@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52E2_HUMAN: (2016-01-12 )
MFLPNDTQFHPSSFLLLGIPGLETLHIWIGFPFCAVYMIALIGNFTILLVIKTDSSLHQPMFYFLAMLATTDVGLSTATIPKMLGIFWINLRGIIFEACLTQMFFIHNFTLMESAVLVAMAYDSYVAICNPLQYSAILTNKVVSVIGLGVFVRALIFVIPSILLILRLPFCGNHVIPHTYCEHMGLAHLSCASIKINIIYGLCAICNLVFDITVIALSYVHILCAVFRLPTHEARLKSLSTCGSHVCVILAFYTPALFSFMTHRFGRNVPRYIHILLANLYVVVPPMLNPVIYGVRTKQIYKCVKKILLQEQGMEKEEYLIHTRF
Atome Classification :
(20 SA)
----------....---..---------------...10-----------.---.....-...20........30.---....------...40..-....--.----.50........60........70.-.......-80------......---..--.90........100-.----------------.......110....--...120----..---.......130------------------.......---..140.....-...------150.......160----------..-...-..-----170..-------.......180.....--..190--------..--..---------...200------.-.....---------.210....--...220......----.230-----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.......240-.......---------------------.250.......260.....----------.----------.----270-----........280...-..--..---290.......300.......310.------......320...----------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MFLP---ND---------------TQFH------------P---S
S
F
L
L
-
L
GIPG
L
E
T
L
H
I
W
IG
F
P
---
F
C
A
V
------
Y
M
I
A
L
IG-N
F
T
I
--
L
----
L
V
I
KTDSSLH
Q
P
M
F
Y
F
L
A
M
L
A
TTD-VGLS
T
A
T
-
I
-------
P
K
M
L
G
I
---
F
W
--
I
N
L
R
G
I
I
F
E
A
C
L
T
--
Q
----------------
M
F
F
I
HN
F
T
L
M
E
S
A
V
--
L
V
A
M
------AY---D
S
Y
V
AICN--------------------
P
L
Q
Y
S
A
I
---
L
T
N
-
K
V
V
S
V
I
-
G
L
G
------
V
F
V
R
A
L
I
F
V
I
P
S
I
----------
L
L
-
I
LR-LP-----F--CG-------NHV
I
P
H
T
Y
C
E
HMGLA--HL
S
C
A
--------
S
I
--
K
I
---------
N
I
I
Y
G
L
------
C
-
A
I
C
N
L
---------
V
F
D
I
T
V
I
A
--
L
S
Y
V
H
I
L
C
A
V
F
R----LP
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
R
L
K
S
L
S
T--CGS
H
V
C
V
---------------------
I
L
A
F
Y
T
P
A
L
F
S
F
M
T
H
R
FGR----------N----------
V
----
P
-
R
-----
Y
I
H
I
L
L
A
N
L
Y
V
VVP-PM--
L
N
---
P
V
I
YG
V
R
T
K
Q
I
Y
K
C
V
K
K
I
L
L
Q
E
QG------MEKE
E
Y
L
I
HTRF----------
28
HHSearch
89.33
19%
-159
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
---------------------------------------------------------------------
V
V
G
M
G
I
V
---
M
S
L
I
------
V
L
A
I
V
F
G
-
N
V
L
V
--
I
----
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
-
L
V
M
G
L
A
V
-
V
-------
P
F
G
A
A
H
---
I
L
--
M
K
M
W
T
F
G
N
F
W
C
E
F
--
W
----------------
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
------
A
V
---
D
R
Y
F
A
I
T
S
--------------------
P
F
K
Y
Q
S
L
---
L
T
K
-
N
K
A
R
V
I
-
I
L
M
------
V
W
I
V
S
G
L
T
S
F
L
P
I
----------
Q
M
H
W
Y
R
-
A
T
-----
H
--------------
Q
E
A
I
N
C
Y
A
E
------
E
T
C
C
--------
D
F
--
F
T
---------
N
Q
A
Y
A
I
------
A
S
S
I
V
S
F
---------
Y
V
P
L
V
I
M
V
--
F
V
Y
S
R
V
F
Q
E
A
K
R
----
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF-
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
K
A
L
K
T
--
L
G
I
I
M
G
T
---------------------
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----------
N
----------
L
----
I
-
R
-----
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
