@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2A5_HUMAN: (2016-01-12 )
MTKNQTWVTEFILLGFPLSLRIQMLLSGLFSLLYVFTLLGNGAILGLIWLDSRLHTPMYFFLSHLAIIDISYASNNVPKMLTNLGLNKRKTISFVPCTMQTFLYMAFAHTECLILVMMSYDRYMAICHPLQYSVIMRWGVCTVLAVTSWACGSLLALVHVVLILRLPFCGPHEINHFFCEILSVLKLACADTWLNQVVIFAASVFILVGPLCLVLVSYSRILAAILRIQSGEGRRKAFSTCSSHLCMVGLFFGSAIVMYMAPKSRHPEEQQKVLSLFYSLFNPMLNPLIYSLRNAEVKGALKRVLWKQRSK
Atome Classification :
(20 SA)
-------------------------------------.........10--------------.....-----...--.------------20........30.--.......40--..-.......50.---.......60......-..70.....------...80........90........100--------.--......110..--...-..120..--.....--130......----.140.......--------150....-------....160--.........170-----------------..-----.......180.......-------------190-----...-......200.---....-----..--------210.......220--......----.-----.--------------------230--..-----------.-----------------..----..---..240....---...250------........260-----....---.----.---.---.---------.-------270...--------....----------280....-----------...--------.290.......300.......310-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------------------------MTK
N
Q
T
W
V
T
E
---------------
F
I
L
LG-----F
P
L
--
S
------------
L
R
I
Q
M
L
L
S
G
L
F
S
L
--
L
Y
V
F
T
L
LG---N
G
-
A
I
L
G
L
I
W
LDS---RLH
T
P
M
Y
F
F
L
S
H
L
A
I
-
I
D
I
SYASNN------
V
P
K
M
L
T
NLGLNKR
K
T
I
S
F
V
P
C
T
M
Q
T
F
--------
L
--
Y
M
A
F
AHT
E
C
L
I
--
L
V
M-MSY
D
R
Y
M
--
A
I
C
H
P
--
L
Q
Y
S
V
I
M
R
W
----
G
V
C
T
V
L
A
V
T
SW--------
A
C
-
G
S
L
L
-------
A
L
V
H
V
----
V
L
I
L
RLPFC
G
-------------------
P
H
-----
E
I
N
H
F
F
C
E
I
L
S
V
L
K
L
A
C
-------------
A
-------
D
T
W
-
L
N
Q
V
V
I
F
A
A
S
---
V
F
I
L
-----
V
G
--------
P
L
C
L
V
L
V
S
Y
S
R
I
---
L
A
A
I
L
R
----I-----Q--------------------S----GE-----------
G
-----------------
R
R
----
K
A
---
F
S
T
C
S
S
H
L
C
---
M
V
G
L
-
F
------
F
G
S
A
I
V
M
Y
M-------APKS---R----H---
P
---
E
---------
E
-------
Q
Q
K
V
L
S
--------
L
F
Y
S
----------
L
F
-
N
P
M
L
-----------
N
P
L
--------
I
Y
S
LRN
A
E
V
K
G
A
L
K
R
V
L
W
K
QRSK------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
85.09
16%
-130
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
--------------------------MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
---------------
S
P
F
E
A
-----
P
Q
Y
--
Y
------------
L
A
E
P
W
Q
F
S
M
L
A
A
Y
--
M
F
L
L
I
M
L
G
F
P
I
N
F
-
L
T
L
Y
V
T
V
Q
H
K
---
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-
A
D
L
F
M
V
F
G
G
-------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--------
F
--
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
--
V
V
C
K
P
--
M
S
-
N
F
R
F
G
E
----
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
-
A
L
A
C
-------
A
A
P
P
L
----
V
G
W
S
R
Y
I
P
E
G
--------------------------------------
M
Q
C
S
C
-------------
G
I
DYYTPH
E
E
T
-
N
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
-----
I
I
--------
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
----
A
-----
A
--------------------
A
----
S
A
-----------
T
-----------------
T
Q
----
K
A
---
E
K
E
V
T
R
M
V
I
---
I
M
V
I
-
A
------
F
L
I
C
W
L
P
Y
A
-------
G
