@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O6C65_HUMAN: (2016-01-12 )
MPNMTSIREFILLGFTDNPELQVVIFFFMLITYLLSVSGNMIIIMLTLSNIHLKTPMYFFLRNFSFLEISFTTVFIPRFLINIATGDTTISYNASMAQVFFLILLGSTEFFLLAVMSYDRYVAICKPLHYTTIMSNKVCNWLVISSWLAGFLIIFPPVIMGLQLDFCDSSTIDHFICDSSPMLLIACTDTQFLELMAFLLAVFTLMVTLALVVLSYTLILKTILKIPSAQQRKKAFSTCSSHMIVVSVSYGSCIFMCVKTSAKEGMALSKGVAVLNTSVAPMLNPFIYTLRNQQVKQALREFTKKILSLNKQ
Atome Classification :
(20 SA)
.........10..-----.----------------...---------------..20........30......----..40........50.---------------------------....----------...60........70....---------....80........90.-----.......100.......110.......120.......130----------.......140--.......150.....-------..-------160-----..-.....---170......---.180.....--..190.......200.......210----........-------220...---------....-----------230------------------..-----.......240.......250.----------......260----.-.------.---..-.----.270---------.........280..---..------....290.......300------------------.......310---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MP
N
M
T
S
I
R
E
F
I
L
L
-----G----------------FTD---------------NP
E
L
Q
V
V
I
F
F
F
M
L
I
T
Y
L
L
SV----SG
N
M
I
I
I
M
L
T
LS
N
I
H
---------------------------LK
T
P
----------
M
Y
F
F
LRNF
S
F
L
E
I
S
F
T
T
V
F
---------
I
P
R
F
L
I
N
IATGD
T
T
I
S
Y-----N
A
S
M
A
Q
V
F
F
L
I
L
LGSTE
F
F
L
L
A
V
MSYD
R
Y
V
A
I
CKP
L
H
Y
T
T
----------IMSNKVC
N
W
L
--
V
I
S
S
W
L
A
G
F
L
I
I
F
P
P
-------
V
I
-------M
G
L
-----
Q
L
-DFCDS---ST
I
D
H
F
ICD---SS
P
M
L
L
I
A
C--T
D
T
Q
F
L
E
L
M
A
F
L
L
A
V
F
T
L
M
V
T
L
A
L
-----
V
V
L
S
Y
T
L
I
-------
L
K
T
I
L
K---------IP
S
A
-----------
Q
--------------------
Q
R
-----
K
K
A
F
S
TCSS
H
M
I
V
V
S
VSYG
S
C
----------
I
F
M
C
VKTSA----K-E------G---MA-L----SK-----------
G
V
A
V
LNT
S
V
A
-
P
M
L
---
N
P
------
F
I
Y
T
L
R
N
Q
Q
V
K
Q
A
L
R
E
F
------------------
T
K
K
I
L
SLNKQ---------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.01
22%
-147
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
L
GWNNCGQ----------S
Q
G
C
G
E
---
G
Q
V
A
C
L
F
E
D
---
V
V
P
M
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
----
I
F
L
A
A
R
R
Q
-------
L
K
Q
M
E
S
---------
Q
P
L
P
-----------
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.42
22%
-142
- C5 -
4UG2
3
?
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
K
E
G
K
A
H
S
Q
---
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
----------------------------------------------------A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.00
22%
-146
- C5 -
3VG9
8
?
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
L
GWNNCGQ----------S
Q
G
C
G
E
---
G
Q
V
A
C
L
F
E
D
---
V
V
P
M
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
----
I
F
L
A
A
R
R
Q
-------
L
K
Q
M
E
S
---------
Q
P
L
P
-----------
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.91
22%
-140
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
K
E
G
K
A
------
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
---------
Q
P
L
P
-----------
G
--------------------
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
84.12
16%
-135
- C5 -
2Z73
5
OPSD_TODPA
A:
[34-333]
---------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
----
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
---------------------------
L
Q
T
P
----------
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
--------
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
-----
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
----------
K
M
S
H
R
R
A
F
I
M
--
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
-------
I
F
-------
G
W
G
-----
A
Y
-
T
L
-------
E
G
V
L
C
N
C
S
---
F
D
Y
I
S
-------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
-----
I
F
F
C
Y
F
N
I
-------
V
M
S
V
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
-----
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
----------
A
V
V
A
L
L
A
Q
F
----
G
-
P
LEW---
V
---
T
P
-
Y
----
A
A
-----------
Q
L
P
V
M
F
A
K
A
S
-
A
I
H
---
N
P
------
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
------------------
F
P
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
82.81
21%
-148
- C5 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
A
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
-----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
A
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
82.69
22%
-139
- C5 -
2YDV
6
?
