@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51E2_HUMAN: (2016-01-12 )
MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK
Atome Classification :
(20 SA)
--------------.........10...--.....--------------20...-.....30........40.....-----------------...50........60.....--...70.....-.--..80..-......90........100.......110.......120--.........130....--------...140.......-------------150......-.----160...-....170.....--------..180........190----..-------......200.......210....-----...220....----...230---------------------------------------------------------------------------------------------------------------------------------------------------------------.........240..---.....-------------250......-----.260.-----...-.--.--.270-------.......280....---...290.......----300....--..-------------.310.......320---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MSSCN
F
T
H
A
T
F
V
L
I
--GIPGL--------------EKA
H
F
-
W
V
G
F
P
L
L
S
M
Y
V
V
A
M
FG
N
C
I
V
V
F
-----------------
I
V
RTERSLHA
P
M
Y
L
F
L
C
M
L
A
--
A
I
D
L
ALSTS
T
-
M
--
P
K
I
L
A
L
-
F
W
FDSRE
I
S
F
E
A
C
L
T
Q
M
F
F
I
H
A
L
S
A
I
E
S
T
I
L
L
A
M
A
F
D
----
R
Y
V
A
I
C
H
P
L
R
H
A
A
V
LN--------NT
V
T
A
Q
I
G
I
V
A
V
V-------------RG
S
L
F
FF
P
L
-
P
----
L
L
I
K
R
L
-
A
F
C
H
S
N
VLSH
S
Y
--------
C
V
H
Q
-
D
V
M
K
L
A
Y
A
D
T
-----
L
P
-------
N
V
V
Y
G
L
T
A
I
L
L
V
MG
V
D
V
M
F
I
S
L
S
-----
Y
F
L
I
I
R
T
V
L
Q----LPS
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
R
A
K
A
F
G
T
C
V
S
H
I
---
G
V
V
L
A
-------------
F
Y
V
P
L
I
G
L
S
-----
V
V
H
R
F-----GN
S
-
L
--
H
--
P
I
V
R
-------
V
V
M
GD
I
Y
L
LLPPV
I
---
N
P
I
IYGA
K
T
K
Q
I
R
----
T
R
V
L
A
M
F
--KI-------------SCDK
D
L
Q
AVGGK-----
1
PsiBlast_PDB
92.72
25%
-160
- C4 -
3VG9
8
?
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
A
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
-------
S
Q
--------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
MNY----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
R
-------------
2
PsiBlast_PDB
92.70
25%
-157
- C4 -
3VGA
1
AA2AR_HUMAN
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
A
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
-------
S
Q
--------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
M
N
Y
----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
--------------
4
PsiBlast_PDB
88.39
24%
-157
- C4 -
2YDV
6
?
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
F
A
I
A
I
-
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
K
E
G
K
A
H
S
Q
--------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
M
N
Y
----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
K
Q
M
ES
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
R
Q
Q
E
P
F
K
A
A
-----
5
PsiBlast_PDB
86.51
24%
-157
- C4 -
4UG2
3
?
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
F
A
I
A
I
-
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
K
E
G
K
A
H
S
Q
--------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
M
N
Y
----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
R
-------------
3
PsiBlast_PDB
86.49
24%
-157
- C4 -
2YDO
3
?
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
F
A
I
A
I
-
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
K
E
G
K
A
H
S
Q
--------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
M
N
Y
----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
-
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
R
Q
Q
E
P
F
K
A
A
-----
6
PsiBlast_PDB
85.13
24%
-154
- C4 -
4UHR
1
AA2AR_HUMAN
A:
[14-296]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
F
A
I
A
I
-
S
--
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
K
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
K
E
G
K
A
-----------
G
C
G
E
-
G
Q
V
A
C
L
F
E
D
V
-----
V
P
M
N
Y
----
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
-----
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
L
A
-------------
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
FCP
D
C
--
H
--
A
--
P
L
W
L
-------
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
---
N
P
F
I
Y
A
Y
R
I
R
E
F
R
----
Q
T
F
R
K
I
I
--
R
S
-------------
H
V
L
R
Q
Q
E
P
F
K
A
A
-----
25
HHSearch
85.11
17%
-152
* C4 *
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
-------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-----------------
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
--
C
A
D
L
I
I
G
V
F
S
-
M
--
N
L
Y
T
L
Y
-
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
----
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
--------
T
K
M
A
G
M
M
I
A
A
A
W
V
-------------
L
S
F
I
L
W
A
P
A
-
I
----
L
F
W
Q
F
I
-
V
G
V
--
R
T
V
E
D
G
E
--------
C
Y
I
Q
-
F
F
--------------
S
-------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
-----
Y
W
H
I
S
R
A
S
K
S
----
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP
S
R
E
K
K
V
T
R
T
I
L
A
I
L
---
L
A
F
I
I
-------------
T
W
A
P
Y
N
V
M
V
-----
L
I
N
T
F
-----
C
A
P
-
C
--
I
--
P
N
T
V
