@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O56A5_HUMAN: (2016-01-12 )
MTLPSNNSTSPVFEFFLICFPSFQSWQHWLSLPLSLLFLLAMGANATLLITIYLEASLHQPLYYLLSLLSLLDIVLCLTVIPKVLAIFWFDLRSISFPACFLQVFIMNSFLTMESCTFMIMAYDRYVAICKPLQYSSIITDQFVARAAIFVVARNGLLTMPIPILSSRLRYCAGHIIKNCICTNVSVSKLSCDDITLNQSYQFVIGWTLLGSDLILIVLSYFFILKTVLRIKGEGDMAKALGTCGSHFILILFFTTVLLVLVITNLARKRIPPDVPILLNILHHLIPPALNPIVYGVRTKEIKQGIQNLLRRL
Atome Classification :
(20 SA)
--------.........10........20......-------..30........40....---------------------------....50.....--...60---------------........70.---------.......80..----..----.....-90........100-.......110---------....--...120.......130......---.140...---....150-.......-..160...-....170.......180.......190....-..-.200.......210.......220.......230------...-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------..-----.------------.240...---....250..--.......260.....----..270.------.--.--..-....280.......290.......300.......--310.------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------MTLPSNNST
S
P
V
F
E
F
F
L
I
CFP
S
F
Q
S
W
Q
-------
H
W
L
S
L
P
L
S
L
L
F
L
L
AMGAN---------------------------
A
T
L
L
I
T
I
Y
L
EA--SLH
Q
P
---------------
L
Y
Y
L
L
S
L
L
S
L
L
---------
D
I
V
L
C
L
T
V
-
I
P
----
K
V
----
L
A
I
F
W
-
F
D
L
RSIS
F
P
A
C
F
L
-
Q
V
F
I
M
N
S
FLT---------MES
C
--
T
F
M
I
M
A
YD
R
Y
V
A
I
CKPL
Q
Y
S
S
I
---
I
T
D
Q
F
V
A
---
R
A
A
I
F
---
V
V
ARN
G
L
-
L
TM
P
I
P
I
L
-
S
S
R
L
R
Y
C
A
G
H
I
I
K
N
C
ICTNV
S
V
S
KLSCD
D
I
T
-LN-Q
S
Y
Q
F
V
I
G
W
T
LLG
S
D
L
I
L
I
V
L
S
Y
F
F
I
L
K
T
V
L
RI-------KGE-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------
D
M
-----
A
------------
K
A
L
G
TCG---
S
H
F
I
L
--
I
L
--
F
F
T
T
V
L
L
V
L
V
I
T
N
L
A
----RKR--I------P--P--D
V
-
P
I
L
L
N
I
L
H
H
LIPP
A
L
N
P
I
V
YGV
R
T
K
E
I
K
Q
G
I
Q
N
L
--
L
R
RL------------------------
1
PsiBlast_PDB
87.47
25%
-159
- C5 -
4GBR
1
ADRB2_HUMAN
A:
[2-286]
-------------------------------
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
----
F
G
----
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
---------
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
Q
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------
D
K
FC
L
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
--
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
----------------
E
V
-
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
---------------------------
2
PsiBlast_PDB
86.25
25%
-161
- C5 -
4QKX
2
ADRB2_HUMAN
A:
[174-461]
--------------------------
A
Y
A
A
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
----
F
G
----
A
A
C
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
---------
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FAL
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
--
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
----------------
E
V
-
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
--
L
C
L
-------------------------
4
PsiBlast_PDB
82.50
24%
-162
- C5 -
4LDL
3
ADRB2_HUMAN
A:
[174-461]
--------------------------
A
Y
A
A
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
----
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FA
L
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
--
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
----------------
E
V
-
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
--
L
C
L
-------------------------
5
PsiBlast_PDB
82.35
24%
-162
- C5 -
4LDO
3
A:
[174-461]
--------------------------
A
Y
A
A
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
----
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FAL
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
--
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
----------------
E
V
-
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
--
L
C
L
-------------------------
3
PsiBlast_PDB
81.94
24%
-166
- C5 -
4LDE
3
A:
[174-461]
--------------------------
A
Y
A
A
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
----
L
T
K
T
W
-------
T
F
G
N
F
W
C
-
E
F
W
T
S
I
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
FAL
K
E
H
------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
--
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
----------------
E
V
-
Y
I
L
L
N
W
I
G
Y
-
V
N
S
G
F
N
P
L
I
Y
-
C
R
S
P
D
F
R
I
A
F
Q
E
L
--
L
C
L
-------------------------
20
PsiBlast_PDB
80.88
23%
-157
- C5 -
2YCW
7
ADRB1_MELGA
A:
[8-297]
-------------------------------
Q
Q
W
E
-------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
