@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O56B4_HUMAN: (2016-01-12 )
MDTSTSVTYDSSLQISQFILMGLPGIHEWQHWLSLPLTLLYLLALGANLLIIITIQHETVLHEPMYHLLGILAVVDIGLATTIMPKILAIFWFDAKAISLPMCFAQIYAIHCFFCIESGIFLCMAVDRYIAICRPLQYPSIVTKAFVFKATGFIMLRNGLLTIPVPILAAQRHYCSRNEIEHCLCSNLGVISLACDDITVNKFYQLMLAWVLVGSDMALVFSSYAVILHSVLRLNSAEAMSKALSTCSSHLILILFHTGIIVLSVTHLAEKKIPLIPVFLNVLHNVIPPALNPLACALRMHKLRLGFQRLLGLGQDVSK
Atome Classification :
(20 SA)
-------------------------------------.....-....10----------......----.-----------------.------.20--.......----.-----.---30........40..-------...------...50........-60.....--...70----------......----------------..80..-...-------..------.90.-----.------..----....100-------...-.---....110......-.120---..-.------.....130.---------......140--..-------.--..--------------...150-.......160...-----....-.170.......180..---.....190---.....-..--.--.200-----.....-..---------------210....--------...220....-...230-------.-----------.-------------....-------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------..240-----.-....-----...250.-----.-.....260..------.....270----------.-----------.-------.--.....280-.......290.-......300--........310....----------...-------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------MDTST-
S
V
T
YD-----------SS
L
Q
I
S
----
Q
-----------------
F
------
I
L
---MGLP
G
I
H
----
E
-----
W
---
Q
H
W
L
S
L
P
L
T
L
L
Y
L
L
-------
A
LG------A
N
L
L
I
I
I
T
IQH
E
T
-
V
L
H
E
P
M
Y
--
H
L
L
G
I
----------
L
A
V
V
D
I
----------------
G
L
A
T
T
I
-
M
P
K
-------
I
L
------
A
I
F
W
-----F------DA----KAI
S
L
P
--------
M
C
F
-
A
---
Q
I
Y
A
I
H
C
F
F
C
I
ES-
G
I
-
F
---
L
C
-
M
------
A
V
D
R
Y
I
A
I
C---------RPLQ
Y
P
S
I
---
V
T
-------
K
--
A
F
--------------
V
F
KA
T
G
-
F
I
M
L
RN
G
L
L
-TI
P
-----
V
P
I
L
-
A
A
Q
R
HYC
S
R
N
E
I
E
H
C
L
---
C
SNL
G
V
-----
I
S
L
AC-DD--
I
--
T
V
N
K
-----
F
Y
Q
L
M
-
L
A
---------------
W
V
L
VGS
D
--------
M
A
L
V
F
S
S
Y
A
V
-
I
L
H
S
---------
V
-----------
L
-------------RL
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
A
M
S
------
K
-
A
L
S
T
-----
C
S
S
H
L
I
L
-----
I
-
L
FHT
G
I
I
V
L
S
------
V
T
H
L
AEK-----------K-----------I-------P--
L
I
P
V
F
L
N
V
-
L
H
N
VIPPA
L
N
P
-
L
A
C
A
L
R
M
H
---
K
L
R
L
G
F
Q
R
L
LGLGQD----------VSK-------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
87.14
18%
-160
- C7 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------------------------------------------------------------------------------------
P
L
V
V
V
L
S
T
I
C
L
V
-------
T
V
G
------
L
N
L
L
V
L
Y
A
V
R
S
E
R
-
K
L
H
T
V
G
N
--
L
Y
I
V
S
----------
L
S
V
A
D
L
----------------
I
V
G
A
V
V
-
M
P
M
-------
N
I
------
L
Y
L
L
-----
M
------
S
K
----
W
S
L
G
R
P
--------
L
C
L
-
F
---
W
L
S
M
D
Y
V
A
S
T
A
S
I
-
F
S
-
V
---
F
I
-
L
------
C
I
D
R
Y
R
S
V
Q
---------
Q
P
L
R
Y
L
K
Y
---
R
T
-------
K
--
T
R
--------------
A
S
A
T
I
L
-
G
A
W
F
L
S
F
L
W
-
V
I
P
-----
I
L
G
--
W
N
H
--------
R
R
E
D
K
---
C
E
T
D
F
Y
-------------------
D
V
T
-----
W
F
K
V
M
-
T
A
---------------
I
I
N
F
Y
L
P
--------
T
L
L
M
L
W
F
Y
A
K
-
I
Y
K
A
---------
V
-----------
R
-------------
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH--
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
------
K
-
A
A
K
Q
-----
L
G
F
I
M
A
A
-----
F
I
L
C
W
I
P
Y
F
I
F
F
------
M
V
I
A
F
C
K
-----------
N
C----------
C
-------
N
--
E
H
L
H
M
F
T
I
-
W
L
G
Y
I
N
S
T
L
N
P
-
L
I
Y
P
L
C
N
E
---
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
