@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O4F17_HUMAN: (2016-01-12 )
MVTEFIFLGLSDSQGLQTFLFMLFFVFYGGIVFGNLLIVITVVSDSHLHSPMYFLLANLSLIDLSLSSVTAPKMITDFFSQRKVISFKGCLVQIFLLHFFGGSEMVILIAMGFDRYIAICKPLHYTTIMCGNACVGIMAVAWGIGFLHSVSQLAFAVHLPFCGPNEVDSFYCDLPRVIKLACTDTYRLDIMVIANSGVLTVCSFVLLIISYTIILMTIQHRPLDKSSKALSTLTAHITVVLLFFGPCVFIYAWPFPIKSLDKFLAVFYSVITPLLNPIIYTLRNKDMKTAIRQLRKWDAHSSVKF
Atome Classification :
(20 SA)
---------------....-----...-----------------..----------------10.......---------------.20........30........40........50...---------------.....60......----..70.........80........90........100.......110.....-----..120.......130.......140.......150..-.....-160---.........170.......----------180--...--....190.......------200.......210----------....-------.....220..---------------.---------------------...------.230...----------------------....240....-...250----...-----.--------.-----.---.-260----........270---.......280.------------......290...----------------....300...-----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------MV
T
E
-----
F
I
F
-----------------
L
G----------------LSDSQ
G
L
Q
T
---------------
F
L
F
M
L
F
F
V
F
Y
G
G
I
V
FG
N
L
L
I
V
I
T
VVSDSHLH
S
P
M
Y
F
---------------
L
L
AN
L
S
L
I
D
L
SLS----SVT-
A
P
K
M
I
T
D
F
F
SQRK
V
I
S
F
K
G
C
L
V
Q
I
F
L
L
H
FFGG
S
E
M
V
I
L
I
A
MGF
D
R
Y
I
-----
A
I
CKP
L
H
Y
T
T
I
MCGN
A
C
V
G
I
M
A
V
A
W
G
I
G
F
L
H
S
V
S
Q
L
A
-
F
A
V
HL-P-----FCGP
N
E
V
D
S
F
Y
CD
L
P
R
V
I
K
----------
L
AC--T
D
T
--
Y
R
L
D
I
M
V
I
ANS
G
V
L
------
T
V
C
S
F
V
L
L
I
I
S
------------
Y
T
I
I
-------
L
M
T
I
QHRPLD---------------K---------------------
S
S
K
------
A
L
S
T
L
T
A
----------------------
H
I
T
V
V
L
LFFG
P
-
C
V
F
I
Y
A----WPF-----
P
--------
I
-----
K
---
S
-
L
D
-----
K
F
L
A
V
F
Y
S
V
I
T
---
P
L
L
N
P
I
I
Y
T
LR------------NK
D
M
K
T
A
I
R
Q
L
R
----------------
K
WDAHSSVKF-----------
4
PsiBlast_PDB
89.21
24%
-154
- C3 -
3REY
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
---------------------
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
7
PsiBlast_PDB
88.36
24%
-153
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
---------------------
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
3
PsiBlast_PDB
88.29
24%
-154
- C3 -
3PWH
1
?
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
LF
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
GE
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
---------------------
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
6
PsiBlast_PDB
88.19
24%
-151
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
---------------------
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
5
PsiBlast_PDB
87.51
24%
-151
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
----GCGEGQ----
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
---------------------
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
----------------------
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
A
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
-------------------
14
PsiBlast_PDB
86.21
23%
-148
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
AGCGEGQ---
V
A
C
LF
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------------------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
2
PsiBlast_PDB
86.11
24%
-156
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
-----SQGCGEGQ--
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------------------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
----------------
1
PsiBlast_PDB
85.66
24%
-160
- C3 -
3VG9
8
?
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
-----SQGCGEGQ--
V
A
C
L
F
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-------------------------------------
G
E
R
------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------
13
PsiBlast_PDB
85.42
23%
-152
- C3 -
4UG2
3
?
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
-------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
---------------
11
PsiBlast_PDB
84.83
23%
-155
- C3 -
2YDO
3
?
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
12
PsiBlast_PDB
84.27
23%
-156
- C3 -
2YDV
6
?
