@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2J1_HUMAN: (2016-01-13 )
MLMKKNASFEDFFLLLGFSNWPHLEVVLFVVILIFYLITLIGNLFIIILSYLDSHLHTPMYFFLSNLSFLDLCYTTSSIPQLLVNLWGPEKTISYAGCTVQLYFVLALGTAECVLLVVMSYDRYAAVCRPLHYTVLMHPRFCRLLAAASWVSGFTTSALHSSFTFWIPLCRHRLVDHFFCEVPALLRLSCVDTQANELTLMVMSSIFVLIPLILILTSYGAIARAVLSMQSTTGLQKVLRTCGAHLMVVSLFFIPVMCMYLQPPSENSQDQGKFIALFYTVVTPSLNPLIYTFRNKDVRGAVKRLMGWEWGM
Atome Classification :
(20 SA)
.........10-----------.........20---------------........30........40........50........60........70.......-.80....------....90.....------...100.......110.......120.......130.......140.......150.......160.......170.......180.......190------..------......200.....--..210.......----220--.........230--------.-----------.--------------------.....240-------------.---......250---.----..---....-260..-.--.--..----.270.-------.---.....280.----......290.......300.......310------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLMKKNA
S
F
E
------------
D
F
F
L
L
L
GFSNW---------------
P
H
L
E
V
V
L
F
V
V
I
L
I
F
Y
L
I
T
L
I
G
N
L
F
I
I
I
L
S
Y
L
D
S
HLH
T
P
M
Y
F
F
L
SNL
S
F
L
D
L
CYTT
S
S
-
I
P
Q
L
L
V
N
------LWGPEK
T
I
SYA------
G
C
T
V
Q
L
Y
F
V
L
A
LGT
A
E
C
V
L
L
V
V
MSY
D
R
Y
A
A
V
CR
P
L
H
Y
T
V
LM
H
P
R
F
C
R
L
L
A
A
A
S
W
VSG
F
T
T
S
A
L
HSS
F
T
F
W
I
P
L
C
R
H
R
L
V
D
H
F
F
C
E
V
P
A
L
L
R
L
S
CV-------DT------QANE
L
T
L
M
V
M
S
S
I
F
--
V
L
I
P
L
I
L
I
L
TS
Y
----
G
----
A
I
A
R
A
V
L
S
M
QS
T
--------
T
-----------
G
--------------------
L
Q
K
V
L
R
TC-------------G---
A
H
L
M
V
V
S
L
F
---
F
----
I
P
---
V
M
C
M
-YLQPP-S--E--NS----QDQ
G
K
-------
F
---
I
A
L
F
Y
T
VVT----PSLN
P
L
I
Y
T
FRNK
D
V
R
G
A
V
K
R
L
MGWEWGM------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Fugue
97.07
20%
-127
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRS
P
F
E
A
P
Q
Y
Y
L
A
E
---------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--------------
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
----
Q
L
V
F
T
V
K
E
A
A
A
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
----
L
I
---
C
W
L
P
-
Y
A
G
V
A
-
F
--
Y
--
I
F
----
T
H
Q
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
94.48
21%
-153
- C1 -
3PWH
1
?
A:
[8-303]
-----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
-
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
-------
F
E
------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
----
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
-----------
T
--------------------
L
Q
K
E
V
H
A
A
-------------
K
---
S
A
A
I
I
A
G
L
F
A
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-
C
--
S
--
H
A
----
P
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.23
21%
-155
- C1 -
3REY
1
AA2AR_HUMAN
A:
[8-303]
-----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
-
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
-------
F
E
------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
----
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPGE
R
A
R
S
-----------
T
--------------------
L
Q
K
E
V
H
A
A
-------------
K
---
S
A
A
I
I
A
G
L
F
A
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-
C
--
S
--
H
A
----
P
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
93.06
21%
-151
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[8-303]
-----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
-
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
-------
F
E
------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
----
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPG
E
R
A
R
S
-----------
T
--------------------
L
Q
K
E
V
H
A
A
-------------
K
---
S
A
A
I
I
A
G
L
F
A
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-
C
--
S
--
H
A
----
P
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.84
21%
-153
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[8-303]
-----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
-
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
-------
F
E
------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
----
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPG
E
R
A
R
S
-----------
T
--------------------
L
Q
K
E
V
H
A
A
-------------
K
---
S
A
A
I
I
A
G
L
F
A
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-
C
--
S
--
H
A
----
P
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
92.72
21%
-153
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[8-303]
-----------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
--------------
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
--
T
P
M
L
G
W
N
N
-
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
-------
F
E
------
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
AC
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
----
A
A
R
R
Q
L
K
Q
M
E
S
Q
PLPG
E
R
A
R
S
-----------
T
--------------------
L
Q
K
E
V
H
A
A
-------------
K
---
S
A
A
I
I
A
G
L
F
A
L
C
W
----
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
-
C
--
S
--
H
A
----
P
L
W
L
M
-------
Y
---
L
A
I
V
L
A
H
T
N
----
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
91.03
20%
-127
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---
M
N
G
T
E
G
P
------------
N
F
Y
V
P
F
S
N
K
T
G
VVRSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
----
Q
L
V
F
T
V
K
E
A
A
A
Q
--------
Q
-----------
Q
ESA
T
----------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
----
L
I
---
C
W
L
P
-
Y
A
G
V
A
-
F
--
Y
--
I
F
----
T
H
Q
G
S
DFGPIFM
T
---