84.49
19%
-155
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
------------------------------------------------------------------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
-------
I
V
F
------
G
N
V
L
V
I
T
A
I
A
K
F
E
-
R
L
Q
T
V
T
N
--
Y
F
I
T
S
----------
L
A
C
A
D
L
----------------
V
M
G
L
A
V
-
V
P
F
-------
G
A
------
A
H
I
L
-----
M
------
K
M
----
W
T
F
G
N
F
--------
W
C
E
-
F
---
W
T
S
I
D
V
L
C
V
T
A
S
I
-
E
T
-
L
---
C
V
-
I
------
A
V
D
R
Y
F
A
I
T
---------
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
--
N
K
--------------
A
R
V
I
I
L
-
M
V
W
I
V
S
G
L
T
-
S
F
L
-----
P
I
Q
M
H
W
Y
R
A
T
H
-----
Q
E
A
I
N
---
C
Y
A
E
E
---------
T
C
-
C
D
--
F
--
F
T
N
Q
-----
A
Y
A
I
A
-
S
S
---------------
I
V
S
F
Y
V
P
--------
L
V
I
M
V
F
V
Y
S
R
-
V
F
Q
E
---------
A
-----------
K
-------------
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKF--
C
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
H
------
K
-
A
L
K
T
-----
L
G
I
I
M
G
T
-----
F
T
L
C
W
L
P
F
F
I
V
N
------
I
V
H
V
I
Q
D
N----------
L
-----------
I
-------
R
--
K
E
V
Y
I
L
L
N
-
W
I
G
Y
V
N
S
G
F
N
P
-
L
I
Y
C
-
R
S
P
---
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
83.49
16%
-160
- C7 -
3EML
13
ENLYS_BPT4
A:
[21-471]
------------------------------------------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
-------
A
I
L
------
G
N
V
L
V
C
W
A
V
W
L
N
S
-
N
L
Q
N
V
T
N
--
Y
F
V
V
S
----------
L
A
A
A
D
I
----------------
A
V
G
V
L
A
-
I
P
F
-------
A
I
------
T
I
S
T
-------------
G
----
F
C
A
A
C
H
--------
G
C
L
-
F
---
I
A
C
F
V
L
V
L
T
Q
S
S
I
-
F
S
-
L
---
L
A
-
I
------
A
I
D
R
Y
I
A
I
R
---------
I
P
L
R
Y
N
G
L
---
V
T
-------
G
--
T
R
--------------
A
K
G
I
I
A
-
I
C
W
V
L
S
F
A
I
-
G
L
T
-----
P
M
L
G
-
W
N
N
C
G
Q
-------
S
Q
G
---
C
G
E
G
Q
V
--------
A
C
-
L
F
--
E
DV
V
P
M
N
-----
Y
M
V
Y
F
-
N
F
---------------
F
A
C
V
L
V
P
--------
L
L
L
M
L
G
V
Y
L
R
-
I
F
L
A
---------
A
-----------
R
-------------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
-
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
------
H
-
A
A
K
S
-----
L
A
I
I
V
G
L
-----
F
A
L
C
W
L
P
L
H
I
I
N
------
C
F
T
F
F
C
P
DCS--------
H
-----------
A
-------
P
--
L
W
L
M
Y
L
A
I
-
V
L
S
H
T
N
S
V
V
N
P
-
F
I
Y
A
Y
R
I
R
---
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
----------
R
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
82.01
16%
-161
- C7 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
-------
I
V
F
------
G
N
G
L
V
C
M
A
V
L
K
E
R
-
A
L
Q
T
T
T
N
--
Y
L
V
V
S
----------
L
A
V
A
D
L
----------------
L
V
A
T
L
V
-
M
P
W
-------
V
V
------
Y
L
E
V
T
----
G
------
G
V
----
W
N
F
S
R
I
--------
C
C
D
-
V
---
F
V
T
L
D
V
M
M
C
T
A
S
I
-
W
N
-
L
---
C
A
-
I
------
S
I
D
R
Y
T
A
V
V
---------
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
-------
C
--
R
R
--------------
V
A
L
M
I
T
-
A
V
W
V
L
A
F
A
V
-
S
C
P
-----
L
L
F
G
-
F
N
T
T
-------
G
D
P
T
V
---
C
S
I
S
N
P
---------------------------
D
F
V
I
Y
-
S
S
---------------
V
V
S
F
Y
L
P
--------
F
G
V
T
V
L
V
Y
A
R
-
I
Y
V
V
---------
L
-----------
K
-------------
Q
R
R
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
------
K
-
A
T
Q
M
-----
V
A
I
V
L
G
A
-----
F
I
V
C
W
L
P
F
F
L
T
H
------
V
L
N
T
H
C
Q
-----------
T
CH---------
V
-------
S
--
P
E
L
Y
S
A
T
T
-
W
L
G
Y
V
N
S
A
L
N
P
-
V
I
Y
T
T
F
N
I
---
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
81.53
21%
-177
- C2 -
4FS7
2
?
