@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1I1_HUMAN: (2016-01-12 )
MEPEKQTEISEFFLQGLSEKPEHQTLLFTMFLSTYLVTIIGNALIILAIITDSHLHTPMYFFLFNLSLVDTLLSSTTVPKMLANIQAQSRAIPFVGCLTQMYAFHLFGTMDSFLLAVMAIDRFVAIVHPQRYLVLMCSPVCGLLLGASWMITNLQSLIHTCLMAQLTFCAGSEISHFFCDLMPLLKLSGSDTHTNELVIFAFGIVVGTSPFSCILLSYIRIFWTVFKIPSTRGKWKAFSTCGLHLTVVSLSYGTIFAVYLQPTSPSSSQKDKAAALMCGVFIPMLNPFIYSIRNKDMKAALGKLIGKVAVPCPRPEQLLDVYHVPGSLLAARDTEMHPIPYPGGVQSLAGNRDME
Atome Classification :
(20 SA)
-----------.........10------------....--.....20........30........40...--------------.....50........60........70.--.....-..80.....-...90......--..--------100.......110.-----......120..----.....130...---....140.......150.....-----..160---......-.170....---...180.--.-....-.190--..------.....200.......210.......220......--.-----------230----------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------....-----..------..240.......------250.......260.---------....------------.------------..270-------.....--..280------.......290.......300.......310-.........320.......330.......340.......350...-----------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------MEP
E
K
Q
T
E
I
S
-------------
E
F
F
L
--
Q
GLSEKPEH
Q
T
L
L
F
T
M
F
L
S
T
Y
L
V
T
I
IGN
A
L
--------------
I
I
L
A
I
ITDSHLHT
P
M
Y
F
F
L
F
N
L
S
L
V
D
T
L
--
L
SST
T
-
V
P
K
M
L
A
N
I
Q
-AQSRA
I
P
F
V
G
C
--
L
T
--------
Q
M
Y
A
F
H
L
F
G
T
M
D
S
F
-----
L
L
A
V
M
A
I
D
R
F
V
----
A
I
VHP
Q
R
Y
L
V
L
---MC
S
P
V
C
G
L
L
LG
A
S
W
M
I
T
N
L
Q
S
L
-----
I
H
T
C
L
---
M
A
Q
L
T
F-CAG
S
E
I
S
H
---
F
F
C
D
L
M
P
--
L
-
L
KLS-GSDT--HT------
N
E
L
V
I
F
A
F
G
I
V
VGT
S
P
F
S
C
I
L
L
S
Y
I
R
I
F
W
T
V
FKI--P-----------S------------------------------------------------------------------------------------------------------------------------------------------------------------------T-------------------------------------------------------------------------------------------------------------------------------------------------------------------RGK
W
-----
K
A
------
F
S
TC
G
L
H
L
T
V
V
S
------LSY
G
T
I
F
A
V
Y
L
Q-P---------TSPS------------S------------SQ
K
D
K
-------
A
A
A
L
M
--
C
G
V
F
I
------
P
M
L
N
P
F
I
Y
S
IRN
K
D
M
K
A
A
L
G
K
L
I
G
K
VAV---PCP
R
P
E
Q
L
L
D
V
YHVPG
S
L
L
AARDTEMHPIPYPG
G
V
Q
S
LAGNRDME-----------------------------------------------------------------------------------------------------------------
28
HHSearch
94.43
22%
-132
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
-------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
--------
W
T
S
I
D
V
L
C
V
T
A
S
I
E
-----
T
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
M
H--
W
Y
R
A
T
H
------
Q
E
A
---
I
N
C
Y
A
E
E
-------
T
-
C
C
D
F
--
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
-----------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
-----
K
A
------
L
K
T
L
G
I
I
M
G
T
F
T
------
L
C
W
L
P
F
F
I
V
N
I
V
-
H
---------
V
I
Q
D
NL----------
I
------------
R
K
E
V
Y
-------
I
L
L
N
W
--
I
G
Y
V
N
------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
84.28
17%
-135
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
-------------------------------------------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
--------------
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
--
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
--
D
L
--------
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
-----
N
L
L
I
I
S
F
D
R
Y
F
----
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
-----
P
A
I
L
F
---
W
Q
F
I
V
G
-
V
R
--
T
V
E
D
---
G
E
C
Y
I
Q
F
--
F
-------------
S
------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
--
I
-----------
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
K
-----
K
V
------
T
R
T
I
L
A
I
L
L
A
F
I
------
I
T
W
A
P
Y
N
V
M
V
L
I
-
N
---------
T
F
C
A
PC----------
I
------------
P
N
T
V
W
-------
T
I
G
Y
W
--
L
C
Y
I
N
------
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.61
17%
-140
- C4 -
