@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1L6_HUMAN: (2016-01-12 )
MSYFYRLKLMKEAVLVKLPFTSLPLLLQTLSRKSRDMEIKNYSSSTSGFILLGLSSNPQLQKPLFAIFLIMYLLAAVGNVLIIPAIYSDPRLHTPMYFFLSNLSFMDICFTTVIVPKMLVNFLSETKVISYVGCLAQMYFFMAFGNTDSYLLASMAIDRLVAICNPLHYDVVMKPRHCLLMLLGSCSISHLHSLFRVLLMSRLSFCASHIIKHFFCDTQPVLKLSCSDTSSSQMVVMTETLAVIVTPFLCIIFSYLRIMVTVLRIPSAAGKWKAFSTCGSHLTAVALFYGSIIYVYFRPLSMYSVVRDRVATVMYTVVTPMLNPFIYSLRNKDMKRGLKKLQDRIYR
Atome Classification :
(20 SA)
--------.........10........20........30------........-----.40........50..----......60.......-----------.70......-..80........90......---------..100...-------.....110..-...-----------..120--..-......130.......--------140...--....150..-------.....160..--.....170---..-------.....180.......190..-----....-.200.......210.......220-...----..-------.-------..230.....-----....240....---------...250.....------..260---.....------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------.270-----.......280-.......------.290.......300.----.----.-------.----...-----------310.....------..320.--......330..---..--...340-----------------......-----------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------M
S
Y
F
Y
R
L
K
L
M
K
E
A
V
L
V
KLPFT
S
L
P
L
L
L
Q
T
L
-------
S
RKSRD
M
E
-----
I
KNYSSSTS
G
F
I
L
L
G----LSSNPQLQ
K
P
L
F
A
I
F
-----------
L
I
M
Y
L
L
A
AV-G
N
V
L
I
I
P
AIYSDPRLH
T
P
M
Y
---------
F
F
L
-SNL
S
-------
F
M
D
I
C
F
T
T
V
I
-
V
P
K
-----------
M
L
V
N
---
F
L
-
S
E
T
K
V
I
S
Y
V
G
C
L
A
Q
M
Y
--------
F
F
M
A
FG--NT
D
S
Y
L
L
A
S
-------
M
A
I
D
R
L
V
A
I
C--NP
L
H
YDVV---MK-------
P
R
H
C
L
L
M
L
L
GSC
S
I
S
H
L
H
S
L
-----
F
R
V
L
-
L
M
S
R
L
S
F
C
A
S
H
I
I
K
H
FFCDTQ
P
-
V
-
L
K
L
----SC-------S-------DTS--S
S
Q
M
V
-----
V
M
T
E
T
L
A
V
I
V
T
---------
P
F
L
C
I
I
F
S
Y
L
R
------
I
M
V
T
V
---
L
RIPS------------------------------------------------------------------------------------------------------------------------------------------------------------------A-------------------------------------------------------------------------------------------------------------------------------------------------------------------AGKW-----
K
A
F
S
T
C
G
S
H
--
L
T
A
V
A
L
F
------
Y
G
S
I
I
Y
V
Y
FR
P
L
S
M
Y
----
S
----
V
-------
V
----
R
D
R
-----------
V
A
T
V
M
Y
T
V
------
V
T
P
M
L
N
--
P
F
I
Y
S
LR
N
K
D
M
---
K
R
--
G
L
K
K
L
------------------
Q
D
R
IYR-----------------------------------
27
HHSearch
87.99
19%
-141
- C5 -
3EML
13
ENLYS_BPT4
A:
[21-469]
------------------------------------------------------------------------------------
S
S
V
Y
I
T
V
E
-----------
L
A
I
A
V
L
A
I
L
-
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
---------
Y
F
V
-
V
S
L
A
-------
A
A
D
I
A
V
G
V
L
A
-
I
P
F
-----------
A
I
T
I
---
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
V
L
V
L
T
--
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
--
I
P
L
R
Y
N
G
L
---
V
T
-------
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
-----
T
P
M
L
-
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
-
V
--------
A
C
-------
L
-------
F
E
D
VV
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
---------
P
L
L
L
M
L
G
V
Y
L
R
------
I
F
L
A
A
---
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
V
-----
H
A
A
K
S
L
A
I
I
--
V
G
L
F
A
L
C
------
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
DCSH
A
----
P
-------
L
----
W
L
M
-----------
Y
L
A
I
V
L
S
H
------
T
N
S
V
V
N
--
P
F
I
Y
A
Y
R
I
R
E
F
---
R
Q
--
T
F
R
K
I
------------------
I
R
S
H
V
L
-----------------------------------
24
HHSearch
86.83