A:
[2-394]
-------------------------------------
Y
D
F
V
I
D
E
I
T
Y
N
F
T
KEH------
G
T
V
E
V
S
----
G
-----------------
L
REFLNP
L
V
---
V
N
I
P
P
V
V
----
T
-----
Y
---
K
D
N
K
Y
D
V
V
S
I
G
Y
A
A
-------
F
Q
G
------
C
R
K
V
T
E
I
K
I
P
S
T
V
R
E
I
G
E
F
A
F
--
E
N
C
S
K
----------
L
E
I
I
N
I
P
DSVKMIGRCTFSGCY
A
L
K
S
I
L
-
L
P
L
M------
L
K
------
S
I
G
V
EAFKG
C
------
D
F
----
K
E
I
T
I
P
EGVTVIGD
E
A
F
-
A
---
T
C
E
S
L
E
Y
V
S
L
P
D
S
M
E
T
-
L
HNG
L
F
-
S
------
G
C
G
K
L
K
S
I
K
---------
L
P
R
N
L
K
I
I
---
R
D
-------
Y
--
C
F
AECILLE
N
M
E
F
P
NS
L
Y
Y
L
G
D
-
F
A
L
S
K
T
G
V
K
-
N
I
I
-----
I
P
---------
D
S
F
T
E
L
G
K
S
V
FYG
C
T
D
L
E
S
-----
I
S
I
Q
N
-
N
K
--
L
--
R
I
G
G
SL---
F
Y
N
C
S
G
L
K
---------------
K
V
I
Y
G
S
V
--------
I
V
P
E
K
T
F
Y
G
C
S
S
L
T
E
---------
V
-----------
K
-------------
L
L
D
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
I
G
------
E
E
A
F
E
S
-----
C
T
S
-
L
V
S
-----
I
-
D
L
P
Y
L
V
E
E
I
G
KRSFRG
C
T
S
L
S
N
I
-----------
N
-----------
F
-------
P
LS
L
R
K
I
G
A
N
A
-
F
Q
G
C
I
N
--
L
K
K
-
V
E
L
P
K
R
L
E
---
Q
Y
R
Y
D
F
E
-------
D
----------
T
T
K
F
K
W
I
K--------------------------------------------------------------------------------------------------------------------------------------------------
53
Fugue
79.31
14%
-132
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-------------------------------------
M
N
G
T
E
-
G
P
N
F
Y
-----------
V
P
F
S
N
K
----
T
-----------------
G
------
V
V
RSP
F
E
A
P
Q
Y
Y
LAE
P
W
-----
Q
---
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
-------
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
--
Y
I
L
L
N
----------
L
A
V
A
D
L
----------------
F
M
V
F
G
G
-
F
T
T
-------
T
L
------
Y
T
S
L
-----
H
------
G
Y
----
F
V
F
G
P
T
--------
G
C
N
-
L
---
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
-
L
---
V
V
-
L
------
A
I
E
R
Y
V
V
V
C
---------
K
P
M
S
N
F
R
F
---
G
E
-------
N
--
H
A
--------------
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
-
A
P
P
-----
L
V
G
W
-
S
--------
R
Y
I
P
E
G
M
---
Q
C
S
C
G
I
-----
D
Y
Y
T
P
-
H
E
--
E
--
T
N
N
E
-----
S
F
V
I
Y
-
M
F
---------------
V
V
H
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
---------
V
-----------
K
-------------
E
A
A
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
------
K
-
A
E
K
E
-----
V
T
R
M
V
I
I
-----
M
-
V
I
A
F
L
I
C
W
L
P
------
Y
A
G
V
A
F
Y
-----------
I
-----------
F
T
H
QGSDF
G
--
P
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
-
V
I
Y
I
M
M
N
K
---
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------
P
S
T
TVSKTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
77.50
15%
-153
- C7 -
2Z73
5
OPSD_TODPA
A:
[31-333]
---------------------------------------------------------------------------------------------------------
D
----
A
-----
V
---
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
-------
G
C
G
------
G
N
G
I
V
I
Y
L
F
T
K
T
K
-
S
L
Q
T
P
A
N
--
M
F
I
I
N
----------
L
A
F
S
D
F
----------------
T
F
S
L
V
N
G
F
P
L
-------
M
T
------
I
S
C
F
-----
L
------
K
K
----
W
I
F
G
F
A
--------
A
C
K
-
V
---
Y
G
F
I
G
G
I
F
G
F
M
S
I
-
M
T
-
M
---
A
M
-
I
------
S
I
D
R
Y
N
V
I
G
---------
R
P
M
A
A
S
K
K
---
M
S
-------
H
--
R
R
--------------
A
F
I
M
I
I
-
F
V
W
L
W
S
V
L
W
-
A
I
G
-----
P
I
F
G
-
W
G
A
Y
T
L
----
E
G
V
L
C
N
---
C
S
F
D
Y
I
-----
S
R
--------
D
--
S
T
T
R
-----
S
N
I
L
C
-
M
F
---------------
I
L
G
F
F
G
P
--------
I
L
I
I
F
F
C
Y
F
N
-
I
V
M
S
---------
V
-----------
S
-------------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