3EML
13
ENLYS_BPT4
A:
[20-472]
------------------------------------------------
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
--------------
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
--
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
--
L
F
--------
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
-----
S
L
L
A
I
A
I
D
R
Y
I
----
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-----
T
P
M
L
G
---
W
N
N
C
G
Q
--------
S
---
Q
G
C
G
E
G
Q
--
V
----
A
-
C
L
F
E
DV
V
P
------
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
--
L
-----------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
-----
H
A
------
A
K
S
L
A
I
I
V
G
L
F
A
------
L
C
W
L
P
L
H
I
I
N
C
F
-
T
---------
F
F
C
P
DCSH--------
A
------------
P
L
W
L
M
-------
Y
L
A
I
V
--
L
S
H
T
N
------
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
---
R
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
82.07
18%
-141
* C4 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
----------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
--------------
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
--
V
A
T
L
V
-
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
--
D
V
--------
F
V
T
L
D
V
M
M
C
T
A
S
I
W
-----
N
L
C
A
I
S
I
D
R
Y
T
----
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-----
P
L
L
F
G
---
F
N
T
T
--------
G
D
P
---
T
V
C
S
I
S
N
------------------------
P
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
--
R
-----------
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
-----
K
A
------
T
Q
M
V
A
I
V
L
G
A
F
I
------
V
C
W
L
P
F
F
L
T
H
V
L
-
N
---------
T
H
C
Q
TCH---------
V
------------
S
P
E
L
Y
-------
S
A
T
T
W
--
L
G
Y
V
N
------
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
81.53
22%
-135
- C4 -
4GBR
1
ADRB2_HUMAN
A:
[17-284]
-------------------------------------------------------------
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
--------
S
I
D
V
L
C
V
T
A
S
I
E
T
-------
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
---------
L
---
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
E
A
---
I
N
C
------
Y
-
A
E
E
T
-
C
C
D
F
--
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
-----------
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
F
C
L
K
E
H
K
A
------
L
K
T
L
G
I
I
M
G
T
F
T
------
L
C
W
L
P
F
F
I
V
N
I
V
-
H
---------
V
I
Q
D
------------
N
------------
L
I
R
K
E
-------
V
Y
I
L
L
N
W
I
G
Y
V
N
------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.43
22%
-136
- C4 -
4LDO
3
A:
[194-461]
-------------------------------------------------------------
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
--------
S
I
D
V
L
C
V
T
A
S
I
E
T
-------
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
---------
L
---
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
E
A
---
I
N
C
------
Y
-
A
E
E
T
-
C
C
D
F
--
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
-----------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
AL
K
E
H
K
A
------
L
K
T
L
G
I
I
M
G
T
F
T
------
L
C
W
L
P
F
F
I
V
N
I
V
-
H
---------
V
I
Q
D
------------
N
------------
L
I
R
K
E
-------
V
Y
I
L
L
N
W
I
G
Y
V
N
------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
80.39
16%
-101
- C4 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------------------------
S
F
K
--
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
--------------
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
--
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
F
N
-
K
T
D
W
I
F
G
D
A
M
C
--
K
L
--------
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
-----
F
L
T
C
I
S
A
H
R
Y
S
----
G
V
V
Y
P
K
-----------
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
-----
I
V
V
V
A
---
I
S
P
I
L
F
-
Y
S
G
T
G
V
R
K
NKT
I
T
C
Y
D
---------
T
-
T
S
D
E
--
Y
L
------
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
--
L
-----------
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