-
S
G
--
F
N
---
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------------------
27
HHSearch
83.44
17%
-150
- C7 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
----------------------------------------------------------------------
M
P
L
V
V
V
---
L
S
T
I
------
C
L
V
T
V
G
L
-
N
L
L
V
--
L
----
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
-
L
I
V
G
A
V
V
-
M
-------
P
M
N
I
L
Y
---
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
--
W
----------------
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
--
V
F
I
L
------
C
I
---
D
R
Y
R
S
V
Q
Q
--------------------
P
L
R
Y
L
K
Y
---
R
T
K
-
T
R
A
S
A
T
-
I
L
G
------
A
W
F
L
S
F
L
W
V
I
P
I
L
----------
G
--
W
N
H
-----------------------
R
R
E
D
K
C
E
T
D
F
Y
---------------------
D
---------
V
T
W
F
K
V
------
M
T
A
I
I
N
F
---------
Y
L
P
T
L
L
M
L
--
W
F
Y
A
K
I
Y
K
A
V
R
Q
----
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
K
A
A
K
Q
--
L
G
F
I
M
A
A
---------------------
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
----------
N
----------
C
----
C
-
N
-----
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
-
S
T
--
L
N
---
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-------------------------------
31
HHSearch
81.92
18%
-159
- C7 -
3EML
13
ENLYS_BPT4
A:
[21-472]
---------------------------------------------------------------------
S
S
V
Y
I
T
V
---
E
L
A
I
------
A
V
L
A
I
L
G
-
N
V
L
V
--
C
----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
A
V
G
V
L
A
-
I
-------
P
F
A
I
T
I
---
S
T
----
G
F
C
A
A
C
H
G
C
L
F
--
I
----------------
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
I
------
A
I
---
D
R
Y
I
A
I
R
I
--------------------
P
L
R
Y
N
G
L
---
V
T
G
-
T
R
A
K
G
I
-
I
A
I
------
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
-
W
N
N
-
C
G
-----
Q
----------------
S
Q
G
C
G
E
G
Q
V
-----
A
C
L
--------
F
E
DV
V
P
---------
M
N
Y
M
V
Y
------
F
N
F
F
A
C
V
---------
L
V
P
L
L
L
M
L
--
G
V
Y
L
R
I
F
L
A
A
R
R
----
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
H
A
A
K
S
--
L
A
I
I
V
G
L
---------------------
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
----------
D
CS--------
H
----
A
-
P
-----
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
-
S
V
--
V
N
---
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
------
R
Q
--------------------
42
Fugue
81.77
17%
-147
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------
M
N
G
T
---
E
G
---------------
P
N
F
Y
VPFSNKTGVVRS
P
---
F
E
A
P
Q
-
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
---
F
L
L
I
-------
M
L
G
F
P
I
-
N
F
L
T
--
L
----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-------
T
T
T
L
Y
T
---
S
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
----------------
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
------
A
I
---
E
R
Y
V
V
V
C
K
--------------------
P
M
S
-
N
F
R
---
F
G
E
-
N
H
A
I
M
G
-
V
A
F
------
T
W
V
M
A
L
A
C
A
A
P
P
L
----------
V
G
-
W
S
R
----------------------
Y
I
P
E
------
G
M
---
Q
C
S
C
G
I
DYYTPHE
E
T
--
N
N
---------
E
S
F
V
I
Y
------
M
-
F
V
V
H
F
---------
I
I
P
L
I
V
I
F
--
F
C
Y
G
Q