---------------------------
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
---------------
T
N
L
F
I
T
S
L
A
C
A
---------
D
L
V
V
G
L
L
V
-
V
P
----
F
G
----
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
---
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
-
V
S
F
-
L
P
I
M
-
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
F
V
-
T
N
-
R
A
Y
A
-------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
-------
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
I
R
K
I
D
R
-----
A
SKRKR
V
M
L
M
R
E
H
K
A
L
K
T
L
G
------
I
I
--
M
G
--
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
--
V
------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
--
L
A
F
-------------------------
19
PsiBlast_PDB
79.51
23%
-160
- C5 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
---------------------------------
W
E
-------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
---------------------------
V
L
V
I
A
A
I
G
S
T
Q
--
R
L
Q
T
L
---------------
T
N
L
F
I
T
S
L
A
C
A
---------
D
L
V
V
G
L
L
V
-
V
P
----
F
G
----
A
T
L
V
----
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
---------
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
---
A
---
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
-
V
S
F
-
L
P
I
M
-
M
H
W
W
R
D
E
D
P
Q
A
L
K
-------
C
Y
Q
D
P
G
C
C
D
F
V
-
T
N
-
R
A
Y
A
-------
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
-------
Y
R
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
E
Q
IR----------
E
H
----------
K
A
L
K
T
L
G
------
I
I
--
M
G
--
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
--
V
------
P
--
D
--
W
L
-
F
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
--
L
A
--------------------------
23
HHSearch
79.07
20%
-149
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
----
F
G
----
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
---------
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
---
V
I
I
L
M
---
V
W
I
V
S
G
L
-
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-------
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
-------
K
E
-----
H
------------
K
A
L
K
T
L
G
---
I
I
M
G
T
--
F
T
--
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
----
Q
D
N
--
L
------
I
--
R
--
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
--
L
C
L
-------------------------
39
Fugue
76.52
16%
-155
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
-------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---------------------------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
---------------
L
N
Y
I
L
L
N
L
A
V
A
---------
D
L
F
M
V
F
G
G
-
F
T
----
T
T
----
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
---------
I
A
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
---
G
V
A
F
T
---
W
V
M
A
L
A
C
-
A
A
P
P
L
V
G
W
-
S
---
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
------
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
AASATTQ
K
A
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
E
V
-----
T
------------
R
M
V
I
I
M
V
---
I
A
F
L
I
--
C
W
--
L
P
Y
A
G
V
A
F
Y
I
F
T
H
------
Q
G
S
--
D
------
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
C
C
G
KNPSTTVSKTETS
Q
V
A
P
A------
32
HHSearch
76.17
16%
-152
- C5 -
2Z73
5
OPSD_TODPA
A:
[32-332]
--------------------------------
A
V
Y
-------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
---------------------------
G
I
V
I
Y
L
F
T
K
T
K
--
S
L
Q
T
P
---------------
A
N
M
F
I
I
N
L
A
F
S
---------
D
F
T
F
S
L
V
N
G
F
P
----
L
M
----
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
-
Y
G
F
I
G
G
I
F
G
F
---------
M
S
I
M
--
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
---
I
M
I
I
F
---
V
W
L
W
S
V
L
-
W
A
I
G
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-----
D
S
-
T
T
-
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
-------
A
E
-----
M
------------
R
L
A
K
I
S
I
---
V
I
V
S
Q
--
F
L
--
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
----
G
P
L
E-
W
------
V
--
T
--
P
Y
-
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
--
F
P
W
V
------------------------
22
HHSearch
75.83
18%
-158
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
-------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
---------------------------
L
L
V
L
Y
A
V
R
S
E
R
--
K
L
H
T
V
---------------
G
N
L
Y
I
V
S
L
S
V
A
---------
D
L
I
V
G
A
V
V
-
M
P
----
M
N
----
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
-
W
L
S
M
D
Y
V
A
S
T
---------
A
S
I
F
--