A:
[21-302]
---------------------------------------------------------------------------------------------------
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
A
A
A
A
D
I
L
V
G
----
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------
V
L
S
-
F
A
I
G
L
T
P
-----
M
L
G
W
N
N
-----
C
G
Q
P
K
E
G
K
A
H
S
Q
GCGEGQ
V
A
C
LF
E
D
V
--
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
---------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
----
W
L
M
----------------------------------
Y
L
A
I
V
L
S
H
T
N
---
S
V
V
N
P
F
I
Y
A
Y
R
------------
I
R
E
F
R
Q
T
F
R
K
I
I
----------------
R
S
H
V
L
R
Q
Q
E
P
-----------
40
Fugue
82.07
19%
-124
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------
M
N
G
T
E
G
PNF
Y
V
P
-----------------
F
S
NKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
---------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
---------------
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
-
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
-
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
T
--------------
N
--
N
E
S
--
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
V
I
F
F
C
Y
G
Q
L
V
------------
F
T
V
K
-------
E
A
A
A
Q
Q
Q
E
S
A
---------------
T
---------------------
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
QGS
D
--------
F
-----
G
---
P
-
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
---
A
V
Y
N
P
V
I
Y
I
M
M
------------
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A----------
30
HHSearch
79.94
15%
-140
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-326]
--------------------------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
---------------
F
L
V
N
L
A
F
A
E
A
S
M
A
----
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
-----
A
I
I
H
P
L
Q
P
R
L
S
--
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
T
T
--
E
-----
T
----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
----------
P
-----
N
K
--
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
------
Y
F
L
P
L
L
V
I
G
Y
A
------------
Y
T
V
V
-------
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
---
A
---------------------
K
R
K
------
V
V
K
M
M
I
V
----------------------
V
V
C
T
F
A
I
C
W
L
P
-
F
H
I
F
F
L
----
L
P
Y
-----
I
--------
N
PDLYL
K
KFI
Q
-
Q
V
-----
Y
L
A
I
M
W
L
A
M
S
S
---
T
M
Y
N
P
I
I
Y
C
C
L
------------
N
D
R
F
R
L
G
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
G
D
-----------
33
HHSearch
79.49
16%
-137
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-------------------------------------------------------------------
A
V
Y
Y
---------------
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
---------------
F
I
I
N
L
A
F
S
D
F
T
F
S
----
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
-----
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-
G
W
G
A
Y
-
T
-----
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----------------
R
D
--
S
T
T
R
S
N
I
L
C
M
F
I
L
G
------
F
F
G
P
I
L
I
I
F
F
C
------------
Y
F
N
I
-------
V
M
S
V
S
N
H
E
K
E
---------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
------
L
A
K
I
S
I
V
----------------------
I
V
S
Q
F
L
L
S
W
S
P
-
Y
A
V
V
A
L
----
L
A
Q
-----
F
--------
G
PLEWV
T
---
P
-
Y
A
-----
A
Q
L
P
V
M
F
A
K
A
S
---
A
I
H
N
P
M
I
Y
S
V
S
------------
H
P
K
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
F
D
-----------
41
Fugue
75.08
15%
-131
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------MN
G
T
E
G
P
N
-----
F
Y
V
PFSNKTGVVRSPFEAPQ
Y
Y
----------------
L
A
E
P
W
Q
F
S
M
---------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
---------------
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
-
P
E
GMQC
S
C
G
I
D
----
Y
Y
T
P
H
E
E
--------------
T
N
--
N
E
S
--
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
------
I
V
I
F
F
C
Y
G
Q
L
V
------------
F
T
V
K
-------
E
A
A
A
S
A
T
T
Q
K
---------------
A
---------------------
E
K
E
------
V
T
R
M
V
I
I
----------------------
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
----
Y
I
F
T
H
QGS
D
--------
F
-----
G
---
P
-
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
---
A
V
Y
N
P
V
I
Y
I
M
M
------------
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A
31
HHSearch
72.29
16%
-131
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-327]
----------------------------------------------------------------------
S
---------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
