@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1D2_HUMAN: (2016-01-12 )
MDGGNQSEGSEFLLLGMSESPEQQRILFWMFLSMYLVTVVGNVLIILAISSDSRLHTPVYFFLANLSFTDLFFVTNTIPKMLVNLQSHNKAISYAGCLTQLYFLVSLVALDNLILAVMAYDRYVAICCPLHYTTAMSPKLCILLLSLCWVLSVLYGLIHTLLMTRVTFCGSRKIHYIFCEMYVLLRMACSNIQINHTVLIATGCFIFLIPFGFVIISYVLIIRAILRIPSVSKKYKAFSTCASHLGAVSLFYGTLCMVYLKPLHTYSVKDSVATVMYAVVTPMMNPFIYSLRNKDMHGALGRLLDKHFKRLT
Atome Classification :
(20 SA)
.........10........----------------20---------------.........30........40........50........60........70......-..80........90.........100.....-..110.-------......120.......130.......140.......150.......160.......170.......180.....----..-------190-----.........200.......210.......220--...----..-----------------------------------.---..--------230----------.--------------------..--------.------------....240----......---..250.......260---..----.------.-.----.-----..270-......--------..280--.........290.......300.......310----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDGGNQSEGS
E
F
L
L
L
GMSE----------------S----------------P
E
Q
Q
R
I
L
F
W
M
F
L
S
M
Y
L
V
T
V
VG
N
V
L
I
I
L
A
ISSDSRLHT
P
V
Y
F
F
LANLS
F
T
D
L
F
F
V
T
NT-
I
P
K
M
L
V
N
L
QSHNK-
A
I
S
Y
A
G
C
L
T
Q
L
Y
F
L
V
S
L
-
V
A
L
D
N
L
-------
I
L
A
V
M
AYD
R
Y
V
A
I
C
CPLHYTTAM
S
P
K
L
C
I
L
L
L
S
L
C
W
V
L
S
V
L
Y
G
L
I
H
T
L
L
M
T
R
V
T
FCGS
R
K
I
H
Y
I
F
C
E
M
Y
V
L
L
R
M
----
A
C-------S-------N
I
Q
I
N
H
T
V
L
I
AT
G
C
F
I
F
L
I
P
F
G
F
V
I
I
S
Y
V
L
I
---
I
R
A
----
I
L
-----------------------------------R---IP--------SV-----------
S
--------------------
K
K
--------
Y
------------
K
A
F
S
T
C
-----
A
S
H
L
G
A
---
V
S
L
F
Y
G
T
L
C
M
V
Y
LK----PL----H------T-Y----S-----
V
K
D
S
--
V
A
T
V
M
Y
--------
A
V
V
----
T
P
M
M
N
P
F
I
Y
S
LRNK
D
M
H
G
A
L
G
R
L
L
D
K
H
F
K
RLT----------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
90.39
23%
-159
- C3 -
4UHR
1
AA2AR_HUMAN
A:
[14-309]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
-
T
A
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
---
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
L
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
---
H
A
P
L
W
L
M
Y
L
----
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
89.87
25%
-169
- C3 -
2YCX
3
ADRB1_MELGA
A:
[23-294]
-------------------------------------------------------------------
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
---
Y
R
E
A
K
E
Q
I
R
-----------------------------------
K
---
I
D
--------
R
A
-----------
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
------------
K
A
L
K
T
L
-----
G
I
I
M
G
V
---
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
----
F
------
N
-
R
----
D
L----
V
P
D
W
L
F
V
A
F
N
W
L
--------
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
89.65
23%
-161
- C3 -
4UG2
3
?
A:
[14-309]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
-
T
A
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
L
A
-----------
A
--------------------
R
R
--------
Q
L------------
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
----
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
89.54
23%
-159
- C3 -
2YDV
6
?
A:
[14-309]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
-
T
A
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
L
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
ESQ--------
S
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
----
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.67
22%
-174
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
-
A
Q
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
88.48
25%
-170
- C3 -
2YCW
7
ADRB1_MELGA
A:
[23-297]
-------------------------------------------------------------------
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
---
Y
R
E
A
K
E
Q
I
R
-----------------------------------
K
---
I
D
--------
R
A
-----------
S
--------------------
K
R
KR
V
M
L
M
R
E
H
------------
K
A
L
K
T
L
-----
G
I
I
M
G
V
---
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
----
F
------
N
-
R
----
D
L----
V
P
D
W
L
F
V
A
F
N
W
L
--------
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.21
23%
-158
- C3 -
2YDO
3
?
A:
[14-309]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
A
--
I
S
T
G
F
-
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
-
T
A
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
K
E
G
K
A
H
S
Q
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
L
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S----------
T
L
-----
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
----
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.67
22%
-175
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
-
A
Q
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.66
22%
-175
- C3 -
3PWH
1
?