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
---
A
T
I
L
G
---
A
W
F
L
S
F
L
-
W
V
I
P
I
L
G
W
-
N
-
H
--------
R
R
E
D
K
C
E
T
D
F
Y
----------
D
V
-
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
-------
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLHM--
N
-------
R
E
-----
R
------------
K
A
A
K
Q
L
G
---
F
I
M
A
A
--
F
I
--
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
----
C
K
N
--
C
------
C
--
N
--
E
H
-
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
--
L
H
I
-------------------------
40
Fugue
73.22
17%
-128
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PN
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
-------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
---------------------------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
---------------
L
N
Y
I
L
L
N
L
A
V
A
---------
D
L
F
M
V
F
G
G
-
F
T
----
T
T
----
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
---------
I
A
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
---
G
V
A
F
T
---
W
V
M
A
L
A
C
-
A
A
---
P
P
L
-
V
G
W
S
R
Y
I
P
E
G
M
--
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
-
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
AAQ----
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------
A
T
-----
T
------------
Q
K
A
E
K
E
V
---
T
R
M
V
I
--
I
M
--
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
----
F
Y
I
--
F
T
H
QGSD
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
C
C
G
KNPLGDDEA
S
T
T
V
S
K
TETSQVAPA
45
Fugue
72.44
17%
-164
- C2 -
4R6H
5
MSME_BACSU
A:
[28-421]
-ADTA
K
K
T
L
T
I
Y
S
T
M
S
T
D
S
E
R
D
T
F
R
K
L
A
A
A
F
E
K
E
H
SD
I
H
V
S
L
H
F
P
G
N
D
Y
E
N
M
M
R
V
R
M
A
A
N
DLPD
L
F
D
THGWGKIRYGEYTADLRDMK
W
T
Q
D
L
D
P
N
L
N
S
--
I
L
K
N
K
SGKVYAYPI
N
Q
A
K
D
G
L
A
Y
N
R
N
I
L
D
R
Y
GIAPPET
M
D
D
F
I
K
A
L
R
T
-
I
K
----
E
K
S
K
GS
I
V
P
F
W
-
F
A
G
Y
D
K
S
S
F
A
Q
Y
Y
-
D
Q
F
A
T
P
L
L
I
T
DPAHNE
K
K
Q
L
I
N
G
--
T
F
Q
W
S
K
F
T
Y
L
S
E
I
L
K
Q
M
Q
K
E
K
L
---
I
N
I
D
A
V
T
AKK
S
Q
L
I
E
---
L
M
A
Q
N
K
I
A
F
T
M
Q
G
G
T
L
-
G
Q
D
V
A
Q
I
N
P
N
V
-
K
V
G
I
I
P
T
P
A
I
H
P
G
D
D
P
I
W
I
-
G
G
-
E
R
Y
T
L
A
A
W
K
D
S
P
Q
L
K
E
A
K
D
F
I
A
F
M
A
R
P
A
N
A
K
Q
M
-------
A
E
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
-------
S
L
-----
P
------------
S
G
L
T
N
V
K
---
A
D
I
F
Y
--
A
N
--
D
Y
E
Y
Y
Q
D
V
K
V
E
P
Y
F
D
----
R
L
Y
--
L
------
P
--
N
--
G
M
W
D
V
L
G
T
V
G
Q
E
L
A
A
D
I
L
A
-------
P
Q
D
I
S
Q
K
L
G
R
E
--
Y
K
R
L
R
E
Q
S
E
T------------------
26
HHSearch
70.94
16%
-156
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-467]
----------------------------------
S
-------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
---------------------------
V
L
V
C
W
A
V
W
L
N
S
--
N
L
Q
N
V
---------------
T
N
Y
F
V
V
S
L
A
A
A
---------
D
I
A
V
G
V
L
A
-
I
P
----
F
A
----
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
-
I
A
C
F
V
L
V
L
T
Q
---------
S
S
I
F
--
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
---
G
I
I
A
I
---
C
W
V
L
S
F
A
-
I
G
L
T
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-------
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
-------
K
E
-----
V
------------
H
A
A
K
S
L
A
---
I
I
V
G
L
--
F
A
--
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
CS
H
------
A
--
P
--
L
W
-
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
--
I
R
S
H
------------------------
30
HHSearch
69.32
16%
-149
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
---------------------------
G
L
V
C
M
A
V
L
K
E
R
--
A
L
Q
T
T
---------------
T
N
Y
L
V
V
S
L
A
V
A
---------
D
L
L
V
A
T
L
V
-
M
P
----
W
V
----
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
-
F
V
T
L
D
V
M
M
C
T
---------
A
S
I
W
--
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
---
L
M
I
T
A
---
V
W
V
L
A
F
A
-
V
S
C
P
L
L
F
G
-
F
N
T
T
G
-------
D
P
T
V
C
S
I
S
N
--------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
-------
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
-------
R
E
-----
K
------------
K
A
T
Q
M
V
A
---
I
V
L
G
A
--
F
I
--
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
----
C
Q
T
--
C
H-----
V
--
S
--
P
E
-
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
--
L
S
C
-------------------------
33
HHSearch
66.27
17%
-143
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[61-493]
--------------------------------
N
S
I
-------
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
---------------------------
I
F
V
L
L
T
I
W
K
T
K
--
K
F
H
R
P