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
K
E
G
K
A
H
S
Q
---
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
---------
Q
-------------------------------------S
T
L
--
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
82.59
22%
-139
- C5 -
2YDO
3
?
A:
[18-304]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
A
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
K
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
K
E
G
K
A
H
S
Q
---
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------T
L
---
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
S
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.05
21%
-148
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
A
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
-----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
A
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.84
21%
-147
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
A
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
-----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
A
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.76
21%
-146
- C5 -
3PWH
1
?
A:
[18-305]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
A
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
-----------
G
C
G
E
G
Q
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
A
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.44
21%
-146
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
---------------------------------------------------------------------
V
L
A
I
----
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
---------------------------
L
Q
N
V
----------
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
---------
I
P
-
F
A
I
T
I
S
T
G
F
C
A
A
C
H
-----
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
-
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
----------
L
V
T
G
T
R
A
A
G
I
--
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
-------
M
----------
L
-----
G
W
-
N
N
C
G
Q
---
P
-----------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
-----
M
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
--
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
----
A
-
P
------
L
---
W
L
-
M
----
Y
L
-----------
A
I
V
L
A
H
T
N
---
S
V
V
---
N
P
------
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
------------------
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
77.38
15%
-137
- C5 -
2KS9
1
NK1R_HUMAN
A:
[33-325]
----------------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
----
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
---------------------------
M
R
T
V
----------
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
---------
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
-----
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
------------
S
A
T
A
T
K
V
V
--
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
-------
G
Y
-------
Y
S
T
-----
T
E
-
T
M
--------
P
S
R
V
V
C
M
---
I
E
W
P
E
H
P
-----
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
-----
I
G
Y
A
Y
T
V
V
-------
G
I
T
L
W
A
---------
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
-----
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
----------
H
I
F
F
L
L
P
Y
I
----
N
-
P
------
D
LYL
K
K
F
I
----
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
S
-
T
M
Y
---
N
P
------
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
------------------
F
R
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
74.37
15%
-117
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
-----
F
SNKTGVVRSPFEAPQY
Y
L
A
---------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---------------------------
L
R
T
P
----------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
---------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------
F
G
E
N
H
A
I
M
G
--
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
LVGW
S
R
Y
I
P
-------
E
G
M
-----
Q
C
-----
S
---
C
G
I
D
Y
Y
T
P
H
---
E
E
T
N
---
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
-----
L
V
F
T
V
K
E
A
-------
A
A
S
A
T
T
---------
Q
K
A
E
-----------
K
--------------------
E
V
-----
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
----------
A
F
Y
I
F
T
H
Q
G
----
S
-
D
------
F
---
G
P
-
I
----
F
M
-----------
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
---
N
P
------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
61
Fugue
73.24
14%
-123
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
----
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
---------------------------
L
Q
T
V
----------
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
---------
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
----------
L
L
T
K
N
K
A
R
V
I
--
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
Q
-------
M
H
W
-----
Y
-----
R
A
---
T
H
Q
E
A
I
N
C
Y
---
A
E
E
T
---
C
C
--
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
-----
V
F
V
Y
S
R
V
F
-------
Q
E
A
K
R
Q
---------
L
N
I
F
-----------
E
--------------------
M
L
-----
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
----------
I
G
H
L
L
T
K
S
P
----
S
-
L
------
N
---
A
A
-
K
----
S
E
-----------
L
D
K
A
I
G
R
N
T
N
G
V
I
T
---
K
D
------
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
------------------
