@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1C1_HUMAN: (2016-01-12 )
MEKRNLTVVREFVLLGLPSSAEQQHLLSVLFLCMYLATTLGNMLIIATIGFDSHLHSPMYFFLSNLAFVDICFTSTTVPQMVVNILTGTKTISFAGCLTQLFFFVSFVNMDSLLLCVMAYDRYVAICHPLHYTARMNLCLCVQLVAGLWLVTYLHALLHTVLIAQLSFCASNIIHHFFCDLNPLLQLSCSDVSFNVMIIFAVGGLLALTPLVCILVSYGLIFSTVLKITSTQGKQRAVSTCSCHLSVVVLFYGTAIAVYFSPSSPHMPESDTLSTIMYSMVAPMLNPFIYTLRNRDMKRGLQKMLLKCTVFQQQ
Atome Classification :
(20 SA)
--------------.........10......--..20.....--------...30........40........---50........60........70......-..80...-.....90.........100.--......110.......120......---.130.......-----------140...--....150........160....--------------------------------...170....-------------...180..-...-----------------..-------190--------.........200......--.210.......220---...---.----...-------230----------.--------------------.--......240------------------.--........250---......--------..260..-.--------.----.------..270....--...280.......290.......300..-.-.------------------...310..---------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MEKR
N
L
T
V
V
R
E
F
V
L
LGL--PS
S
A
E
Q
Q
H
L
--------
L
S
V
L
F
L
C
M
Y
L
A
T
T
LG
N
M
L
I
I
A
T
I---GFDSHLH
S
P
M
Y
F
F
L
SNL
A
F
V
D
I
CFTST
T
-
V
P
Q
M
V
V
N
-
I
LTGTK-T
I
S
F
A
G
C
L
T
Q
L
F
F
--
F
V
S
F
V
N
M
D
S
L
L
L
C
V
M
A
YD
R
Y
V
A
I
CH---P
L
H
Y
T
A
R
M
N
L
C
-----------
L
C
V
Q
L
V
--
A
G
L
W
L
V
-
T
Y
L
H
A
L
L
H
T
V
L
I
A
Q
L
--------------------------------
S
F
C
A
S
N
I
I
H
H
-------------
F
FCDL
N
P
L
-
L
Q
L
-----------------SC-------S----------DV
S
F
N
V
M
I
I
F
AVG
G
L
L
A
L
--
T
P
L
V
C
I
L
V
S
Y
G
L
I
F
---
S
T
V
---
L
----
K
I
T-------ST-----------Q--------------------G--K
Q
R
A
V
S
T
--------------------
C
--
S
C
H
L
S
V
V
V
L
F
----YG
T
A
I
A
--------
V
Y
FSPSS-P--------H----M------PES
D
T
L
S
T
I
--
M
Y
S
M
V
A
P
M
L
N
P
F
I
Y
T
LRN
R
D
M
K
R
G
L
Q
K
M
-
L
-
L
------------------
K
C
TVFQQQ---------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
90.20
23%
-164
- C3 -
2YDV
6
?
A:
[22-312]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
K
E
G
K
A
H
S
-------------
Q
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
----
K
Q
M
-------
E
S
-----------
Q
----------------------------
S
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.08
23%
-162
- C3 -
2YDO
3
?
A:
[22-312]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
K
E
G
K
A
H
S
-------------
Q
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
----
K
Q
M
-------
E
S
-----------------------------------------
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.22
23%
-157
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[22-312]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
K
E
G
K
A
----------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
----
K
Q
M
-------
E
S
-----------
Q
--------------------
P
LP
G
E
R
A
R
S
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
----------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
R
Q
Q
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.85
23%
-168
- C3 -
4UG2
3
?
A:
[22-309]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
A
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
K
E
G
K
A
H
S
-------------
Q
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
87.11
23%
-161
- C3 -
3PWH
1
?
A:
[22-305]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
A
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
---------------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
----
K
Q
M
-------
E
S
-----------
Q
PL------------------
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
I
I
N
C
F
------------------
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.10
23%
-164
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[22-305]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
A
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
---------------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
----
K
Q
M
-------
E
S
-----------
Q
PL------------------
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
I
I
N
C
F
------------------
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
87.04
24%
-156
- C3 -
3VG9
8
?