---------------
M
Y
Y
F
I
G
N
L
A
L
S
---------
D
L
L
A
G
V
A
Y
-
T
A
----
N
L
----
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
-
R
E
G
S
M
F
V
A
L
S
---------
A
S
V
F
--
S
L
L
A
I
A
I
E
R
Y
I
T
M
L
K
-----------
N
N
F
R
L
F
---
L
L
I
S
A
---
C
W
V
I
S
L
I
-
L
G
G
L
P
I
M
G
-
W
N
C
I
-------
S
A
L
S
S
C
S
T
V
L
P
L
---------
Y
H
-
K
H
Y
I
L
F
-
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
-------
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
S
--
S
-------
E
N
-----
V
------------
A
L
L
K
T
V
I
---
I
V
L
S
V
--
F
I
--
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
----
C
K
V
--
K
------
T
--
C
D
I
L
F
-
R
A
E
Y
F
L
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
--
M
G
R
P
------------------------
21
HHSearch
64.85
15%
-154
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
---------------------------
I
L
V
M
V
S
I
K
V
N
R
--
H
L
Q
T
V
---------------
N
N
Y
F
L
F
S
L
A
C
A
---------
D
L
I
I
G
V
F
S
-
M
N
----
L
Y
----
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
-
W
L
A
L
D
Y
V
V
S
N
---------
A
S
V
M
--
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
---
M
M
I
A
A
---
A
W
V
L
S
F
I
-
L
W
A
P
A
I
L
F
-
W
Q
F
I
V
G
V
R
--
T
V
E
D
G
E
C
Y
I
Q
F
---------
F
-
S
N
-
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
-------
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
-------
R
E
-----
K
------------
K
V
T
R
T
I
L
---
A
I
L
L
A
--
F
I
--
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
----
C
A
P
--
C
------
I
--
P
--
N
T
-
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
--
L
M
--------------------------
27
HHSearch
64.29
12%
-147
* C5 *
2KS9
1
NK1R_HUMAN
A:
[33-322]
------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
---------------------------
V
V
V
M
W
I
I
L
A
H
K
--
R
M
R
T
V
---------------
T
N
Y
F
L
V
N
L
A
F
A
---------
E
A
S
M
A
A
F
N
-
T
V
----
V
N
----
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
-
H
N
F
F
P
I
A
A
V
F
---------
A
S
I
Y
--
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
---
V
V
I
C
V
---
I
W
V
L
A
L
L
-
L
A
F
P
Q
G
Y
Y
-
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
-
Y
E
-
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
-------
E
I
P
GDSSDRYH
E
Q
V
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------
A
K
-----
R
------------
K
V
V
K
M
M
I
---
V
V
V
C
T
--
F
A
--
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
----
N
P
D
--
L
YL----
K
KF
I
--
Q
Q
-
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
--
F
R
C
C
------------------------
28
HHSearch
64.15
16%
-126
- C5 -
1U19
14
OPSD_BOVIN
A:
[38-324]
--------------------------------
W
Q
F
-------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
---------------------------
F
L
T
L
Y
V
T
V
Q
H
K
--
K
L
R
T
P
---------------
L
N
Y
I
L
L
N
L
A
V
A
---------
D
L
F
M
V
F
G
G
-
F
T
----
T
T
----
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
-
E
G
F
F
A
T
L
G
G
E
---------
I
A
L
W
--
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
---
M
G
V
A
F
---
T
W
V
M
A
L
A
-
C
A
A
P
P
L
V
G
-
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
-
N
N
-
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-------
A
A
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------
A
E
-----
K
------------
E
V
T
R
M
V
I
---
I
M
V
I
A
--
F
L
--
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
----
H
Q
G
S-
D
------
F
--
G
--
P
I
-
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
--
L
C
C
G
------------------------
18
PsiBlast_PDB
62.59
25%
-154
- C5 -
3P0G
1
ENLYS_BPT4
A:
[31-207]
---------------------
D
---
V
T
Q
Q
R
D
E
V
W
V
-------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
---------------------------
V
L
V
I
T
A
I
A
K
F
E
--
R
L
Q
T
V
---------------
T
N
Y
F
I
T
S
L
A
C
A
---------
D
L
V
M
G
L
A
V
-
V
P
----
F
G
----
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
-
W
T
S
I
D
V
L
C
V
T
---------
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
-
K
A
---
R
V
I
I
L
---
M
V
W
I
V
S
G
-
L
T
S
F
L
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
-
N
C
------
Y
A
E
E
T
C
C
D
F
F
-
T
N
-
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
L
K
-------
E
H
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------
L
K
-----
T
------------
L
G
I
I
M
G
T
---
F
T
L
C
W
--
L
P
--
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
----
R
K
E
--
V
------
Y
--
I
--
L
L
-
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
R
R
-------------------------------