M
K
K
-----
Y
T
------
C
T
V
C
G
Y
I
Y
N
P
E
D
GDPDNG
V
N
P
G
T
D
F
K
D
I
V
C
-
P
LCGVGKDQ
F
E
E
V
E
------------
E
------------
P
L
R
R
K
-------
S
I
Y
L
V
--
I
I
V
L
T
------
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
-
P
A
---
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
----------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
80.28
22%
-137
- C4 -
4LDL
3
ADRB2_HUMAN
A:
[194-461]
-------------------------------------------------------------
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
--------
S
I
D
V
L
C
V
T
A
S
I
E
T
-------
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
---------
L
---
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
E
A
---
I
N
C
------
Y
-
A
E
E
T
-
C
C
D
F
--
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
-----------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
K
A
------
L
K
T
L
G
I
I
M
G
T
F
T
------
L
C
W
L
P
F
F
I
V
N
I
V
-
H
---------
V
I
Q
D
------------
N
------------
L
I
R
K
E
-------
V
Y
I
L
L
N
W
I
G
Y
V
N
------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.18
22%
-138
- C4 -
4LDE
3
A:
[194-461]
-------------------------------------------------------------
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
--------
S
I
D
V
L
C
V
T
A
S
I
E
T
-------
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
---------
L
---
P
I
Q
M
H
W
-
Y
R
A
T
H
Q
E
A
---
I
N
C
------
Y
-
A
E
E
T
-
C
C
D
F
--
F
T
------
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
--
L
-----------
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
AL
K
E
H
K
A
------
L
K
T
L
G
I
I
M
G
T
F
T
------
L
C
W
L
P
F
F
I
V
N
I
V
-
H
---------
V
I
Q
D
------------
N
------------
L
I
R
K
E
-------
V
Y
I
L
L
N
W
I
G
Y
V
N
------
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
79.33
18%
-133
- C4 -
2Z73
5
OPSD_TODPA
A:
[31-335]
----------------------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
--------------
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
--
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
W
I
F
G
F
A
A
C
--
K
V
--------
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
-----
T
M
A
M
I
S
I
D
R
Y
N
----
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-----
G
P
I
F
G
---
W
G
A
Y
T
L
-----
E
G
V
L
---
C
N
C
S
F
D
Y
--
I
-
S
------
R
D
--
S
T
------
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
--
E
-----------
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-----
R
L
------
A
K
I
S
I
V
I
V
S
Q
F
L
------
L
S
W
S
P
Y
A
V
V
A
L
L
-
A
---------
Q
F
G
P
LEW---------
V
------------
T
P
Y
A
A
-------
Q
L
P
V
M
--
F
A
K
A
S
------
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
---
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
78.10
17%
-99
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
--------------
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
--
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
--
E
F
--------
W
T
S
I
D
V
L
C
V
T
A
S
I
E
-----
T
L
C
V
I
A
V
D
R
Y
F
----
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
M
HWY
R
A
T
H
Q
E
-
A
I
N
C
Y
A
E
E
---
T
C
C
D
F
---------
F
-
T
N
Q
A
--
Y
A
------
I
A
S
S
I
V
S
F
-----
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
-----
M
L
------
R
I
D
E
G
L
R
L
K
I
Y
K
------
D
T
E
G
Y
Y
T
I
G
I
G
H
-
L
---------
L
T
K
S
------------
P
------------
S
L
N
A
A
-------
K
S
E
L
D
--
K
A
I
G
R
------
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
29
HHSearch
77.89
17%
-134
- C4 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
--------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
--------------
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
--
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
--
L
F
--------
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
-----
S
V
F
I
L
C
I
D
R
Y
R
----
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-----
P
I
L
G
W
----
N
H
---------
R
R
E
---
D
K
C
E
T
D
F
--
Y
-
D
------------------