L
V
F
T
V
K
E
----
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
K
A
E
K
E
--
V
T
R
M
V
I
I
---------------------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
----------
F
----------
T
----
H
-
Q
GSDFG
P
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
--
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A------
41
Fugue
80.80
19%
-121
- C7 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFY
V
P
F
S
---
N
K
---------------
T
G
V
V
------------
R
---
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
---
M
F
L
L
------
I
M
L
G
F
P
I
-
N
F
L
T
--
L
----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-------
T
T
T
L
Y
T
---
S
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
----------------
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
------
A
I
---
E
R
Y
V
V
V
C
K
--------------------
P
M
S
N
F
R
F
---
G
E
N
-
H
A
I
M
G
V
-
A
F
-------
T
W
V
M
A
L
A
C
A
A
P
P
L
----------
V
G
-
W
S
R
Y
I
P
E
GMQC
S
--
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
I
P
--------
L
I
--
V
I
---------
F
F
C
Y
G
------------
Q
L
---------
V
F
T
V
K
E
A
A
--
A
Q
------
Q
Q
E
S
----
A
T
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
--
V
I
I
M
V
I
A
---------------------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
----------
G
----------
S
----
D
F
G
-----
P
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
--
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------
P
L
G
D
D
E
A
S
T
T
V
S
K
TETSQVAPA
23
HHSearch
80.66
17%
-164
- C7 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
----------------------------------------------------------------------
V
F
I
V
L
V
---
A
G
S
L
------
S
L
V
T
I
I
G
-
N
I
L
V
--
M
----
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
-
L
I
I
G
V
F
S
-
M
-------
N
L
Y
T
L
Y
---
T
V
--
I
G
Y
W
P
L
G
P
V
V
C
D
L
--
W
----------------
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
--
L
L
I
I
------
S
F
---
D
R
Y
F
C
V
T
K
--------------------
P
L
T
Y
P
V
K
---
R
T
T
-
K
M
A
G
M
M
-
I
A
A
------
A
W
V
L
S
F
I
L
W
A
P
A
I
----------
L
F
-
W
Q
F
-
I
V
-----
G
--
V
R
---------
T
V
E
D
G
E
C
Y
I
Q
F
F
---------------------
S
---------
N
A
A
V
T
F
------
G
T
A
I
A
A
F
---------
Y
L
P
V
I
I
M
T
--
V
L
Y
W
H
I
S
R
A
S
K
S
----
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
K
V
T
R
T
--
I
L
A
I
L
L
A
---------------------
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
----------
P
----------
C
----
I
-
P
-----
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
-
S
T
--
I
N
---
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------------------
24
HHSearch
80.37
15%
-145
- C7 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-499]
------------------------------------------------------------------
N
F
N
K
I
F
L
P
T
I
---
Y
S
I
I
------
F
L
T
G
I
V
G
-
N
G
L
V
--
I
----
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
-
L
L
F
V
-
I
T
-
L
-------
P
F
W
A
V
D
---
A
V
---
A
N
W
Y
F
G
N
F
L
C
K
A
--
V
----------------
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
--
L
A
F
I
------
S
L
---
D
R
Y
L
A
I
V
H
--------------------
A
T
N
S
Q
R
P
---
R
K
L
-
L
A
E
K
V