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
-
A
Q
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
86.56
22%
-176
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
-
A
Q
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.21
22%
-175
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[14-305]
---------------------------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
G
F
C
-
A
A
C
H
-
G
C
L
F
I
A
C
F
V
L
V
L
-
A
Q
S
S
I
F
-------
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
----
F
E
-------
D
-------
V
V
P
M
N
Y
M
V
Y
-----
F
N
F
---
F
A
C
V
L
V
P
L
L
L
M
---
L
G
V
----
Y
L
-----------------------------------
R
---
I
F
--------
A
A
-----------
A
--------------------
R
R
--------
Q
L
K
Q
M
E
S
QPLPG
E
R
A
R
S
T
L
-----
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
-----
P
L
----
H
I
I
N
C
F
-
T
-
F
----
F
-----
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
85.27
19%
-138
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
---
T
E
G
P
N
F
Y
V
P
F
S
N
K
----------------
T
GVVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
-
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
----
S
C
-------
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
VFT
V
K
E
----
A
A
-----------------------------------
A
---
S
A
--------
T
T
-----------
Q
--------------------
K
A
--------
E
------------
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
---
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
----
Q
G
----
S
------
D
-
F
----
G
-----
P
I
F
M
--
T
I
P
A
F
F
--------
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
TVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.51
25%
-167
- C3 -
2VT4
8
ADRB1_MELGA
A:
[23-297]
-------------------------------------------------------------------
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
-
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
------------
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
---
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------------------------------------------
E
-------
H
------------
K
A
L
K
T
L
-----
G
I
I
M
G
V
---
F
T
L
C
W
L
P
F
F
L
V
N
I
V
----
N
V
----
F
------
N
-
R
----
D
L----
V
P
D
W
L
F
V
A
F
N
W
L
--------
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
83.43
18%
-157
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-325]
----------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
-
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
-
V
F
A
S
I
Y
-------
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
T
T
E
T
-----
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
---------------------
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
---
G
I
T
----
L
W
-----------------------------------
A
---
S
E
--------
I
P
GDSSDRYH
E
Q
V
S
--------------------
A
K
--------
R
------------
K
V
V
K
M
M
-----
I
V
V
V
C
T
---
F
A
I
C
W
L
P
F
H
I
F
F
L
L
----
P
Y
----
I
------
N
-
P
DLYL
K
KFI--
Q
Q
V
Y
--
L
A
I
M
W
L
--------
A
M
S
----
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
82.21
17%
-171
* C3 *
2Z73
5
OPSD_TODPA
A:
[34-332]
-------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
-
G
F
M
S
I
M
-------
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
E
----
G
V
L
C
N
C
S
F
D
Y
I
S
-----------------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
---
V
M
S
----
V
S
-----------------------------------
N
---
H
E
--------
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
--------
M
------------
R
L
A
K
I
S
-----
I
V
I
V
S
Q
---
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
----
A
Q
----
F
------
G
-
P
LEWV
T
-----
P
Y
A
A
--
Q
L
P
V
M
F
--------
A
K
A
----
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
79.85
17%
-149
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------
S
F
K
C
A
L
T
K
----------------
T
----------------
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
-
T
-
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
-
L
Y
G
S
I
L
-------
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
-
V
V
V
A
I
S
P
I
L
F
Y
S
G
---
T
G
V
R
K
N
K
T
I
T
C
Y
D
----
T
T
----
S
D
-------
E
-------
Y
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
---
V
R
A
----
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDI
V
---
C
P
--------
L
C
-----------
G
--------------------
V
G
--------
K
------------
D
Q
F
E
E
V
-----
E
E
P
L
R
R
---
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
----
H
------
V
-
M
----
K
-----
T
M
N
L
--
R
A
R
L
D
F
--------
Q
------
T
P
A
M
C
A
F
N
D
R
V
Y
-
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR----------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
77.25
17%
-133
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------
D
----------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
-
V
T
A
S
I
E
-------
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-------
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
----
C
C
---------------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
----
A
K
-----------------------------------
R
Q
LN
I
F
--------
E
M
-----------
L
--------------------
R
I
--------
D
------------
E
G
L
R
L
K
-----
I
Y
K
D
T
E
---
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
----
P
S
----
L
------
N
-
A
----
A
-----
K
S
E
L
--
D
K
A
I
G
R
--------
N
T
N
----
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
41
Fugue
77.21
18%
-124
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
TGVVRSPFEAPQYYLA
E
----------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
-
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
--------------
M
Q
C
----
S
C
G
I
DYYTP
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
----
V
K
-----------------------------------
E
---
A
A
AQQQESA
T
T
Q
-----------
K
--------------------
A
E
--------
K
------------
E
V
T
R
M
V
-----
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
F
T
H
QG
S
------
D
-
F
----
G
-----
P
I
F
M
--
T
I
P
A
F
F
--------
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
DDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
73.28
19%
-138
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
--------------------------------------------------------
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
-
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
-
F
Y
S
G
I
L
-------
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
H
P
----
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
----------------------
T
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
---
L
R
T
----
L
F
-----------------------------------
K
---
A
H
--------
M
------------
G
--------------------
Q
K
--------
H
------------
R
A
M
R
V
I
-----
F
A
V
V
L
I
---
F
L
L
C
W
L
P
Y
N
L
V
L
L
A
----
D
T
----
L
M
RTQVI
Q
E
S
C
---
E
R
R
N
N
I
G
R
A
L
--
D
A
T
E
I
L
--------
G
F
L
----
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
72.97
17%
-136
- C3 -
1U19
14
OPSD_BOVIN
A:
[41-327]
--------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
-
G
E
I
A
L
W
-------
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
--------------
H
-------
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
----
V
K
-----------------------------------
E
---
A
A
--------
A
Q
-----------
Q
QESA
T
T
Q
K
------------
A
E
--------
K
------------
E
V
T
R
M
V
-----
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
----
I
F
----
T
H
-----
Q
G
S
----
D
FG---
P
I
F
M
--
T
I
P
A
F
F
--------
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
----------------------------------------------------------------------------------------------------------------------------------------------------------