V
A
F
---
Y
----
I
---
F
---
T
---------
H
QGSDFGP
I
F
M
T
I
P
--------
A
F
F
A
----------
K
T
-
S
A
V
Y
-----------
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
84.67
23%
-156
- C3 -
3VGA
1
AA2AR_HUMAN
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
A
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
------------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
L
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
Q
PLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
---
I
V
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
S
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
83.45
23%
-156
- C3 -
3REY
1
AA2AR_HUMAN
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
L
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
P
-------------
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
A
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
QPLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
---
I
A
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
A
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.31
23%
-157
- C3 -
3RFM
1
AA2AR_HUMAN
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
L
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
P
-------------
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
A
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
QPLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
---
I
A
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
A
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.14
23%
-159
- C3 -
3UZC
1
AA2AR_HUMAN
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
L
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
P
-------------
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
A
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
QPLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
---
I
A
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
A
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.13
23%
-159
- C3 -
3UZA
1
AA2AR_HUMAN
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
L
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
P
-------------
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
A
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
QPLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
---
I
A
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
A
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
83.00
23%
-157
- C3 -
3PWH
1
?
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
L
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
A
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
A
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
P
-------------
G
C
G
E
G
Q
V
A
C
LF-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
A
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
QPLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
A
A
I
---
I
A
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
A
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
82.86
23%
-161
- C3 -
3VG9
8
?
A:
[18-303]
-----------------------------------------------------------------------------------------------------------