V
-
Y
V
G
------
V
W
I
P
A
L
L
L
T
I
P
D
F
----------
I
F
-
A
N
V
-
S
E
-------------------
A
D
D
R
Y
I
C
D
R
F
Y
P
N
----------------
D
--
L
W
---------
V
V
V
F
Q
F
------
Q
H
I
M
V
G
L
---------
I
L
P
G
I
V
I
L
--
S
C
Y
C
I
I
I
S
K
L
S
H
----
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
--
T
V
I
L
I
L
A
---------------------
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
----------
N
----
T
-
V
-----
H
K
W
I
S
I
T
E
A
L
A
F
F
H
-
C
C
--
L
N
---
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
------
L
E
V
L
F
Q
----------------
47
Fugue
78.00
18%
-172
- C6 -
4CVH
3
ISPD_HUMAN
A:
[1-411]
--SMHPQA
V
A
A
V
L
P
AGP
T
P
---------------
K
Q
F
C
------------
P
ILE
R
P
L
I
S
-
Y
T
L
Q
A
L
E
R
V
-
C
W
I
K
D
I
---
V
V
A
V
T
GEN
M
E
V
M
K
S
I
I
Q
-
K
Y
Q
H
KR
I
----
S
L
V
E
A
G
V
T
R
H
R
S
I
F
N
G
L
K
A
L
A
E
D
Q
-
I
N
-
S
K
L
S
-
K
-------
P
E
V
V
I
I
---
H
D
--
A
-
V
R
P
F
V
E
E
G
V
L
L
--
K
----------------
V
V
T
A
A
K
E
H
G
A
A
G
A
I
--
R
P
L
V
------
S
T
---
V
V
S
P
S
A
D
G
--------------------
C
L
D
Y
S
L
E
---
R
A
R
-
H
R
A
S
E
M
-
P
Q
A
------
F
L
F
D
V
I
Y
E
A
Y
Q
Q
C
S
D
Y
D
L
E
FGTE
C
L
-
Q
L
A
-
L
K
-----
Y
--
C
C
-------
T
K
A
K
L
V
E
G
S
P
D
L
W
K
V
TY
K
R
D
L
Y
--------
A
A
--
E
S
---------
I
I
K
E
R
I
------
S
-
Q
E
I
C
V
---------
V
M
D
T
E
E
D
N
--
K
H
V
G
H
L
L
E
E
V
L
K
----
S
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
K
V
T
S
E
A
L
DQ
C
Y
N
F
V
C
V
N
VTTSDF
Q
E
T
Q
K
L
L
S
M
L
E
E
SS
L
C
I
L
Y
P
V
V
V
V
S
V
H
F
L
D
F
K
L
----------
V
----------
P
----
P
-
S
-----
Q
K
M
E
N
L
M
Q
I
R
E
F
A
K
-
E
V
K
E
R
N
---
I
L
L
Y
G
L
L
I
S
Y
P
Q
D
D
Q
K
L
Q
E
S
L
R
Q
G
------
A
I
I
I
A
S
L
I
K
E
R
N
SGLIG
Q
L
L
I
A
34
HHSearch
77.48
16%
-160
* C7 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
------------------------------------------------------------------------
Y
A
L
S
---
Y
C
A
L
------
I
L
A
I
V
F
G
-
N
G
L
V
--
C
----
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
-
L
L
V
A
T
L
V
-
M
-------
P
W
V
V
Y
L
---
E
V
T
-
G
G
V
W
N
F
S
R
I
C
C
D
V
--
F
----------------
V
T
L
D
V
M
M
C
T
A
S
I
W
N
--
L
C
A
I
------
S
I
---
D
R
Y
T
A
V
V
M
--------------------
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
-
R
R
V
A
L
M
-
I
T
A
------
V
W
V
L
A
F
A
V
S
C
P
L
L
----------
F
G
-
F
N
T
-
T
---------------------
G
D
P
T
V
C
S
I
S
N
---------------------------------
P
D
F
V
I
------
Y
S
S
V
V
S
F
---------
Y
L
P
F
G
V
T
V
--
L
V
Y
A
R
I
Y
V
V
L
K
Q
----
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
K
A
T
Q
M
--
V
A
I
V
L
G
A
---------------------
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
----------
T
C---------
H
----
V
-
S
-----
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
-
S
A
--
L
N
---
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-------------------------------
33
HHSearch
76.46
17%
-141
- C7 -
1U19
14
OPSD_BOVIN
A:
[38-329]
-------------------------------------------------------------------
W
Q
F
S
M
L
A
A
Y
---
M
F
L
L
------
I
M
L
G
F
P
I
-
N
F
L
T
--
L
----
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
-
L
F
M
V
F
G
G
-
F
-------
T
T
T
L
Y
T
---
S
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
