@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51I2_HUMAN: (2016-01-12 )
MGLFNVTHPAFFLLTGIPGLESSHSWLSGPLCVMYAVALGGNTVILQAVRVEPSLHEPMYYFLSMLSFSDVAISMATLPTVLRTFCLNARNITFDACLIQMFLIHFFSMMESGILLAMSFDRYVAICDPLRYATVLTTEVIAAMGLGAAARSFITLFPLPFLIKRLPICRSNVLSHSYCLHPDMMRLACADISINSIYGLFVLVSTFGMDLFFIFLSYVLILRSVMATASREERLKALNTCVSHILAVLAFYVPMIGVSTVHRFGKHVPCYIHVLMSNVYLFVPPVLNPLIYSAKTKEIRRAIFRMFHHIKI
Atome Classification :
(20 SA)
--------------.........10.......---------------.20........30........---40........50........60........70......-..---80........90........100.......110-------..--.....120.......130.......140.......150..-..-...160-......----.170.......180.......190-----..-....-...200.......210.......220...------....--------230-----------------------------------------------------------------------------------------------------------------------------------------------------------------....------....240.......250........260....--.----------.--.--270.........280.......290.......300.......310-------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MGLFNVTH
P
A
F
F
L
L
TGIP---------------GLESSHSWLSG
P
L
C
V
M
Y
A
V
AL---GG
N
T
V
I
L
Q
A
V
RVEPSLH
E
P
M
Y
Y
F
L
S
M
LSF
S
D
V
A
I
S
M
A
T
-
L
P
---
T
V
L
R
T
F
C
LNARNI
T
F
D
A
C
L
I
Q
M
F
L
I
H
F
F
S
M
M
ES-------
G
I
--
L
L
A
M
SFD
R
Y
V
AICDP
L
R
Y
A
T
V
L
T
T
E
V
I
A
A
MG
L
G
A
A
A
R
S
F
I
-TL-F
P
L
P
F
L
-
I
K
RLPI----
C
R
S
N
VLSHSYCL
H
P
D
M
M
R
L
A
CA-------DI-
S
I
N
S
-
I
Y
G
L
F
V
L
V
S
T
F
G
M
D
L
F
F
I
F
L
S
Y
V
L
I
L
R
S
V
------
M
A
T
A
--------
S
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
R
L
------
K
A
L
N
T
C
V
S
H
I
L
A
V
L
A
F
-
Y
V
P
M
I
G
V
S
T
V
H
R
FGK--H----------V--
P
--
C
--
Y
I
H
V
L
M
SN
V
Y
L
FVPPV
L
N
P
L
I
YSA
K
T
K
E
I
R
R
A
I
F
R
M
F
H
HIKI-------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
90.93
20%
-137
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
---
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
---
M
N
I
L
Y
L
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
-------
F
S
--
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
-
W
V
-
I
P
I
L
G
--
W
N
H
------------
R
R
E
D
K
C
E
T
D
F
Y
-----------------
D
V
T
-
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
------
R
Q
H
C
--------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM-
N
R
E
R
------
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
-
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
--
N
----------
C
--
C
--
N
--
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
89.84
22%
-148
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[9-296]
-----------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
---------
A
R
A
K
V
I
I
C
T
V
-
W
A
I
S
A
L
-
V
S
F
L
P
I
M
M
HW
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
-------
D
F
-
V
T
N
R
-
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
--------
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--
D
L---------
V
--
P
--
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.83
22%
-145
- C1 -
2YCW
7
ADRB1_MELGA
A:
[7-296]
---------------------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
---------
A
R
A
K
V
I
I
C
T
V
-
W
A
I
S
A
L
-
V
S
F
L
P
I
M
M
HW
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
-------
D
F
-
V
T
N
R
-
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
--------
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--
D
L---------
V
--
P
--
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
89.63
22%
-145
- C1 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
-----------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
---------
A
R
A
K
V
I
I
C
T
V
-
W
A
I
S
A
L
-
V
S
F
L
P
I
M
M
HW
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
-------
D
F
-
V
T
N
R
-
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
A
--------
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--
D
L---------
V
--
P
--
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
89.08
18%
-144
* C1 *
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
-------
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
-
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
H
---------
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
-------
D
F
-
F
T
N
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------
K
R
Q
L
--------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC-
L
K
E
H
------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
-
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
--
N
----------
L
--
I
--
R
--
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.02
22%
-148
- C1 -
2VT4
8
ADRB1_MELGA
A:
[10-296]
------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
---------
A
R
A
K
V
I
I
C
T
V
-
W
A
I
S
A
L
-
V
S
F
L
P
I
M
M
HW
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
-------
D
F
-
V
T
N
R
-
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
IR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
----
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--
D
L---------
V
--
P
--
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
87.37
22%
-144
- C1 -
2YCY
6
ADRB1_MELGA
A:
[10-296]
------------------------------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
---------
A
R
A
K
V
I
I
C
T
V
-
W
A
I
S
A
L
-
V
S
F
L
P
I
M
M
HW
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
----
G
C
C
-------
D
F
-
V
T
N
R
-
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R--
D
R
A
--------
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
--
D
L---------
V
--
P
--
D
--
W
L
F
V
A
F
-
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
86.18
19%
-135
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-332]
---------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
---
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
-------
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
-
W
A
-
I
G
P
I
F
G
-
W
G
A
Y
T
L
--------
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
-
S
T
T
R
-
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
------
S
N
H
E
--------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
--
L
E---------
W
--
V
--
T
--
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
86.03
17%
-143
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
----------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
-
A
A
-
P
P
L
V
G
W
-
S
R
Y
I
P
E
-------------------
G
M
Q
C
S
C
G
I
DYYTPH
E
E
-
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
------
K
E
A
A
ASAT----
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
----------
S
--
D
--
F
G-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
85.95
17%
-130
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQYYL
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
-
A
A
-
P
P
L
V
G
W
-
S
R
Y
I
P
E
-------------------
G
M
Q
C
S
C
G
I
DYYTPH
E
E
-
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
------
K
E
A
A
AQQQESA
T
T
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
----------
S
--
D
--
F
G-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
84.96
18%
-144
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