---------------
I
L
L
N
L
A
V
A
D
L
F
M
V
----
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-
G
W
S
R
Y
-
I
-----
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---------------
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
------
F
I
I
P
L
I
V
I
F
F
C
------------
Y
G
Q
L
-------
V
F
T
V
K
E
A
A
A
Q
---------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
------
V
T
R
M
V
I
I
----------------------
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
----
Y
I
F
T
H
---
Q
--------
G
SDF--
G
---
P
-
I
F
-----
M
T
I
P
A
F
F
A
K
T
S
---
A
V
Y
N
P
V
I
Y
I
M
M
------------
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
D
-----------
20
PsiBlast_PDB
72.08
20%
-131
- C3 -
3CAP
4
OPSD_BOVIN
A:
[55-317]
------------------------------------------------------------------------------------------------------
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
---------------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
----
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
-
A
F
T
W
-------
V
M
A
L
A
-
C
A
A
P
--
P
-----
L
V
G
W
S
R
Y
------
I
P
E
G
M
Q
----------
C
S
C
--
G
I
D
--
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
------
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-------
E
A
A
A
Q
Q
Q
E
S
A
---------------
T
---------------------
T
Q
K
------
A
E
K
E
V
T
R
----------------------
M
V
I
I
M
V
I
A
F
L
I
-
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-----
T
--------
H
-----
Q
---
G
-
S
D
FG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
---
A
V
Y
N
P
V
I
Y
I
M
M
------------
N
K
Q
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
----------------
28
HHSearch
69.25
16%
-123
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-------------------------------------------------------------------
L
N
K
Y
---------------
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
---------------
Y
L
L
N
L
A
L
A
D
L
L
F
A
----
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
-----
A
I
V
H
A
T
R
T
L
T
Q
-
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-
F
R
Q
A
Y
-
H
--------
P
-
N
N
S
S
P
V
C
Y
E
V
L
G
N
----------------
D
T
A
--
K
W
R
M
V
L
R
I
L
P
H
T
F
G
------
F
I
V
P
L
F
V
M
L
F
C
------------
Y
G
F
T
-------
L
R
T
L
F
K
A
H
M
G
---------------
Q
---------------------
K
H
R
------
A
M
R
V
I
F
A
----------------------
V
V
L
I
F
L
L
C
W
L
P
-
Y
N
L
V
L
L
----
A
D
T
-----
L
M
RTQVIQE
S
C
E
R
--
R
N
N
I
G
-
R
A
-----
L
D
A
T
E
I
L
G
F
L
H
---
S
C
L
N
P
I
I
Y
A
F
I
------------
G
Q
N
F
R
H
G
F
L
K
I
L
----------------
A
M
H
G
-----------------
48
Fugue
68.98
17%
-155
- C2 -
1A6Q
3
PPM1A_HUMAN
A:
[2-368]
GAFLDKPKM
E
K
H
N
A
Q
G
Q
G
N
-----
G
L
R
-----------------
Y
G
----------------
L
S
S
M
Q
G
W
R
V
EME
D
A
H
T
A
V
I
G
LPSG
L
E
S
W
S
F
F
A
V
Y
D
G
H
A
G
S
Q
V
A
K
Y
C
C
E
H
L
L
D
H
I
T
N
N
Q
D
F
KGSAGAPS
V
E
N
V
K
N
G
I
R
T
G
F
L
E
I
D
E
H
M
R
----
V
M
S
-
E
K
K
H
G
A
D
----
R
S
G
S
T
A
V
G
V
L
I
S
P
Q
H
T
Y
F
I
N
C
G
D
S
R
G
L
L
C
R
N
R
K
V
H
F
F
T
Q
D
H
K
P
S
N
P
L
E
K
E
R
I
Q
N
A
G
G
S
V
M
I
Q
R
V
N
G
S
L
A
V
S
R
A
L
G
D
F
D
-
Y
K
C
V
H
---------
G
K
G
P
T
E
Q
L
V
S
P
E
P
E
V
H
D
----------
I
E
R
--
S
E
E
---
D
D
Q
F
I
I
L
A
C
D
G
I
W
D
V
MG
N
E
E
L
C
D
F
V
R
S
R
L
E
------------
V
T
D
D
-------
L
E
K
V
C
N
E
V
V
D
---------------
T
---------------------
C
L
Y
------
K
G
S
R
--
D
----------------------
N
M
S
V
I
L
I
C
F
P
N
-
A
P
K
V
S
P
----
E
A
V
-----
K
--------
K
-----
E
---
A
E
L
D
-----
K
Y
L
E
C
R
V
E
E
I
I
KGV
P
D
L
V
H
V
M
R
T
L
A
S
E
NIPSLPPGGE
L
A
S
K
R
N
V
I
E
A
V
Y
----------------
N
R
L
N
P
Y
---------------
26
HHSearch
66.52
22%
-150
- C3 -
3EML
8
ENLYS_BPT4
A:
[21-219]
---------------------------------------------------------------------
S
S
---------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------------
F
V
V
S
L
A
A
A
D
I
A
V
G
----
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
-----
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
-
G
-----
Q
-------
S
Q
G
C
G
E
G
Q
V
-------------
A
C
--
L
F
E
DV
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
------
V
L
V
P
L
L
L
M
L
G
V
------------
Y
L
R
I
-------
F
L
A
A
R
R
Q
L
N
I
---------------
F
---------------------
E
M
L
------
R
I
D
E
G
L
R
----------------------
L
K
I
Y
K
D
T
E
G
Y
Y
-
T
I
G
I
G
H
----
L
L
T
-----
K
--------
S
-----
P
---
S
-
L
N
-----
A
A
K
S
E
L
D
K
A
I
G
---
R
N
T
N
G
V
I
T
K
D
E
------------
A
E
K
L
F
N
Q
D
V
D
A
A
----------------
V
R
G
I
L
R
N
A
K
L
-----------