18%
-139
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[10-443]
--------------------------------------------------------------------------------------
P
L
V
V
V
L
-----------
S
T
I
C
L
V
T
V
G
-
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
---------
L
Y
I
-
V
S
L
S
-------
V
A
D
L
I
V
G
A
V
V
-
M
P
M
-----------
N
I
L
Y
---
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
--------
M
D
Y
V
A
S
--
T
A
S
I
F
S
V
F
I
-------
L
C
I
D
R
Y
R
S
V
Q
--
Q
P
L
R
Y
L
K
Y
---
R
T
-------
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
-----
P
I
L
G
-
W
-
N
H
--------
R
R
E
D
K
C
E
T
D
F
-
Y
-
D
-----------------------------
V
T
W
F
-----
K
V
M
T
A
I
I
N
F
Y
L
---------
P
T
L
L
M
L
W
F
Y
A
K
------
I
Y
K
A
V
---
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
R
-----
K
A
A
K
Q
L
G
F
I
--
M
A
A
F
I
L
C
------
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
----
N
CC--
N
-------
E
----
H
L
H
-----------
M
F
T
I
W
L
G
Y
------
I
N
S
T
L
N
--
P
L
I
Y
P
L
C
N
E
N
F
---
K
K
--
T
F
K
R
I
------------------
L
H
I
--------------------------------------
21
HHSearch
86.32
18%
-134
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
-----------
S
L
I
V
L
A
I
V
F
-
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
---------
Y
F
I
-
T
S
L
A
-------
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-----------
G
A
A
H
---
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
-
M
H
W
Y
R
A
T
----
H
Q
E
A
I
N
C
Y
A
E
------
E
----
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
---------
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
---
K
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
H
-----
K
A
L
K
T
L
G
I
I
--
M
G
T
F
T
L
C
------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
NL--
I
----
R
-------
K
----
E
V
Y
-----------
I
L
L
N
W
I
G
Y
------
V
N
S
G
F
N
--
P
L
I
Y
C
-
R
S
P
D
F
---
R
I
--
A
F
Q
E
L
------------------
L
C
L
--------------------------------------
2
PsiBlast_PDB
85.79
22%
-141
- C5 -
2YCW
7
ADRB1_MELGA
A:
[7-296]
--------------------------------------------------------------------------------
S
Q
Q
W
E
A
G
M
S
L
L
M
-----------
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
---------
L
F
I
-
T
S
L
A
-------
C
A
D
L
V
V
G
L
L
V
-
V
P
F
-----------
G
A
T
L
---
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
--------
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-----
L
P
I
M
-
M
-------------
H
W
W
R
D
E
D
P
Q
A
-
L
K
C
Y
Q
D
P
G
C
-------
C
-------
D
F
V
--
T
N
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
---------
P
L
L
I
M
I
F
V
A
L
R
------
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
-----
K
R
V
M
L
M
R
E
H
KA
L
K
T
L
G
I
I
------
M
G
V
F
T
L
C
W
L
-
P
F
F
L
V
----
N
----
I
-------
V
N
V
F
N
R
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
--
P
I
I
Y
C
-
R
S
P
D
F
---
R
K
--
A
F
K
R
L
------------------
L
A
F
--------------------------------------
4
PsiBlast_PDB
83.34
22%
-145
- C5 -
2YCZ
2
ADRB1_MELGA
A:
[9-296]
----------------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
-----------
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
---------
L
F
I
-
T
S
L
A
-------
C
A
D
L
V
V
G
L
L
V
-
V
P
F
-----------
G
A
T
L
---
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
--------
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-----
L
P
I
M
-
M
-------------
H
W
W
R
D
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
--
T
N
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
---------
P
L
L
I
M
I
F
V
A
L
R
------