V
L
A
I
L
G
---
N
V
-
L
V
C
W
A
V
W
L
N
S
---
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
-
A
D
I
A
V
G
V
L
A
------
I
P
F
A
I
T
---
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
--------
F
--
V
L
V
L
T
Q
S
S
I
F
S
--
L
L
A
-
I
A
I
D
R
Y
I
--
A
I
R
I
P
--
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
--------
A
I
-
G
--------------
L
----
T
P
M
L
G
W
N
N
C
G
-------------------
Q
------------
S
Q
G
C
G
E
G
Q
V
A
C
L
F
-----------
E
-------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
---
A
C
V
L
-----
V
---------
P
L
L
L
M
L
G
V
Y
L
R
I
---
F
L
A
A
R
R
Q
L
K
Q
M
-----
E
--------------------
S
Q
PLP
G
E
-----------
R
-----------------
A
R
S
T
L
Q
K
E
---
V
H
A
A
K
S
L
A
I
---
I
V
G
L
-
F
------
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
---
S
----
H
---
A
---
P
---------
L
-------
W
L
M
Y
L
A
--------
I
V
L
S
----------
H
T
-
N
S
V
V
-----------
N
P
F
--------
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
81.23
17%
-132
- C3 -
2Z73
5
OPSD_TODPA
A:
[33-332]
--------------------------------------------------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
--
C
G
I
I
G
C
G
G
---
N
G
-
I
V
I
Y
L
F
T
K
T
K
---
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
-
S
D
F
T
F
S
L
V
N
G
-----
F
P
L
M
T
I
S
C
-
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
--------
I
--
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
-
I
S
I
D
R
Y
N
--
V
I
G
R
P
--
M
A
A
S
K
K
M
S
H
----
R
R
A
F
I
M
I
I
F
V
W
--------
L
W
-
S
V
L
W
-------
A
I
G
P
I
----
F
G
W
G
A
Y
---
T
-------------------
L
------
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------------------------
D
S
-
T
T
R
S
N
I
L
C
M
F
---
I
L
G
F
-----
F
G
--------
P
I
L
I
I
F
F
C
Y
F
N
I
---
V
M
S
V
S
N
----
H
-----
E
--------------------
K
----
E
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
-
R
L
---
A
K
I
S
I
V
I
V
S
---
Q
F
L
L
-
S
------
W
S
P
Y
A
V
V
A
L
-------
L
A
Q
F
---
G
PLE-
W
---
V
---
T
---------
P
-------
Y
A
A
Q
L
P
--------
V
M
F
A
----------
K
A
-
S
A
I
H
-----------
N
P
M
--------
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
80.93
19%
-135
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
------------------------------------------------------------------------------------------------
W
A
A
A
Y
T
V
--
I
V
V
T
S
V
V
G
---
N
V
-
V
V
M
W
I
I
L
A
H
K
---
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
-
A
E
A
S
M
A
A
F
N
------
T
V
V
N
F
T
Y
A
-
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
--------
F
--
P
I
A
A
V
F
A
S
I
Y
S
--
M
T
A
-
V
A
F
D
R
Y
M
--
A
I
I
H
P
--
L
Q
P
R
L
--
S
A
----
T
A
T
K
V
V
I
C
V
I
W
--------
V
L
-
A
L
L
L
-------
A
F
P
Q
G
----
Y
Y
S
T
T
----
E
-------------------
T
------
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
N
-----------------------
K
I
-
Y
E
K
V
Y
H
I
C
V
T
---
V
L
I
Y
-----
F
L
--------
P
L
L
V
I
G
Y
A
Y
T
V
V
---
G
I
T
L
W
A
----
S
-----
E
--------------------
I
----
P
G
DSSDRYH
E
Q
V
S
A
-----------------
K
R
----
K
V
---
V
K
M
M
I
V
V
V
C
---
T
F
A
I
-
C
------
W
L
P
F
H
I
F
F
L
-------
L
P
Y
I
NPD
L
----
Y
---
L
KKF
I
---------
Q
-------
Q
V
Y
L
A
I
--------
M
W
L
A