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
LGDDEA
S
T
T
V
S
K
TETSQVAPA---------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
89.21
17%
-143
- C1 -
2Z73
5
OPSD_TODPA
A:
[33-332]
--------------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
------
C
F
L
K
K
W
I
F
G
F
A
------
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
------
S
T
T
R
S
N
I
L
C
M
F
I
L
G
--
F
F
G
P
I
L
I
I
F
F
C
Y
----
F
----
N
I
V
M
S
V
S
N
H
E
K
E
--------
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
L
A
K
I
S
-------------
I
---
V
I
V
S
Q
F
L
L
S
---
W
----
S
P
---
Y
A
V
V
-
A
L
L
A
Q
-
F
G-
P
LE
W
V
----
T
P
Y
A
A
-------
Q
---
L
P
V
M
F
A
K
A
S
----
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
84.09
21%
-157
- C1 -
3DQB
4
GNAT1_BOVIN (first)
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
83.72
21%
-152
- C1 -
1F88
7
OPSD_BOVIN
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
I
DYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
VF
T
V
K
E
A
A
A
----
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.06
21%
-156
- C1 -
3PQR
9
OPSD_BOVIN
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.69
21%
-148
- C1 -
3C9L
13
OPSD_BOVIN
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
FM
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
82.09
21%
-154
- C1 -
3CAP
4
OPSD_BOVIN
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
82.07
21%
-156
- C1 -
3PXO
4
OPSD_BOVIN
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
81.25
21%
-156
- C1 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[40-314]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
GYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
F
M
T
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
80.60
16%
-123
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
---------------
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
------
I
L
M
K
M
W
T
F
G
N
F
------
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
--
T
H
Q
E
A
I
N
C
Y
A
E
-----
E
T
C
C
D
-------
F
F
------
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
---
Y
V
P
L
V
I
M
V
F
V
Y
----
S
----
R
V
F
Q
E
A
K
R
Q
--
L
--------
N
-----------
I
--------------------
F
E
M
L
R
I
D
E
-------------
G
---
L
R
L
K
I
Y
K
D
T
---
E
----
G
Y
---
Y
T
I
G
-
I
G
H
L
L
-
T
--
K
--
S
P
----
S
L
N
A
A
-------
K
---
S
E
L
D
K
A
I
G
R
NTNG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
29
HHSearch
78.71
14%
-145
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
-----------------------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
------
A
V
H
N
E
W
Y
Y
G
L
F
------
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
---
E
-
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
P
----------
N
K
------
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
--
Y
F
L
P
L
L
V
I
G
Y
A
Y
----
T
----
V
V
G
I
T
L
W
A
S
E
I
P
--------
G
DSSDRYH
E
Q
V
S
A
--------------------
K
R
K
V
V
K
M
M
-------------
I
---
V
V
V
C
T
F
A
I
C
---
W
----
L
P
---
F
H
I
F
-
F
L
L
P
Y
-
I
NP
D
--
L
Y
LKKF
I
Q
Q
V
Y
-------
L
---
A
I
M
W
L
A
M
S
S
----
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
78.13
18%
-132
* C1 *
1U19
14
OPSD_BOVIN
A:
[42-326]
-----------------------------------------------------
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
------
S
L
H
G
Y
F
V
F
G
P
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
---
I
-
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
-------
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
----
Q
L
V
F
T
V
K
E
A
A
A
Q
--------
Q
-----------
Q
ESA
T
T
---------------
Q
K
A
E
K
E
V
T
-------------
R
M
V
I
I
M
V
I
A
F
L
I
C
---
W
----
L
P
---
Y
A
G
V
-
A
F
Y
I
F
T
H
--
Q
GS
D
F
----
G
P
I
F
M
-------
T
---
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.38
21%
-130
- C1 -
1LN6
1
OPSD_BOVIN
A:
[40-312]
--------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
----
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
SLHGYF
V
F
G
P
------
T
------
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
--
P
P
L
V
G
W
---
S
R
Y
---------
I
P
E
G
M
Q
C
S
C
G
IDYYTPH
E
E
------
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
----
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
E
S
--------
A
-----------
T
--------------------
T
Q
K
A
E
K
E
V
-------------
T
---
R
M
V
I
I
M
V
I
A
---
F
LICW
L
P
---
Y
A
G
V
-
A
F
Y
I
F
-
T
--
H
--
Q
G
----
S
D
F
G
P
-------
I
FMT
I
P
A
F
F
A
K
T
S
----
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
V
A
T
T
L
C
C
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
73.51
15%
-120
- C1 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-------
S
F
K
------------
C
A
L
T
K
T
G
F
Q
F
Y
---------------
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
-----
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
L
-
P
A
L
I
F
Y
Y
------
F
N
K
T
D
W
I
F
G
D
A
------
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
--------------
I
L
F
Y
S
G
T
G
V
R
K
N
K
T
I
T
C
Y
-------
D
T
TSDEY
L
R
S
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
G
C
Y
----
G
----
L
I
V
R
A
L
I
Y
K
M
K
K
--------
Y
-----------
T
--------------------
C
T
V
C
G
Y
I
Y
N
PEDGDPDNGVNP
G
---
T
D
F
K
D
I
V
C
P
---
L
----
C
G
---
V
G
K
D
-
Q
F
E
E
V
-
E
--
E
--
P
L
----
R
R
K
S
I
-------
Y
---
L
V
I
I
V
L
T
V
F
----
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
LAGDTFRRR------------------------------------------------------------------------------------------------------------------------