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
-----
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
------
M
G
V
F
T
L
C
W
L
-
P
F
F
L
V
----
N
----
I
-------
V
N
V
F
N
R
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
--
P
I
I
Y
C
-
R
S
P
D
F
---
R
K
--
A
F
K
R
L
------------------
L
A
F
--------------------------------------
3
PsiBlast_PDB
83.21
22%
-141
- C5 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
----------------------------------------------------------------------------------
Q
W
E
A
G
M
S
L
L
M
-----------
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
---------
L
F
I
-
T
S
L
A
-------
C
A
D
L
V
V
G
L
L
V
-
V
P
F
-----------
G
A
T
L
---
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
--------
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-----
L
P
I
M
-
M
-------------
H
W
W
R
D
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
--
T
N
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
---------
P
L
L
I
M
I
F
V
A
L
R
------
V
Y
R
E
A
K
E
Q
I
R
K
I
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
-----
K
R
V
M
L
M
R
E
H
KA
L
K
T
L
G
I
I
------
M
G
V
F
T
L
C
W
L
-
P
F
F
L
V
----
N
----
I
-------
V
N
V
F
N
R
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
--
P
I
I
Y
C
-
R
S
P
D
F
---
R
K
--
A
F
K
-------------------------------------------------------------
5
PsiBlast_PDB
82.80
22%
-142
- C5 -
2YCY
6
ADRB1_MELGA
A:
[10-296]
-----------------------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
-----------
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
---------
L
F
I
-
T
S
L
A
-------
C
A
D
L
V
V
G
L
L
V
-
V
P
F
-----------
G
A
T
L
---
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
--------
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-----
L
P
I
M
-
M
-------------
H
W
W
R
D
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
--
T
N
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
---------
P
L
L
I
M
I
F
V
A
L
R
------
V
Y
R
E
A
K
E
Q
I
R
--
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
-----
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
------
M
G
V
F
T
L
C
W
L
-
P
F
F
L
V
----
N
----
I
-------
V
N
V
F
N
R
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
--
P
I
I
Y
C
-
R
S
P
D
F
---
R
K
--
A
F
K
R
L
------------------
L
A
F
--------------------------------------
29
HHSearch
82.21
18%
-130
* C5 *
2Z73
5
OPSD_TODPA
A:
[32-333]
----------------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
F
I
-----------
G
I
C
G
I
I
G
C
G
-
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
---------
M
F
I
-
I
N
L
A
-------
F
S
D
F
T
F
S
L
V
N
G
F
P
L
-----------
M
T
I
S
---
C
F
-
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
--------
I
G
G
I
F
G
--
F
M
S
I
M
T
M
A
M
-------
I
S
I
D
R
Y
N
V
I
G
--
R
P
M
A
A
S
K
K
---
M
S
-------
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
-----
G
P
I
F
-
G
W
G
A
Y
T
----
L
E
G
V
L
C
N
C
S
F
D
Y
-
I
-
S
-----------------------
R
D
S
--
T
T
R
S
N
-----
I
L
C
M
F
I
L
G
F
F
G
---------
P
I
L
I
I
F
F
C
Y
F
N
------
I
V
M
S
V
---
S
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
M
-----
R
L
A
K
I
S
I
V
I
--
V
S
Q
F
L
L
S
------
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
LEW-
V
----
T
-------
P
----
Y
A
A
-----------
Q
L
P
V
M
F
A
K
------
A
S
A
I
H
N
--
P
M
I
Y
S
V
S
H
P
K
F
---
R
E
--
A
I
S
Q
T
------------------
F
P
W
V
L
T
-----------------------------------
16
PsiBlast_PDB
81.53
21%
-139
- C5 -
4GBR
1
ADRB2_HUMAN
A:
[9-283]
-----------------------------------------------------------------------------------------