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
48
HHSearch
72.39
15%
-125
- C5 -
1U19
14
OPSD_BOVIN
A:
[41-328]
----------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---------------------------
L
R
T
P
----------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
---------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------
F
G
E
N
H
A
I
M
G
--
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
-------
L
V
-------
G
W
S
-----
R
Y
-
I
P
-------
E
G
M
Q
C
S
C
G
---
I
D
Y
Y
T
P
-----
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
-----
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
----------
A
G
V
A
F
Y
I
F
T
H
---
Q
G
S
------
D
F--
G
P
-
I
----
F
M
-----------
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
---
N
P
------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
------------------
L
C
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
58
Fugue
70.89
16%
-113
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
-----
S
----------------
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
----
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---------------------------
L
R
T
P
----------
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
---------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
-----
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-----------
F
G
E
N
H
A
I
M
G
--
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
-------
E
G
M
-----
Q
C
-----
S
---
C
G
I
D
Y
Y
T
P
H
---------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
-----
I
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
---------
A
A
A
Q
-----------
Q
--------------------
Q
E
-----
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
----------
F
L
I
C
W
L
P
Y
A
----
G
-
V
------
A
---
F
Y
-
I
----
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
T
S
-
A
V
Y
---
N
P
------
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
70.62
15%
-117
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-------------------------------------------------------
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
----
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
---------------------------
G
R
S
V
----------
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
---------
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
-----
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-----------
Q
K
R
H
L
V
K
F
V
--
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
-------
F
L
-------
F
R
Q
-----
A
Y
-
H
P
-------
N
N
S
S
P
V
C
Y
---
E
V
L
G
N
D
------
T
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
-----
M
L
F
C
Y
G
F
T
-------
L
R
T
L
F
K
---------
A
H
M
------------
G
--------------------
Q
K
-----
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
----------
N
L
V
L
L
A
D
T
L
M
RTQ
V
-
I
QE
S
C
E
R
R
---
N
N
-
I
----
G
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
-
S
C
L
---
N
P
------
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
------------------
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
69.33
16%
-158
- C2 -
4LYP
3
?
A:
[34-449]
-----
S
E
F
A
F
V
K
I
ASDGK
G
----------------
F
T
R
---------------
Y
G
E
P
Y
L
I
R
G
A
N
Y
W
Q
G
M
N
L
G
A
DDCS
G
G
D
R
K
R
M
E
L
E
I
K
Q
M
A
E
M
GINNLRVMA
S
S
E
G
PDDQPYRMRPSM
M
P
Q
P
GKYN
E
G
V
F
V
G
L
D
Y
L
L
D
T
M
D
R
Y
N
M
T
A
V
M
T
L
GNFWQWSGG
F
G
Q
Y
V
A
W
I
T
-
G
N
Q
T
I
P
Y
PVGDV
T
Y
D
E
F
T
Q
F
A
A
R
F
Y
N
D
S
E
I
A
P
K
A
N
K
L
F
K
D
H
I
Y
T
V
Q
N
R
R
N
T
V
NGKIYKEDPV
I
M
S
W
Q
I
A
N
E
P
QE
A
P
A
S
W
F
E
E
I
S
T
F
I
K
K
G
A
PK
H
L
-
V
S
-------
A
G
L
ESKLD
E
Y
-
D
F
D
R
A
HDH
K
N
I
D
Y
T
T
C
H
C
W
V
E
N
W
G
I
Y
D
P
A
--
D
P
D
G
L
P
H
A
N
E
Y
M
H
D
F
L
E
S
R
S
K
W
A
A
Q
L
N
K
P
I
V
M
E
E
F
G
M
-------
A
R
D
A
W
R
---------
N
P
E
D
-----------
E
--------------------
T
Y
-----
K
Y
L
P
S
T
P
T
S
H
K
D
E
Y
Y
Q
K
A
F
N
Q
----------
I
V
S
L
A
S
N
R
S
----
F
-
S
------
G
---
S
N
-
F
WAYG
G
E
-----------
G
R
S
T
Y
P
P
N
P
Y
-
G
M
V
WLG
D
P
PHEPHG
W
Y
S
V
Y
S
N
D
T
T
V
Q
I
I
K
D
Y
------------------
N
A
N
L
L
K
V
Q
K
E
L
S
K------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
66.12
18%
-150
- C5 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-236]
---------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
----
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
---------------------------
L
Q
T
V
----------
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
---------
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
-----
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
----------
L
L
T
K
N
K
A
R
V
I
--
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
-------
I
Q
-------
M
H
W
-----
Y
R
-
A
T
H
Q
-------
E
A
I
N
C
Y
---
A
----
E
E
T
C
--
C
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-----
M
V
F
V
Y
S
R
V
-------
F
Q
E
A
K
R
---------
Q
L
N
I
-----------
F
--------------------
E
M
-----
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
----------
G
I
G
H
L
L
T
K
S
----
P
-
S
------
L
---
N
A
-
A
----
K
S
-----------
E
L
D
K
A
I
G
R
N
T
-
N
G
V
---
I
T
------
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
------------------
G
I
L
R
N
A
K
L
K
P
---------------------------------------------------------------------------------------------------------------------------------------------------------