-----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
------
R
-
L
A
K
I
-----
S
I
V
I
V
S
Q
-----
F
L
L
S
W
S
P
Y
A
V
V
A
------
L
L
A
Q
F
G
P
LE---------
W
-----------
V
-------
T
--
P
Y
A
A
Q
L
P
V
-
M
F
A
K
A
S
A
I
H
N
P
-
M
I
Y
S
V
S
H
P
---
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
----------
C
C
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
77.40
16%
-154
* C7 *
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------------------------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
-------
T
I
I
------
G
N
I
L
V
M
V
S
I
K
V
N
R
-
H
L
Q
T
V
N
N
--
Y
F
L
F
S
----------
L
A
C
A
D
L
----------------
I
I
G
V
F
S
-
M
N
L
-------
Y
T
------
L
Y
T
V
-----
I
------
G
Y
----
W
P
L
G
P
V
--------
V
C
D
-
L
---
W
L
A
L
D
Y
V
V
S
N
A
S
V
-
M
N
-
L
---
L
I
-
I
------
S
F
D
R
Y
F
C
V
T
---------
K
P
L
T
Y
P
V
K
---
R
T
-------
T
--
K
M
--------------
A
G
M
M
I
A
-
A
A
W
V
L
S
F
I
L
-
W
A
P
-----
A
I
L
F
-
W
Q
F
I
V
G
V
R
--
T
V
E
D
G
E
---
C
Y
I
Q
F
F
-------------------
S
N
A
-----
A
V
T
F
G
-
T
A
---------------
I
A
A
F
Y
L
P
--------
V
I
I
M
T
V
L
Y
W
H
-
I
S
R
A
---------
S
-----------
K
-------------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP--
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
------
K
-
V
T
R
T
-----
I
L
A
I
L
L
A
-----
F
I
I
T
W
A
P
Y
N
V
M
V
------
L
I
N
T
F
C
A
P----------
C
-----------
I
-------
P
--
N
T
V
W
T
I
G
Y
-
W
L
C
Y
I
N
S
T
I
N
P
-
A
C
Y
A
L
C
N
A
---
T
F
K
K
T
F
K
H
L
L
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Fugue
76.76
16%
-179
- C6 -
4PXG
1
T2S3_STAAU
A:
[26-509]
-------------------------------------
T
K
Q
A
V
-
H
N
R
A
K
-----------
E
A
V
G
K
S
----
V
-----------------
L
------
E
L
---
N
G
G
E
S
I
K
----
S
S
V
G
D
A
F
---
E
N
W
F
G
V
A
L
K
A
T
P
F
K
-------
K
L
K
NG
K
Y
S
S
K
E
R
L
V
L
N
I
I
N
Y
E
K
-
V
A
N
E
N
F
E
TS
S
F
L
S
K
----------
N
N
T
I
E
L
----------------
A
F
Y
E
Y
I
-
K
G
T
PSDNWII
K
E
------
A
V
L
Y
-----
E
M-----
H
K
----
N
P
I
D
Y
E
--------
I
I
K
-
Q
---
D
W
E
I
I
N
Q
Y
I
N
E
G
K
-
A
H
-
E
---
L
S
-
E
------
G
L
T
S
Y
L
A
P
C
TKGANASS
L
R
N
Q
P
Y
S
D
I
---
K
A
-------
K
Q
R
A
F
--------------
S
L
K
S
G
Y
M
T
S
I
L
R
K
Y
V
L
G
D
E
K
-----
I
D
S
I
-
V
K
D
P
F
E
I
K
E
K
S
I
E
D
I
V
---
F
E
K
F
Q
P
YINWS
I
D
K
L
C
-
E
H
--
F
--
S
I
N
K
GEKG
L
N
Y
R
I
A
-
S
A
---------------
I
L
N
L
K
G
K
T
T
KSKPFP
E
V
E
E
F
E
K
S
S
I
-
V
V
K
T
---------
V
-----------
H
F
N
KKNVNK
E
S
M
S
F
G
A
F
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
L
A
------
N
-
E
E
W
E
DSEGY
P
S
A
Q
W
R
N
-----
F
-
L
L
E
T
R
F
L
F
F
V
------
V
K
E
D
E
D
G
-----------
V
-----------
D
-------
I
--
F
K
G
I
K
F
F
S
M
P
E
E
D
I
N
G
P
V
K
R
M
W
--
D
D
T
V
K
---
K
L
K
E
G
V
--
T
L
E
A
V
P
D
----------
K
S
T
KDG
W
R
I
K
N
NFVDKSDDLI
C
H
V
R
P
HTNNRDYRGGSN
A
D
K
L
PKKINWINRPDSDDYSDEWM
T
K
Q
S
F
W
I
N
N
D
Y
I
K
K
Q
V
EDLL------------------------------------------------------------------------
43
HHSearch
76.15
16%
-152
- C7 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
---------------------------------------------------------------------------------------------------------
E
----
N
-----
S
---
I
K
L
T
S
V
V
F
I
L
I
C
C
F
-------
I
I
L
------
E
N
I
F
V
L
L
T
I
W
K
T
K
-
K
F
H
R
P
M
Y
--
Y
F
I
G
N
----------
L
A
L
S
D
L
----------------
L
A
G
V
A
Y
-
T
A
N
-------
L
L
------
L
S
G
A
------------
T
T
----
Y
K
L
T
P
A
--------
Q
W
F
-
L
---
R
E
G
S
M
F
V
A
L
S
A
S
V
-
F
S
-
L
---
L
A
-
I
------
A
I
E
R
Y
I
T
M
L
---------
K
-----------
N
-------
N
--
F
R
--------------
L
F
L
L
I
S
-
A
C
W
V
I
S
L
I
L