-------
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
---
N
P
A
C
Y
A
L
C
N
A
T
F
K
----
K
T
F
K
H
L
L
--
M
-------------------------------
35
HHSearch
82.53
18%
-150
- C4 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
-------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-----------------
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
--
F
A
E
A
S
M
A
A
F
N
-
T
--
V
V
N
F
T
Y
-
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
----
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
--------
A
T
A
T
K
V
V
I
C
V
I
W
V
-------------
L
A
L
L
L
A
F
P
Q
-
G
----
Y
Y
S
T
T
E
-
T
-----
M
P
S
R
V
V
--------
C
M
I
E
-
W
P
E
H
P
---
N
K
-----
I
Y
-------
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
-----
Y
T
V
V
G
I
T
L
W
A
----
S
E
I
P
GDSSDRYH
E
Q
V
------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
M
I
V
V
V
---
C
T
F
A
I
-------------
C
W
L
P
F
H
I
F
F
-----
L
L
P
Y
I
-----
N
P
D
-
L
YL
K
KF
I
Q
Q
V
-------
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
---
N
P
I
I
Y
C
C
L
N
D
R
F
R
----
L
G
F
K
H
A
F
--
R
C
-------------
C
P
F
I
S
A
G
D
Y
E
G
L
-----
43
Fugue
79.30
14%
-137
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
--
N
K
T
G
V
VRSPFEAPQYYLAE
P
W
Q
F
S
-
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
--
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
----
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
--------
N
H
A
I
M
G
V
A
F
T
W
V
M
-------------
A
L
A
C
A
A
P
P
L
-
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
----
Y
--------
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
-------
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----
E
--
A
A
A
S
A
T
T
----
Q
K
A
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
---
L
I
C
W
L
-------------
P
Y
A
G
V
A
F
Y
I
-----
F
T
H
Q
-------
G
S
-
D
--
F
--
G
P
I
F
-------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
----
N
C
M
V
T
T
L
C
C
G
K
-------------
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
12
PsiBlast_PDB
78.60
26%
-160
- C4 -
3RFM
1
AA2AR_HUMAN
A:
[14-223]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
A
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
--------GCGEGQVA
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
-----
F
N
-------
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----
R
----
R
Q
L
K
Q
----
M
E
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
A
A
-------------
I
I
A
G
L
F
A
L
C
-----
W
L
P
L
H
-----
I
I
N
-
C
--
F
--
T
F
F
C
-------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
---
I
V
L
A
H
T
N
S
V
V
N
P
F
----
I
Y
A
Y
R
I
R
--
E
F
-------------
R
Q
T
F
R
K
I
I
R
S
-------
11
PsiBlast_PDB
78.50
26%
-157
- C4 -
3REY
1
AA2AR_HUMAN
A:
[14-223]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
A
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
--------GCGEGQVA
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
-----
F
N
-------
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----
R
----
R
Q
L
K
Q
----
M
E
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
A
A
-------------
I
I
A
G
L
F
A
L
C
-----
W
L
P
L
H
-----
I
I
N
-
C
--
F
--
T
F
F
C
-------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
---
I
V
L
A
H
T
N
S
V
V
N
P
F
----
I
Y
A
Y
R
I
R
--
E
F
-------------
R
Q
T
F
R
K
I
I
R
S
-------
47
Fugue
78.32
17%
-140
- C1 -
4BZF
3
GALM_BACSU
A:
[1-322]
------------------
A
N
F
I
E
K
I
T
Y
L
--
G
T
P
A
I
--------------
K
A
------
G
N
E
H
L
E
M
I
V
V
P
E
W
G
S
N
V
I
S
L
-----------------
V
D
K
T
T
N
---------
V
Q
L
L
R
--
E
P
E
T
A
E
S
F
H
D
-
T
--
P
T
L
Y
G
I
P
I
L
F
P
P
N
R
I
S
-
D
G
T
F
S
F
R
G
R
T
Y
H
F
D
I
N
E
K
--------
D
----
K
H
N
H
L
H
G
F
L
Y
H
E
K
-
W
N
--------
V
V
T
T
K
Q
T
D
E
G
V
I
V
-------------
E
T
E
I
D
L
S
E
L
-
P
----
H
V
Q
K
Q
---
F
P
H
H
A
V
V
R
M
T
Y
--------
T
I
K
E
N
T
L
F
K
H
A
T
V
M
N
KGK
E
A
F
P
W
G
I
G
Y
HT
T
F
I
F
P
A
E
S
S
L
F
S
L
T
A
D
Q
Q
W
E
L
D
E
-----
R
L
L
P
T
G
K
L
M
D
----
V
P
Y
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
L
H
E
G
M
D
L
R
H
K
Q
L
---
D
D
V
F
L
SSYQKRG
G
E
N
Q
A
V
I
Y
H
Q
H
A
H
I
S
-----
I
I
Y
K
A
-----
D
E
Q
-
F
K-
H
--
W
V
V
Y
NADGKQG
Y
L
C
P
E
P
Y
T
W
V
T
N
A
V
---
N
L
D
L
P
S
S
L
T
G
L
Q
V
L
E
PG
E
E
T
T
A
K
S
--
S
I
-------------
T
I
E
L
N
------------
14
PsiBlast_PDB
78.26
26%
-160
- C4 -
3UZC
1
AA2AR_HUMAN
A:
[14-223]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
A
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
--------GCGEGQVA
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
-----
F
N
-------
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----
R
----
R
Q
L
K
Q
----
M
E
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
A
A
-------------
I
I
A
G
L
F
A
L
C
-----
W
L
P
L
H
-----
I
I
N
-
C
--
F
--
T
F
F
C
-------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
---
I
V
L
A
H
T
N
S
V
V
N
P
F
----
I
Y
A
Y
R
I
R
--
E
F
-------------
R
Q
T
F
R
K
I
I
R
S
-------
10
PsiBlast_PDB
77.75
26%
-160
- C4 -
3PWH
1
?