--
E
----------------
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
------
A
I
---
E
R
Y
V
V
V
C
K
--------------------
P
M
S
N
F
R
F
----
G
E
-
N
H
A
I
M
G
-
V
A
F
------
T
W
V
M
A
L
A
C
A
A
P
P
L
----------
V
G
-
W
S
R
-
Y
I
-----
P
-------------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
--
P
---
H
--------
E
E
--
T
N
---------
N
E
S
F
V
I
------
Y
M
F
V
V
H
F
---------
I
I
P
L
I
V
I
F
--
F
C
Y
G
Q
L
V
F
T
V
K
E
----
A
A
A
QQQESA
T
T
----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
E
V
T
R
M
--
V
I
I
M
V
I
A
---------------------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
----------
G
S---------
D
----
F
-
G
-----
P
I
F
M
T
I
P
A
F
F
A
K
T
S
-
A
V
--
Y
N
---
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
------
P
L
G
D
D
E
A
S
T
T
V
S
----------
29
HHSearch
76.37
17%
-152
- C7 -
2Z73
5
OPSD_TODPA
A:
[31-334]
------------------------------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
---
I
G
I
C
------
G
I
I
G
C
G
G
-
N
G
I
V
--
I
----
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
-
F
T
F
S
L
V
N
G
F
-------
P
L
M
T
I
S
---
C
F
--
L
K
K
W
I
F
G
F
A
A
C
K
V
--
Y
----------------
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
------
S
I
---
D
R
Y
N
V
I
G
R
--------------------
P
M
A
A
S
K
K
---
M
S
H
-
R
R
A
F
I
M
-
I
I
F
------
V
W
L
W
S
V
L
W
A
I
G
P
I
----------
F
G
-
W
G
A
-
Y
T
-----
L
-------------
E
G
V
L
C
N
C
S
F
D
Y
I
S
---------------
R
D
--
S
T
---------
T
R
S
N
I
L
------
C
M
F
I
L
G
F
---------
F
G
P
I
L
I
I
F
--
F
C
Y
F
N
I
V
M
S
V
S
N
----
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
R
L
A
K
I
--
S
I
V
I
V
S
Q
---------------------
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
----------
L
E---------
W
----
V
-
T
-----
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
-
A
I
--
H
N
---
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
------
C
C
Q
F
D
D
K
E
T
E
D
D
----------
32
HHSearch
74.58
16%
-153
- C7 -
2KS9
1
NK1R_HUMAN
A:
[31-326]
--------------------------------------------------------------------
Q
I
V
L
W
A
A
A
---
Y
T
V
I
------
V
V
T
S
V
V
G
-
N
V
V
V
--
M
----
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
-
A
S
M
A
A
F
N
-
T
-------
V
V
N
F
T
Y
---
A
V
--
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
--
H
----------------
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
--
M
T
A
V
------
A
F
---
D
R
Y
M
A
I
I
H
--------------------
P
L
Q
P
R
L
-----
S
A
-
T
A
T
K
V
V
-
I
C
V
------
I
W
V
L
A
L
L
L
A
F
P
Q
G
----------
Y
Y
-
S
T
T
-
E
T
-------------------
M
P
S
R
V
V
C
M
I
E
W
P
E
--
H
---
P
--------
N
K
--
I
Y
---------
E
K
V
Y
H
I
------
C
V
T
V
L
I
Y
---------
F
L
P
L
L
V
I
G
--
Y
A
Y
T
V
V
G
I
T
L
W
A
----
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
K
V
V
K
M
--
M
I
V
V
V
C
T
---------------------
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
----------
D
----------
L
YLKK
F
-
I
-----
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
-
T
M
--
Y
N
---
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
------
I
S
A
G
D
Y
E
G
L
E
M
K
----------
30
HHSearch
71.13
16%
-150