G
I
V
-----------
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
---------
Y
F
I
-
T
S
L
A
-------
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-----------
G
A
A
H
---
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
-
M
H
---
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
A
E
E
----------
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
---------
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
---
K
R
Q
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
--
M
G
T
F
T
L
C
------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----
N
----
L
-------
I
----
R
K
E
-----------
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
--
P
L
I
Y
C
-
R
S
P
D
F
---
R
I
--
A
F
Q
E
L
------------------
L
C
L
--------------------------------------
1
PsiBlast_PDB
81.05
22%
-148
- C5 -
2VT4
8
ADRB1_MELGA
A:
[10-296]
-----------------------------------------------------------------------------------
W
E
A
G
M
S
L
L
M
-----------
A
L
V
V
L
L
I
V
A
-
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
---------
L
F
I
-
T
S
L
A
-------
C
A
D
L
V
V
G
L
L
V
-
V
P
F
-----------
G
A
T
L
---
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
--------
L
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
I
D
R
Y
L
A
I
T
--
S
P
F
R
Y
Q
S
L
---
M
T
-------
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
-----
L
P
I
M
-
M
-------------
H
W
W
R
D
E
D
P
Q
A
-
L
K
C
Y
Q
DP
G
C
-------
C
-------
D
F
V
--
T
N
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
---------
P
L
L
I
M
I
F
V
A
L
R
------
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
G
I
I
------
M
G
V
F
T
L
C
W
L
-
P
F
F
L
V
----
N
----
I
-------
V
N
V
F
N
R
D
L
-----------
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
--
P
I
I
Y
C
-
R
S
P
D
F
---
R
K
--
A
F
K
R
L
------------------
L
A
---------------------------------------
39
Fugue
81.03
16%
-108
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------
M
N
G
T
E
G
P
N
F
-------------------
Y
V
-------
P
F
S
N
K
T
G
V
-----
V
R
S
P
F
E
A
P
Q
Y
Y
L
---------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-----------
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
---------
Y
I
L
-
L
N
L
A
-------
V
A
D
L
F
M
V
F
G
G
-
F
T
T
-----------
T
L
Y
T
---
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--------
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
--------------------------
S
N
F
R
F
G
E
N
H
A
I
-----
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-
E
G
M
Q
C
----
S
C
-------
G
I
DYYTPH
E
E
T
--
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
---------
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
---
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
-----
K
A
E
K
E
V
T
R
M
--
V
I
I
M
V
I
A
------
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
----
F
----
T
H
QGSDFG
P
----
I
F
M
-----------
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
--
P
V
I
Y
I
M
M
N
K
Q
F
---
R
N
--
C
M
V
T
T
------------------
L
C
C
G
K
N
PSTTVSKTETS
Q
V
A
P
A-------------------
40
Fugue
80.31
16%
-122
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----MN
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
--------------------------------------------
A
E
P
W
Q
F
S
M
L
A
A
Y
M
-----------
F
L
L
I
M
L
G
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
---------
Y
I
L
-
L
N
L
A
-------
V
A
D
L
F
M
V
F
G
G
-
F
T
T
-----------
T
L
Y
T
---
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--------
F
A
T
L
G
G
--
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