-
G
G
L
-----
P
I
M
G
-
W
N
C
I
-------
S
A
L
S
S
---
C
S
T
V
L
P
-----
L
-------------
Y
H
K
-----
H
Y
-
I
L
-
F
C
---------------
T
T
V
F
T
L
L
--------
L
L
S
I
V
I
L
Y
C
R
-
I
Y
S
L
---------
V
-----------
R
-------------
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
--
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
------
A
-
L
L
K
T
-----
V
I
I
V
L
S
V
-----
F
I
A
C
W
A
P
L
F
I
L
L
------
L
L
D
V
G
C
K
-----------
V
KTC--------
D
-------
I
--
L
F
R
A
E
Y
F
L
-
V
L
A
V
L
N
S
G
T
N
P
-
I
I
Y
T
L
T
N
K
---
E
M
R
R
A
F
I
R
I
M
G
R
P
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
74.33
14%
-123
- C7 -
1U19
14
OPSD_BOVIN
A:
[38-327]
--------------------------------------------------------------------------------------------------------------
W
-----
Q
---
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
-------
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
--
Y
I
L
L
N
----------
L
A
V
A
D
L
----------------
F
M
V
F
G
G
-
F
T
T
-------
T
L
------
Y
T
S
L
-----
H
------
G
Y
----
F
V
F
G
P
T
--------
G
C
N
-
L
---
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
-
L
---
V
V
-
L
------
A
I
E
R
Y
V
V
V
C
---------
K
P
M
S
N
F
R
F
----
G
-------
E
--
N
H
--------------
A
I
M
G
V
A
-
F
T
W
V
M
A
L
A
C
-
A
A
P
-----
P
L
V
G
-
W
S
R
Y
I
P
----
E
G
M
Q
C
S
---
C
G
I
D
Y
Y
-----
T
P
----
H
E
--
E
--
T
N
N
E
-----
S
F
V
I
Y
-
M
F
---------------
V
V
H
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
---------
V
-----------
K
-------------
E
A
A
A
QQQESA
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
------
E
-
V
T
R
M
-----
V
I
I
M
V
I
A
-----
F
L
I
C
W
L
P
Y
A
G
V
A
------
F
Y
I
F
T
H
Q
GS---------
D
-----------
F
-------
G
--
P
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
-
V
I
Y
I
M
M
N
K
---
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------
P
L
G
-------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
73.68
14%
-123
- C7 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-------------------------------------
M
N
G
T
E
-
G
P
N
F
Y
VPFSNKTGVVR
S
P
F
E
A
P
----
Q
-----------------
Y
------
Y
L
---
A
E
----
P
----
W
-----
Q
---
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
-------
G
F
P
------
I
N
F
L
T
L
Y
V
T
V
Q
H
K
-
K
L
R
T
P
L
N
--
Y
I
L
L
N
----------
L
A
V
A
D
L
----------------
F
M
V
F
G
G
-
F
T
T
-------
T
L
------
Y
T
S
L
-----
H
------
G
Y
----
F
V
F
G
P
T
--------
G
C
N
-
L
---
E
G
F
F
A
T
L
G
G
E
I
A
L
-
W
S
-
L
---
V
V
-
L
------
A
I
E
R
Y
V
V
V
C
---------
K
P
M
S
N
F
R
F
---
G
E
-------
N
--
H
A
--------------
I
M
G
V
A
---
F
T
W
V
M
A
L
A
-
C
A
A
-----
P
P
L
V
-
G
W
S
R
Y
I
P
E
G
M
---
Q
C
S
---
C
G
---
I
-----
D
Y
Y
T
P
-
H
E
--
E
--
T
N
N
E
-----
S
F
V
I
Y
-
M
F
---------------
V
V
H
F
I
I
P
--------
L
I
V
I
F
F
C
Y
G
Q
-
L
V
F
T
---------
V
KEAAAQQQESA
T
-------------
T
Q
K
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
------
R
-
M
V
I
I
-----
M
V
I
A
F
L
I
-----
C
-
W
L
P
Y
A
G
V
A
F
Y
------
I
F
T
H
Q
G
S
-----------
D
-----------
F
-------
G
--
P
I
F
M
T
I
P
A
-
F
F
A
K
T
S
A
V
Y
N
P
-
V
I
Y
I
M
M
N
K
---
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
PLGDDEA
S
T
T
V
S
K
TETSQVAPA----------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
72.89
18%
-140
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------------------------------------------------------------
D
E
----
V
-----
W
---
V
V
G
M
G
I
V
M
S
L
I
V
L
A
-------
I
V
F
------
G
N
V
L
V
I
T
A
I
A
K
F
E
-
R
L
Q
T
V
T
N
--
Y
F
I
T
S
----------
L
A
C
A
D
L
----------------
V
M
G
L
A
V
-
V
P
F
-------
G
A
------
A