A:
[22-309]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
-------
S
-------------
Q
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
----
K
Q
M
-------
E
S
-----------
Q
--------------------
P
LP
G
E
R
A
R
S
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.42
24%
-157
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[22-308]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
K
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
-------
S
-------------
Q
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
---
L
----
K
Q
M
-------
E
S
-----------
Q
--------------------
P
LP
G
E
R
A
R
S
T
L
Q
K
E
V
H
--------------
A
--
A
K
S
L
A
I
I
V
G
L
----
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
86.17
21%
-137
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
--------------
S
F
K
C
A
L
T
-------------
K
T
G
F
Q
F
Y
Y
--------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
---
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
-
L
T
-
L
P
A
L
I
F
Y
-
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
--
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
---
P
-
K
S
L
G
R
L
K
K
K
-----------
N
A
I
C
I
S
--
V
L
V
W
L
I
-
V
V
V
A
I
----------------------------------------------
S
P
I
L
F
Y
-------------
S
G
T
G
V
R
K
N
-
K
T
I
-----------------
T
C
YDTT---
S
----------
D
E
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
---
R
A
L
---
I
Y
K
M
K
K
Y
T
-------
C
T
-----------
V
CG
Y
I
Y
N
PEDG----------
D
--
P
D
N
G
V
N
P
--------------------
G
--
T
D
F
K
D
I
V
C
P
L
----
C
G
V
G
K
D
--------
Q
F
E
E
V
E
E
-
P
--------
L
----
R
------
R
K
S
I
Y
L
V
I
I
--
V
L
T
V
F
A
V
S
Y
I
P
F
-
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
-
A
------------------
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
85.73
23%
-163
- C3 -
3REY
1
AA2AR_HUMAN
A:
[22-305]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
A
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
---------------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
----
K
Q
M
-------
E
S
-----------
Q
PL------------------
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
I
I
N
C
F
------------------
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.72
23%
-164
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[22-305]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
A
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
---------------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
----
K
Q
M
-------
E
S
-----------
Q
PL------------------
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
I
I
N
C
F
------------------
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
85.71
23%
-161
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[22-305]
---------------------------------------------------------------
L
G
N
V
L
V
C
W
A
V
---
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
-
I
S
T
G
F
--
C
A
A
C
H
G
C
L
F
I
A
C
F
--
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
---
P
L
R
Y
N
G
L
V
T
G
T
-----------
R
A
A
G
I
I
--
A
I
C
W
V
L
-
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
--------------------------------
G
Q
P
---------------------
G
C
G
E
G
Q
V
-
A
C
L
-----------------
F
E
-------
D
----------
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
-
L
--
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
---
A
A
A
R
R
Q
L
----
K
Q
M
-------
E
S
-----------
Q
PL------------------
P
--
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
I
I
N
C
F
------------------
T
F
F
C
P
D
C
-
S
--------
H
----
A
------
P
L
W
L
M
Y
L
A
I
--
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
-
I
-
R
------------------
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
84.07
18%
-154
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-332]
-------------------------------------
A
V
Y
Y
S
--------
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
---
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
-
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
--
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
---
P
M
A
A
S
K
K
M
S
H
R
-----------
R
A
F
I
M
I
--
I
F
V
W
L
W
-
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
--------------------------------
T
L
----
E
G
V
L
-------------
C
N
C
S
F
D
Y
I
-
S
R
---------------------------------------
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
--
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
---
M
S
V
---
S
----
N
H
E
-------
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
--
E
M
R
L
A
K
I
--------------------
S
--
I
V
I
V
S
Q
F
L
L
S
----
W
S
P
Y
A
V
--------
V
A
L
L
A
Q
F
-
G
--------
P
LEW-
V
------
T
P
Y
A
A
Q
L
P
V
--
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
-
F
-
P
------------------
W
V
L
T
C
C
Q
F
---------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
80.98
18%
-130
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
E
V
W
V
V
G
--------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
---
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
-
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
---
P
F
K
Y
Q
S
L
L
T
K
N
-----------
K
A
R
V
I
I
--
L
M
V
W
I
V
-
S
G
L
T
S
F
L
P
I
Q
M
------------------------------------
H
W
Y
R
A
T
H
Q
E
A
-------------
I
N
C
Y
A
E
E
T
---------------------
C
C
-------
D
----------
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
-
Y
--
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
---
Q
E
A
---
K
----
R
Q
L
-------
N
I
-----------
F
--------------------
E
--
M
L
R
I
D
E
G
--------------------
L
--
R
L
K
I
Y
K
D
T
E
G
----
Y
Y
T
I
G
I
--------
G
H
L
L
T
K
S
-
P
S
L
------
N
----
A
------
A
K
S
E
L
D
K
A
I
--
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
-
L
-
R
------------------
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
36
HHSearch
78.78
17%
-155
* C3 *
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------
L
--------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
---
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
-
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
--
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
---
P
L
Q
P
R
L
--
S
A
T
-----------
A
T
K
V
V
I
--
C
V
I
W
V
L
-
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
--------------------------------
T
-----
M
P
S
R
-------------
V
V
C
M
I
E
W
P
-
E
H
P
-----------------
N
--------------------
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
--
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
---
I
T
L
---
W
----
A
S
E
-------
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
--
K
R
K
V
V
K
M
--------------------
M
--
I
V
V
V
C
T
F
A
I
C
----
W
L
P
F
H
I
--------
F
F
L
L
P
Y
I
-
N
--------
P
----
D
LYLKKF
I
Q
Q
V
Y
L
A
I
M
--
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
-
F
-
R
------------------
C
C
P
F
I
S
A
G
---------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
77.83
17%
-144
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-328]
----------------------------------------
S
M
--------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
---
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
S
N
F
R
-
F
G
E
N
-----------
H
A
I
M
G
V
--
A
F
T
W
V
M
-
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
--------------------------------
I
P
----
E
G
M
Q
-------------
C
S
C
G
I
D
Y
Y
-
T
P
H
-------------------------------------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
---
K
----
E
A
A
-------
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
--
E
K
E
V
T
R
M
--------------------
V
--
I
I
M
V
I
A
F
L
I
C
----
W
L
P
Y
A
G
--------
V
A
F
Y
I
F
T
H
Q
--------
G
SD--
F
------
G
P
I
F
M
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
-
C
------------------
C
G
K
N
P
L
G
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
77.30
17%
-123
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RS
P
F
E
A
P
Q
Y
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
---
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
-----------------------------
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--------------------------------
A
L
A
C
A
A
P
P
L
V
-------------
G
W
S
R
Y
I
P
E
G
M
Q
C
-----------------
S
C
-------
G
I
DYYTPHEET
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
--
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
---
K
E
A
---
A
----
A
S
A
-------
T
T
-----------
Q
--------------------
K
--
A
E
K
E
V
T
R
--------------------
M
V
I
I
M
V
I
A
F
L
I
C
W
----
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
-
Q
--------
G
----
S
------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
-
C
------------------
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
76.61
22%
-162
- C1 -
4KQ7
6
?