A:
[14-223]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
A
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
--------GCGEGQVA
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
-----
F
N
-------
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----
R
----
R
Q
L
K
Q
----
M
E
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
A
A
-------------
I
I
A
G
L
F
A
L
C
-----
W
L
P
L
H
-----
I
I
N
-
C
--
F
--
T
F
F
C
-------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
---
I
V
L
A
H
T
N
S
V
V
N
P
F
----
I
Y
A
Y
R
I
R
--
E
F
-------------
R
Q
T
F
R
K
I
I
R
S
-------
13
PsiBlast_PDB
77.50
26%
-160
- C4 -
3UZA
1
AA2AR_HUMAN
A:
[14-223]
-------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----------------
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
--
A
A
D
I
L
V
G
V
L
A
-
I
--
P
--
F
A
I
-
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
----
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
--------
G
T
R
A
A
--
G
I
I
A
I
C
-------------
W
V
L
S
F
A
I
G
L
T
P
----
M
L
G
W
N
N
-
C
G
Q
P
--------GCGEGQVA
C
L
F
E
-
D
V
V
P
M
N
Y
M
V
Y
-----
F
N
-------
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
-----
R
----
R
Q
L
K
Q
----
M
E
S
Q
PLP--------------------------------------------------------------------------------------------------------------------------------------------------------------
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
---
A
K
S
A
A
-------------
I
I
A
G
L
F
A
L
C
-----
W
L
P
L
H
-----
I
I
N
-
C
--
F
--
T
F
F
C
-------
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
---
I
V
L
A
H
T
N
S
V
V
N
P
F
----
I
Y
A
Y
R
I
R
--
E
F
-------------
R
Q
T
F
R
K
I
I
R
S
-------
44
Fugue
74.43
13%
-127
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
--
Y
Y
L
A
E
--------------
P
W
Q
F
S
-
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
--
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
----
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
--------
N
H
A
I
M
G
V
A
F
T
W
V
M
-------------
A
L
A
C
A
A
P
P
L
-
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
----
Y
--------
T
P
H
E
-
E
T
N
N
E
S
F
V
I
Y
-----
M
F
-------
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
-----
E
A
A
A
Q
Q
Q
E
S
A
----
T
T
Q
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
---
A
F
L
I
C
-------------
W
L
P
Y
A
G
V
A
F
-----
Y
I
F
T
H
-----
Q
G
S
-
D
--
F
--
G
P
I
F
-------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
----
N
C
M
V
T
T
L
--
C
C
GKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----
36
HHSearch
73.37
18%
-140
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[63-495]
----------------------------------------------------
I
K
-
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
-----------------
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
--
L
S
D
L
L
A
G
V
A
Y
-
T
--
A
N
L
L
L
S
-
G
A
-
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
F
S
L
L
A
I
A
I
E
----
R
Y
I
T
M
L
K
--------
N
--------
N
F
R
L
F
L
L
I
S
A
C
W
V
-------------
I
S
L
I
L
G
G
L
P
-
I
----
M
G
W
N
C
I
-
S
-------
A
L
S
S
--------
C
S
T
V
-
L
P
L
-------------
Y
-------
H
K
H
Y
I
L
F
-
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
-----
Y
C
R
I
Y
S
L
V
R
T
----
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