H
I
L
-----
M
------
K
M
----
W
T
F
G
N
F
--------
W
C
--
E
---
F
W
T
S
I
D
V
L
C
V
T
A
S
-
I
E
-
T
---
L
C
V
I
------
A
V
D
R
Y
F
A
I
T
---------
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
--
N
K
--------------
A
R
V
I
I
L
-
M
V
W
I
V
S
G
L
T
-
S
F
L
------
P
I
Q
-
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
---
E
E
T
-----------
C
C
-
D
---
F
--
F
T
N
Q
-----
A
Y
A
I
A
-
S
S
---------------
I
V
S
F
Y
V
P
--------
L
V
I
M
V
F
V
Y
S
R
-
V
F
Q
E
---------
A
-----------
K
-------------
R
Q
L
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
L
------
R
-
I
D
E
G
-----
L
R
L
K
I
Y
K
D
TEGY
Y
-
T
I
G
I
G
H
L
L
T
K
------
S
P
S
L
N
A
A
-----------
K
-----------
S
-------
E
--
L
D
K
A
I
G
R
N
-
T
N
G
V
I
T
K
D
E
A
E
-
K
L
F
N
Q
D
V
D
---
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
----------
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
34
HHSearch
71.99
16%
-144
- C7 -
3ODU
6
CXCR4_HUMAN (first)
A:
[45-498]
---------------------------------------------------------------------------------------------------------
N
----
F
-----
N
---
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
-------
G
I
V
------
G
N
G
L
V
I
L
V
M
G
Y
Q
K
-
K
L
R
S
M
T
D
--
K
Y
R
L
H
----------
L
S
V
A
D
L
----------------
L
F
V
-
I
T
-
L
P
F
-------
W
A
------
V
D
A
V
------------
A
N
----
W
Y
F
G
N
F
--------
L
C
K
-
A
---
V
H
V
I
Y
T
V
N
L
Y
S
S
V
-
W
I
-
L
---
A
F
-
I
------
S
L
D
R
Y
L
A
I
V
---------
H
A
T
N
S
Q
R
P
---
R
K
-------
L
--
L
A
--------------
E
K
V
V
Y
V
-
G
V
W
I
P
A
L
L
L
-
T
I
P
-----
D
F
I
F
-
A
N
V
S
E
-----
A
D
D
R
Y
I
---
C
D
R
F
Y
P
-----
N
---------
D
--
L
W
V
V
-----
V
F
Q
F
Q
-
H
I
---------------
M
V
G
L
I
L
P
--------
G
I
V
I
L
S
C
Y
C
I
-
I
I
S
K
---------
L
-----------
S
-------------
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
Q
K
R
------
K
-
A
L
K
T
-----
T
V
I
L
I
L
A
-----
F
F
A
C
W
L
P
Y
Y
I
G
I
------
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
-----------
T
-------
V
--
H
K
W
I
S
I
T
E
-
A
L
A
F
F
H
C
C
L
N
P
-
I
L
Y
A
F
L
G
A
---
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
----------
L
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
70.78
13%
-148
- C7 -
2KS9
1
NK1R_HUMAN
A:
[31-324]
--------------------------------------------------------------------------------------------------------------------
Q
---
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
-------
S
V
V
------
G
N
V
V
V
M
W
I
I
L
A
H
K
-
R
M
R
T
V
T
N
--
Y
F
L
V
N
----------
L
A
F
A
E
A
----------------
S
M
A
A
F
N
-
T
V
V
-------
N
F
------
T
Y
A
V
-----
H
------
N
E
----
W
Y
Y
G
L
F
--------
Y
C
K
-
F
---
H
N
F
F
P
I
A
A
V
F
A
S
I
-
Y
S
-
M
---
T
A
-
V
------
A
F
D
R
Y
M
A
I
I
---------
H
P
L
Q
P
R
L
-----
S
-------
A
--
T
A
--------------
T
K
V
V
I
C
-
V
I
W
V
L
A
L
L
L
-
A
F
P
-----
Q
G
Y
Y
-
S
T
T
E
T
-----
M
P
S
R
V
V
---
C
M
I
E
W
P
-----
E
H
P
----
N
--
K
--
I
Y
E
K
-----
V
Y
H
I
C
-
V
T
---------------
V
L
I
Y
F
L
P
--------
L
L
V
I
G
Y
A
Y
T
V
-
V
G
I
T
---------
L
-----------
W
-------------
A
S
E
I
PGDSSDRYH
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
------
K
-
V
V
K
M
-----
M
I
V
V
V
C
T
-----
F
A
I
C
W
L
P
F
H
I
F
F
------
L
L
P
Y
I
N
P
-----------
D
-----------
L
YLKKF--
I
--
Q
Q
V
Y
L
A
I
M
-
W
L
A
M
S
S
T
M
Y
N
P
-
I
I
Y
C
C
L
N
D
---
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
----------
I
S
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
70.22
15%
-131
- C7 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
--------------------------------------------------------------------------------------------------------------