V
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
--
C
-----------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
-----
K
A
------
A
K
Q
L
G
F
I
M
A
A
F
I
------
L
C
W
I
P
Y
F
I
F
F
M
V
-
I
---------
A
F
C
K
NC----------
C
------------
N
E
H
L
H
-------
M
F
T
I
W
--
L
G
Y
I
N
------
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
76.53
15%
-93
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRSP
F
E
A
P
--
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
--------------
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
--------
E
G
F
F
A
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
A
I
E
R
Y
V
----
V
V
C
K
P
-------------------
M
S
N
F
R
F
G
E
N
H
A
I
-----
M
G
V
A
F
---
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
---
G
W
S
R
Y
I
P
--
E
G
M
Q
C
S
C
G
I
D
Y
--
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
-----
K
A
------
E
K
E
V
T
R
M
V
I
I
M
V
------
I
A
F
L
I
C
W
L
P
Y
A
G
-
V
---------
A
F
Y
I
------------
F
------------
T
H
Q
G
S
DFGPIFM
T
I
P
A
F
--
F
A
K
T
S
------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
75.29
14%
-99
- C4 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
-------------
S
P
F
E
AP
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
--------------
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
--------
E
G
F
F
A
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
A
I
E
R
Y
V
----
V
V
C
K
P
M
-------------------
S
N
F
R
F
G
E
N
H
A
I
-----
M
G
V
A
F
---
T
W
V
M
A
L
-
A
C
A
A
P
P
L
V
---
G
W
S
R
Y
I
P
E
G
M
-
Q
C
S
C
-
G
I
D
Y
--
Y
T
PHEETN
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
AQQQESA
T
T
Q
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
T
-----
R
M
------
V
I
I
M
V
I
A
F
L
I
C
W
------
L
P
Y
A
G
V
A
F
Y
I
F
T
-
H
---------
Q
G
S
D
------------
F
------------
G
P
I
F
M
-------
T
I
P
A
F
--
F
A
K
T
S
------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
--------------------------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-----------------------------------------------------------------------------------------------------------------
32
HHSearch
75.05
19%
-126
- C4 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
----------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
--------------
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
--
A
G
V
A
Y
-
T
A
N
L
L
L
S
G
A
--
T
T
Y
K
L
T
P
A
Q
W
--
F
L
--------
R
E
G
S
M
F
V
A
L
S
A
S
V
F
-----
S
L
L
A
I
A
I
E
R
Y
I
----
T
M
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
-----
L
P
I
M
G
---
W
N
C
I
--------
S
A
L
---
S
S
C
S
T
V
L
--
P
-
L
------------------
Y
H
K
H
Y
I
L
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
--
N
-----------
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
-----
A
L
------
L
K
T
V
I
I
V
L
S
V
F
I
------
A
C
W
A
P
L
F
I
L
L
L
L
-
D
---------
V
G
C
K
------------
V
KTC
D
--------
I
L
F
R
A
-------
E
Y
F
L
V
--
L
A
V
L
N
------
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
74.74
15%
-117
- C4 -
1U19
14
OPSD_BOVIN
A:
[37-327]
----------------------------------------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
--------------
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
--
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
--
N
L
--------
E
G
F
F
A
T
L
G
G
E
I
A
L
W
-----
S
L
V
V
L
A
I
E
R
Y
V
----
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-----
P
P
L
V
G
---
W
S
R
Y
I
P
-----
E
G
M
Q
---
C
S
C
G
I
D
Y
--
Y
-
T
P
----
H
E
E
--
T
N
------
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
--
A
-----------
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
K
-----
E
V
------
T
R
M
V
I
I
M
V
I
A
F
L
------
I
C
W
L
P
Y
A
G
V
A
F
Y
-
I
---------
F
T
H
Q
GSD---------
F
------------
G
P
I
F
M
-------
T
I
P
A
F
--
F
A
K
T
S
------
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
---
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
73.81
17%
-120
