@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O6C74_HUMAN: (2016-01-12 )
MRNHTTVANFILLGLTDDPQLQVIIFLLLFFTYMLSITGNLTIITLTLLDLHLKTPMYFFLRNFSFLEVSFTTVYIPKFLVSMATGDKTISYNDCAAQLFFTILLGATEFFLLAAMSYERYVAICKPLHYTTIMSSRVCSLLVFASWMAGFLIIFPPLLMGLQLDFCAANTVDHFFCDVSPILQLSCTDTDIIELMMLLSAILTLLVTLVLVILSYTNIIRTILKIPSSQQRKKAFSTCSSHMVVVSISYGSCIFMYVKPSAKERVSLNKGIALLSTSVAPMLNPFIYTLRNKQVKDVFKHTVKKIELFSMK
Atome Classification :
(20 SA)
.........10........20.----------------.......30........40........50........60........-----70....-....80........90........100-.........110.......120.......130.......140.......150.......-------160.......170.......180.......190...--....200.......210.......220-.....------....-----------230------------------..----.......240.......250.--------......260------.--.---..-..-------..270.......280.......290.......300---.........310------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRNH
T
T
V
A
N
F
I
L
L
GLTDDP
Q
L
Q
----------------
V
I
I
F
L
L
L
F
F
T
Y
M
L
S
ITG
N
L
T
I
I
T
L
T
L
L
D
L
HLK
T
P
M
Y
F
F
L
RNF
S
F
L
E
V
-----
S
F
T
T
V
Y
-
I
P
K
F
L
V
S
MATGD
K
T
I
S
Y
N
D
C
A
A
Q
L
F
---
F
T
I
L
L
G
A
T
E
F
F
L
L
A
A
M
S
Y
E
R
Y
V
A
I
CKP
L
H
Y
T
T
I
M
S
S
R
V
C
S
L
L
V
F
A
S
W
M
A
G
F
L
I
I
F
P
P
L
L
-------MG
L
Q
L
D
F
CAAN
T
V
D
H
F
FCDV
S
P
I
L
Q
LSCT
D
T
D
I
I
E
L
--
M
M
L
L
S
A
I
L
T
L
L
V
T
L
V
L
V
I
L
S
Y
T
N
I
I
---
R
T
I
L
K------IPS
S
-----------
Q
--------------------
Q
R
----
K
K
A
F
S
TCSS
H
M
V
V
V
S
ISYG
S
C
--------
I
F
M
Y
VKPS-------A--
K
---
E
R
-
V
S-------LNK
G
I
A
L
L
S
T
S
V
A
P
M
L
N
P
F
I
Y
T
LRN
K
Q
V
K
D
V
F
K
-----
H
T
V
K
K
I
E
L
FSMK------------
6
PsiBlast_PDB
90.22
21%
-138
- C2 -
4UHR
1
AA2AR_HUMAN
A:
[18-314]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
------
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------
4
PsiBlast_PDB
87.83
21%
-132
- C2 -
2YDV
6
?
A:
[18-314]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
ESQ---------------------------------------S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------
3
PsiBlast_PDB
87.41
21%
-131
- C2 -
2YDO
3
?
A:
[18-314]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S----------------------------------------T
L
--
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
------------
5
PsiBlast_PDB
86.96
21%
-138
- C2 -
4UG2
3
?
A:
[18-309]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
A
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-------------------------------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------
1
PsiBlast_PDB
85.67
21%
-146
- C2 -
3VG9
8
?
A:
[18-309]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
NY
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------
2
PsiBlast_PDB
85.55
21%
-140
- C2 -
3VGA
1
AA2AR_HUMAN
A:
[18-308]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
---------------------
17
PsiBlast_PDB
84.91
19%
-140
- C2 -
3DQB
4
GNAT1_BOVIN (first)
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
----------------
44
Fugue
84.77
19%
-123
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
-----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
-
S
C
G
I
---
D
Y
Y
----------
T
P
H
E
E
T
N
N
E
S
--
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
S
-----------
A
--------------------
T
T
----
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
-------
F
--
Y
---
I
F
-
T
H
QGSDFGP
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A
18
PsiBlast_PDB
84.74
19%
-138
- C2 -
3PQR
9
OPSD_BOVIN
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FG
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
----------------
20
PsiBlast_PDB
84.72
19%
-138
- C2 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
----------------
39
HHSearch
84.60
15%
-132
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-334]
--------------------
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
-----
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
---
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-------
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
-----
R
D
S
T
T
R
S
--
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
---
M
S
V
S
N
------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
----
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
--------
A
V
V
A
L
L
A
Q
-------
F
--
G
PLE
W
V
-
T
P
-------
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
-----
Q
T
F
P
W
V
L
T
C
C
Q
F
------------
16
PsiBlast_PDB
84.44
19%
-138
- C2 -
1F88
7
OPSD_BOVIN
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
-----------------------------------SATT
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
P
S
T
T
------------
8
PsiBlast_PDB
84.44
20%
-139
- C2 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S------------------------
19
PsiBlast_PDB
84.40
19%
-137
- C2 -
3PXO
4
OPSD_BOVIN
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
----------------
7
PsiBlast_PDB
84.14
20%
-139
- C2 -
3PWH
1
?
A:
[18-305]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S------------------------
10
PsiBlast_PDB
83.89
20%
-142
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S------------------------
9
PsiBlast_PDB
83.69
20%
-141
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S------------------------
14
PsiBlast_PDB
83.43
19%
-136
- C2 -
3CAP
4
OPSD_BOVIN
A:
[40-315]
--------------------
L
A
----------------
A
Y
M
F
L
L
I
----
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
C
S
-----------
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
--
Y
M
F
---
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
K
E
------
A
A
A
Q
-----------
Q
--------------------
Q
E
S
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
---
D
F
-
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
-----
T
T
L
C
C
G
K
N
----------------
35
HHSearch
83.25
17%
-135
* C2 *
2KS9
1
NK1R_HUMAN
A:
[33-324]
--------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
-----
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
---
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-------
Y
S
T
T
E
T
M
-----
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---
N
K
I
Y
E
K
V
--
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
---
I
T
L
W
A
------
S
E
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
----
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
L
P
Y
-------
I
NP
D
---
L
Y
L
K
K
FI
Q
----
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
-----
H
A
F
R
C
C
P
F
I
S
A
G
------------
11
PsiBlast_PDB
83.18
20%
-143
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
-------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
-----
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-----------
R
--------------------
A
R
S
T
L
-
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-------
C
--
S
---
H
A
-
P
L
-------
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S------------------------