L
-----
N
---
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
-------
S
L
L
------
G
N
S
L
V
M
L
V
I
L
Y
S
R
-
V
G
R
S
V
T
D
--
V
Y
L
L
N
----------
L
A
L
A
D
L
----------------
L
F
A
L
T
--
L
P
I
-------
W
A
------
A
S
K
------
V
------
N
G
----
W
I
F
G
T
F
--------
L
C
K
-
V
---
V
S
L
L
K
E
V
N
F
Y
S
G
I
-
L
L
-
L
---
A
C
-
I
------
S
V
D
R
Y
L
A
I
V
---------
H
A
T
R
T
L
T
Q
----
K
-------
R
--
H
L
--------------
V
K
F
V
C
L
-
G
C
W
G
L
S
M
N
L
-
S
L
P
-----
F
F
L
F
-
R
Q
A
Y
H
P
----
N
N
S
S
P
V
---
C
Y
E
V
L
G
-----
N
D
-----
T
--
A
--
K
W
R
M
-----
V
L
R
I
L
-
P
H
---------------
T
F
G
F
I
V
P
--------
L
F
V
M
L
F
C
Y
G
F
-
T
L
R
T
---------
L
-----------
F
-------------
K
A
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
------
R
-
A
M
R
V
-----
I
F
A
V
V
L
I
-----
F
L
L
C
W
L
P
Y
N
L
V
L
------
L
A
D
T
L
M
R
-----------
T
QVIQE
S
C
E
R
R
N
N
-------
I
--
G
R
A
L
D
A
T
E
-
I
L
G
F
L
H
S
C
L
N
P
-
I
I
Y
A
F
I
G
Q
---
N
F
R
H
G
F
L
K
I
L
A
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
67.03
11%
-114
- C5 -
1ATI
-
SYG_THET8
A:
[1-394]
--------------------------------AASS
L
D
E
L
V
A
-
L
C
K
R
R
-----------
G
F
I
F
Q
S
----
S
-----------------
E
------
I
Y
---
G
G
L
Q
G
V
Y
----
D
-----
Y
G
P
L
G
V
E
L
K
N
N
L
K
Q
A
W
W
R
-------
R
N
V
------
Y
E
R
D
D
M
E
G
L
D
A
S
V
-
L
T
H
R
L
V
L
--
H
Y
S
G
H
----------
E
A
T
F
A
D
----------------
P
M
V
D
N
W
-
T
P
P
-------
R
Y
------
F
N
M
M
-----
F
------
Q
D
----
L
R
G
P
R
G
--------
G
---------
R
G
L
L
A
Y
L
R
P
E
T
-
A
Q
-
G
---
I
F
-
V
------
N
F
K
N
V
L
D
A
T
---------
S
R
K
L
G
F
G
I
---
A
Q
-------
I
--
G
K
--------------
A
F
R
N
E
---
I
T
P
R
N
F
I
F
-
R
V
R
-----
E
F
E
Q
-
M
E
I
E
Y
F
V
R
P
G
E
D
E
Y
W
H
---
R
Y
W
V
E
E
-----
R
L
K
W
W
-
Q
E
M
G
L
--
S
R
E
N
-----
L
V
P
Y
Q
-
Q
P
PESSAH---------
Y
A
K
A
T
V
D
--------
I
L
Y
R
F
P
H
G
S
L
-
E
L
E
G
---------
I
-----------
A
-------------
Q
R
T
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
G
S
------
H
-
T
K
D
Q
-----
E
A
L
G
I
T
A
-----
R
-
V
L
R
N
E
H
S
T
Q
R
------
L
A
Y
R
D
P
E
T
----------
G
-----------
K
-------
W
--
F
V
P
Y
V
I
E
P
-
S
A
G
V
D
R
G
V
L
A
L
-
L
A
E
A
F
T
R
E
---
E
L
P
N
G
E
E
R
I
V
L
K
L
K
P
----------
Q
L
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
60.98
10%
-146
- C3 -
3P24
7
?
A:
[33-397]
-PV
T
A
S
I
D
LQSVS
Y
T
D
L
A
T
Q
L
N
D
VSDF
G
K
M
I
I
L
K
D
NG
F
N
R
Q
V
-
H
V
S
M
D
-----------
K
R
T
K
I
Q
L
DN
E
N
-----------------
V
------
R
L
---
F
N
G
R
D
K
D
----
S
-----
T
---
N
F
I
L
G
D
E
F
A
V
L
R
F
Y
-------
R
N
G
------
E
S
I
S
Y
I
A
Y
---------
K
E
A
Q
--
M
M
N
E
I
----------
A
E
F
Y
A
A
----------------
P
F
K
K
T
R
-
A
I
N
-------
E
K
------
E
A
F
E
-----
C
I
Y
D
SRT
R
S
----
A
G
K
Y
P
V
--------
S
V
K
-
I
---
N
V
D
K
A
K
K
I
L
N
L
P
E
-
C
D
-
Y
---
I
N
-
D
------
Y
I
K
T
P
Q
V
T
R
---------
A
V
P
S
E
P
K
T
---
V
Y
-------
V
--
I
C
--------------
L
R
E
N
G
S
-
T
V
--
Y
P
N
E
V
-
S
A
Q
-----
M
Q
D
A
-
A
N
S
V
Y
A
V
H
G
L
K
R
Y
V
N
L
---
H
F
V
L
Y
T
-----
T
E
Y
A
C
-
P
S
--
G
--
N
A
D
E
-----
G
L
D
G
F
-
T
A
---------------
S
L
K
A
N
P
K
--------
A
E
G
Y
D
D
Q
I
Y
F
-
L
I
R
W
GTWDNNIL
G
I
-----------
S
-------------
W
L
N
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
N
T
ASDFKA
S
-
G
M
S
T
-----
T
Q
L
M
Y
P
G
-----
V
-
M
A
H
E
L
G
H
I
L
G
------
A
N
H
A
D
D
P
-----------
K
-----------
D
-------
L
--
M
Y
S
K
Y
T
G
Y
-
L
F
H
L
--------------
S
E
---
K
N
M
D
I
I
A
K
N
L
G
W
E
I
A
----------
D
G
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
58.26
14%
-173
- C4 -
4C1N
2
?
