@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O6C76_HUMAN: (2016-01-12 )
MKNRTSVTDFILLGLTDNPQLQVVIFSFLFLTYVLSVTGNLTIISLTLLDSHLKTPMYFFLRNFSLEISFTSVCNPRFLISILTGDKSISYNACAAQLFFFIFLGSTEFFLLASMSYDCYVAICKPLHYTTIMSDRICYQLIISSWLAGFLVIFPPLAMGLQLDFCDSNVIDHFTCDSAPLLQISCTDTSTLELMSFILALFTLISTLILVILSYTYIIRTILRIPSAQQRKKAFSTCSSHVIVVSISYGSCIFMYVKTSAKEGVALTKGVAILNTSVAPMLNPFIYTLRNQQVKQAFKDVLRKISHKKKKH
Atome Classification :
(20 SA)
.........10......---------------..20.----------------.......30........40........50........60....-..------..70...-.....80...-.....90........---100.......110.......120.......130.......140.......150.....-------..160.......170-.......180....-----...190.......200..--.....210.....--..220--..---------.....----------------230--.----..---------------......240.......--------250--------.....----..260.---..-------...---.270.......280.......290.......300.......310-----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKNRTSV
T
D
F
I
L
L
GLTD---------------NP
Q
L
Q
----------------
V
V
I
F
S
F
L
F
L
T
Y
V
L
S
VTG
N
L
T
I
I
S
L
T
L
L
D
S
H
LK
T
P
M
Y
F
F
L
RNF
S
-
L
E
------
I
S
F
TSVC-N
P
R
F
L
I
S
I
LT-GDKSI
S
Y
N
A
C
A
A
Q
L
F
---
F
F
I
F
LGST
E
F
F
L
L
A
SMSY
D
C
Y
V
A
I
CKPL
H
Y
T
T
IM
S
D
R
I
C
Y
Q
L
I
I
S
S
W
L
A
G
F
L
V
IFPPL-------AM
G
L
Q
L
DFCDSN
V
I
D
-
H
FTCDSA
P
L
L
Q
I
SC-----TD
T
S
T
L
E
L
M
S
F
I
L
A
L
F
T
L
--
I
S
T
L
I
L
V
I
L
S
Y
T
Y
--
I
I
R
T
I
--
L
R---------IP
S
A
Q
----------------
Q
----
R
----
K
K
---------------
A
F
S
TCSS
H
V
I
V
V
S
ISY--------G
S
C
--------
I
F
M
Y
V
----KTSAKE---G
V
-------
A
LT---K
G
V
A
I
LNT
S
V
A
P
M
L
N
P
F
I
Y
T
L
R
N
Q
Q
V
K
Q
A
F
K
D
V
L
R
K
I
S
H
KKKKH-----------------
9
PsiBlast_PDB
89.50
21%
-126
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[18-311]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
-
K
A
---
G
C
G
E
G
Q
V
A
C
LF---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
-
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
R
Q
Q
-----------------
7
PsiBlast_PDB
87.26
21%
-122
- C5 -
2YDV
6
?
A:
[18-311]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
-
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L
K
Q
M
ESQ----------------------------S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
R
Q
Q
-----------------
8
PsiBlast_PDB
86.07
21%
-124
- C5 -
4UG2
3
?
A:
[18-309]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
-
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L----------------------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
R
-------------------
6
PsiBlast_PDB
84.07
21%
-121
- C5 -
2YDO
3
?
A:
[18-311]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
A
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
K
E
G
-
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
LF---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L
K
Q
M
E
S-----------------------------T
L
--
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
R
Q
Q
-----------------
43
HHSearch
83.60
17%
-128
- C5 -
2Z73
5
OPSD_TODPA
A:
[33-335]
-----------------------------------
V
Y
----------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
------
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
-
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
---
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
-------
F
G
W
G
A
Y
T
L
----
E
G
V
-
L
C
N
C
S
F
D
Y
I
S
----------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
--
F
G
P
I
L
I
I
F
F
C
Y
F
N
--
I
V
M
S
V
--
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
----
G
----
A
N
---------------
A
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
--------
L
L
S
--------
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW
V
T
-------
P
Y
A
---
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
-----------------
12
PsiBlast_PDB
82.57
21%
-125
- C5 -
4EA3
3
C562_ECOLX (first)
A:
[124-405]
-----------------------------------
L
K
----------------
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
-
L
A
------
D
T
L
V
L
L
T
-
L
P
F
Q
G
T
D
I
L
L
-
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
---
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
-------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
-------
I
M
G
------
S
A
Q
V
E
D
E
E
I
E
C
----
L
V
E
I
P
T
-----
P
Q
D
Y
W
G
P
V
F
A
I
C
I
F
L
F
S
F
--
I
V
P
V
L
V
I
S
V
C
Y
S
L
--
M
I
R
R
L
RG
V
R
---------
L
L
S
G
S
----------------
R
----
E
----
K
D
R
N
L
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
--------
G
------------
L
G
V
----
Q
P
S
S
E
T
---
A
V
-------
A
I
L
---
R
F
C
T
A
L
G
Y
-
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
------------------------------
10
PsiBlast_PDB
82.07
21%
-134
- C5 -
3VG9
8
?