--
K
P
M
--------------------------
S
N
F
R
F
G
E
N
H
A
I
-----
M
G
V
A
-
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
-
E
G
M
Q
C
----
S
C
G
I
DYYTP
H
-------
E
E
T
--
N
N
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
---------
P
L
I
V
I
F
F
C
Y
G
Q
------
L
V
F
T
V
---
K
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
E
S
-----
A
T
T
Q
K
A
E
K
E
--
V
T
R
M
V
I
I
------
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
----
A
----
F
-------
Y
----
I
F
T
H
QGSDFGPIFM
T
I
P
A
F
F
A
K
------
T
S
A
V
Y
N
--
P
V
I
Y
I
M
M
N
K
Q
F
---
R
N
--
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
VAPA-------------------------------
18
PsiBlast_PDB
80.27
21%
-141
- C5 -
4LDL
3
ADRB2_HUMAN
A:
[186-460]
-----------------------------------------------------------------------------------------
G
I
V
-----------
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
---------
Y
F
I
-
T
S
L
A
-------
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-----------
G
A
A
H
---
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
-
M
H
---
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
A
E
E
----------
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
---------
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
---
K
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
A
L
K
E
H
K
A
L
K
T
L
G
I
I
--
M
G
T
F
T
L
C
------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----
N
----
L
-------
I
----
R
K
E
-----------
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
--
P
L
I
Y
C
-
R
S
P
D
F
---
R
I
--
A
F
Q
E
L
------------------
L
C
L
--------------------------------------
17
PsiBlast_PDB
79.91
21%
-139
- C5 -
4LDE
3
A:
[186-460]
-----------------------------------------------------------------------------------------
G
I
V
-----------
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
---------
Y
F
I
-
T
S
L
A
-------
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-----------
G
A
A
H
---
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
-
M
H
---
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
A
E
E
----------
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
---------
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
---
K
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
AL
K
E
H
K
A
L
K
T
L
G
I
I
--
M
G
T
F
T
L
C
------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----
N
----
L
-------
I
----
R
K
E
-----------
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
--
P
L
I
Y
C
-
R
S
P
D
F
---
R
I
--
A
F
Q
E
L
------------------
L
C
L
--------------------------------------
19
PsiBlast_PDB
79.58
21%
-138
- C5 -
4LDO
3
A:
[186-460]
-----------------------------------------------------------------------------------------
G
I
V
-----------
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
---------
Y
F
I
-
T
S
L
A
-------
C
A
D
L
V
M
G
L
A
V
-
V
P
F
-----------
G
A
A
H
---
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
D
V
L
C
V
--
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
--
S
P
F
K
Y
Q
S
L
---
L
T
-------
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
-----
L
P
I
Q
-
M
H
---
W
Y
R
A
T
H
-
Q
E
A
I
N
C
Y
A
E
E
----------
T
C
-------
C
-------
D
F
F
--
T
N
Q
A
Y
-----
A
I
A
S
S
I
V
S
F
Y
V
---------
P
L
V
I
M
V
F
V
Y
S
R
------
V
F
Q
E
A
---
K
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
AL
K
E
H
K
A
L
K
T
L
G
I
I
--
M
G
T
F
T
L
C
------
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
----
N
----
L
-------
I
----
R
K
E
-----------
V
Y
I
L
L