- C7 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
---
F
I
L
I
------
C
C
F
I
I
L
E
-
N
I
F
V
--
L
----
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
-
L
L
A
G
V
A
Y
-
T
-------
A
N
L
L
L
S
---
G
A
---
T
T
Y
K
L
T
P
A
Q
W
F
L
--
R
----------------
E
G
S
M
F
V
A
L
S
A
S
V
F
S
--
L
L
A
I
------
A
I
---
E
R
Y
I
T
M
L
K
-------------------------------
N
N
-
F
R
L
F
L
L
-
I
S
A
------
C
W
V
I
S
L
I
L
G
G
L
P
I
----------
M
G
-
W
N
C
-
I
---------------------
S
A
L
S
S
C
S
T
V
L
P
L
--------------------
Y
---------
H
K
H
Y
I
L
------
F
-
C
T
T
V
F
---------
T
L
L
L
L
S
I
V
--
I
L
Y
C
R
I
Y
S
L
V
R
T
----
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
A
L
L
K
T
--
V
I
I
V
L
S
V
---------------------
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
----------
V
KT--------
C
----
D
-
I
-----
L
F
R
A
E
Y
F
L
V
L
A
V
L
N
-
S
G
--
T
N
---
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
-----------------------------
48
Fugue
67.92
17%
-177
- C2 -
1WCD
-
POLS_IBDVC
J:
[11-431]
---IVPFIRS
L
L
M
P
---
T
T
GPASIPDDTLEKHTL
R
S
E
T
------------
S
---
T
Y
N
L
T
-
V
G
D
T
G
S
G
L
I
V
F
F
P
G
F
P
GSI
V
G
A
H
------
Y
T
L
Q
G
N
G
-
N
Y
K
F
--
D
----
Q
M
L
L
T
A
Q
N
L
P
A
S
--
Y
N
Y
C
R
L
V
S
R
S
-
L
T
V
R
S
S
T
-
L
-------
P
G
G
V
Y
A
---
L
N
--
G
T
I
N
A
V
T
F
Q
G
S
L
S
--
E
LTDVSYNGLMSATANI
N
D
K
I
G
N
V
L
V
G
E
G
V
T
--
V
L
S
L
------
P
T
SYD
L
G
Y
V
R
L
G
D
PIPAIGLDPKMVATCDSSDR
P
R
V
Y
T
I
T
---
A
A
D
-
D
Y
Q
F
S
S
-
Q
Y
Q
PGGVTI
T
L
F
S
A
N
I
D
A
I
T
S
L
----------
S
V
-
G
G
E
-
L
V
-----
F
RT
S
V
-------
H
G
L
V
L
G
A
T
I
Y
L
I
G
F
D
--
G
T
T
V
I
--------
T
R
--
A
V
---------
A
A
N
N
G
L
TTGTDN
L
-
M
P
F
N
L
---------
V
I
P
T
N
E
I
T
QP
I
T
S
I
K
L
E
I
V
T
S
K
----
S
G
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
D
Q
M
S
W
S
A
--
R
G
S
L
A
V
T
---------------------
I
H
G
G
N
Y
P
G
A
L
R
P
V
T
L
V
A
Y
E
----------
R
----------
V
----
A
-
T
GS---
V
V
T
V
A
G
V
S
N
F
E
L
I
P
N
P
E
--
L
A
KNL
V
T
E
Y
G
R
F
D
P
G
A
M
N
Y
T
K
L
I
L
S
E
R
D
R
LGIKTV
W
P
T
R
E
Y
T
D
F
R
E
Y
FMEVAD----
35
HHSearch
64.98
15%
-151
- C7 -
2LNL
-
CXCR1_HUMAN
A:
[37-322]
-------------------------------------------------------------------
L
N
K
Y
V
V
I
I
A
---
Y
A
L
V
------
F
L
L
S
L
L
G
-
N
S
L
V
--
M
----
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
-
L
L
F
A
L
T
--
L
-------
P
I
W
A
A
S
---
K
---
V
N
G
W
I
F
G
T
F
L
C
K
V
--
V
----------------
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
--
L
A
C
I
------
S
V
---
D
R
Y
L
A
I
V
H
--------------------
A
T
R
T
L
T
----
Q
K
R
-
H
L
V
K
F
V
-
C
L
G
------
C
W
G
L
S
M
N
L
S
L
P
F
F
----------
L
F
-
R
Q
A
-
Y
H
-----
P
-------------
N
N
S
S
P
V
C
Y
E
V
L
G
N
------
D
--------
T
A
--
K
W
---------
R
M
V
L
R
I
------
L
P
H
T
F
G
F
---------
I
V
P
L
F
V
M
L
--
F
C
Y
G
F
T
L
R
T
L
F
K
----
A
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
R
A
M
R
V
--
I
F
A
V
V
L
I
---------------------
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
R
----------
T
QVIQE
S
C
E
R
R
N
----
N
-
I
-----
G
R
A
L
D
A
T
E
I
L
G
F
L
H
-
S
C
--
L
N
---
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------
45
Fugue
61.13
11%
-171
- C1 -
4YPT
6
?