A:
[1-442]
GLT
G
L
E
I
Y
K
H
LPKKNCKECGQPT
C
L
A
F
A
M
Q
I
A
A
GKAG
L
D
A
C
P
-
Y
V
S
D
E
-----------
A
K
E
L
L
E
----
S
A
S
APP
V
A
L
I
K
V
G
KGEK
V
L
------
E
I
---
G
H
E
T
V
L
F
----
R
-----
H
---
D
K
R
F
E
H
P
C
G
L
A
I
L
V
E
DTLS
E
G
E
I
K
------
E
R
V
E
K
I
N
K
L
V
F
D
R
-
V
G
Q
M
H
S
V
--
N
L
V
A
L
K
GSSQD
A
A
T
F
A
K
A
V
A
T
----------------
A
R
E
V
T
D
-
L
P
F
-------
I
L
I
G
T
P
E
Q
L
A
A
A
-----
L
------
E
T
----
E
G
A
N
N
P
--------
L
L
Y
-
A
ATA
D
N
Y
E
Q
M
V
E
L
A
K
K
Y
-
N
V
-
P
---
L
T
-
V
S
A
K
G
L
D
A
L
A
E
L
V
Q
K
I
---------
T
A
L
G
Y
K
N
L
---
I
L
D
PQPEN
I
S
--
E
G
--------------
L
F
Y
Q
T
Q
-
I
R
R
L
A
I
K
K
L
-
F
R
P
FG
Y
P
T
I
A
F
A
-
L
D
E
N
P
Y
Q
A
V
M
E
A
S
V
Y
I
---
A
K
Y
A
G
I
-----
I
V
L
N
T
V
E
P
--
A
--
D
I
L
P
-----
L
I
T
L
R
-
L
N
I
Y
TDPQKPIAVEP
K
V
Y
E
I
L
N
P
G
PD
A
P
V
F
--
I
T
T
N
F
S
L
T
Y
F
-
C
V
A
G
---------
D
-----------
V
-------------
E
G
A
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
Y
I
------
L
-
P
V
D
T
-----
D
G
T
S
-
V
L
-----
T
-
A
W
A
A
G
--
K
F
T
------
P
E
K
I
A
Q
F
L
----------
K
-----------
E
-------
S
--
G
I
A
E
K
V
N
H
-
R
K
A
I
L
P
G
G
V
A
V
-
L
S
G
K
L
Q
E
L
SG
W
E
I
L
V
G
P
R
E
S
S
G
I
N
S
F
----------
I
K
Q
RW-----------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
57.05
26%
-153
- C7 -
2Y01
4
ADRB1_MELGA
A:
[8-126]
---------------------------------------------------------------------------------------------------------
Q
----
Q
-----
W
---
E
A
G
M
S
L
L
M
A
L
V
V
L
L
-------
I
V
A
------
G
N
V
L
V
I
A
A
I
G
S
T
Q
-
R
L
Q
T
L
T
N
--
L
F
I
T
S
----------
L
A
C
A
D
L
----------------
V
V
G
L
L
V
-
V
P
-------------------------
F
------
G
A
T
L
V
V
R
G
T
W
L
W
--------
G
S
F
L
C
---
E
L
W
T
S
L
D
V
L
C
V
T
A
-
S
I
E
T
---
L
C
V
I
------
A
I
D
R
Y
L
A
I
T
---------
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
--
A
R
--------------
A
K
V
I
I
C
-
T
V
W
A
I
S
A
L
V
-
S
F
L
-----
P
I
M
M
-
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
---
P
G
C
C
D
F
-----
V
T
N
R
A
-
Y
A
--
I
--
A
S
S
I
-----
I
S
F
Y
I
-
P
L
---------------
L
I
M
I
F
V
A
--------
L
R
V
Y
R
E
A
K
E
Q
-
S
R
V
M
---------
L
-----------
M
-------------
R
E
H
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
T
L
------
G
-
I
I
M
G
-----
V
F
T
L
C
W
L
-----
P
-
F
F
L
V
N
I
V
N
V
F
------
N
R
D
L
V
P
D
-----------
W
-----------
L
-------
F
--
V
A
F
N
W
L
G
Y
-
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
---
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------