N
W
I
G
Y
----
V
N
S
G
F
N
--
P
L
I
Y
C
-
R
S
P
D
F
---
R
I
--
A
F
Q
E
L
------------------
L
C
L
--------------------------------------
30
HHSearch
76.81
18%
-129
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------------------------------------------
Y
A
L
S
Y
-----------
C
A
L
I
L
A
I
V
F
-
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
---------
Y
L
V
-
V
S
L
A
-------
V
A
D
L
L
V
A
T
L
V
-
M
P
W
-----------
V
V
Y
L
---
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
--------
L
D
V
M
M
C
--
T
A
S
I
W
N
L
C
A
-------
I
S
I
D
R
Y
T
A
V
V
--
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
-------
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
-----
P
L
L
F
-
G
F
N
T
-------
T
G
D
P
T
V
C
S
I
S
N
--------------------------------
P
--
D
F
-----
V
I
Y
S
S
V
V
S
F
Y
L
---------
P
F
G
V
T
V
L
V
Y
A
R
------
I
Y
V
V
L
---
K
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
K
-----
K
A
T
Q
M
V
A
I
V
--
L
G
A
F
I
V
C
------
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
TCH-
V
----
S
-------
P
----
E
L
Y
-----------
S
A
T
T
W
L
G
Y
------
V
N
S
A
L
N
--
P
V
I
Y
T
T
F
N
I
E
F
---
R
K
--
A
F
L
K
I
------------------
L
S
C
--------------------------------------
31
HHSearch
74.62
16%
-124
- C5 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
------------------------------------------------------------------------------------
I
V
L
W
A
A
A
Y
-----------
T
V
I
V
V
T
S
V
V
-
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
---------
Y
F
L
-
V
N
L
A
-------
F
A
E
A
S
M
A
A
F
N
-
T
V
V
-----------
N
F
T
Y
---
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
--------
F
P
I
A
A
V
--
F
A
S
I
Y
S
M
T
A
-------
V
A
F
D
R
Y
M
A
I
I
--
H
P
L
Q
P
R
L
-----
S
-------
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
-----
P
Q
G
Y
-
Y
S
T
T
-----
E
T
M
P
S
R
V
V
C
M
I
E
W
-
P
-
E
H
P
---------------------
N
K
I
--
Y
E
K
V
Y
-----
H
I
C
V
T
V
L
I
Y
F
L
---------
P
L
L
V
I
G
Y
A
Y
T
V
------
V
G
I
T
L
---
W
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
R
-----
K
V
V
K
M
M
I
V
V
--
V
C
T
F
A
I
C
------
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
----
D
----
L
YLKKFI-
Q
----
Q
V
Y
-----------
L
A
I
M
W
L
A
M
------
S
S
T
M
Y
N
--
P
I
I
Y
C
C
L
N
D
R
F
---
R
L
--
G
F
K
H
A
------------------
F
R
C
C
P
F
-----------------------------------
28
HHSearch
73.88
17%
-129
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
---------------------------------------------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
-----------
I
L
I
C
C
F
I
I
L
-
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
---------
Y
F
I
-
G
N
L
A
-------
L
S
D
L
L
A
G
V
A
Y
-
T
A
N
-----------
L
L
L
S
---
G
A
--
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
--------
S
M
F
V
A
L
--
S
A
S
V
F
S
L
L
A
-------
I
A
I
E
R
Y
I
T
M
L
--
K
-----------
N
-------
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
-----
L
P
I
M
-
G
W
N
C
-------
I
S
A
L
S
S
C
S
T
V
L
-
P
-
L
----------------------------
Y
H
K
H
Y
------
I
L
F
C
T
T
V
F
T
L
---------
L
L
L
S
I
V
I
L
Y
C
R
------
I
Y
S
L
V
---
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYA
S
R
-
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
N
V
-----
A
L
L
K
T
V
I
I
V
--
L
S
V
F
I
A
C
------
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
----
V
KTC
D
I
-------
L
----
F
R
A
-----------
E
Y
F
L
V
L
A
V
------
L
N
S
G
T
N
--
P
I
I
Y
T
L
T
N
K
E
M
---
R
R
--
A
F
I
R
I
------------------
M
G
R
P
L
------------------------------------
45
Fugue
72.92
18%
-136
- C3 -
4IWS
-
?