----------
M
S
-
S
T
M
Y
-----------
N
P
I
--------
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
76.73
14%
-109
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
--------------------------------------
M
N
G
T
E
G
P
N
F
---------------
Y
V
P
F
S
-----
N
K
T
--
G
VVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
L
A
A
Y
--
M
F
L
L
I
M
L
G
---
F
P
-
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-
A
D
L
F
M
V
F
G
G
-------
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--------
F
--
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
--
V
V
C
K
P
--
M
S
-
N
F
R
F
G
E
----
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
-
A
L
A
C
-------
A
A
P
P
L
----
V
G
W
S
R
Y
I
P
E
G
--------------------------------------
M
Q
C
S
C
-------------
G
I
DYYTPH
E
E
T
-
N
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
-----
I
I
--------
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
----
A
AAQQQ
E
--------------------
S
----
A
T
-----------
T
-----------------
Q
K
----
A
E
---
K
E
V
T
R
M
V
I
I
---
M
V
I
A
-
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
-------
T
H
Q
G
---
S
----
D
---
F
---
G
---------
P
-------
I
F
M
T
I
P
--------
A
F
F
A
----------
K
T
-
S
A
V
Y
-----------
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
75.47
15%
-117
- C3 -
1U19
14
OPSD_BOVIN
A:
[42-326]
-----------------------------------------------------------------------------------------------
M
L
A
A
Y
M
F
L
--
L
I
M
L
G
F
P
I
---
N
F
-
L
T
L
Y
V
T
V
Q
H
K
---
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
-
A
D
L
F
M
V
F
G
G
------
F
T
T
T
L
Y
T
S
-
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
--------
F
--
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
-
L
A
I
E
R
Y
V
--
V
V
C
K
P
--
M
S
N
F
R
-
F
G
E
----
N
H
A
I
M
G
V
A
F
T
W
--------
V
M
-
A
L
A
C
-------
A
A
P
P
L
----
V
G
W
S
R
Y
---
I
-------------------
P
------
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------------
H
-------
E
E
T
-
N
N
E
S
F
V
I
Y
M
F
---
V
V
H
F
-----
I
I
--------
P
L
I
V
I
F
F
C
Y
G
Q
L
---
V
F
T
V
K
E
----
A
-----
A
--------------------
A
----
Q
Q
-----------
Q
ESA
T
T
Q
K
A
---------
E
K
----
E
V
---
T
R
M
V
I
I
M
V
I
---
A
F
L
I
-
C
------
W
L
P
Y
A
G
V
A
F
-------
Y
I
F
T
H
--
Q
GS--
D
---
F
---
G
---------
P
-------
I
F
M
T
I
P
--------
A
F
F
A
----------
K
T
-
S
A
V
Y
-----------
N
P
V
--------
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
75.32
17%
-129
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------------------------------------------
D
------------
E
V
W
V
V
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
-
L
V
I
T
A
I
A
K
F
E
---
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
-
A
D
L
V
M
G
L
A
V
------
V
P
F
G
A
A
H
I
L
M
K
M
W
-
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
--
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
-
I
A
V
D
R
Y
F
--
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
----
N
K
A
R
V
I
I
L
M
V
W
--------
I
V
-
S
G
L
T
-------
S
F
L
P
I
----
Q
M
-------
H
-------------------
W
Y
-----
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
-------------
D
-------
F
F
--
T
N
Q