A:
[2-374]
----QSNMTN
E
M
F
D
L
A
K
L
K
S
G
V
K
N
K
R
I
S
S
T
D
--
P
T
G
G
N
R
D
H
L
--------
E
P
F
---------
K
P
G
E
K
R
I
I
A
D
I
K
G
M
G
V
I
N
H
I
W
V
T
I
A
P
P
P
P
T
L
----------
S
-
R
N
D
I
I
I
R
M
Y
W
D
G
N
D
-
Y
P
S
V
E
S
P
I
G
P
F
F
G
QG
W
D
E
R
Y
N
Y
A
S
L
P
L
S
A
G
P
E
N
G
T
G
L
S
C
Y
F
A
M
P
F
E
K
G
A
R
I
E
I
E
N
QSDRNID
A
F
Y
F
Y
V
D
Y
L
E
M
A
K
L
P
K
D
M
G
R
F
H
A
W
Y
N
H
N
L
T
E
A
L
PEGETEWGVT
G
A
Q
K
P
N
TTGERNYVF
M
E
T
Q
G
K
G
H
F
V
G
I
N
Y
Y
V
H
C
PTPMWYGE
G
D
D
M
W
F
I
D
G
E
K
V
-
P
S
L
I
G
T
G
T
E
D
F
F
NTAWCPK
E
A
F
-------
S
----------
H
P
Y
F
G
Y
P
R
V
N
N
D
I
G
W
L
G
R
--
T
H
V
Y
R
F
F
I
E
D
P
I
F
F
---
E
K
S
---
L
----
K
G
T
-------
I
E
-----------
H
--------------------
G
--
S
N
---
N
N
--------------------
L
--
T
L
D
L
S
T
V
A
Y
W
----
Y
Q
D
----------------
S
A
-
V
--------
A
----
L
------
P
E
A
P
T
-------
K
A
Q
R
A
P
--
K
P
F
I
N
H
V
D
I
H
R
W
R
D
A
W
R
K
S
-
K
G
N
------------------
K
A
T
L
W
G
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
76.21
18%
-126
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
--
A
E
P
W
Q
F
S
M
L
--------
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
---
Q
H
-
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
-
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
---
P
M
-----------------------------
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--------------------------------
A
L
A
C
A
A
P
P
L
V
-------------
G
W
S
R
Y
I
P
E
G
M
Q
C
-----------------
S
C
G
I
DYYTP
H
----------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
--
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
---
F
T
V
---
K
----
E
A
A
AQQQESA
T
T
-----------
Q
--------------------
K
--
A
E
K
E
V
T
R
--------------------
M
--
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
--------
Y
I
F
T
H
Q
G
-
S
--------
D
----
F
------
G
P
I
F
M
T
I
P
A
--
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
-
L
-
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
73.62
19%
-132
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
----------------------------------------
Y
V
--------
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
---
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
-
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
--
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
---
A
T
R
T
L
T
Q
-
K
R
H
-----------
L
V
K
F
V
C
--
L
G
C
W
G
L
-
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
--------------------------------
H
P
----
N
N
S
S
-------------
P
V
C
Y
E
V
L
G
-
N
D
T
--------------------------------------
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
--
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
---
R
T
L
---
F
----
K
A
H
-------
M
------------
G
--------------------
Q
--
K
H
R
A
M
R
V
--------------------
I
--
F
A
V
V
L
I
F
L
L
C
----
W
L
P
Y
N
L
--------
V
L
L
A
D
T
L
-
M
RTQVIQE
S
C
E
R
R
N
N
------
I
G
R
A
L
D
A
T
E
--
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
-
L
-
A
------------------
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------