
P
E
GMQC
S
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
-----
F
I
I
P
L
I
V
I
F
F
C
Y
--------
G
Q
L
V
F
T
V
K
E
A
A-
A
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
------------------
Y
A
G
V
A
F
Y
--------------
I
--------------
F
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-------------
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
TS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
78.09
16%
-142
- C1 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
-----------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
-
V
V
G
N
V
V
V
M
W
I
I
---------
L
A
H
K
R
M
R
T
V
T
N
Y
-----------
F
L
V
N
L
A
F
A
E
A
S
M
A
A
-----------
F
N
-
T
V
----
V
N
F
T
Y
A
V
-
H
N
E
W
Y
----
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
---------
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
R
L
S
-----
A
-
T
A
T
K
V
V
I
C
V
I
W
V
L
---
A
L
L
L
A
-
F
P
Q
G
Y
-
Y
-
S
T
T
E
T
----------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
---
P
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
--------
T
V
V
G
I
T
L
W
A
S
--
E
I
PGDSSDRYH
E
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
------------------
F
L
L
P
Y
I
N
--------------
P
DLYLKKFI------
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
-------------
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
77.58
16%
-110
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
---------------
P
F
S
N
K
T
G
V
V
R
S
P
F
E
-----
A
P
Q
Y
Y
L
A
---
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
---------
V
Q
H
K
K
L
R
T
P
L
N
Y
-----------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
-
R
---
F
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
-
A
P
P
L
V
G
W
-
S
R
Y
I
P
E
GMQC
S
C
G
I
--------
D
Y
Y
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
--------
T
V
K
E
A
A
A
Q
Q
Q
--
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
------------------
Y
A
G
V
A
F
Y
--------------
I
--------------
F
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-------------
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
74.70
16%
-143
- C1 -
2Z73
5
OPSD_TODPA
A:
[31-334]
--------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
-
C
G
G
N
G
I
V
I
Y
L
F
---------
T
K
T
K
S
L
Q
T
P
A
N
M
-----------
F
I
I
N
L
A
F
S
D
F
T
F
S
L
-----------
V
N
G
F
P
----
L
M
T
I
S
C
F
-
L
K
K
W
I
----
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
---------
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
--
A
A
S
K
K
---
M
S
H
-
R
R
A
F
I
M
I
I
F
V
W
L
W
---
S
V
L
W
A
-
I
G
P
I
F
-
G
-
W
G
A
Y
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
--
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
--------
F
N
I
V
M
S
V
S
N
H
--
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
------------------
A
L
L
A
Q
F
G
PLEWV---------
T
--------------
P
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
-------------
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
-------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.45
15%
-142
- C1 -
1U19
14
OPSD_BOVIN
A:
[37-329]
--------------------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
-
F
P
I
N
F
L
T
L
Y
V
T
---------
V
Q
H
K
K
L
R
T
P
L
N
Y
-----------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
-----------
G
G
-
F
T
----
T
T
L
Y
T
S
L
-
H
G
Y
F
V
----
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
---------
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
----
G
E
-
N
H
A
I
M
G
V
A
F
T
W
V
M
---
A
L
A
C
A
-
A
P
P
L
V
-
G
-
W
S
R
Y
I
-----
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
--------
G
Q
L
V
F
T
V
K
E
A
--
A
A
QQQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
------------------
A
F
Y
I
F
T
H
QGSDF---------
G
--------------
P
I
F
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-------------
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
73.31
16%
-120
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
Q
S
L
---
L
T
K
-
N
K
A
R
V
I
I
L
M
V
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-------------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
--
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
Y
--------
S
R
V
F
Q
E
A
K
R
Q
LN
I
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
------------------
L
L
T
K
S
P
S
--------------
L
--------------
N
A
A
K
---------
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
-------------
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
39
HHSearch
72.79
19%
-127
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
---------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
-
L
L
G
N
S
L
V
M
L
V
I
---------
L
Y
S
R
V
G
R
S
V
T
D
V
-----------
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-----------
T
--
L
P
----
I
W
A
A
S
K
--
V
N
G
W
I
----
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
---------
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
--
R
T
L
T
Q
----
K
R
-
H
L
V
K
F
V
C
L
G
C
W
G
L
---
S
M
N
L
S
-
L
P
F
F
L
-
F
-
R
Q
A
Y
H
---------
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----
T
--
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
--------
G
F
T
L
R
T
L
F
K
A
--
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
V
------------------
L
L
A
D
T
L
M
--------------
R
TQVIQE
S
C
E
R
R
N
N
I
G
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
-------------
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
63.10
16%
-139
- C1 -
4XGC
-
?