A
Y
A
I
A
S
S
---
I
V
S
F
-----
Y
V
--------
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
Q
---
L
-----
N
--------------------
I
----
F
E
-----------
M
-----------------
L
R
----
I
D
---
E
G
L
R
L
K
I
Y
K
---
D
T
E
G
-
Y
------
Y
T
I
G
I
G
H
L
L
-------
T
K
S
P
---
S
----
L
---
N
---
A
---------
A
-------
K
S
E
L
D
K
--------
A
I
G
R
----------
N
T
N
G
V
I
T
-----------
K
D
E
--------
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
49
Fugue
75.10
21%
-132
- C2 -
4FDT
2
?
A:
[21-425]
------------------------------------M
Q
T
K
I
Q
K
Y
A
G
T
AMPYPNRTDGMTPF
Y
I
N
H
L
G
R
H
GAR
F
P
T
--
S
R-----------
K
A
L
D
K
V
E
K
V
L
V
S
A
--
Q
Q
E
N
G
L
T
S
---
E
G
M
A
L
L
S
M
I
R
R
L
S
---
R
L
F
D
G
Q
W
G
K
L
S
K
L
G
E
-
T
E
Q
E
G
I
A
G
R
------
M
I
R
N
Y
P
Q
L
F
S
N
S
A
K
I
E
A
I
A
-----
T
Y
--------
V
--
P
R
S
I
N
S
M
D
A
F
L
--
S
C
M
-
I
R
H
N
P
A
L
--
Q
V
Q
R
S
E
G
K
Q
Y
N
H
I
L
R
F
----
F
D
L
N
K
S
Y
V
N
Y
K
--------
E
K
-
G
D
W
L
P
I
Y
K
---
A
F
V
H
K
K
ISP
V
P
I
M
K
K
F
L
L
N
-------------------
P
E
QYL
D
K
E
A
E
E
F
V
M
A
L
F
S
V
A
A
I
L
P
DTSIPLNLEDLFT
L
-------
D
E
W
-
H
R
Y
W
Q
T
Q
N
L
R
---
Q
Y
M
S
-----
K
S
SAPVGKM
L
P
V
A
I
A
W
P
L
L
S
E
F
---
I
R
S
A
Q
E
----
V
-----
I
--------------------
S
----
G
K
-----------
S
-----------------
D
Y
----
Q
A
N
F
R
F
A
H
A
E
T
V
I
P
---
F
V
S
L
-
M
G-----
I
E
K
T
D
V
Q
V
C
-------
R
P
D
S
---
V
----
S
---
V
---
Y
---------
W
-------
K
D
Y
E
I
S
PMA
A
N
V
Q
W
L
F
Y
R
D
RDQ
R
I
W
V
K
I
L
L
-
N
E
E
A
-----------
A
A
L
PISTACFP
Y
Y
S
W
E
K
T
R
I
F
F
N
Q
R
I
E
M
A
K
K
T
L
S
V
F
N---------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
72.82
18%
-129
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------------------------
S
F
K
C
A
---------------
L
T
K
T
G
-----
F
-------------------
Q
F
Y
Y
L
P
A
V
Y
I
L
--
V
F
I
I
G
F
L
G
---
N
S
-
V
A
I
W
M
F
V
F
H
M
---
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
-
A
D
F
L
Y
V
-
L
T
------
L
P
A
L
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
--------
I
--
F
H
V
N
L
Y
G
S
I
L
F
--
L
T
C
-
I
S
A
H
R
Y
S
--
G
V
V
Y
P
---
K
S
L
G
R
L
K
K
----
K
N
A
I
C
I
S
V
L
V
W
-------------
L
I
-------
V
V
V
A
I
----
S
P
I
L
F
Y
S
G
T
G
-------------------
V
R
-----
K
N
K
T
I
T
C
Y
D
T
T
-------------------
S
-------
D
E
Y
-
L
R
S
Y
F
I
Y
S
M
C
---
T
T
V
A
MF---
C
V
--------
P
L
V
L
I
L
G
C
Y
G
L
I
---
V
R
A
L
I
Y
----
K
-----
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPD
N
----
G
V
-----------
N
-----------------
P
G
----
T
D
---
F
K
D
I
V
C
P
L
C
---
G
V
G
----------
K
D
Q
F
E
E
V
E
-------
E
P
L
R
---
R
----
K
---
S
---
I
---------
Y
L
------
V
I
I
V
L
T
--------
V
F
A
V
----------
S
Y
-
I
P
F
H
-----------
V
M
K
--------
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR-----------------------------------------------------------------------------------------------------------------------------
46
Fugue
67.12
15%
-114
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
----------------------------------P
C
F
R
E
E
N
A
N
F
------------------------------------------------
N
K
I
F
L
P
T
I
Y
S
I
--
I
F
L
T
G
I
V
G
---
N
G
-
L
V
I
L
V
M
G
Y
Q
K
---
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