A:
[11-388]
-IQLD
D
D
A
R
V
F
V
Q
A
---
N
M
---------------
D
C
L
P
------------
T
---
D
W
R
L
V
-
N
K
F
D
S
V
D
G
V
R
T
I
K
Y
F
E
---
C
P
G
G
------
I
F
V
S
S
Q
G
K
K
F
G
Y
--
V
Q
NG
S
F
K
E
A
S
V
S
Q
I
R
A
L
L
A
N
K
V
D
V
L
C
T
V
D
G
V
N
F
R
S
C
C
-
V
A
E
GEVFG
K
T
L
G
S
V
---
F
C
DG
I
N
V
T
K
V
R
C
S
A
I
Y
K
G
K
V
----------------
F
F
Q
Y
S
D
L
S
E
A
D
L
V
A
--
V
K
D
A
FGFD
E
P
Q
L
---
L
K
Y
Y
T
M
L
G
--------------------
M
C
K
W
P
V
V
---
V
C
G
-
N
Y
F
A
F
K
Q
S
N
N
------
N
Y
I
N
V
A
C
L
M
L
Q
H
L
----------
S
L
-
K
F
P
-
K
W
-----
Q
--
W
Q
-------
E
A
W
N
E
F
R
S
G
K
P
L
R
F
V
--
S
L
V
L
A
--------
K
G
--
S
F
KFN
E
P
S
D
S
I
D
F
M
R
V
V
------
L
-
R
E
A
D
L
SG
A
T
C
N
L
E
F
V
C
K
C
G
V
K
Q
--
E
Q
R
K
G
V
D
A
V
M
H
F
GTLD
K
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
G
Y
N
I
A
C
T
--
C
G
S
K
L
V
H
---------------------
C
T
Q
F
N
V
P
F
L
I
C
S
N
T
P
E
G
R
K
----------
L
----------
P
----
D
---------
D
V
V
A
A
N
I
F
T
G
G
S
-
V
G
--
H
Y
---
T
H
V
K
C
K
P
K
Y
Q
L
Y
D
A
C
N
V
N
K
V
S
E
A
K
------
G
N
F
T
D
C
L
Y
L
K
N
L
----------
8
PsiBlast_PDB
59.33
25%
-159
- C7 -
4EIY
18
AA2AR_HUMAN (first)
A:
[40-191]
---------------------------------------------------------------------------------
A
I
------
A
V
L
A
I
L
G
-
N
V
L
V
--
C
----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
A
V
G
V
L
A
-
I
-------
P
F
A
I
T
I
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
F
V
-------------------------
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
------
A
I
---
D
R
Y
I
A
I
R
I
--------------------
P
L
R
Y
N
G
L
---
V
T
G
---
T
R
A
K
-
G
I
I
------
A
I
C
W
V
L
S
F
A
I
-
G
L
----------
T
P
-
M
L
G
-
W
N
-----
N
--
C
G
-------
Q
P
K
E
G
K
N
H
S
Q
G
C
G
E
G
--
Q
V
A
C
L
--------
F
E
--
D
V
---------
V
P
M
N
Y
M
------
V
-
Y
F
N
F
F
---------
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
L
R
I
F
L
A
----
A
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
D
L
E
D
N
W
E
--
T
L
N
D
N
L
K
---------------------
V
I
E
K
A
D
N
A
A
Q
V
K
D
A
L
T
K
M
R
----------
A
----------
A
----
A
-
L
-----
D
A
Q
K
M
K
D
F
R
H
G
F
D
I
-
L
V
--
G
Q
---
I
D
D
A
L
K
L
A
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
------
T
T
R
N
A
Y
I
Q
K
Y
L
E
----------
6
PsiBlast_PDB
58.27
24%
-168
- C7 -
3UZA
1
AA2AR_HUMAN
A:
[15-166]
---------------------------------------------------------------------------------
A
I
------
A
V
L
A
I
L
G
-
N
V
L
V
--
C
----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
L
V
G
V
L
A
-
I
-------
P
F
A
I
T
I
ST
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
F
V
-------------------------
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
------
A
I
---
D
R
Y
I
A
I
A
I
--------------------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
-
A
I
C
------
W
V
L
S
F
A
I
G
L
T
P
---------------
M
L
G
-
W
N
-----