------------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
V
T
I
---
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
---
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
-------
M
N
--
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
-
L
W
-
A
P
A
I
L
F
-
W
Q
F
I
V
G
----
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
F
-----------------
S
N
A
-
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
------
K
S
R
I
--------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP-
S
R
E
K
------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
-
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
--
P
----------
C
--
I
--
P
--
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
84.73
17%
-151
- C1 -
3EML
13
ENLYS_BPT4
A:
[22-469]
-----------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
---
F
A
I
T
I
S
T
--
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
-------
F
S
--
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
-
I
G
-
L
T
P
M
L
G
-
W
N
N
C
G
Q
-----------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
-------
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
------
R
R
Q
L
--------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
Q
K
E
V
------
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
-
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
DC
S
----------
H
--
A
--
P
--
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
81.65
15%
-137
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
------------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
---
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
---
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
-------
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
-
L
A
-
F
P
Q
G
Y
Y
-
S
T
T
E
T
---------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
-
I
Y
E
K
-
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
------
W
A
S
E
--------
I
P
GDSSDRYH
E
Q
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
------
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
-
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
--
D
----------
L
YL
K
--
K
FI
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
81.43
17%
-123
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-326]
-----------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
---
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
-
C
A
-
A
P
P
L
V
G
-
W
S
R
Y
I
P
--------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
-------
E
E
-
T
N
N
E
-
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
------
K
E
A
A
--------
A
Q
QQESA
T
T
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
--
G
S---------
D
--
F
--
G
--
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
79.64
18%
-140
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[61-495]
--------------------------------------------------
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
---
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
-
T
A
---
N
L
L
L
S
G
A
-
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
V
-------
F
S
--
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
--------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
-
L
G
-
G
L
P
I
M
G
-
W
N
C
I
S
-----------
A
L
S
S
C
S
T
V
L
P
L
----------------
Y
H
K
-
H
Y
-
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
------
R
T
R
N
--------
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
-
S
E
N
V
------
A
L
L
K
T
V
I
I
V
L
S
V
F
I
A
C
-
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
--
V
----------
K
--
T
C
D
I
--
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
77.10
16%
-131
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
---
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
---
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
-------
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
-
L
S
-
L
P
F
F
L
F
-
R
Q
A
Y
H
P
--------
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
-----------
T
A
-
K
W
R
M
-
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
------
F
K
A
H
--------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
-
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
--
T
QVIQE
S
C
E
R
R
N
--
N
--
I
--
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.68
25%
-150
- C1 -
4EIY
21
AA2AR_HUMAN (first)
A:
[24-213]
-----------------------------
G
A
P
---------------
P
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
-
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-------
L
V
L
T
Q
S
-------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
I
-
A
I
C
W
V
L
S
F
A
-
I
G
L
T
P
M
---------
L
G
W
N
N
C
G
Q
P
K
E
G
K
N
H
S
Q
-------
G
C
-
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
------
M
L
G
V
--------
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
L
------
A
A
R
R
Q
L
A
D
L
E
D
N
W
E
T
L
-
N
D
N
L
K
V
I
E
K
A
D
N
A
A
Q
--
V
----------
K
--
D
--
A
--
L
T
K
M
R
A
A
A
L
D
A
Q
K
M
K
D
F
R
H
G
F
D
I
L
V
G
Q
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
70.76
14%
-126
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
---
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
-------
E
T
--
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
--------
K
N
K
A
R
V
I
I
L
-
M
V
-
W
I
V
S
G
L
-
T
S
F
L
P
I
----
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------
D
F
-
F
T
N
Q
-
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
------
K
R
Q
L
--------
N
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
-
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
--
L
----------
N
--
A
--
A
--
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
3
PsiBlast_PDB
68.68
25%
-158
- C1 -
3EML
8
ENLYS_BPT4
A:
[18-203]
------------------------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
-
V
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-------
L
V
L
T
Q
S
-------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
I
-
A
I
C
W
V
L
S
F
A
-
I
G
L
T
P
M
---------
L
G
W
N
N
C
G
Q
-------
S
Q
-------
G
C
-
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
------
M
L
G
V
--------
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
L
------
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
-
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--
I
----------
G
--
I
--
G
--
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.63
24%
-149
- C1 -
2YDV
6
?
A:
[19-188]
-----------------------------------------------------------------
L
A
I
---
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
-------
L
V
L
T
A
S
-------
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
---------
G
T
R
A
K
G
I
I
-
A
I
C
W
V
L
S
F
A
-
I
G
L
T
P
M
---------
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
-------
G
C
-
G
E
G
Q
-
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
------
M
L
G
V
--------
Y
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
F
L
------
A
A
R
R
Q
L
K
Q
M
E
S
Q
S
T
L
Q
-
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
--
F
----------
A
--
L
--
C
--
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------