-
A
D
L
L
F
V
-
I
T
------
L
P
F
W
A
V
D
A
V
A
N
W
--
Y
F
G
N
F
L
C
K
A
V
H
V
--------
I
--
Y
T
V
N
L
Y
S
S
V
W
I
--
L
A
F
-
I
S
L
D
R
Y
L
--
A
I
V
H
A
--
T
N
S
Q
R
P
R
K
L
----
L
A
E
K
V
V
Y
V
G
V
W
--------
I
P
-
A
L
L
L
-------
T
I
P
D
F
----
I
F
A
N
V
S
E
-----------------------
A
-----
D
D
R
Y
I
C
D
R
F
Y
P
N
D
L
W
V
V
-------------
V
-------
F
Q
F
-
Q
H
I
M
V
G
L
I
L
P
---
G
I
V
I
-----
L
S
--------
C
Y
C
I
I
I
S
K
L
S
H
S
GSN
I
F
E
M
L
R
----
I
-----
D
--------------------
E
----
G
L
-----------
R
-----------------
L
K
----
I
Y
---
K
D
T
E
G
Y
Y
T
I
---
G
I
G
H
-
L
------
L
T
K
S
P
S
L
N
A
-------
A
K
S
E
---
L
----
D
---
K
---
A
IGRNTNGVI
T
-------
K
D
E
A
E
K
--------
L
F
N
Q
----------
D
V
-
D
A
A
V
-----------
R
G
I
L
R
NAKLK
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ---
31
HHSearch
66.45
16%
-118
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[40-323]
----------------------------------------------------------------------------------------------
Y
V
V
I
I
A
Y
A
L
--
V
F
L
L
S
L
L
G
---
N
S
-
L
V
M
L
V
I
L
Y
S
R
---
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
-
A
D
L
L
F
A
L
-
T
------
L
P
I
W
A
A
S
K
--
V
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
--------
L
--
K
E
V
N
F
Y
S
G
I
L
L
--
L
A
C
-
I
S
V
D
R
Y
L
--
A
I
V
H
A
--
T
R
T
L
T
-
Q
K
R
----
H
L
V
K
F
V
C
L
G
C
W
--------
G
L
-
S
M
N
L
-------
S
L
P
F
F
----
L
F
R
Q
A
Y
---
H
-------------------
P
------
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
------------------------
T
A
K
-
W
R
M
V
L
R
I
L
P
H
---
T
F
G
F
-----
I
V
--------
P
L
F
V
M
L
F
C
Y
G
F
T
---
L
R
T
L
F
K
----
A
-----
H
--------------------
M
-----
G
-----------
Q
-----------------
K
H
----
R
A
---
M
R
V
I
F
A
V
V
L
---
I
F
L
L
-
C
------
W
L
P
Y
N
L
V
L
L
-------
A
D
T
L
M
RT
Q
VIQE
S
C
E
R
R
---
N
N
I
-------
G
-------
R
A
L
D
A
T
--------
E
I
L
G
----------
F
L
-
H
S
C
L
-----------
N
P
I
--------
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
66.32
15%
-153
* C2 *
4R6Y
2
PHNS_SALTY
A:
[1-317]
---------------------------------------
S
M
E
S
V
V
T
V
---------------
Y
S
I
D
G
-----
L
H
D
GD
N
------------
S
W
Y
Q
V
Q
F
D
A
F
T
K
A
TG
I
T
V
R
Y
V
E
G
---
G
G
-
G
V
V
V
E
R
L
A
K
E
---
R
T
N
P
Q
A
D
V
L
V
T
A
P
P
F
-
I
Q
R
A
A
A
----------
E
K
L
L
A
N
F
N
T
D
T
A
S
A
I
P
D
A
N
N
L
Y
S
P
L
--------
V
K
N
Y
L
S
F
I
Y
N
S
K
L
L
--
K
T
A
P
A
S
W
Q
D
L
L
DG
K
F
K
N
K
--
L
Q
Y
S
T
P
G
Q
A
----
A
D
G
T
A
V
M
L
Q
A
F
--------
H
S
F
G
S
K
D
-------
A
G
F
A
Y
----
L
G
K
L
Q
A
N
N
V
G
-------------------
P
S
-----
A
S
T
G
K
L
T
A
L
V
N
K
G
E
I
Y
V
-------------
A
-------
N
G
D
-
L
Q
M
N
L
A
Q
M
E
R
NPN
V
K
I
F
W
P
A
N
D
K
G
--------
E
R
S
A
L
A
I
P
Y
--
V
---
I
G
L
V
Q
G
----
A
-----
P
--------------------
Q
----
S
E
-----------
N
-----------------
G
K
----
K
L
---
I
N
F
L
L
S
K
E
A
Q
T
R
V
S
E
L
-
S
------
W
G
M
P
V
R
S
D
V
-------
T
P
S
D
---
E
----
H
---
Y
---
K
---------
A
-------
A
T
A
A
L
E
--------
G
V
Q
S
----------
W
Q
-
P
---------------------------
N
W
D
D
V
A
V
S
L
S
A
D
I
S
R
W
H
K
V
T
E
S-----------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
65.47
17%
-162
- C1 -
4XGC
-
?