N
--
C
G
-------
Q
P
--------
G
C
G
E
G
--
Q
V
A
C
L
--------
F
E
--
D
V
---------
V
P
M
N
Y
M
------
V
-
Y
F
N
F
F
---------
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
L
R
I
F
A
A
----
A
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
Q
M
E
S
Q
P
L
--
P
G
E
R
A
R
S
---------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
----------
A
----------
L
----
C
-
W
-----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
--
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
------
A
Y
R
I
R
E
F
R
Q
T
F
R
----------
3
PsiBlast_PDB
57.95
24%
-165
- C7 -
3PWH
1
?
A:
[15-166]
---------------------------------------------------------------------------------
A
I
------
A
V
L
A
I
L
G
-
N
V
L
V
--
C
----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
L
V
G
V
L
A
-
I
-------
P
F
A
I
T
I
ST
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
F
V
-------------------------
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
------
A
I
---
D
R
Y
I
A
I
A
I
--------------------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
-
A
I
C
------
W
V
L
S
F
A
I
G
L
T
P
---------------
M
L
G
-
W
N
-----
N
--
C
G
-------
Q
P
--------
G
C
G
E
G
--
Q
V
A
C
L
--------
F
E
--
D
V
---------
V
P
M
N
Y
M
------
V
-
Y
F
N
F
F
---------
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
L
R
I
F
A
A
----
A
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
Q
M
E
S
Q
P
L
--
P
G
E
R
A
R
S
---------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
----------
A
----------
L
----
C
-
W
-----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
--
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
------
A
Y
R
I
R
E
F
R
Q
T
F
R
----------
5
PsiBlast_PDB
57.85
24%
-166
- C7 -
3RFM
1
AA2AR_HUMAN
A:
[15-166]
---------------------------------------------------------------------------------
A
I
------
A
V
L
A
I
L
G
-
N
V
L
V
--
C
----
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
-
I
L
V
G
V
L
A
-
I
-------
P
F
A
I
T
I
S
T
G
F
C
--
A
A
C
H
G
C
L
F
I
A
C
F
V
-------------------------
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
------
A
I
---
D
R
Y
I
A
I
A
I
--------------------
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
A
G
I
I
-
A
I
C
------
W
V
L
S
F
A
I
G
L
T
P
---------------
M
L
G
-
W
N
-----
N
--
C
G
-------
Q
P
--------
G
C
G
E
G
--
Q
V
A
C
L
--------
F
E
--
D
V
---------
V
P
M
N
Y
M
------
V
-
Y
F
N
F
F
---------
A
C
V
L
V
P
L
L
--
L
M
L
G
V
Y
L
R
I
F
A
A
----
A
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
Q
M
E
S
Q
P
L
--
P
G
E
R
A
R
S
---------------------
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
----------
A
----------
L
----
C
-
W
-----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
C
--
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
------
A
Y
R
I
R
E
F
R
Q
T
F
R
----------