A:
[23-515]
M
N
R
S
A
L
D
F
R
H
F
V
D
H
L
R
R
Q
G
D
L
V
D
V
H
T
E
V
D
A
-
N
L
E
I
G
A
I
-------
T
R
R
V
Y
E
R
R
A
P
A
P
L
F
H
N
I
R
D
S
L
P
G
A
R
V
L
G
APAG
L
R
A
D
R
A
R
A
H
S
R
L
A
L
H
F
GLPEHSG
P
R
D
I
V
A
M
L
R
A
A
M
-
R
A
E
P
I
A
P
R
R
L
E
R
G
P
V
Q
E
N
V
W
L
GEQVDLTR
F
P
V
-
P
L
L
H
EQDGGRY
F
G
T
Y
G
F
H
V
V
Q
-
T
P
D
GS
W
D
S
W
S
V
G
R
L
M
L
V
D
RN
T
L
A
-
G
P
T
I
P
T
Q
H
I
G
I
I
R
E
Q
W
R
R
L
GK
P
T
P
W
A
M
A
L
G
--
A
P
P
A
A
L
A
A
A
G
MPLPEG
V
S
E
A
G
Y
V
G
A
L
--
V
G
E
P
V
E
V
V
---
R
T
QTNGLWV
P
A
N
T
E
I
V
L
E
G
E
I
S
L
D
E
T
A
L
E
GPMGE
Y
H
G
Y
-
S
F
P
I
G
K
P
Q
P
L
F
H
V
H
A
L
S
F
R
D
Q
P
-
I
-
L
P
I
----
C
V
-------
A
-------
G
T
P
--
P
E
E
N
H
T
I
W
G
T
M
I
S
A
Q
L
L
D
V
A
Q
N
A
GL-----
P
V
D
M
V
W
C
S
Y
E
A
ATC
W
A
V
L
S
I
D
V
---
Q
R
L
A
A
L
GTD
A
A
A
F
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
A
E
-----
T
V
F
G
S
H
A
G
H
--
L
V
P
K
L
I
L
------
V
G
N
D
I
D
V
T
-
E
I
D
Q
V
V
----
W
----
A
-------
L
----
A
T
R
-----------
A
H
P
L
H
D
H
F
------
A
F
P
Q
I
R
DF
P
M
V
P
Y
L
D
A
E
D
K
---
A
R
GS
G
G
R
L
V
------------------
I
N
C
L
Y
P
E
Q
F
A
GQMRAATASFRHAYP
T
A
L
R
R
R
V
E
E
R
W
SDYGF
42
Fugue
71.91
11%
-142
* C6 *
3NMZ
-
APC_HUMAN
A:
[326-736]
---DKD
D
M
S
R
T
L
L
A
M
S
S
S
Q
D
S
C
I
S
M
R
Q
S
G
C
L
P
L
L
I
Q
L
L
HGNDKDS
V
L
S
R
G
S
K
E
-----
A
R
A
R
A
S
A
A
L
H
N
I
I
H
S
----
Q
P
D
D
K
R
G
R
R
E
I
R
V
L
H
-----------
L
L
E
Q
I
R
A
Y
C
-
E
T
C
W
E
W
Q
E
A
H
E
P
G
M
D
Q
D
K
N
P
---------
A
P
V
E
H
Q
I
C
-------
P
A
V
C
V
L
M
K
L
S
-
F
D
E
-----------
E
H
R
H
---
A
M
-
N
E
L
G
G
L
Q
A
I
A
E
L
L
Q
V
D
--------
C
E
M
Y
G
L
TN
D
H
Y
S
I
T
L
R
R
-------
Y
A
G
M
A
L
T
N
L
T
FG
D
V
A
N
K
A
T
L
---
C
S
-------
M
K
G
C
M
R
A
L
V
A
Q
L
K
S
E
S
E
D
L
Q
-----
Q
V
I
A
S
V
L
R
N
L
S
W
R
A
D
V
N
S
K
K
T
L
R
E
V
G
S
-
V
-
K
A
L
----
M
E
-------
C
-------
A
L
E
--
V
K
K
E
S
-----
T
L
K
S
V
L
S
A
L
W
N
L
S
A
HC
T
E
N
K
A
D
I
C
A
V
D
G
A
L
A
------
F
L
V
G
T
---
L
T
Y
R
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
N
T
L
-----
A
I
I
E
S
G
G
G
I
--
L
R
N
V
S
S
L
I
A
T
N
E
D
H
R
Q
I
L
R
E
N
N
C
L
Q
T
L
L
----
Q
----
H
-------
L
----
K
S
H
-----------
S
L
T
I
V
S
N
A
------
C
G
T
L
W
N
--
L
S
A
R
N
P
K
D
Q
E
A
L
W
D
M
G
--
A
V
S
M
L
------------------
K
N
L
I
H
S
KH
K
M
I
A
M
G
S
A
A
A
L
R
N
L
M
A
N
RPAK------------