S
E
N
V
A
L
L
K
T
V
I
I
V
L
---
S
V
F
I
A
-------------
C
W
A
P
L
F
I
L
L
-----
L
L
D
V
G
-----
C
K
V
-
K
TC
D
--
I
L
F
R
-------
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
---
N
P
I
I
Y
T
L
T
N
K
E
M
R
----
R
A
F
I
R
I
M
--
G
R
-------------
P
L
---------------
50
Fugue
72.74
21%
-164
- C2 -
3FHC
-
NU214_HUMAN
A:
[9-405]
---------I
P
E
R
E
M
K
D
F
Q
F
R
A
L
K
K
V
R
I
FD
S
P
E
E
L
--------------
P
K
E
R
S
S
L
L
A
V
S
N
K
Y
G
L
V
F
A
G
G
A
S
G
L
Q
I
F
PTKNL
L
I
Q
N
K
PGDDPNK
I
V
D
K
V
Q
G
L
L
V
P
M
K
F
P
I
H
H
L
A
L
S
C
D
N
L
T
L
S
A
C
M
-
M
S
S
E
Y
G
S
I
I
-
A
F
F
D
V
R
T
F
S
N
E
A
-
Q
K
R
P
F
A
Y
H
K
L
L
K
D
A
G
G
M
V
I
D
M
K
W
N
PTVP
S
M
V
A
V
C
L
A
D
G
S
I
A
V
L
Q
V
T
E
T
V
K
V
C
A
T
L
P
S
T
V
A
V
T
S
V
C
W
S
PKGK
Q
L
A
V
G
K
Q
N
G
T
V
V
Q
Y
L
P
-
T
----
L
Q
E
K
K
V
-
I
P
C
P
P
F
Y
E
S
D
H
P
--------
V
R
V
L
-
D
V
L
W
I
G
--
T
Y
-----
V
F
-------
A
I
V
Y
A
A
A
D
G
T
L
E
T
S
P
D
V
V
M
A
L
L
P
KKEEK
H
P
E
I
F
V
N
F
M
E
----
P
C
Y
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
C
T
E
R
Q
H
H
Y
Y
L
S
Y
I
EEW
D
L
V
L
A
-------------
A
S
A
A
S
T
E
V
S
-----
I
L
A
R
Q
-----
S
D
Q
-
I
--
N
--
W
E
S
W
-------
L
L
E
D
S
S
R
A
E
L
P
V
T
D
KS
D
D
S
L
P
M
G
V
V
V
D
Y
T
N
----
A
P
V
L
M
L
----
L
-------------
S
T
D
G
V
L
C
P
F
Y
M
I
N----
37
HHSearch
72.12
15%
-144
- C4 -
2Z73
5
OPSD_TODPA
A:
[32-333]
--------------------------------------------------
A
V
Y
Y
-
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-----------------
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
--
F
S
D
F
T
F
S
L
V
N
G
F
--
P
L
M
T
I
S
-
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
----
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
--------
H
R
R
A
F
I
M
I
I
F
V
W
L
-------------
W
S
V
L
W
A
I
G
P
-
I
----
F
G
W
G
A
Y
-
T
L
----
E
G
V
L
C
N
--------
C
S
F
D
-
Y
I
S
R
-----
D
-----
S
T
-------
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
-----
Y
F
N
I
V
M
S
V
S
N
----
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
---------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
S
I
V
I
V
---
S
Q
F
L
L
-------------
S
W
S
P
Y
A
V
V
A
-----
L
L
A
Q
F
-----
G
P
L
E
W
--
V
--
T
P
Y
A
-------
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
---
N
P
M
I
Y
S
V
S
H
P
K
F
R
----
E
A
I
S
Q
T
F
--
P
W
-------------
V
L
T
C
C
Q
F
D
D
K
E
T
-----
31
HHSearch
72.08
14%
-139
- C4 -
1U19
14
OPSD_BOVIN
A:
[41-329]
-----------------------------------------------------
S
-
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----------------
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
--
V
A
D
L
F
M
V
F
G
G
-
F
--
T
T
T
L
Y
T
-
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
----
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
--------
E
N
H
A
I
M
G
V
A
F
T
W
V
-------------
M
A
L
A
C
A
A
P
P
-
L
----
V
G
W
S
R
Y
-
I
P
----
E
G
M
Q
C
S
--------
C
G
I
D
-
Y
Y
T
P
---
H
E
E
-----
T
N
-------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
E
----
A
A
A
Q
QQESA
T
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
V
I
I
M
V
---
I
A
F
L
I
-------------
C
W
L
P
Y
A
G
V
A
-----
F
Y
I
F
T
-----
H
Q
G
S
D
--
F
--
G
P
I
F
-------
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
---
N
P
V
I
Y
I
M
M
N
K
Q
F
R
----
N
C
M
V
T
T
L
--
C
C
-------------
G
K
N
P
L
G
D
D
E
A
S
T
-----