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-498]
--------------------------------------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
--------------
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
--
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
--
K
A
--------
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
-----
I
L
A
F
I
S
L
D
R
Y
L
----
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
-----
P
D
F
I
F
---
A
N
V
S
E
------
A
D
D
R
---
Y
I
C
D
R
F
Y
--
P
--------
N
D
--
L
W
------
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
--
G
-----------
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
-----
K
A
------
L
K
T
T
V
I
L
I
L
A
F
F
------
A
C
W
L
P
Y
Y
I
G
I
S
I
-
D
---------
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
------------
V
H
K
W
I
-------
S
I
T
E
A
--
L
A
F
F
H
------
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
---
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
70.18
14%
-124
- C4 -
2KS9
1
NK1R_HUMAN
A:
[32-326]
-------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
--------------
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
--
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
--
K
F
--------
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
-----
S
M
T
A
V
A
F
D
R
Y
M
----
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-----
P
Q
G
Y
Y
---
S
T
T
E
T
------
M
P
S
R
---
V
V
C
M
I
E
W
--
P
-
E
H
----
P
N
K
--
I
Y
------
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
--
E
-----------
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
-----
K
V
------
V
K
M
M
I
V
V
V
C
T
F
A
------
I
C
W
L
P
F
H
I
F
F
L
L
-
P
---------
Y
I
N
P
------------
D
LYLKKF------
I
Q
Q
V
Y
-------
L
A
I
M
W
--
L
A
M
S
S
------
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
---
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------------------------
36
HHSearch
70.07
19%
-116
- C4 -
2LNL
-
CXCR1_HUMAN
A:
[36-322]
----------------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
--------------
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
--
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
--
K
V
--------
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
-----
L
L
A
C
I
S
V
D
R
Y
L
----
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
-----
P
F
F
L
F
---
R
Q
A
Y
H
P
-----
N
N
S
S
---
P
V
C
Y
E
V
L
--
G
-
N
-----
D
T
A
--
K
W
------
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
--
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
H
-----
R
A
------
M
R
V
I
F
A
V
V
L
I
F
L
------
L
C
W
L
P
Y
N
L
V
L
L
A
-
D
---------
T
L
M
R
------------
T
QVIQE
S
C
E
R
R
N
N
I
G
R
A
L
-------
D
A
T
E
I
--
L
G
F
L
H
------
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Fugue
69.27
14%
-135
* C5 *
2CE7
1
FTSH_THEMA
A:
[5-457]
-----------
Y
K
P
S
G
N
K
R
V
T
-------------
F
K
D
V
--
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
L
K
D
P
S
K
F
N
R
I
G
A
R
M
PK
G
I
L
L
V
G
P
P
GTG
K
T
L
L
A
R
A
V
A
G
E
A
N
V
P
-
F
F
H
I
S
G
S
D
F
V
E
L
F
VG
V
G
A
A
R
-
V
R
D
L
F
A
Q
A
K
-
A
H
A
P
C
I
V
F
I
D
E
--
I
D
AVGRHD
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
DSKEG
I
I
V
M
A
A
T
N
R
P
D
ILDP
A
L
L
R
P
G
R
F
D
K
K
---
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
ED
V
N
L
E
I
---
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
---
L
V
N
E
A
A
L
--
L
-
A
A
R
E
-
G
R
D
K
--
I
T
------
M
K
D
F
E
E
A
I
D
R
V
I
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
-----------
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
P
V
H
-----
R
I
SIIKYL
V
S
R
N
E
L
L
D
K
L
T
A
------
L
L
G
G
R
A
A
E
E
V
V
F
G
D
---------
V
T
S
G
------------
A
------------
A
N
D
I
E
-------
R
A
T
E
I
--
A
R
N
M
V
CQLGMS
E
E
L
G
P
L
A
W
G
-
K
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
--------
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S-------------------------------------------------------------------------------------------------------------