A:
[18-309]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
A
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
R
-------------------
48
Fugue
81.54
18%
-111
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
---------------
T
G
V
V
R
SPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
------
D
L
F
M
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
P
E
G
M
Q
C
----
S
C
G
I
D
-
Y
Y
T
P
H
E
E
T
N
---------------
N
E
S
F
V
I
Y
M
F
V
V
H
F
--
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
--
K
E
---------
A
A
A
S
A
----------------
T
----
T
----
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
--------
W
L
P
Y
A
----
G
V
A
F
Y
I
---
F
T
H
QGSDFG
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
SKTETS
Q
V
A
P
A------
11
PsiBlast_PDB
81.25
21%
-129
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[18-308]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
A
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
--------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
L
A
A
--
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
L
A
I
I
V
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
H
V
L
--------------------
38
HHSearch
81.13
17%
-125
* C5 *
2KS9
1
NK1R_HUMAN
A:
[33-326]
-----------------------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
------
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
-
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
---
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
-------
Y
Y
S
T
T
E
T
M
-----
P
S
-
R
V
V
C
M
I
E
W
P
E
H
P
--------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
--
F
L
P
L
L
V
I
G
Y
A
Y
T
V
--
V
G
I
T
L
--
W
A
---------
S
E
I
P
G
DSSDRYH
E
Q
V
S
-----
A
----
K
----
R
K
---------------
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
--------
L
P
F
--------
H
I
F
F
L
----
L
P
Y
I
N
P
---
D
L
YLK----
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
-----------------
1
PsiBlast_PDB
80.09
21%
-132
- C5 -
3PWH
1
?
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
LF---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
A
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
-----------------------
3
PsiBlast_PDB
79.57
21%
-128
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
A
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
-----------------------
2
PsiBlast_PDB
79.33
21%
-130
- C5 -
3REY
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
A
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
-----------------------
4
PsiBlast_PDB
79.18
21%
-128
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
A
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
-----------------------
5
PsiBlast_PDB
78.79
21%
-130
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[18-305]
----------------------------------------------------------------
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
-
A
A
------
D
I
L
V
G
V
L
-
A
I
P
F
A
I
T
I
S
T
-
G
F
C
A
----
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
----------
L
G
W
N
N
C
G
Q
P
---------
G
C
G
E
G
Q
V
A
C
L
F
---
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
--
I
F
A
A
A
--
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
----------------
A
----
R
S
T
L
-
Q
K
---------------
E
V
H
A
A
K
S
A
A
I
I
A
G
L
-
F
--------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
----
C
P
D
C
S
H
---
A
P
-------
L
W
L
---
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
--
S
-----------------------
49
Fugue
77.86
18%
-105
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
----------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
------
D
L
F
M
V
F
G
-
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
-
W
V
M
A
L
A
C
A
A
P
P
L
--------
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
S
C
G
I
DYY
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
--
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
--
K
E
---------
A
A
A
Q
Q
----------------
Q
ESA
T
T
----
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
--------
W
L
P
Y
A
----
G
V
A
F
Y
I
---
F
T
H
QGSDFG
P
I
F
---
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
EA
S
T
T
V
S
K
TETSQVAPA
19
PsiBlast_PDB
77.22
20%
-128
- C5 -
1F88
7
OPSD_BOVIN
A:
[42-315]
---------------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
P
E
G
M
Q
---
C
S
C
G
-
I
D
-
Y
Y
T
P
H
E
E
------------
T
N
N
E
-----
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
--
K
E
---------
A
A
A
------------------------SATT
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
----
H
Q
G
S
D
F
---
G
P
-------
I
F
M
---
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
-----------------
20
PsiBlast_PDB
76.53
20%
-128
- C5 -
3DQB
4
GNAT1_BOVIN (first)
A:
[42-315]
---------------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
P
E
G
M
Q
---
C
S
C
G
-
I
D
-
Y
Y
T
P
H
E
E
------------
T
N
N
E
-----
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
--
K
E
---------
A
A
A
Q
Q
----------------
Q
----
E
S
A
T
T
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
----
H
Q
G
S
D
F
---
G
P
-------
I
F
M
---
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------
18
PsiBlast_PDB
75.33
20%
-126
- C5 -
3C9L
13
OPSD_BOVIN
A:
[42-315]
---------------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
VGW
S
R
Y
I
P
E
G
M
Q
---
C
S
C
G
-
I
D
-
Y
Y
T
P
H
E
E
------------
T
N
N
E
-----
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
--
K
E
---------
A
A
A
Q
Q
----------------
Q
----
E
S
A
T
T
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
----
H
Q
G
S
D
F
---
G
P
-------
I
F
M
---
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
-------------------
17
PsiBlast_PDB
74.14
20%
-122
- C5 -
3CAP
4
OPSD_BOVIN
A:
[42-315]
---------------------------------------------------------
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
-
V
A
D
L
F
M
V
F
G
G
F
T
T
T
------
L
Y
T
S
L
H
-
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
---
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
G
M
Q
---
C
S
C
G
-
I
D
-
Y
Y
T
P
H
E
E
------------
T
N
N
E
-----
S
F
V
I
Y
M
F
V
V
HF
I
I
P
L
I
V
I
F
F
C
Y
G
Q
--
L
V
F
T
V
--
K
E
---------
A
A
A
Q
Q
----------------
Q
----
E
S
A
T
T
Q
K
---------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
--------
F
Y
I
F
T
----
H
Q
G
S
D
F
---
G
P
-------
I
F
M
---
T
I
P
A
F
F
A
K
T
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
----------------------