D:
[5-457]
D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RD
Y
T
T
L
R
G
Y
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
MG
E
S
N
S
L
L
L
L
G
--
P
R
G
S
G
K
T
T
L
I
N
S
V
L
A
D
L
L
P
N
K
S
F
G
E
N
T
L
I
V
H
L
D
GNLHTD
D
R
V
A
L
K
S
I
T
V
Q
M
Q
L
ENAADGKVFGS
F
A
E
N
L
A
F
L
L
Q
C
L
K
S
K
S
V
I
F
I
L
E
E
F
D
L
F
-
C
A
HHNQ
T
L
L
Y
N
L
F
-
D
V
S
Q
S
AQ
A
P
I
C
V
L
G
V
T
C
R
L
D
V
I
E
L
L
E
K
R
V
K
S
R
FS
H
R
Q
V
F
L
F
P
S
L
R
R
F
E
D
Y
V
D
L
C
R
D
L
--
L
S
L
P
T
---
G
N
S
-
L
L
L
A
A
E
K
I
Y
N
L
Q
N
IQS
G
A
L
Y
F
-
S
R
N
H
F
-
D
-
P
G
E
Y
G
-----
F
-
S
P
R
L
R
D
A
W
N
K
Q
I
C
K
V
L
A
T
Q
Q
A
R
--
S
T
L
Q
A
L
H
D
F
D
I
S
E
A
Y
L
K
N
F
L
F
R
L
V
A
H
L
RPQSPHIT
A
E
K
M
A
A
V
G
S
Q
--
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
K
I
E
L
L
C
G
L
S
V
L
E
L
C
L
I
I
A
I
K
H
H
S
Q
I
Y
DRDSFN
F
E
I
I
Y
A
R
F
S
K
F
A
K
V
S
T
T
--------------
M
--------------
Q
A
V
E
---------
R
S
I
V
L
K
A
F
E
H
L
R
I
A
E
L
I
M
P
L
T
K
V
Q
K
E
F
E
M
H
K
L
ALT
Y
S
Q
I
H
H
C
M
Q
R
Y
Q
A
L
P
T
E
V
A
Q
W
A
Q
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
59.36
32%
-156
- C1 -
4LDO
3
A:
[191-308]
--------------------------------------------------------------------
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--------
R
Q
L
Q
K
F
A
L
K
E
--
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
------------------
I
Q
D
N
L
I
R
--------------
K
--------------
E
V
Y
I
---------
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-------------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
59.21
32%
-152
- C1 -
3PDS
4
ADRB2_HUMAN (first)
A:
[18-141]
--------------------------------------------------------------------
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
C
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
KY
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--------
R
Q
L
N
I
F
E
M
L
R
--
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
------------------
S
L
N
A
A
K
S
--------------
E
--------------
L
D
K
A
---------
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-------------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
58.97
32%
-161
- C1 -
4QKX
2
ADRB2_HUMAN
A:
[191-308]
--------------------------------------------------------------------
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
C
I
L
-
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--------
R
Q
L
Q
K
F
A
L
K
E
--
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
------------------
I
Q
D
N
L
I
R
--------------
K
--------------
E
V
Y
I
---------
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-------------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
58.45
32%
-156
- C1 -
2RH1
5
ADRB2_HUMAN (first)
A:
[49-166]
--------------------------------------------------------------------
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
M
K
M
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
KY
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--------
R
Q
L
N
I
F
E
M
L
R
--
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
------------------
S
L
N
A
A
K
S
--------------
E
--------------
L
D
K
A
---------
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
-------------
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
58.22
32%
-157
- C1 -
4LDL
3
ADRB2_HUMAN
A:
[191-308]
--------------------------------------------------------------------
L
I
V
L
A
I
-
V
F
G
N
V
L
V
I
T
A
I
---------
A
K
F
E
R
L
Q
T
V
T
N
Y
-----------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-----------
A
V
-
V
P
----
F
G
A
A
H
I
L
-
T
K
T
W
T
----
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
---
K
N
K
A
R
V
I
I
L
M
V
---
W
I
V
---
S
G
L
T
S
-
F
L
P
I
Q
-
M
-
H
W
Y
R
A
-----
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
--
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
--------
R
Q
L
Q
K
F
A
L
K
E
--
H
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
------------------
I
Q
D
N
L
I
R
--------------
K
--------------
E
V
Y
I
---------
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
-------------
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------