D:
[5-457]
D
R
E
L
V
S
I
R
R
F
L
K
E
R
L
Q
RDYTTLRGY
A
K
E
R
S
N
V
R
L
L
L
Q
R
T
A
E
M
G
E
S
N
S
---------------
L
L
L
L
G
-----
P
R
G
--
S
------------
G
K
T
T
L
I
N
S
V
L
A
D
L
--
L
P
N
K
S
F
------
G
-
E
N
T
L
I
V
H
L
D
G
---
N
L
H
T
D
D
R
V
A
L
K
S
I
T
V
Q
M
Q
L
E
N
A
A
D
G
KVFGS
F
A
E
N
L
A
F
L
L
Q
C
L
K
S
K
S
V
I
F
I
L
E
E
F
D
L
F
C
A
HHNQ
T
L
L
--
Y
N
L
F
D
V
S
Q
S
A
Q
A
P
I
C
V
-
L
G
V
T
C
R
L
--
D
V
I
E
L
--
L
E
K
R
V
K
S
R
F
----
S
H
R
Q
V
F
L
F
P
S
L
RR
F
E
D
Y
V
D
L
C
-
R
D
L
L
S
L
P
T
G
N
S
L
L
L
A
A
----
E
K
I
Y
N
L
Q
N
I
Q
SGALYFSRNHFDPGE
Y
G
F
S
P
R
-----
L
R
D
A
W
N
K
Q
I
C
K
V
L
A
T
Q
Q
-------------
A
-------
R
S
T
-
L
Q
A
L
H
D
F
D
I
S
----
E
A
Y
-----
L
K
--------
N
F
L
F
R
L
V
A
H
L
R
P
---
Q
S
P
H
I
T
----
A
-----
E
--------------------
K
----
M
A
-----------
A
-----------------
V
G
----
S
Q
---
F
E
G
D
D
K
I
E
L
---
L
C
G
L
S
V
------
L
E
L
C
L
I
I
A
I
-------
K
H
H
S
---
Q
----
I
---
Y
---
D
---------
R
-------
D
S
F
N
F
E
--------
I
I
Y
A
----------
R
F
-
S
K
F
A
K
V
STTMQAVER
S
I
V
--------
L
K
A
F
E
H
L
R
I
A
E
L
I
M
P
L
T
K
V
Q
K
E
F
E
M
H
K
L
ALT
Y
S
Q
I
H
H
C
M
Q
R
YQALPT
E
V
A
Q
W
A
QSS---------------------------------------------------------------------------------------------------------------------------
26
HHSearch
64.81
21%
-156
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[36-236]
-----------------------------------------------------------------------------
D
------------
E
V
W
V
V
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
G
---
N
V
-
L
V
I
T
A
I
A
K
F
E
---
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
-
A
D
L
V
M
G
L
A
V
------
V
P
F
G
A
A
H
I
-
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
--------
I
--
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
-
I
A
V
D
R
Y
F
--
A
I
T
S
P
--
F
K
Y
Q
S
L
L
T
K
----
N
K
A
R
V
I
I
L
M
V
W
--------
I
V
-
S
G
L
T
-------
S
F
L
P
I
----
Q
M
H
W
Y
R
A
T
H
----------------------------
Q
E
A
I
N
C
Y
A
E
----
E
T
C
-------------
C
-------
D
F
F
-
T
N
Q
A
Y
A
I
A
S
S
---
I
V
S
F
-----
Y
V
--------
P
L
V
I
M
V
F
V
Y
S
R
V
---
F
Q
E
A
K
R
----
Q
-----
L
--------------------
N
----
I
F
-----------
E
-----------------
M
L
----
R
I
---
D
E
G
L
R
L
K
I
Y
---
K
D
T
E
-
G
------
Y
Y
T
I
G
I
G
H
L
-------
L
T
K
S
---
P
----
S
---
L
---
N
---------
A
-------
A
K
S
E
L
D
--------
K
A
I
G
----------
R
N
-
T
N
G
V
-----------
I
T
K
--------
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
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